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The map label for this gene is hisG

Identifier: 15603060

GI number: 15603060

Start: 1390300

End: 1391199

Strand: Direct

Name: hisG

Synonym: PM1195

Alternate gene names: 15603060

Gene position: 1390300-1391199 (Clockwise)

Preceding gene: 15603059

Following gene: 15603061

Centisome position: 61.59

GC content: 43.44

Gene sequence:

>900_bases
ATGATTGAAAGTAAAAGACTGCGCATTGCGATGCAAAAATCAGGACGCTTAAGCCAAGAATCACAAGCCTTATTGAAACA
ATGCGGTGTAAAAATAAATTTACAGGAACAACGCCTAATTGCTTACGCTGAAAATATGCCGATTGATATTTTACGGGTGC
GTGACGATGATATTCCCGGTCTCGTCTTTGATGGTGTGGTTGATCTCGGGATCATTGGTGAAAACGTCTTAGAAGAGGAA
GAACTCACTCGTCAAGCTGCTGGTGAAACAGTCAATTACAAAAAATTACGCCGTTTAGATTTTGGCGGTTGCCGTTTATC
AATCGCCATACCGCAAGACGAAGCTTACAATGGCATAAGTGATCTCAAAAATGCACGTATTGCTACCTCTTACCCGAATT
TACTCAAACGTTATATGCAACAACAAGGTGTGGATTTTAAAACCTGTTCACTCACAGGATCAGTGGAAGTCGCGCCCCGT
GCCGGACTTGCCGATGCGATTTGTGATTTAGTGTCTTCTGGTGCCACACTTGAAGCTAATGGTTTAAAGGAAGTGGAAAT
CATTTACCGCTCAAAATCCTGCCTCATTCAACGTGCCGCTGAACTTAGCCCAGAAAAACAAGCCTTAGTGGATAAGTTAC
TCACACGCATCCAAGGTGTACAACAAGCGGCAGAATCAAAATACATCATGCTTCACGCCCCAAAAGAAAAACTGGAAGAA
ATCACCGCACTTTTACCCGGCGTGGAAAACCCCACTATTTTGCCATTAGCACACGACAATTCGAAAGTCGCTATGCATGT
CGTCAGTCAAGAAAATCTGTTCTGGGAAACCATGGAACAGCTGAAAGATGCTGGCGCCAGTTCGATTTTAGTGCTACCAA
TTGAGAAAATGATGGGGTAA

Upstream 100 bases:

>100_bases
CGAGTGTGCGATAAAATGACGAACAATATAAACCTCTCGGAAGCCATTTCGAGAGGTTTTTTTATCACTAAAATTAACAA
CATCTACTAGGATAAGAATT

Downstream 100 bases:

>100_bases
CTTGATGCCATTTACACTTTCACAACAACAATCGCTGTTAGCACAAAAAGGCATCGGCACCACCATTCTCAAACGCTTGC
AAGAGATGGGGCTAGATGAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MIESKRLRIAMQKSGRLSQESQALLKQCGVKINLQEQRLIAYAENMPIDILRVRDDDIPGLVFDGVVDLGIIGENVLEEE
ELTRQAAGETVNYKKLRRLDFGGCRLSIAIPQDEAYNGISDLKNARIATSYPNLLKRYMQQQGVDFKTCSLTGSVEVAPR
AGLADAICDLVSSGATLEANGLKEVEIIYRSKSCLIQRAAELSPEKQALVDKLLTRIQGVQQAAESKYIMLHAPKEKLEE
ITALLPGVENPTILPLAHDNSKVAMHVVSQENLFWETMEQLKDAGASSILVLPIEKMMG

Sequences:

>Translated_299_residues
MIESKRLRIAMQKSGRLSQESQALLKQCGVKINLQEQRLIAYAENMPIDILRVRDDDIPGLVFDGVVDLGIIGENVLEEE
ELTRQAAGETVNYKKLRRLDFGGCRLSIAIPQDEAYNGISDLKNARIATSYPNLLKRYMQQQGVDFKTCSLTGSVEVAPR
AGLADAICDLVSSGATLEANGLKEVEIIYRSKSCLIQRAAELSPEKQALVDKLLTRIQGVQQAAESKYIMLHAPKEKLEE
ITALLPGVENPTILPLAHDNSKVAMHVVSQENLFWETMEQLKDAGASSILVLPIEKMMG
>Mature_299_residues
MIESKRLRIAMQKSGRLSQESQALLKQCGVKINLQEQRLIAYAENMPIDILRVRDDDIPGLVFDGVVDLGIIGENVLEEE
ELTRQAAGETVNYKKLRRLDFGGCRLSIAIPQDEAYNGISDLKNARIATSYPNLLKRYMQQQGVDFKTCSLTGSVEVAPR
AGLADAICDLVSSGATLEANGLKEVEIIYRSKSCLIQRAAELSPEKQALVDKLLTRIQGVQQAAESKYIMLHAPKEKLEE
ITALLPGVENPTILPLAHDNSKVAMHVVSQENLFWETMEQLKDAGASSILVLPIEKMMG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=298, Percent_Identity=74.496644295302, Blast_Score=456, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320896, Length=297, Percent_Identity=28.6195286195286, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PASMU (P57919)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246132.1
- ProteinModelPortal:   P57919
- SMR:   P57919
- GeneID:   1244542
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1195
- NMPDR:   fig|272843.1.peg.1195
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- BioCyc:   PMUL272843:PM1195-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 33033; Mature: 33033

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESKRLRIAMQKSGRLSQESQALLKQCGVKINLQEQRLIAYAENMPIDILRVRDDDIPG
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHCCCCEEEEEECCCCCCC
LVFDGVVDLGIIGENVLEEEELTRQAAGETVNYKKLRRLDFGGCRLSIAIPQDEAYNGIS
CHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCCHHCCCHH
DLKNARIATSYPNLLKRYMQQQGVDFKTCSLTGSVEVAPRAGLADAICDLVSSGATLEAN
HHCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEECC
GLKEVEIIYRSKSCLIQRAAELSPEKQALVDKLLTRIQGVQQAAESKYIMLHAPKEKLEE
CCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
ITALLPGVENPTILPLAHDNSKVAMHVVSQENLFWETMEQLKDAGASSILVLPIEKMMG
HHHHHCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECHHHCC
>Mature Secondary Structure
MIESKRLRIAMQKSGRLSQESQALLKQCGVKINLQEQRLIAYAENMPIDILRVRDDDIPG
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHCCCCEEEEEECCCCCCC
LVFDGVVDLGIIGENVLEEEELTRQAAGETVNYKKLRRLDFGGCRLSIAIPQDEAYNGIS
CHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCCHHCCCHH
DLKNARIATSYPNLLKRYMQQQGVDFKTCSLTGSVEVAPRAGLADAICDLVSSGATLEAN
HHCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEECC
GLKEVEIIYRSKSCLIQRAAELSPEKQALVDKLLTRIQGVQQAAESKYIMLHAPKEKLEE
CCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
ITALLPGVENPTILPLAHDNSKVAMHVVSQENLFWETMEQLKDAGASSILVLPIEKMMG
HHHHHCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100