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The map label for this gene is groEL [H]

Identifier: 15602972

GI number: 15602972

Start: 1302012

End: 1303655

Strand: Direct

Name: groEL [H]

Synonym: PM1107

Alternate gene names: 15602972

Gene position: 1302012-1303655 (Clockwise)

Preceding gene: 15602971

Following gene: 15602973

Centisome position: 57.68

GC content: 43.98

Gene sequence:

>1644_bases
ATGGCAGCAAAAGACGTAAAATTTGGTAATGATGCACGTGTCAAAATGTTAGCGGGTGTCAATATTCTTGCGGATGCAGT
AAAAGTTACCTTAGGTCCTAAAGGTCGTAATGTCGTATTAGATAAATCTTTCGGTGCACCGACTATCACTAAAGATGGTG
TATCAGTGGCGCGTGAAATCGAATTAGAAGATAAATTCGAAAATATGGGTGCACAAATGGTAAAAGAAGTGGCGTCAAAA
GCGAATGATGCGGCAGGTGACGGTACCACGACAGCAACCGTTTTAGCACAAGCTATCGTCAATGAAGGCTTAAAAGCGGT
GGCAGCGGGTATGAACCCAATGGATTTAAAACGTGGTATCGACAAAGCGGTAACCGCAGTGGTTACAGAATTAAAAGCCC
TTTCAAAACCTTGTGAAACCTCAAAAGAAATCGAACAAGTGGGAACAATCTCTGCTAACTCAGACAGTATTGTTGGTCAA
ATCATTGCACAAGCGATGGATAAAGTAGGTAAAGAAGGCGTGATCACCGTTGAAGATGGCACAGGTTTAGAAGACGAACT
TGCCGTTGTAGAAGGGATGCAATTCGATCGCGGTTATTTATCACCTTACTTCATCAACAAACCAGAAACAGCAACAGTTG
AATTAGACAATCCATTTATTTTATTAGTGGACAAAAAAGTGTCCAACATTCGTGAATTGTTACCGGTGTTAGAAGGTGTA
GCAAAAGCGGGCAAACCATTATTAATTATCGCAGAAGATGTCGAAGGTGAAGCACTTGCAACCTTAGTCGTGAACACAAT
GCGTGGAATTGTGAAAGTCGCAGCAGTGAAAGCACCTGGCTTTGGTGACCGTCGTAAAGCCATGTTACAAGATATCGCGA
TCTTAACGGCTGGTACGGTTATTTCTGAAGAAATCGGTATGGAATTAGAAAAAGCCACACTTGAAGATCTTGGTCAAGCA
AAACGTGTAGTCATCAACAAAGACAATACCACGATTATTGATGGTATCGGTGACGAAGCACAAATCCAAGGTCGTGTGGC
ACAAATTCGTCAACAAATCGAAGAATCCACCTCTGATTACGACAAAGAAAAATTACAAGAGCGCGTAGCTAAACTCGCTG
GCGGTGTCGCAGTTATTAAAGTGGGTGCAGCAACCGAAGTAGAAATGAAAGAGAAAAAAGCGCGCGTAGAAGACGCACTC
CACGCAACACGTGCGGCGGTTGAAGAAGGTATCGTTGCTGGTGGTGGTGTTGCCTTAATCCGTGCCGCTAGCAAAGTCGC
TGGTCTTCAAGGTGATAATGAAGAACAAAATGTGGGAATCAAACTTGCCTTACGTGCAATGGAAGCCCCATTACGTCAGA
TCGTAGCCAACGCAGGTGAAGAAGCGTCTATCGTAGCAAGTGCAGTGAAAAATGGCGAAGGTAACTTCGGTTATAACGCA
GGTACAGAACAGTACGGCGATATGATCGAAATGGGTATCTTAGACCCAACAAAAGTTACCCGTTCTGCATTACAATTTGC
GGCTTCTGTTGCTGGCTTAATGATCACCACTGAATGTATGGTCACTGACCTACCAAAAGAGGATAAAGCCGACTTAGGTG
CTGCTGGTATGGGTGGCATGGGTGGTATGGGCGGTATGATGTAA

Upstream 100 bases:

>100_bases
AATAATTTTTATCAACAACACAAAATCGTTATTTCTATAAATAAACAAACTTAAAATAGCAATTTGCATAACAAGATTCG
AAATGAGAGGAAGATAAAAA

Downstream 100 bases:

>100_bases
TCTTCCCCCTTTTCACATACGAAAAAAGGATTGAGTATAACGCTCAATCCTTTTTTATTCGTTAAATTCGATATATTACA
TTTTATATAATGATTATGTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVKFGNDARVKMLAGVNILADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVTAVVTELKALSKPCETSKEIEQVGTISANSDSIVGQ
IIAQAMDKVGKEGVITVEDGTGLEDELAVVEGMQFDRGYLSPYFINKPETATVELDNPFILLVDKKVSNIRELLPVLEGV
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEDLGQA
KRVVINKDNTTIIDGIGDEAQIQGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRAASKVAGLQGDNEEQNVGIKLALRAMEAPLRQIVANAGEEASIVASAVKNGEGNFGYNA
GTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKEDKADLGAAGMGGMGGMGGMM

Sequences:

>Translated_547_residues
MAAKDVKFGNDARVKMLAGVNILADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVTAVVTELKALSKPCETSKEIEQVGTISANSDSIVGQ
IIAQAMDKVGKEGVITVEDGTGLEDELAVVEGMQFDRGYLSPYFINKPETATVELDNPFILLVDKKVSNIRELLPVLEGV
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEDLGQA
KRVVINKDNTTIIDGIGDEAQIQGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRAASKVAGLQGDNEEQNVGIKLALRAMEAPLRQIVANAGEEASIVASAVKNGEGNFGYNA
GTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKEDKADLGAAGMGGMGGMGGMM
>Mature_546_residues
AAKDVKFGNDARVKMLAGVNILADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKA
NDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVTAVVTELKALSKPCETSKEIEQVGTISANSDSIVGQI
IAQAMDKVGKEGVITVEDGTGLEDELAVVEGMQFDRGYLSPYFINKPETATVELDNPFILLVDKKVSNIRELLPVLEGVA
KAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEDLGQAK
RVVINKDNTTIIDGIGDEAQIQGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALIRAASKVAGLQGDNEEQNVGIKLALRAMEAPLRQIVANAGEEASIVASAVKNGEGNFGYNAG
TEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKEDKADLGAAGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=52.0833333333333, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=52.0833333333333, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI5453607, Length=539, Percent_Identity=21.7068645640074, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=89.0977443609023, Blast_Score=942, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=52.4621212121212, Blast_Score=552, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=51.4285714285714, Blast_Score=214, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.8022813688213, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322524, Length=180, Percent_Identity=26.1111111111111, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.9411764705882, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.9411764705882, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=51.8026565464896, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=51.8026565464896, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=51.8026565464896, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI17864606, Length=554, Percent_Identity=43.5018050541516, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=36.6037735849057, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=36.6037735849057, Blast_Score=335, Evalue=7e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57292; Mature: 57160

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGNDARVKMLAGVNILADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREI
CCCCCCCCCCCCCEEEECCHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHC
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVTAVVTELKALSKPCETSKEIEQVGTISANSDSIVGQIIAQAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
TGLEDELAVVEGMQFDRGYLSPYFINKPETATVELDNPFILLVDKKVSNIRELLPVLEGV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEIGMELEKATLEDLGQAKRVVINKDNTTIIDGIGDEAQIQGRVAQIRQQIEESTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVAGLQGDNEEQNVGIKLALRAMEAPLRQIVANAGEEASIVASAVKNGEGNFGYNA
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
GTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKEDKADLGAAGMGGM
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGMGGMM
CCCCCCC
>Mature Secondary Structure 
AAKDVKFGNDARVKMLAGVNILADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREI
CCCCCCCCCCCCEEEECCHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHC
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVTAVVTELKALSKPCETSKEIEQVGTISANSDSIVGQIIAQAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
TGLEDELAVVEGMQFDRGYLSPYFINKPETATVELDNPFILLVDKKVSNIRELLPVLEGV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEIGMELEKATLEDLGQAKRVVINKDNTTIIDGIGDEAQIQGRVAQIRQQIEESTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVAGLQGDNEEQNVGIKLALRAMEAPLRQIVANAGEEASIVASAVKNGEGNFGYNA
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
GTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKEDKADLGAAGMGGM
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGMGGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA