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The map label for this gene is lacA [H]

Identifier: 15602921

GI number: 15602921

Start: 1244495

End: 1245106

Strand: Reverse

Name: lacA [H]

Synonym: PM1056

Alternate gene names: 15602921

Gene position: 1245106-1244495 (Counterclockwise)

Preceding gene: 15602922

Following gene: 15602920

Centisome position: 55.15

GC content: 40.85

Gene sequence:

>612_bases
ATGTTGACAGACAAAGAAAAACGACATTTAGGTTTAGCGCATCAGCCTTATGATCCGGAATTGGCAGAGATGCGTTTACG
TAATAAAGAATTATTGCATGAATATAATGTGTTAACTCGCCCTTCAGATAAACAAACAAAAGCCCGTTTGATCTTATCTA
TTCTTGGTAAAGCTGCGAATACACCTCACATTAATACGCCTTTTTATTGTGATTACGGGCAATTTATTGAAGTCGGAAAA
AACTTTTTTGCGAATTATCACTGTACTATCCTAGATACAGGAGGCGTGAAGATTGGCGATGATGTGTTATTTGCTCCGAA
TGTGAGTTTATACACCGTAGGGCATCCAATTGATCCTGAATTGCGTAAGGCAGAATGGGAACAAGCACTACCCATTGTGA
TTGGGAATAATGTGTGGATTGGGGGCAATGTGGTGATTTTAGGCGGCGTTACTATTGGTGACAATACTGTGATTGGGGCG
GGTTCTGTGGTCACAAAAGATATTCCGGCAAATTGTGTAGCCGTGGGCAATCCATGTAAAGTACAACGAATGATTAGCCC
GCAGGACCGAGAGGATTATTTACAACGTTTTAAACCAGACTGGAATGATTGA

Upstream 100 bases:

>100_bases
TGGTATTTGAAGATGCTGATTTAGGTGTTCAAGCAGGACTTGCAGCAGGTATGCATGTTTTTGATGTCAGAACCCATACA
TTAATCACAGAGTAACAACG

Downstream 100 bases:

>100_bases
TTTTTGGACATGGGATTTTTGGCAACAACATAGCTTATGGTTTATGTTTGCTAGTGCCTTTTTGAGTGCCACGCTTTTAC
CCGGTAATTCAGAAATCGTG

Product: hypothetical protein

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLTDKEKRHLGLAHQPYDPELAEMRLRNKELLHEYNVLTRPSDKQTKARLILSILGKAANTPHINTPFYCDYGQFIEVGK
NFFANYHCTILDTGGVKIGDDVLFAPNVSLYTVGHPIDPELRKAEWEQALPIVIGNNVWIGGNVVILGGVTIGDNTVIGA
GSVVTKDIPANCVAVGNPCKVQRMISPQDREDYLQRFKPDWND

Sequences:

>Translated_203_residues
MLTDKEKRHLGLAHQPYDPELAEMRLRNKELLHEYNVLTRPSDKQTKARLILSILGKAANTPHINTPFYCDYGQFIEVGK
NFFANYHCTILDTGGVKIGDDVLFAPNVSLYTVGHPIDPELRKAEWEQALPIVIGNNVWIGGNVVILGGVTIGDNTVIGA
GSVVTKDIPANCVAVGNPCKVQRMISPQDREDYLQRFKPDWND
>Mature_203_residues
MLTDKEKRHLGLAHQPYDPELAEMRLRNKELLHEYNVLTRPSDKQTKARLILSILGKAANTPHINTPFYCDYGQFIEVGK
NFFANYHCTILDTGGVKIGDDVLFAPNVSLYTVGHPIDPELRKAEWEQALPIVIGNNVWIGGNVVILGGVTIGDNTVIGA
GSVVTKDIPANCVAVGNPCKVQRMISPQDREDYLQRFKPDWND

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=178, Percent_Identity=49.438202247191, Blast_Score=173, Evalue=6e-45,
Organism=Escherichia coli, GI1786664, Length=181, Percent_Identity=45.3038674033149, Blast_Score=159, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322243, Length=173, Percent_Identity=53.757225433526, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 22624; Mature: 22624

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDKEKRHLGLAHQPYDPELAEMRLRNKELLHEYNVLTRPSDKQTKARLILSILGKAAN
CCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
TPHINTPFYCDYGQFIEVGKNFFANYHCTILDTGGVKIGDDVLFAPNVSLYTVGHPIDPE
CCCCCCCEEECCHHHHHHHHHHHCCEEEEEEECCCEEECCCEEECCCCEEEECCCCCCHH
LRKAEWEQALPIVIGNNVWIGGNVVILGGVTIGDNTVIGAGSVVTKDIPANCVAVGNPCK
HHHHHHHHCCCEEECCCEEECCCEEEEEEEEECCCEEEECCCEEECCCCCCEEEECCCCE
VQRMISPQDREDYLQRFKPDWND
EEECCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MLTDKEKRHLGLAHQPYDPELAEMRLRNKELLHEYNVLTRPSDKQTKARLILSILGKAAN
CCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
TPHINTPFYCDYGQFIEVGKNFFANYHCTILDTGGVKIGDDVLFAPNVSLYTVGHPIDPE
CCCCCCCEEECCHHHHHHHHHHHCCEEEEEEECCCEEECCCEEECCCCEEEECCCCCCHH
LRKAEWEQALPIVIGNNVWIGGNVVILGGVTIGDNTVIGAGSVVTKDIPANCVAVGNPCK
HHHHHHHHCCCEEECCCEEECCCEEEEEEEEECCCEEEECCCEEECCCCCCEEEECCCCE
VQRMISPQDREDYLQRFKPDWND
EEECCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]