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The map label for this gene is ppiB [H]

Identifier: 15602808

GI number: 15602808

Start: 1114225

End: 1114776

Strand: Reverse

Name: ppiB [H]

Synonym: PM0943

Alternate gene names: 15602808

Gene position: 1114776-1114225 (Counterclockwise)

Preceding gene: 15602809

Following gene: 15602807

Centisome position: 49.38

GC content: 40.4

Gene sequence:

>552_bases
ATGTTAAGAATAATTACCGCACTTTTGCTTGCTGGTGTTGTTTGTGTTGCTCAAGCAAAGAATGTGGTTTTACATACAAA
TTATGGCGATATTAAAATGGTGTTAGAAGAGGAGAAAGCGCCCATTAGCACTCAGAATTTTCTACGTTATAGCCAAGCGG
GATTTTATAACGGTACGATTTTTCATCGTGTTATTCCCGGTTTTATGATTCAAGCTGGGGGATTTGAGGTTGGGATGAAG
CAAAAGAAAACCGACGCGCCTATTACAAATGAGGCGAATAATGGTTTGAAAAATTTGCGCGGTACTGTTGCAATGGCACG
GACGTCTGATCCACATTCTGCCACAGCGCAATTCTTTATTAATACAGTTGACAATGATTTTTTGAATTTTAGTGCAGAAA
CGCAAAAAGGTTGGGGATATGCGGTTTTTGCTAACGTAGTGGCAGGTATGGACGTGGTTGATCGTATTAGCCAAGTAGAT
ACTGAGCGATCAGGATTTCACCGTGATGTACCAAAAGCGCCAGTGATCATTAAAAGTGTCACTATTGAATAG

Upstream 100 bases:

>100_bases
CCAAGATGTACCACAAGAAGCCATCGTGATTACTGCAGTGACCGTTGAATAATCAGTCTCTCCCCTCGTAATTGAGGGGA
TTCTTTTAGGAGAAGAGAAA

Downstream 100 bases:

>100_bases
AGCAAGGCTAGCATCACTTTTATGGGCGCGATAGCGGGTCGTTATTTTGATTATTCAGGGAAAATAACTCTCTAGTTCTA
ATGCATAAGAATGAATAGAA

Product: hypothetical protein

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLRIITALLLAGVVCVAQAKNVVLHTNYGDIKMVLEEEKAPISTQNFLRYSQAGFYNGTIFHRVIPGFMIQAGGFEVGMK
QKKTDAPITNEANNGLKNLRGTVAMARTSDPHSATAQFFINTVDNDFLNFSAETQKGWGYAVFANVVAGMDVVDRISQVD
TERSGFHRDVPKAPVIIKSVTIE

Sequences:

>Translated_183_residues
MLRIITALLLAGVVCVAQAKNVVLHTNYGDIKMVLEEEKAPISTQNFLRYSQAGFYNGTIFHRVIPGFMIQAGGFEVGMK
QKKTDAPITNEANNGLKNLRGTVAMARTSDPHSATAQFFINTVDNDFLNFSAETQKGWGYAVFANVVAGMDVVDRISQVD
TERSGFHRDVPKAPVIIKSVTIE
>Mature_183_residues
MLRIITALLLAGVVCVAQAKNVVLHTNYGDIKMVLEEEKAPISTQNFLRYSQAGFYNGTIFHRVIPGFMIQAGGFEVGMK
QKKTDAPITNEANNGLKNLRGTVAMARTSDPHSATAQFFINTVDNDFLNFSAETQKGWGYAVFANVVAGMDVVDRISQVD
TERSGFHRDVPKAPVIIKSVTIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=171, Percent_Identity=31.5789473684211, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=31.0975609756098, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=31.0975609756098, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=31.0975609756098, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI24308049, Length=168, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=33.5329341317365, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=69.5652173913043, Blast_Score=232, Evalue=1e-62,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=56.7901234567901, Blast_Score=191, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17506311, Length=185, Percent_Identity=33.5135135135135, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=33.8028169014084, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=33.8028169014084, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=170, Percent_Identity=31.7647058823529, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=160, Percent_Identity=30.625, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922912, Length=137, Percent_Identity=37.2262773722628, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17986117, Length=169, Percent_Identity=29.585798816568, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24652460, Length=166, Percent_Identity=28.3132530120482, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20067; Mature: 20067

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIITALLLAGVVCVAQAKNVVLHTNYGDIKMVLEEEKAPISTQNFLRYSQAGFYNGTI
CHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCH
FHRVIPGFMIQAGGFEVGMKQKKTDAPITNEANNGLKNLRGTVAMARTSDPHSATAQFFI
HHHHHCCCEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCCCHHHHHEE
NTVDNDFLNFSAETQKGWGYAVFANVVAGMDVVDRISQVDTERSGFHRDVPKAPVIIKSV
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEEE
TIE
ECC
>Mature Secondary Structure
MLRIITALLLAGVVCVAQAKNVVLHTNYGDIKMVLEEEKAPISTQNFLRYSQAGFYNGTI
CHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCH
FHRVIPGFMIQAGGFEVGMKQKKTDAPITNEANNGLKNLRGTVAMARTSDPHSATAQFFI
HHHHHCCCEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCCCHHHHHEE
NTVDNDFLNFSAETQKGWGYAVFANVVAGMDVVDRISQVDTERSGFHRDVPKAPVIIKSV
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEEE
TIE
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]