Click here to switch to the map view.

The map label for this gene is lpxK

Identifier: 15602725

GI number: 15602725

Start: 1011033

End: 1012010

Strand: Reverse

Name: lpxK

Synonym: PM0860

Alternate gene names: 15602725

Gene position: 1012010-1011033 (Counterclockwise)

Preceding gene: 15602726

Following gene: 15602724

Centisome position: 44.83

GC content: 41.62

Gene sequence:

>978_bases
ATGCAATTTTGGTATTCACGCACGTGGATCACTTGGTTGATGCTGCCACTTTCTTTTTTATTTTGGCTTATCAGTACCTG
CCGCCAGTTCCTCTTTAGAAAAGGGATATTCGCCTCTTATCGCGCGCCTGTGCCCGTGATTGTCGTAGGAAATCTTTCTG
TGGGGGGAAACGGTAAAACCCCTGTCGTTATTTGGCTGGTCAAACAGTTACAACAAAAAGGTCTCAAGGTTGGTGTGATT
TCTCGTGGCTACGGAAGCCAATCATCTGTGTATCCCTTACTTGTGACGCCAGACACGGATCCCATTCAGGGGGGCGATGA
ACCTGTCCTTATTGCAAAACGTACACAAGTCCCTGTTTGTATTTCTGCTAATCGTCAACATGCCATTGAATTGTTATTAC
AGCATCAACCTGATTGTGATTTGATCATTAGTGATGATGGATTACAGCATTATAGATTACAACGTGATTTTGAAATTGTG
GTGCTCGATGTACAACGTGGATTCGGTAATGGCTTTTTACTACCTGCTGGACCATTACGTGAGTTACCAAGCCGTTTAAA
TACAGTAGATCTGATTATTTGTCATGGTCAGGCGAGCAAGTATAGTGATGTAGAAATGACACTTGTACCTCATCATGCCA
TTAATCTTGTGACAGGTGAATCACGCTTATTGAGTGATTTCCATCGTGTTTCTGCTATTGCGGGTATTGGGCATCCACAA
CGTTTTTTCTCGATGTTAGAAAACTTATCAATGCAATTAATTCAAACCAAAGCGTTTCAAGATCATCAAACGTTTGAGGC
AGCACAATTTGTCGATTTTGATCAAACTCAGCCTTTGTTAATGACGGAAAAAGATGCGGTCAAATGTCTGTCTTTTGCGC
AAAAGAATTGGTGGTATGTCCCCGTAGAGGCAGAGATTAAAGGTGAAAAAGTGCGGTCATTTTTGGCAAAATTTGATGAA
ATTCGCAAAACAGTATGA

Upstream 100 bases:

>100_bases
TCACATAGCGAACTGCTTGCATTAAATGGTGCATACAAACAGTTACATCATATTCAAGTTAATCATTAATTCTTTTTAAC
TATCACAGAAAGGGGTATCT

Downstream 100 bases:

>100_bases
AGTGAGGAAACATGGATTCAACATTATTAGAGATTGTCGCTTGTCCTATTTGTCATGGGCGTTTAGCGCTTGATCAAACC
AGCCAGAAATTAGTCTGTCA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MQFWYSRTWITWLMLPLSFLFWLISTCRQFLFRKGIFASYRAPVPVIVVGNLSVGGNGKTPVVIWLVKQLQQKGLKVGVI
SRGYGSQSSVYPLLVTPDTDPIQGGDEPVLIAKRTQVPVCISANRQHAIELLLQHQPDCDLIISDDGLQHYRLQRDFEIV
VLDVQRGFGNGFLLPAGPLRELPSRLNTVDLIICHGQASKYSDVEMTLVPHHAINLVTGESRLLSDFHRVSAIAGIGHPQ
RFFSMLENLSMQLIQTKAFQDHQTFEAAQFVDFDQTQPLLMTEKDAVKCLSFAQKNWWYVPVEAEIKGEKVRSFLAKFDE
IRKTV

Sequences:

>Translated_325_residues
MQFWYSRTWITWLMLPLSFLFWLISTCRQFLFRKGIFASYRAPVPVIVVGNLSVGGNGKTPVVIWLVKQLQQKGLKVGVI
SRGYGSQSSVYPLLVTPDTDPIQGGDEPVLIAKRTQVPVCISANRQHAIELLLQHQPDCDLIISDDGLQHYRLQRDFEIV
VLDVQRGFGNGFLLPAGPLRELPSRLNTVDLIICHGQASKYSDVEMTLVPHHAINLVTGESRLLSDFHRVSAIAGIGHPQ
RFFSMLENLSMQLIQTKAFQDHQTFEAAQFVDFDQTQPLLMTEKDAVKCLSFAQKNWWYVPVEAEIKGEKVRSFLAKFDE
IRKTV
>Mature_325_residues
MQFWYSRTWITWLMLPLSFLFWLISTCRQFLFRKGIFASYRAPVPVIVVGNLSVGGNGKTPVVIWLVKQLQQKGLKVGVI
SRGYGSQSSVYPLLVTPDTDPIQGGDEPVLIAKRTQVPVCISANRQHAIELLLQHQPDCDLIISDDGLQHYRLQRDFEIV
VLDVQRGFGNGFLLPAGPLRELPSRLNTVDLIICHGQASKYSDVEMTLVPHHAINLVTGESRLLSDFHRVSAIAGIGHPQ
RFFSMLENLSMQLIQTKAFQDHQTFEAAQFVDFDQTQPLLMTEKDAVKCLSFAQKNWWYVPVEAEIKGEKVRSFLAKFDE
IRKTV

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=318, Percent_Identity=47.4842767295598, Blast_Score=318, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_PASMU (Q9CMG8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245797.1
- ProteinModelPortal:   Q9CMG8
- GeneID:   1244207
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0860
- NMPDR:   fig|272843.1.peg.860
- HOGENOM:   HBG663914
- OMA:   GNIHAGG
- ProtClustDB:   PRK00652
- BioCyc:   PMUL272843:PM0860-MONOMER
- BRENDA:   2.7.1.130
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36839; Mature: 36839

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFWYSRTWITWLMLPLSFLFWLISTCRQFLFRKGIFASYRAPVPVIVVGNLSVGGNGKT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEECEEECCCCCC
PVVIWLVKQLQQKGLKVGVISRGYGSQSSVYPLLVTPDTDPIQGGDEPVLIAKRTQVPVC
CEEEHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCEE
ISANRQHAIELLLQHQPDCDLIISDDGLQHYRLQRDFEIVVLDVQRGFGNGFLLPAGPLR
EECCHHHHHHHHHHCCCCCCEEECCCCCHHHEECCCCEEEEEEEECCCCCCEECCCCHHH
ELPSRLNTVDLIICHGQASKYSDVEMTLVPHHAINLVTGESRLLSDFHRVSAIAGIGHPQ
HHHHHCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHH
RFFSMLENLSMQLIQTKAFQDHQTFEAAQFVDFDQTQPLLMTEKDAVKCLSFAQKNWWYV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHCCCEEE
PVEAEIKGEKVRSFLAKFDEIRKTV
EEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQFWYSRTWITWLMLPLSFLFWLISTCRQFLFRKGIFASYRAPVPVIVVGNLSVGGNGKT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEECEEECCCCCC
PVVIWLVKQLQQKGLKVGVISRGYGSQSSVYPLLVTPDTDPIQGGDEPVLIAKRTQVPVC
CEEEHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCEE
ISANRQHAIELLLQHQPDCDLIISDDGLQHYRLQRDFEIVVLDVQRGFGNGFLLPAGPLR
EECCHHHHHHHHHHCCCCCCEEECCCCCHHHEECCCCEEEEEEEECCCCCCEECCCCHHH
ELPSRLNTVDLIICHGQASKYSDVEMTLVPHHAINLVTGESRLLSDFHRVSAIAGIGHPQ
HHHHHCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHH
RFFSMLENLSMQLIQTKAFQDHQTFEAAQFVDFDQTQPLLMTEKDAVKCLSFAQKNWWYV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHCCCEEE
PVEAEIKGEKVRSFLAKFDEIRKTV
EEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100