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The map label for this gene is ribA

Identifier: 15602542

GI number: 15602542

Start: 785764

End: 786423

Strand: Direct

Name: ribA

Synonym: PM0677

Alternate gene names: 15602542

Gene position: 785764-786423 (Clockwise)

Preceding gene: 15602537

Following gene: 15602545

Centisome position: 34.81

GC content: 40.3

Gene sequence:

>660_bases
ATGGCAAAAATTCAACGCGTTACCGAGGCTAATTTGCCAACGGAATTTGGCATGTTTAGAATTGTCGGTTTTGAATTTCC
AGACACCAAAAAAGAACATGTGGCATTAGTATTGGGAGAGGTAGAAAACACCGACGAGCCAATTTTAGCCCGCATCCATT
CTGAATGCTTAACGGGTGATGCCCTTTACAGCTTAAAATGCGATTGTGGCTTTCAACTGGCCGCTGCCTTACGTCAAATT
AGCCAAGAAGGTCGTGGTGTATTAATTTATCACCGCGAGGAAGGACGTGGTATCGGTTTAATTAATAAAATCCGCGCCTA
TTCCCTTCAAGACAAAGGCATGGATACGATTGAAGCAAATCTTGCATTAGGCTTTGCGGCAGATGAACGAAATTTTGAAG
TGTGTGCCGATATTTTTGCGTTGTTAGGCATTAATAAAGTTCGCTTATTAACCAATAACCCAAACAAAATTGACACCATG
AAAAAGGCAGGGATCAATATTGTAGAACGTGTCGCATTAAATGTAGGCGAAAACCGCTATAACACGGAATATTTAGACAC
AAAAGCCAAAAAAATGGGGCATTTTATTATTCATAATCAGCAAAAATACCCACTTGAGTGCCCTTATTGCTCAGAAGAAG
TTCCTGTGCAAGAGAAATAA

Upstream 100 bases:

>100_bases
TATATAATGATAATCTTTTTAACATATTCGCAACCATAAAATGAATCATCTGAAAGAGCGATATTCTATCAGATAACGCA
TAAAAGAATAAGGATTGATT

Downstream 100 bases:

>100_bases
ACGCAATGCCCCACTCAATCAGTGGGGCATGTGCAATCAATAGAGCGCATATTATTTATGCTCACTGACCTTACGGTATA
AATCTTTGCTATACATCGTT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MAKIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGDALYSLKCDCGFQLAAALRQI
SQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTM
KKAGINIVERVALNVGENRYNTEYLDTKAKKMGHFIIHNQQKYPLECPYCSEEVPVQEK

Sequences:

>Translated_219_residues
MAKIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGDALYSLKCDCGFQLAAALRQI
SQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTM
KKAGINIVERVALNVGENRYNTEYLDTKAKKMGHFIIHNQQKYPLECPYCSEEVPVQEK
>Mature_218_residues
AKIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGDALYSLKCDCGFQLAAALRQIS
QEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLALGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTMK
KAGINIVERVALNVGENRYNTEYLDTKAKKMGHFIIHNQQKYPLECPYCSEEVPVQEK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=65.4639175257732, Blast_Score=269, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319438, Length=196, Percent_Identity=40.8163265306122, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_PASMU (P57863)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245614.1
- ProteinModelPortal:   P57863
- SMR:   P57863
- GeneID:   1244024
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0677
- NMPDR:   fig|272843.1.peg.677
- HOGENOM:   HBG735778
- OMA:   QGFILYL
- ProtClustDB:   PRK00393
- BioCyc:   PMUL272843:PM0677-MONOMER
- BRENDA:   3.5.4.25
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 24635; Mature: 24503

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: ACT_SITE 128-128 ACT_SITE 130-130 BINDING 72-72 BINDING 116-116 BINDING 151-151 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGD
CCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCC
ALYSLKCDCGFQLAAALRQISQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEAN
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEE
LALGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTMKKAGINIVERVALNVGENRY
EEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCHHHHHHHHHHCCCCCC
NTEYLDTKAKKMGHFIIHNQQKYPLECPYCSEEVPVQEK
CCHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGD
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCC
ALYSLKCDCGFQLAAALRQISQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEAN
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEE
LALGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTMKKAGINIVERVALNVGENRY
EEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCHHHHHHHHHHCCCCCC
NTEYLDTKAKKMGHFIIHNQQKYPLECPYCSEEVPVQEK
CCHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100