Click here to switch to the map view.

The map label for this gene is hbpA [H]

Identifier: 15602457

GI number: 15602457

Start: 685467

End: 687062

Strand: Reverse

Name: hbpA [H]

Synonym: PM0592

Alternate gene names: 15602457

Gene position: 687062-685467 (Counterclockwise)

Preceding gene: 15602461

Following gene: 15602452

Centisome position: 30.43

GC content: 42.92

Gene sequence:

>1596_bases
ATGAAGTTGACAACCAAACTCTCATTCATTGCCGCAGGATTGATGATTTTTAACAGTGCACAAGCCAGTAATAAAACCTT
TATTAACTGCGTCAGCCGTGCACCAAGTAGCTTTAGCCCTGCCCTCGTCATGGAAGGTATTTCGTATAATGCCAGTTCTC
AACAAGTGTACAATCGTTTGATTGAATTTAAACGAGGATCGACCGATATCGAACCTGCGTTGGCAGAAAGTTGGCAAATT
AGCGATGACGGATTGACGTACACTTTTCATTTACGTAAAGGCGTGAAATTCCACAAAACCAAAGACTATCAGCCGAGTCG
TGAATTTAACGCCGATGACGTGATTTTCTCTTTCCAACGTCAGTTGGACAAAACCCATCCTTATCACGAGGTATCGAAAG
GCACTTATCCGTATTTCAATGCGATGAAGTTTCCAAAATTGTTGCAAGCAGTAGAAAAAGTGGATGATTACACAGTGAAA
ATCACCTTAACCAAGCCCGATGCGACTTTCTTAGCGAGCTTAGGGATGGATTTTATTTCTATTTATTCTGCCGAATATGC
CGATAAAATGATGAAGGCAGGTACACCAGAAAAAGTAGATACCACCCCGATTGGTACGGGTCCCTTTATTTTTGCAGGTT
ATCAGTTAGAACAAAAAATTCCTTTCCTCGCGAACCCTGATTATTGGCAACCGAAAGCCGAAATTGATCGTTTGATTTTT
GATATTGTGCCTGATGCGGGGACACGTTATGCCAAATTACAATCTGGTGCGTGTGATATGATCGACTTCCCGAATATCGC
CGATTTAGCCAAAATGAAAGCCGATCCGAAAATTCAGTTGATGTCAAAAGAAGGCTTAAACATTGCCTATATTGCGTTTA
ATACCGAAAAAGCGCCGTTTGATAATGTGAAAGTGCGCCAAGCTTTAAACTATGCTACCGATAAAAAAGCCATCATTGAT
GTGGTGTACCAAGGCGCTGGTGTGATGGCGAAAAATGTCCTACCACCAACGATTTGGAGCTATAACGATGATGTACAGGA
CTACCCATTTGATATTGAAAAAGCCAAACAACTCTTAGCCGAAGCCGGTTATCCAAACGGATTTGAAACCGAAATTTGGG
TGCAACCGGTGGTGCGTGCCTCAAACCCGAACCCACGTCGTATGGCTGAAGTGATTCAAAATGACTGGGCAAAAGCGGGT
GTGAAAGCTAAATTGGTCAGTTATGAATGGGGGGATTACATTAAACGCACCAAAGCAGGTGAACTCACCGCGGGTACTTA
CGGTTGGTCAGGCGATAATGGCGATCCAGATAACTTCTTATCACCGTTATTAGGCACCGAAAACATCGGTAACAGTAACT
ATGCCCGTTGGAGCAATCCAGAGTTTGATGCGTTATTAAGCAAAGCAATCAGCTTATCTAACCAAGCAGAACGCGCTGAA
CTATACAAAAAAGCGCAAGTGATCGCGAAAGAACAAGCACCGTGGATTACTGTCGCCCACTCCATTACCAATACCGCATT
AAGTCTGCGCGTTAAAGACTATAAACAAAGCCCATTTGGTTATAGTTACTTCTACGGCACTAAGTTAGCGGATTAA

Upstream 100 bases:

>100_bases
TAGCAATCTGTTATAAATTAAAACAGCAAATTCTTTGGGTTATCCTAGCGATTTCGCTTAGTATACAGGGAAATGATGTA
TTTACTTAAAAGGAGACTGT

Downstream 100 bases:

>100_bases
TAAAACCTAGCAAAAAACAACCGCACTTTAGTGATAAAGTGCGGTTGTTTTTTAGAAAAAAGATAAGGTTATTTAATAAT
GAAGATTTTCCAATCGGGGT

Product: HbpA

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKLTTKLSFIAAGLMIFNSAQASNKTFINCVSRAPSSFSPALVMEGISYNASSQQVYNRLIEFKRGSTDIEPALAESWQI
SDDGLTYTFHLRKGVKFHKTKDYQPSREFNADDVIFSFQRQLDKTHPYHEVSKGTYPYFNAMKFPKLLQAVEKVDDYTVK
ITLTKPDATFLASLGMDFISIYSAEYADKMMKAGTPEKVDTTPIGTGPFIFAGYQLEQKIPFLANPDYWQPKAEIDRLIF
DIVPDAGTRYAKLQSGACDMIDFPNIADLAKMKADPKIQLMSKEGLNIAYIAFNTEKAPFDNVKVRQALNYATDKKAIID
VVYQGAGVMAKNVLPPTIWSYNDDVQDYPFDIEKAKQLLAEAGYPNGFETEIWVQPVVRASNPNPRRMAEVIQNDWAKAG
VKAKLVSYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLLGTENIGNSNYARWSNPEFDALLSKAISLSNQAERAE
LYKKAQVIAKEQAPWITVAHSITNTALSLRVKDYKQSPFGYSYFYGTKLAD

Sequences:

>Translated_531_residues
MKLTTKLSFIAAGLMIFNSAQASNKTFINCVSRAPSSFSPALVMEGISYNASSQQVYNRLIEFKRGSTDIEPALAESWQI
SDDGLTYTFHLRKGVKFHKTKDYQPSREFNADDVIFSFQRQLDKTHPYHEVSKGTYPYFNAMKFPKLLQAVEKVDDYTVK
ITLTKPDATFLASLGMDFISIYSAEYADKMMKAGTPEKVDTTPIGTGPFIFAGYQLEQKIPFLANPDYWQPKAEIDRLIF
DIVPDAGTRYAKLQSGACDMIDFPNIADLAKMKADPKIQLMSKEGLNIAYIAFNTEKAPFDNVKVRQALNYATDKKAIID
VVYQGAGVMAKNVLPPTIWSYNDDVQDYPFDIEKAKQLLAEAGYPNGFETEIWVQPVVRASNPNPRRMAEVIQNDWAKAG
VKAKLVSYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLLGTENIGNSNYARWSNPEFDALLSKAISLSNQAERAE
LYKKAQVIAKEQAPWITVAHSITNTALSLRVKDYKQSPFGYSYFYGTKLAD
>Mature_531_residues
MKLTTKLSFIAAGLMIFNSAQASNKTFINCVSRAPSSFSPALVMEGISYNASSQQVYNRLIEFKRGSTDIEPALAESWQI
SDDGLTYTFHLRKGVKFHKTKDYQPSREFNADDVIFSFQRQLDKTHPYHEVSKGTYPYFNAMKFPKLLQAVEKVDDYTVK
ITLTKPDATFLASLGMDFISIYSAEYADKMMKAGTPEKVDTTPIGTGPFIFAGYQLEQKIPFLANPDYWQPKAEIDRLIF
DIVPDAGTRYAKLQSGACDMIDFPNIADLAKMKADPKIQLMSKEGLNIAYIAFNTEKAPFDNVKVRQALNYATDKKAIID
VVYQGAGVMAKNVLPPTIWSYNDDVQDYPFDIEKAKQLLAEAGYPNGFETEIWVQPVVRASNPNPRRMAEVIQNDWAKAG
VKAKLVSYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLLGTENIGNSNYARWSNPEFDALLSKAISLSNQAERAE
LYKKAQVIAKEQAPWITVAHSITNTALSLRVKDYKQSPFGYSYFYGTKLAD

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=520, Percent_Identity=52.6923076923077, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1787551, Length=509, Percent_Identity=34.9705304518664, Blast_Score=341, Evalue=9e-95,
Organism=Escherichia coli, GI1787052, Length=432, Percent_Identity=31.9444444444444, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787762, Length=490, Percent_Identity=26.530612244898, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789887, Length=471, Percent_Identity=25.2653927813163, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789397, Length=508, Percent_Identity=26.3779527559055, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787495, Length=523, Percent_Identity=25.2390057361377, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI87081878, Length=520, Percent_Identity=24.8076923076923, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 59510; Mature: 59510

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTTKLSFIAAGLMIFNSAQASNKTFINCVSRAPSSFSPALVMEGISYNASSQQVYNRL
CCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHH
IEFKRGSTDIEPALAESWQISDDGLTYTFHLRKGVKFHKTKDYQPSREFNADDVIFSFQR
HHHCCCCCCCCCHHHCCEEECCCCEEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHH
QLDKTHPYHEVSKGTYPYFNAMKFPKLLQAVEKVDDYTVKITLTKPDATFLASLGMDFIS
HHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHH
IYSAEYADKMMKAGTPEKVDTTPIGTGPFIFAGYQLEQKIPFLANPDYWQPKAEIDRLIF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECEEHHCCCCCCCCCCCCCCHHHHHHHHH
DIVPDAGTRYAKLQSGACDMIDFPNIADLAKMKADPKIQLMSKEGLNIAYIAFNTEKAPF
HHCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCCC
DNVKVRQALNYATDKKAIIDVVYQGAGVMAKNVLPPTIWSYNDDVQDYPFDIEKAKQLLA
CCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EAGYPNGFETEIWVQPVVRASNPNPRRMAEVIQNDWAKAGVKAKLVSYEWGDYIKRTKAG
HCCCCCCCCCEEEEEEHEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHCCCC
ELTAGTYGWSGDNGDPDNFLSPLLGTENIGNSNYARWSNPEFDALLSKAISLSNQAERAE
CEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
LYKKAQVIAKEQAPWITVAHSITNTALSLRVKDYKQSPFGYSYFYGTKLAD
HHHHHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKLTTKLSFIAAGLMIFNSAQASNKTFINCVSRAPSSFSPALVMEGISYNASSQQVYNRL
CCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHH
IEFKRGSTDIEPALAESWQISDDGLTYTFHLRKGVKFHKTKDYQPSREFNADDVIFSFQR
HHHCCCCCCCCCHHHCCEEECCCCEEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHH
QLDKTHPYHEVSKGTYPYFNAMKFPKLLQAVEKVDDYTVKITLTKPDATFLASLGMDFIS
HHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHH
IYSAEYADKMMKAGTPEKVDTTPIGTGPFIFAGYQLEQKIPFLANPDYWQPKAEIDRLIF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECEEHHCCCCCCCCCCCCCCHHHHHHHHH
DIVPDAGTRYAKLQSGACDMIDFPNIADLAKMKADPKIQLMSKEGLNIAYIAFNTEKAPF
HHCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCCC
DNVKVRQALNYATDKKAIIDVVYQGAGVMAKNVLPPTIWSYNDDVQDYPFDIEKAKQLLA
CCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EAGYPNGFETEIWVQPVVRASNPNPRRMAEVIQNDWAKAGVKAKLVSYEWGDYIKRTKAG
HCCCCCCCCCEEEEEEHEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHCCCC
ELTAGTYGWSGDNGDPDNFLSPLLGTENIGNSNYARWSNPEFDALLSKAISLSNQAERAE
CEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
LYKKAQVIAKEQAPWITVAHSITNTALSLRVKDYKQSPFGYSYFYGTKLAD
HHHHHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]