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The map label for this gene is folP [H]

Identifier: 15602304

GI number: 15602304

Start: 515215

End: 516042

Strand: Direct

Name: folP [H]

Synonym: PM0439

Alternate gene names: 15602304

Gene position: 515215-516042 (Clockwise)

Preceding gene: 15602303

Following gene: 15602305

Centisome position: 22.82

GC content: 42.75

Gene sequence:

>828_bases
ATGAAATTATACGCAAACAATAAAGTATTAGACTTATCTACGCCCCAAATCATGGGGATTTTAAATTTCACACCGGATTC
CTTTTCAGACAGTGGTCAATTCTTTGCGTTAGACAAAGCCCTTTTTCATGTGGAGAAAATGTTAAATGCTGGGGCAACTA
TCATCGATATTGGTGGTGAGTCAACGCGTCCTATGGCAGAAGAAGTGACGCTTGAACAAGAATTAGATCGTGTTATTCCT
GTGGTGGAAGCGGTGCGCCAGAACTTTGATTGCTGGATTTCTGTGGATACCTCGAAAGCGGAAGTGATGAAAGAAGCCGC
TCGAGTAGGAATGGATCTGATCAATGATATTCGTGCACTACGTGAGCCAAATGCATTACTCACTGCGGCGCAACTGGATT
TACCAGTATGTATTATGCATATGCAAGGAGAACCCCGTACTATGCAGCAGAATCCGTATTATGAGGATGTTGTGGCTGAA
GTTTTCGCCTTTTTACAAACGCGTTCTGCAGAATGTATAAGCGCGGGTATTCGACAAGAAAATATTATTTGGGATATGGG
CTTTGGTTTTGGTAAAACCGTTGTACATAACTATAAATTATTGCAAAACTTAGCGCACTTTTGTGCTGCAGGCTTTCCCG
TATTAGCGGGCTTATCCCGAAAATCGATGATTGGGAATGTGTTAGATAAAGCGGTAGAAGACCGTGTTGTTGGGAGTGTT
GCTGGTGCGTTAATTGCAATGGTGCATGGTGCAGCAATTGTACGTGTGCATGATGTTGAACACACAGCGGATGCGCTCAA
AATTTGGCAAGCAACAAAGAATGCTTAA

Upstream 100 bases:

>100_bases
GGTTTTTTATTTCCCTCTTGACGCGTTTTGACAATAAGTTATTTTTTCTATGGCAATCTTTCGCTATAATTAGCCATACC
TTTCATCGTGGTAATCATCA

Downstream 100 bases:

>100_bases
ATAAAGAAGGATGGATAAATATGGCAGAACGTAAGTATTTTGGTACAGATGGTGTCCGCGGCAAAGTGGGAACATTCCCA
ATTACCCCTGATTTTGCTTT

Product: hypothetical protein

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MKLYANNKVLDLSTPQIMGILNFTPDSFSDSGQFFALDKALFHVEKMLNAGATIIDIGGESTRPMAEEVTLEQELDRVIP
VVEAVRQNFDCWISVDTSKAEVMKEAARVGMDLINDIRALREPNALLTAAQLDLPVCIMHMQGEPRTMQQNPYYEDVVAE
VFAFLQTRSAECISAGIRQENIIWDMGFGFGKTVVHNYKLLQNLAHFCAAGFPVLAGLSRKSMIGNVLDKAVEDRVVGSV
AGALIAMVHGAAIVRVHDVEHTADALKIWQATKNA

Sequences:

>Translated_275_residues
MKLYANNKVLDLSTPQIMGILNFTPDSFSDSGQFFALDKALFHVEKMLNAGATIIDIGGESTRPMAEEVTLEQELDRVIP
VVEAVRQNFDCWISVDTSKAEVMKEAARVGMDLINDIRALREPNALLTAAQLDLPVCIMHMQGEPRTMQQNPYYEDVVAE
VFAFLQTRSAECISAGIRQENIIWDMGFGFGKTVVHNYKLLQNLAHFCAAGFPVLAGLSRKSMIGNVLDKAVEDRVVGSV
AGALIAMVHGAAIVRVHDVEHTADALKIWQATKNA
>Mature_275_residues
MKLYANNKVLDLSTPQIMGILNFTPDSFSDSGQFFALDKALFHVEKMLNAGATIIDIGGESTRPMAEEVTLEQELDRVIP
VVEAVRQNFDCWISVDTSKAEVMKEAARVGMDLINDIRALREPNALLTAAQLDLPVCIMHMQGEPRTMQQNPYYEDVVAE
VFAFLQTRSAECISAGIRQENIIWDMGFGFGKTVVHNYKLLQNLAHFCAAGFPVLAGLSRKSMIGNVLDKAVEDRVVGSV
AGALIAMVHGAAIVRVHDVEHTADALKIWQATKNA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=275, Percent_Identity=56.3636363636364, Blast_Score=319, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6324073, Length=323, Percent_Identity=29.1021671826625, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30234; Mature: 30234

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYANNKVLDLSTPQIMGILNFTPDSFSDSGQFFALDKALFHVEKMLNAGATIIDIGGE
CEEECCCEEEECCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEECCCC
STRPMAEEVTLEQELDRVIPVVEAVRQNFDCWISVDTSKAEVMKEAARVGMDLINDIRAL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
REPNALLTAAQLDLPVCIMHMQGEPRTMQQNPYYEDVVAEVFAFLQTRSAECISAGIRQE
HCCCHHEEHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCC
NIIWDMGFGFGKTVVHNYKLLQNLAHFCAAGFPVLAGLSRKSMIGNVLDKAVEDRVVGSV
CEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGALIAMVHGAAIVRVHDVEHTADALKIWQATKNA
HHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLYANNKVLDLSTPQIMGILNFTPDSFSDSGQFFALDKALFHVEKMLNAGATIIDIGGE
CEEECCCEEEECCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEECCCC
STRPMAEEVTLEQELDRVIPVVEAVRQNFDCWISVDTSKAEVMKEAARVGMDLINDIRAL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
REPNALLTAAQLDLPVCIMHMQGEPRTMQQNPYYEDVVAEVFAFLQTRSAECISAGIRQE
HCCCHHEEHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCC
NIIWDMGFGFGKTVVHNYKLLQNLAHFCAAGFPVLAGLSRKSMIGNVLDKAVEDRVVGSV
CEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AGALIAMVHGAAIVRVHDVEHTADALKIWQATKNA
HHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]