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The map label for this gene is phoR [H]

Identifier: 15602296

GI number: 15602296

Start: 506318

End: 507613

Strand: Reverse

Name: phoR [H]

Synonym: PM0431

Alternate gene names: 15602296

Gene position: 507613-506318 (Counterclockwise)

Preceding gene: 15602297

Following gene: 15602293

Centisome position: 22.49

GC content: 36.73

Gene sequence:

>1296_bases
ATGAAAAGAACCTTTTCAATTAAGTATTTTTTTATTGAATTAGCGATAAGCCTACTGATTGCCAGTCTTTTTTCCTATTT
TACTCAATCCTTTACATTCTGGTTTATTGCAGTGCTCCTCTGCTTTCTGATTTTTCATCATTACAATGAATTTAAGTTGT
TGAAAATGCTCTATCCAGATGCGACTGACACACTGAAAAAAACACATCTTCTGGATAATATTTCTCAAACCACTGCCTAC
TATAAAAGTAAAAATCGAAAAGAAAGAATTAAAACGTTACGTTTACTTTCGAAATTAAATAAAAATATTCAATACCTCCC
CGATGCCATTATCATTTGTGACAATGAAGGTAATATCTCTTGGTGCAATAACGCCTCGCAAGAAATGTTCATGTTTTATT
GGAATAAGAAAATAAACAGTAAAAATCTCTTCAATGTCATTTTCTATAACGAATTTAAGCACTACTTTTATCAATCCATG
AGAAAACGCCCTTTGGTGTTACTCACCAATGAAAACCGCTACATTGAGATCAACATTAATCATTATGACAACGAATCACG
TGTGATTATTGCACGAGATGTCACTCAAATGATCCGTTTATTACATTCTCGCCAAACCTTTTTATCGAATATCAACCACG
AACTACGCACGCCGTTAACGGTATTACAAGGTTACTTAGAGTTGCTAGAAGCAGAAAAAGATCACAGTGCACTGGCACAA
AAAGCCATTCACGCCATGCAAGCACAAAGTCAGCGGATGGCAAATTTACTGCAACAACTCAATGTGTTGGCGAAAATTGA
AAGCTCGTCTAATCAAGAGCACGAACCCGTGGATATGTCGCGCTTAATCTTAAATTTAAAAGAGAATGCACACTTTTTAA
ATCACTATCATCATCAAATCCATTTTGATATCGCACCAGACATTTATGTATTCGGCGATGAAAGCCAGCTACAAAGTGCG
GTTTCCAATCTCATTTATAATGCGATAAAACATTCTGGTGAGAATTGTCAAATCAACGTCAGTTGGCAACTTTGTGCTGA
GGGGGCTAAATTTAGTGTGACCGATAATGGAATAGGTATTGCAACACATCATTTATATCATTTAACTGAGCGTTTTTACC
GTGTGGATGAATCCCGCAGTAACCAAACTGGCGGTCATGGTTTAGGTTTAGCAATCGTTAAACATGCCCTTGAACAGCAT
CACGCCCAACTGGAGATTGAAAGCAAAGAAGGCGAAGGAAGCTGTTTTTCTTTTATTATTCCGAAGAAGTTATTGTGTGA
GAGCGCTTCAGCCTAA

Upstream 100 bases:

>100_bases
GCTTACGCAAAAGCCTTGAGCAATATGGTTTTGATCGCTATATCCAAACGGTACGTGGGGCGGGCTATCGTTTTTCGCCT
CATTTTCAGGACGAGATGAA

Downstream 100 bases:

>100_bases
CAGCACTAACATAAGAAAAACACATCGTTTTTCTAGCAAAATGTCATCACGCCTTACCAAAAAACGCCAAAATATTCTCC
CGAATCGCACGTACAGGGAA

Product: PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKRTFSIKYFFIELAISLLIASLFSYFTQSFTFWFIAVLLCFLIFHHYNEFKLLKMLYPDATDTLKKTHLLDNISQTTAY
YKSKNRKERIKTLRLLSKLNKNIQYLPDAIIICDNEGNISWCNNASQEMFMFYWNKKINSKNLFNVIFYNEFKHYFYQSM
RKRPLVLLTNENRYIEININHYDNESRVIIARDVTQMIRLLHSRQTFLSNINHELRTPLTVLQGYLELLEAEKDHSALAQ
KAIHAMQAQSQRMANLLQQLNVLAKIESSSNQEHEPVDMSRLILNLKENAHFLNHYHHQIHFDIAPDIYVFGDESQLQSA
VSNLIYNAIKHSGENCQINVSWQLCAEGAKFSVTDNGIGIATHHLYHLTERFYRVDESRSNQTGGHGLGLAIVKHALEQH
HAQLEIESKEGEGSCFSFIIPKKLLCESASA

Sequences:

>Translated_431_residues
MKRTFSIKYFFIELAISLLIASLFSYFTQSFTFWFIAVLLCFLIFHHYNEFKLLKMLYPDATDTLKKTHLLDNISQTTAY
YKSKNRKERIKTLRLLSKLNKNIQYLPDAIIICDNEGNISWCNNASQEMFMFYWNKKINSKNLFNVIFYNEFKHYFYQSM
RKRPLVLLTNENRYIEININHYDNESRVIIARDVTQMIRLLHSRQTFLSNINHELRTPLTVLQGYLELLEAEKDHSALAQ
KAIHAMQAQSQRMANLLQQLNVLAKIESSSNQEHEPVDMSRLILNLKENAHFLNHYHHQIHFDIAPDIYVFGDESQLQSA
VSNLIYNAIKHSGENCQINVSWQLCAEGAKFSVTDNGIGIATHHLYHLTERFYRVDESRSNQTGGHGLGLAIVKHALEQH
HAQLEIESKEGEGSCFSFIIPKKLLCESASA
>Mature_431_residues
MKRTFSIKYFFIELAISLLIASLFSYFTQSFTFWFIAVLLCFLIFHHYNEFKLLKMLYPDATDTLKKTHLLDNISQTTAY
YKSKNRKERIKTLRLLSKLNKNIQYLPDAIIICDNEGNISWCNNASQEMFMFYWNKKINSKNLFNVIFYNEFKHYFYQSM
RKRPLVLLTNENRYIEININHYDNESRVIIARDVTQMIRLLHSRQTFLSNINHELRTPLTVLQGYLELLEAEKDHSALAQ
KAIHAMQAQSQRMANLLQQLNVLAKIESSSNQEHEPVDMSRLILNLKENAHFLNHYHHQIHFDIAPDIYVFGDESQLQSA
VSNLIYNAIKHSGENCQINVSWQLCAEGAKFSVTDNGIGIATHHLYHLTERFYRVDESRSNQTGGHGLGLAIVKHALEQH
HAQLEIESKEGEGSCFSFIIPKKLLCESASA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=420, Percent_Identity=39.5238095238095, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=29.5652173913043, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=28.6995515695067, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI145693157, Length=284, Percent_Identity=28.5211267605634, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=27.3469387755102, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=28.1938325991189, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=28.110599078341, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788713, Length=385, Percent_Identity=24.4155844155844, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=27.4021352313167, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=27.8969957081545, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=28.4444444444444, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789403, Length=233, Percent_Identity=29.6137339055794, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=27.0386266094421, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=25.2136752136752, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=25.7009345794392, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=222, Percent_Identity=24.3243243243243, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=346, Percent_Identity=20.5202312138728, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=201, Percent_Identity=27.8606965174129, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787374, Length=258, Percent_Identity=27.1317829457364, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50193; Mature: 50193

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTFSIKYFFIELAISLLIASLFSYFTQSFTFWFIAVLLCFLIFHHYNEFKLLKMLYPD
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
ATDTLKKTHLLDNISQTTAYYKSKNRKERIKTLRLLSKLNKNIQYLPDAIIICDNEGNIS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCCEE
WCNNASQEMFMFYWNKKINSKNLFNVIFYNEFKHYFYQSMRKRPLVLLTNENRYIEININ
ECCCCCHHEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEE
HYDNESRVIIARDVTQMIRLLHSRQTFLSNINHELRTPLTVLQGYLELLEAEKDHSALAQ
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCHHHHHHH
KAIHAMQAQSQRMANLLQQLNVLAKIESSSNQEHEPVDMSRLILNLKENAHFLNHYHHQI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEE
HFDIAPDIYVFGDESQLQSAVSNLIYNAIKHSGENCQINVSWQLCAEGAKFSVTDNGIGI
EEEECCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEECCCCCCH
ATHHLYHLTERFYRVDESRSNQTGGHGLGLAIVKHALEQHHAQLEIESKEGEGSCFSFII
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEEEC
PKKLLCESASA
CHHHHHCCCCC
>Mature Secondary Structure
MKRTFSIKYFFIELAISLLIASLFSYFTQSFTFWFIAVLLCFLIFHHYNEFKLLKMLYPD
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
ATDTLKKTHLLDNISQTTAYYKSKNRKERIKTLRLLSKLNKNIQYLPDAIIICDNEGNIS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCCEE
WCNNASQEMFMFYWNKKINSKNLFNVIFYNEFKHYFYQSMRKRPLVLLTNENRYIEININ
ECCCCCHHEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEE
HYDNESRVIIARDVTQMIRLLHSRQTFLSNINHELRTPLTVLQGYLELLEAEKDHSALAQ
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCHHHHHHH
KAIHAMQAQSQRMANLLQQLNVLAKIESSSNQEHEPVDMSRLILNLKENAHFLNHYHHQI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEE
HFDIAPDIYVFGDESQLQSAVSNLIYNAIKHSGENCQINVSWQLCAEGAKFSVTDNGIGI
EEEECCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCEEEECCCCCCH
ATHHLYHLTERFYRVDESRSNQTGGHGLGLAIVKHALEQHHAQLEIESKEGEGSCFSFII
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEEEC
PKKLLCESASA
CHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]