Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 15602294

GI number: 15602294

Start: 503443

End: 505479

Strand: Direct

Name: uvrB [H]

Synonym: PM0429

Alternate gene names: 15602294

Gene position: 503443-505479 (Clockwise)

Preceding gene: 15602292

Following gene: 15602295

Centisome position: 22.3

GC content: 41.04

Gene sequence:

>2037_bases
ATGGCGTATAAAATGCATACTAAATCATTTATTTTGCATTCGGATTTTTCTCCTTCTGGTGATCAACCGCAAGCAATTAC
GCAGCTGATTGAGGGGCTTGAAAATGGGCTTGCTCATCAAACCTTGTTGGGGGTAACAGGGTCAGGTAAGACCTTTACGA
TTGCTAATGTGATTGCAAAATTAAATCGTCCCGCTATGGTACTTGCCCCGAATAAAACCCTCGCAGCACAGCTTTATGCT
GAAATGAAAGCATTTTTTCCAGAAAATGCAGTTGAATATTTTGTATCTTACTATGATTACTATCAGCCAGAAGCTTATGT
GCCAAGTAGCGATACTTTTATTGAGAAAGATGCGTCGATTAATGATCAAATCGAACAAATGCGCTTATCTGCCACTAAAT
CGTTTTTAGAGCGTCGAGATACTATTGTGGTTGCCTCGGTATCCGCCATTTATGGTTTAGGCGATCCAGATTCTTATTTA
AAAATGATGCTCCATTTACAAACGGGTGCGATTATTAATCAACGTCAAATCTTAGCGCAATTGGCTGAATTGCAGTACAC
ACGCAATGATCAGGCGTTTGAGCGTGGTACCTTTCGTGTGCGCGGTGAAATCATTGATATTTTCCCCGCAGAATCTGATG
ATAAAGCGATACGGATAGAATTATTTGACGATGAAATCGAGCGATTAAGTTTATTTGATCCGCTAACTGGCTCAAGTTTT
GGTCCTGTCCCTCGTTATACTATTTATCCGAAAACGCACTATGTCACACCAAGAGAGCGGATTTTAAATGCCATTGAAAA
AATCAAACAAGAACTGGCGGAGCGTCGCCAATTCTTATTGGAAAATAACAAATTACTCGAAGAACAGCGCATTACACAAC
GCACCCAATTCGATATTGAAATGATGAATGAATTGGGATATTGCTCAGGTATCGAAAACTATTCACGCTATTTATCAGGG
CGTAACGAAGGCGAGCCACCGCCAACCTTATTTGATTATATGCCTTCAGATGCGTTGCTGATTATCGATGAATCTCATGT
GACGGTGCCGCAAATTGGTGGTATGTATCGTGGTGATCGTTCTCGTAAAGAAACGCTGGTGGAATATGGCTTTCGTTTGC
CTTCTGCGTTAGATAATCGTCCTTTGCGTTTTGAGGAGTTTGAACGTTTAGCACCGCAAACAATTTATGTCTCCGCCACA
CCGGGTCCTTATGAATTAGAGAAATCGGGTGGTGAAATTATTGATCAAGTGGTGCGCCCAACAGGCTTATTGGATCCGGA
AATTGAAATTCGTCCTGTCGCGATTCAAGTGGATGATTTATTGTCTGAGGCTCGTCAAAGGGCGGATCAAAATGAACGAG
TTTTAGTCACTACCTTAACCAAAAAAATGGCGGAAGATCTGACGGATTATTTAGATGAACACGGTATTCGTGTCCGTTAT
TTACATTCAGATATTGATACGGTTGAGCGGGTAGAAATTATCCGTGATCTGCGTTTAGGGGAATTTGATGTGTTAGTTGG
GATCAACTTATTGCGTGAAGGATTGGATATTCCAGAAGTGTCTTTGGTGGCGATTTTAGATGCCGACAAAGAAGGCTTCT
TACGTTCAGAACGTTCCTTAATTCAGACAATTGGACGCGCAGCACGTAACTTAAAAGGGAAAGCGATTCTATATGCGGAT
CGCATCACCAATTCTATGCAAAAAGCCATCACCGAAACCAATCGCCGTCGTGAAAAACAAATGAAATATAATGAAGCACG
CGGTATTGTGCCACAAGCATTGAATAAAAAAGTGGGAGAATTATTAGACATCGGTCAAGGGGCGAATCAAAAAGCTAAAG
CGAATAGAAACGCGAAAAAAGTGGCAGAACCGACCGCACTTTATGTTGTACCACAAACGGCGAAAGAATATCAGCAACAG
ATTAAGAAATTAGAACAACAAATGTATAAATATGCACAGGATCTTGAATTTGAAAAAGCAGCGGCTGTGCGGGATCAATT
ACAACAATTACGTGAACATTTTTTTGAGGTGCAATAA

Upstream 100 bases:

>100_bases
CAAATATAACTCTGTGTAAAACTTACATTTTTTAAATCCAAAACTGTTACAAAATTGTGATAAAATTGACCGCACTTTGA
ATAGAATTGAGTATAAGACT

Downstream 100 bases:

>100_bases
AGCAAATTAATTATGTTAGATGAACAATTAAGTCAACGTTTTTTGGCAGTTGCAGGAGCGGCGATTGAACTAGCCAAACA
GAAAAAGACCAAAGCAGCTT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MAYKMHTKSFILHSDFSPSGDQPQAITQLIEGLENGLAHQTLLGVTGSGKTFTIANVIAKLNRPAMVLAPNKTLAAQLYA
EMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYL
KMMLHLQTGAIINQRQILAQLAELQYTRNDQAFERGTFRVRGEIIDIFPAESDDKAIRIELFDDEIERLSLFDPLTGSSF
GPVPRYTIYPKTHYVTPRERILNAIEKIKQELAERRQFLLENNKLLEEQRITQRTQFDIEMMNELGYCSGIENYSRYLSG
RNEGEPPPTLFDYMPSDALLIIDESHVTVPQIGGMYRGDRSRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSAT
PGPYELEKSGGEIIDQVVRPTGLLDPEIEIRPVAIQVDDLLSEARQRADQNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLKGKAILYAD
RITNSMQKAITETNRRREKQMKYNEARGIVPQALNKKVGELLDIGQGANQKAKANRNAKKVAEPTALYVVPQTAKEYQQQ
IKKLEQQMYKYAQDLEFEKAAAVRDQLQQLREHFFEVQ

Sequences:

>Translated_678_residues
MAYKMHTKSFILHSDFSPSGDQPQAITQLIEGLENGLAHQTLLGVTGSGKTFTIANVIAKLNRPAMVLAPNKTLAAQLYA
EMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYL
KMMLHLQTGAIINQRQILAQLAELQYTRNDQAFERGTFRVRGEIIDIFPAESDDKAIRIELFDDEIERLSLFDPLTGSSF
GPVPRYTIYPKTHYVTPRERILNAIEKIKQELAERRQFLLENNKLLEEQRITQRTQFDIEMMNELGYCSGIENYSRYLSG
RNEGEPPPTLFDYMPSDALLIIDESHVTVPQIGGMYRGDRSRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSAT
PGPYELEKSGGEIIDQVVRPTGLLDPEIEIRPVAIQVDDLLSEARQRADQNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLKGKAILYAD
RITNSMQKAITETNRRREKQMKYNEARGIVPQALNKKVGELLDIGQGANQKAKANRNAKKVAEPTALYVVPQTAKEYQQQ
IKKLEQQMYKYAQDLEFEKAAAVRDQLQQLREHFFEVQ
>Mature_677_residues
AYKMHTKSFILHSDFSPSGDQPQAITQLIEGLENGLAHQTLLGVTGSGKTFTIANVIAKLNRPAMVLAPNKTLAAQLYAE
MKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLK
MMLHLQTGAIINQRQILAQLAELQYTRNDQAFERGTFRVRGEIIDIFPAESDDKAIRIELFDDEIERLSLFDPLTGSSFG
PVPRYTIYPKTHYVTPRERILNAIEKIKQELAERRQFLLENNKLLEEQRITQRTQFDIEMMNELGYCSGIENYSRYLSGR
NEGEPPPTLFDYMPSDALLIIDESHVTVPQIGGMYRGDRSRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSATP
GPYELEKSGGEIIDQVVRPTGLLDPEIEIRPVAIQVDDLLSEARQRADQNERVLVTTLTKKMAEDLTDYLDEHGIRVRYL
HSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLKGKAILYADR
ITNSMQKAITETNRRREKQMKYNEARGIVPQALNKKVGELLDIGQGANQKAKANRNAKKVAEPTALYVVPQTAKEYQQQI
KKLEQQMYKYAQDLEFEKAAAVRDQLQQLREHFFEVQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=78.8059701492537, Blast_Score=1064, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.7785016286645, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77403; Mature: 77272

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKMHTKSFILHSDFSPSGDQPQAITQLIEGLENGLAHQTLLGVTGSGKTFTIANVIAK
CCEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHEEECCCCCEEHHHHHHHH
LNRPAMVLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASI
CCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCC
NDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLKMMLHLQTGAIINQRQILAQ
HHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
LAELQYTRNDQAFERGTFRVRGEIIDIFPAESDDKAIRIELFDDEIERLSLFDPLTGSSF
HHHHHHCCCCHHHHCCCEEEECEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCCCCCCC
GPVPRYTIYPKTHYVTPRERILNAIEKIKQELAERRQFLLENNKLLEEQRITQRTQFDIE
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MMNELGYCSGIENYSRYLSGRNEGEPPPTLFDYMPSDALLIIDESHVTVPQIGGMYRGDR
HHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
SRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGPYELEKSGGEIIDQVVRP
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEECCCCCCHHHCCCHHHHHHHHCC
TGLLDPEIEIRPVAIQVDDLLSEARQRADQNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
CCCCCCCCEEEEEEEEHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSL
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNLKGKAILYADRITNSMQKAITETNRRREKQMKYNEARGIVPQALNKKVGE
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLDIGQGANQKAKANRNAKKVAEPTALYVVPQTAKEYQQQIKKLEQQMYKYAQDLEFEKA
HHHCCCCCCCHHHCCCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AAVRDQLQQLREHFFEVQ
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AYKMHTKSFILHSDFSPSGDQPQAITQLIEGLENGLAHQTLLGVTGSGKTFTIANVIAK
CEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHEEECCCCCEEHHHHHHHH
LNRPAMVLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASI
CCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCC
NDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLKMMLHLQTGAIINQRQILAQ
HHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
LAELQYTRNDQAFERGTFRVRGEIIDIFPAESDDKAIRIELFDDEIERLSLFDPLTGSSF
HHHHHHCCCCHHHHCCCEEEECEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCCCCCCC
GPVPRYTIYPKTHYVTPRERILNAIEKIKQELAERRQFLLENNKLLEEQRITQRTQFDIE
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MMNELGYCSGIENYSRYLSGRNEGEPPPTLFDYMPSDALLIIDESHVTVPQIGGMYRGDR
HHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
SRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGPYELEKSGGEIIDQVVRP
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEECCCCCCHHHCCCHHHHHHHHCC
TGLLDPEIEIRPVAIQVDDLLSEARQRADQNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
CCCCCCCCEEEEEEEEHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSL
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNLKGKAILYADRITNSMQKAITETNRRREKQMKYNEARGIVPQALNKKVGE
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLDIGQGANQKAKANRNAKKVAEPTALYVVPQTAKEYQQQIKKLEQQMYKYAQDLEFEKA
HHHCCCCCCCHHHCCCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AAVRDQLQQLREHFFEVQ
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA