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The map label for this gene is pgi

Identifier: 15602281

GI number: 15602281

Start: 488453

End: 490102

Strand: Direct

Name: pgi

Synonym: PM0416

Alternate gene names: 15602281

Gene position: 488453-490102 (Clockwise)

Preceding gene: 15602280

Following gene: 15602283

Centisome position: 21.64

GC content: 39.88

Gene sequence:

>1650_bases
ATGAAAAACATCAATCCTACAACAACAAACGCGTGGAAAGCCTTACAACAACATCATAAAACGCAAAGTGCGGTGACAAT
TCAACAACTTTTTGCGCAAGAAAAAGATCGTTTTACGGATTATTCCTTGTCTTTTAACAATGAAGTGTTAGTGGACTTCT
CCAAAAACAATGTGACAAAAGAAACCTTAGGATTATTGCGCCAGTTAGCGCAAGAATGTGCATTGTCTGAGGCAGTGGAC
GCGATGTTTAGTGGGGCAAAAATCAATAAAACGGAAGATCGCGCCGTATTACATACCGCACTTCGTAATCGTTCTAATTC
GCCTGTGTTGGTTGATGGGAAAGATGTGATGCCAGAAGTGAATGCGGTTTTAGCCAAAATGAAAGATTTTTGCCATCGTG
TGATTTCTGGTGAATGGAAAGGTTATACTGGTAAAGCGATTACAGATGTGGTGAACATCGGAATTGGTGGGTCTGATTTA
GGACCTTATATGGTAACAGAAGCCTTACGTCCTTATAAAAATCATTTGAATCTACATTTCGTGTCTAACGTAGATGGTAC
ACATATTGCGGAGACCTTAAAGAAAGTTAATCCAGAAACCACGCTATTTTTGGTTGCGTCAAAAACCTTTACCACACAAG
AAACTATGACCAATGCGCATTCTGCGCGTAATTGGTTCTTAGCCACGGCAAAAGACGAAAGTCATGTGGCAAAACACTTT
GCAGCACTGTCCACAAACAGTAAAGCCGTTGCTGAATTTGGTATTGATACGAATAATATGTTTGAATTTTGGGATTGGGT
AGGGGGTCGTTATTCATTATGGTCAGCGATTGGTTTATCTATTGCCCTTTCAATCGGTTTTGAGCATTTTGAAGCGCTTT
TAGCGGGTGCACACGAAATGGATAAACATTTCCGTACTGCCCCAATTGAGCAAAATATTCCGACCACATTAGCGTTAATT
GGTTTGTGGAATACCAATTTCTTAGGTGCACAAACCGAAGCGATTCTACCTTATGATCAATATTTACACCGTTTTGCAGC
GTATTTCCAACAAGGCAATATGGAATCCAATGGGAAATATGTTGATCGTAATGGCGAAGTGATCGATAACTACCAAACGG
GACCAATTATTTGGGGCGAACCTGGTACCAATGGTCAACATGCGTTCTATCAATTAATTCACCAAGGCACTACCTTGATT
CCTTGTGATTTCATCGCGCCAGCACAAACCCATAATCCATTAGCGGATCATCATGAAAAATTACTTTCAAACTTCTTTGC
ACAAACCGAAGCGTTGGCTTTTGGTAAAACGAAAGAAGAGGTAGAAGCAGAATTCGTGAAAGCAGGTAAATCTTTAGATG
AGGTGAAAGAGGTTGTGCCATTTAAAGTGTTTACGGGAAATAAACCAACCAACTCGATTTTGGTCCAAAAAATTACACCA
TTTACTTTAGGTGCTCTCATTGCAATGTACGAACACAAGATTTTTGTACAAGGGGTAATGTTTAATATTTATAGCTTTGA
CCAATGGGGCGTTGAGTTGGGCAAACAGCTTGCGAATCGTATTTTGCCAGAGCTAGCAAACCGCGAAACAATTACAACTC
ATGACAGTTCAACTAATGGCTTAATTAACCAATATAAACAATGGCGTTAA

Upstream 100 bases:

>100_bases
AAAAGCGAAAGTTGTTCTGCCTCAAAGTTTGCCCCTTAACCTACACGCCAATTTAGTATATTATTTTCCACATTCGATAT
TATAAAAAAGGAAAACAATA

Downstream 100 bases:

>100_bases
GCGAAAGAACAAAAAGTGCGGTCAAAATGACCGCACTTTTTTTGTGTGTGAGTGCACCATGTCGTATGATTTCTACAGCC
TTACTAAATTAAGTGATGAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKNINPTTTNAWKALQQHHKTQSAVTIQQLFAQEKDRFTDYSLSFNNEVLVDFSKNNVTKETLGLLRQLAQECALSEAVD
AMFSGAKINKTEDRAVLHTALRNRSNSPVLVDGKDVMPEVNAVLAKMKDFCHRVISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNLHFVSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAHSARNWFLATAKDESHVAKHF
AALSTNSKAVAEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFEHFEALLAGAHEMDKHFRTAPIEQNIPTTLALI
GLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKYVDRNGEVIDNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLI
PCDFIAPAQTHNPLADHHEKLLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDEVKEVVPFKVFTGNKPTNSILVQKITP
FTLGALIAMYEHKIFVQGVMFNIYSFDQWGVELGKQLANRILPELANRETITTHDSSTNGLINQYKQWR

Sequences:

>Translated_549_residues
MKNINPTTTNAWKALQQHHKTQSAVTIQQLFAQEKDRFTDYSLSFNNEVLVDFSKNNVTKETLGLLRQLAQECALSEAVD
AMFSGAKINKTEDRAVLHTALRNRSNSPVLVDGKDVMPEVNAVLAKMKDFCHRVISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNLHFVSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAHSARNWFLATAKDESHVAKHF
AALSTNSKAVAEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFEHFEALLAGAHEMDKHFRTAPIEQNIPTTLALI
GLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKYVDRNGEVIDNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLI
PCDFIAPAQTHNPLADHHEKLLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDEVKEVVPFKVFTGNKPTNSILVQKITP
FTLGALIAMYEHKIFVQGVMFNIYSFDQWGVELGKQLANRILPELANRETITTHDSSTNGLINQYKQWR
>Mature_549_residues
MKNINPTTTNAWKALQQHHKTQSAVTIQQLFAQEKDRFTDYSLSFNNEVLVDFSKNNVTKETLGLLRQLAQECALSEAVD
AMFSGAKINKTEDRAVLHTALRNRSNSPVLVDGKDVMPEVNAVLAKMKDFCHRVISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNLHFVSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAHSARNWFLATAKDESHVAKHF
AALSTNSKAVAEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFEHFEALLAGAHEMDKHFRTAPIEQNIPTTLALI
GLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKYVDRNGEVIDNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLI
PCDFIAPAQTHNPLADHHEKLLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDEVKEVVPFKVFTGNKPTNSILVQKITP
FTLGALIAMYEHKIFVQGVMFNIYSFDQWGVELGKQLANRILPELANRETITTHDSSTNGLINQYKQWR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=543, Percent_Identity=63.9042357274402, Blast_Score=730, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=545, Percent_Identity=59.4495412844037, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=77.0491803278689, Blast_Score=907, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=519, Percent_Identity=64.354527938343, Blast_Score=699, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=519, Percent_Identity=64.354527938343, Blast_Score=699, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=546, Percent_Identity=59.8901098901099, Blast_Score=654, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=547, Percent_Identity=65.0822669104205, Blast_Score=725, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=547, Percent_Identity=65.0822669104205, Blast_Score=725, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=547, Percent_Identity=65.0822669104205, Blast_Score=725, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_PASMU (Q9CNL2)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245353.1
- ProteinModelPortal:   Q9CNL2
- SMR:   Q9CNL2
- PRIDE:   Q9CNL2
- GeneID:   1243763
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0416
- NMPDR:   fig|272843.1.peg.416
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- BioCyc:   PMUL272843:PM0416-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61438; Mature: 61438

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 355-355 ACT_SITE 387-387 ACT_SITE 515-515

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPTTTNAWKALQQHHKTQSAVTIQQLFAQEKDRFTDYSLSFNNEVLVDFSKNNVTK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCH
ETLGLLRQLAQECALSEAVDAMFSGAKINKTEDRAVLHTALRNRSNSPVLVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHH
NAVLAKMKDFCHRVISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNLHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAHSARNWFLATAKDESHVAKHF
ECCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHH
AALSTNSKAVAEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFEHFEALLAGAHEM
HHHCCCCCHHHEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKHFRTAPIEQNIPTTLALIGLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKY
HHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGEVIDNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLIPCDFIAPAQTHNPLADHHEK
ECCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHH
LLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDEVKEVVPFKVFTGNKPTNSILVQKITP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCCCCEEEECCCH
FTLGALIAMYEHKIFVQGVMFNIYSFDQWGVELGKQLANRILPELANRETITTHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
LINQYKQWR
HHHHHHCCC
>Mature Secondary Structure
MKNINPTTTNAWKALQQHHKTQSAVTIQQLFAQEKDRFTDYSLSFNNEVLVDFSKNNVTK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCH
ETLGLLRQLAQECALSEAVDAMFSGAKINKTEDRAVLHTALRNRSNSPVLVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHH
NAVLAKMKDFCHRVISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNLHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAHSARNWFLATAKDESHVAKHF
ECCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHH
AALSTNSKAVAEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFEHFEALLAGAHEM
HHHCCCCCHHHEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKHFRTAPIEQNIPTTLALIGLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKY
HHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGEVIDNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLIPCDFIAPAQTHNPLADHHEK
ECCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHH
LLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDEVKEVVPFKVFTGNKPTNSILVQKITP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCCCCEEEECCCH
FTLGALIAMYEHKIFVQGVMFNIYSFDQWGVELGKQLANRILPELANRETITTHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
LINQYKQWR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100