Click here to switch to the map view.

The map label for this gene is nhaP [H]

Identifier: 15602230

GI number: 15602230

Start: 427790

End: 429115

Strand: Reverse

Name: nhaP [H]

Synonym: PM0365

Alternate gene names: 15602230

Gene position: 429115-427790 (Counterclockwise)

Preceding gene: 15602231

Following gene: 15602220

Centisome position: 19.01

GC content: 40.72

Gene sequence:

>1326_bases
ATGAATATTTATACCTATATTTGTTTTTTATCCGCGATCTCCATTTTTATTGGGTTTGTCACCCGGAAACTCAGCGATAA
AATCCAATACACCATCGCCATCACCGCCACCTCCATTATCGTTTCTGTTCTCTTCCTCATTTTCGGTCACCTTTCTTGGT
TTAAATTAGATATCATTGCCACACAAGTCATGGAACAACTCGATTTCAAAAGTTTTCTGCTCAATGGTATCCTCGGTTTC
TTATTATTTGCCGGTGCATTAGGTATAAAATTACCCGTTTTAAAAAACCAAAAATGGGAAATCACGGTGTTTGCGCTCTT
TTCCACACTTGCCTCTACCTTTATTATCGGCGTCTTGCTTTACAGTGTTGCTTATCTCATTGGTCTACCAATTGACCTGA
TCTATTGCATTTTATTTGGCGCTTTAATTTCGCCAACAGACCCTATCGCTGTACTGGCAATTATTAAAAATTTAAAAGCA
CCAAAACGCCTTTCCATGCAAGTCGAAGGCGAGTCCTTGTTTAATGACGGAGTTGGTTTGGTAATTTTTACTACGATTTT
TGCTGTCGCGTTTGGCGGGCACGCCCCAACATTAGCAGGCATTACGGAATTATTCTTACAAGAAGCTGTTGGCGGAATTT
TGTTTGGTCTCGTGATTGGCTTCGTAGCACATTTATTGATTTCATCCACAGACGATGGAAGTTTGGAAATTCTATTGACT
CTGACGATTCCTACCGCTGGTTTTATGCTCGCGAATATGTTGCATGTTTCTGGCGCTCTCGCCATGGTCGTAGCAGGTAT
TTTAATCGGCAACTGGACACGACACACGGGGTTTTCCAAACAAAGCCAACTCTACCTTGATCATTTTTGGGAAATGATTG
ATCACTTCTTAAATTCCCTCCTGTTCTTATTGATCGGCTTAGCACTGCTTTTAGTCGATTTCGGTGCTCAAGGCTTTATT
TTATTGATACTCGCGATTCCAATTTGTTTAATCGGACGCTATATCAGCGTGTGGATGCCTTTCAAAGTGATGCAACGTTT
TCGCTCCTATAATCCTTATACACTACGTATTCTAACATGGGGTGGACTACGTGGTGGTTTGTCACTTGCTATGGCATTAT
CGATTCCGAAAGGCATGTTATATCTTGAGCATATTGGGATGGATGTCCGAGATTTATTACTGGTAATGACTTATGCGGTA
GTCACCTTCTCAATTCTAGTACAGGGTTCTACGATTGAAACGATGATCAAAAAATCCAAAGAAAGTATTCTACATCAACG
AGGTTATGTCGGATTGCACCCGAACAAGACAAGTTCTGAAGACTAA

Upstream 100 bases:

>100_bases
ACAATTTTCCATTCTAAATGCACCTATTTTGTCTTATACTTAGCGGGCTGATTTTCACGAAAAATCAGCCTTTTTTCTTT
TACTCTCTGGAAAGCAACCT

Downstream 100 bases:

>100_bases
AAATACGCCCTCAAGATTGAGGGCGTGAAAATTCTCGTAAAATCGACCGCACTTAAATTGGTTTTACTGTCGAAAGCTCG
ATTTCTGCACTAAATTCATG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNIYTYICFLSAISIFIGFVTRKLSDKIQYTIAITATSIIVSVLFLIFGHLSWFKLDIIATQVMEQLDFKSFLLNGILGF
LLFAGALGIKLPVLKNQKWEITVFALFSTLASTFIIGVLLYSVAYLIGLPIDLIYCILFGALISPTDPIAVLAIIKNLKA
PKRLSMQVEGESLFNDGVGLVIFTTIFAVAFGGHAPTLAGITELFLQEAVGGILFGLVIGFVAHLLISSTDDGSLEILLT
LTIPTAGFMLANMLHVSGALAMVVAGILIGNWTRHTGFSKQSQLYLDHFWEMIDHFLNSLLFLLIGLALLLVDFGAQGFI
LLILAIPICLIGRYISVWMPFKVMQRFRSYNPYTLRILTWGGLRGGLSLAMALSIPKGMLYLEHIGMDVRDLLLVMTYAV
VTFSILVQGSTIETMIKKSKESILHQRGYVGLHPNKTSSED

Sequences:

>Translated_441_residues
MNIYTYICFLSAISIFIGFVTRKLSDKIQYTIAITATSIIVSVLFLIFGHLSWFKLDIIATQVMEQLDFKSFLLNGILGF
LLFAGALGIKLPVLKNQKWEITVFALFSTLASTFIIGVLLYSVAYLIGLPIDLIYCILFGALISPTDPIAVLAIIKNLKA
PKRLSMQVEGESLFNDGVGLVIFTTIFAVAFGGHAPTLAGITELFLQEAVGGILFGLVIGFVAHLLISSTDDGSLEILLT
LTIPTAGFMLANMLHVSGALAMVVAGILIGNWTRHTGFSKQSQLYLDHFWEMIDHFLNSLLFLLIGLALLLVDFGAQGFI
LLILAIPICLIGRYISVWMPFKVMQRFRSYNPYTLRILTWGGLRGGLSLAMALSIPKGMLYLEHIGMDVRDLLLVMTYAV
VTFSILVQGSTIETMIKKSKESILHQRGYVGLHPNKTSSED
>Mature_441_residues
MNIYTYICFLSAISIFIGFVTRKLSDKIQYTIAITATSIIVSVLFLIFGHLSWFKLDIIATQVMEQLDFKSFLLNGILGF
LLFAGALGIKLPVLKNQKWEITVFALFSTLASTFIIGVLLYSVAYLIGLPIDLIYCILFGALISPTDPIAVLAIIKNLKA
PKRLSMQVEGESLFNDGVGLVIFTTIFAVAFGGHAPTLAGITELFLQEAVGGILFGLVIGFVAHLLISSTDDGSLEILLT
LTIPTAGFMLANMLHVSGALAMVVAGILIGNWTRHTGFSKQSQLYLDHFWEMIDHFLNSLLFLLIGLALLLVDFGAQGFI
LLILAIPICLIGRYISVWMPFKVMQRFRSYNPYTLRILTWGGLRGGLSLAMALSIPKGMLYLEHIGMDVRDLLLVMTYAV
VTFSILVQGSTIETMIKKSKESILHQRGYVGLHPNKTSSED

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=344, Percent_Identity=25.8720930232558, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI15529998, Length=325, Percent_Identity=26.7692307692308, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI41872703, Length=353, Percent_Identity=25.2124645892351, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI27777632, Length=348, Percent_Identity=26.1494252873563, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI194239733, Length=328, Percent_Identity=26.5243902439024, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI294997330, Length=421, Percent_Identity=23.2779097387173, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI110227626, Length=421, Percent_Identity=23.2779097387173, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI5454070, Length=345, Percent_Identity=25.2173913043478, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4759144, Length=340, Percent_Identity=26.7647058823529, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI14211919, Length=333, Percent_Identity=27.9279279279279, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1790501, Length=322, Percent_Identity=30.7453416149068, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71999819, Length=339, Percent_Identity=25.9587020648968, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71999817, Length=339, Percent_Identity=25.9587020648968, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71999821, Length=337, Percent_Identity=26.1127596439169, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71987535, Length=375, Percent_Identity=26.4, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71987537, Length=375, Percent_Identity=26.4, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25150332, Length=326, Percent_Identity=22.0858895705521, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993590, Length=294, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71993582, Length=294, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71980847, Length=345, Percent_Identity=22.0289855072464, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71990924, Length=349, Percent_Identity=23.2091690544413, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990932, Length=330, Percent_Identity=24.2424242424242, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=275, Percent_Identity=24.7272727272727, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=275, Percent_Identity=24.7272727272727, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25147678, Length=300, Percent_Identity=25.6666666666667, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320663, Length=311, Percent_Identity=27.6527331189711, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281360447, Length=335, Percent_Identity=28.6567164179104, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221510734, Length=293, Percent_Identity=25.938566552901, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221510738, Length=293, Percent_Identity=25.938566552901, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281364513, Length=356, Percent_Identity=26.9662921348315, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221473212, Length=356, Percent_Identity=26.9662921348315, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510736, Length=325, Percent_Identity=25.8461538461538, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221473222, Length=356, Percent_Identity=26.9662921348315, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510732, Length=325, Percent_Identity=25.8461538461538, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221473215, Length=356, Percent_Identity=26.9662921348315, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585580, Length=325, Percent_Identity=25.8461538461538, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585578, Length=325, Percent_Identity=25.8461538461538, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221510740, Length=325, Percent_Identity=25.8461538461538, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 48533; Mature: 48533

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYTYICFLSAISIFIGFVTRKLSDKIQYTIAITATSIIVSVLFLIFGHLSWFKLDIIA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TQVMEQLDFKSFLLNGILGFLLFAGALGIKLPVLKNQKWEITVFALFSTLASTFIIGVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
YSVAYLIGLPIDLIYCILFGALISPTDPIAVLAIIKNLKAPKRLSMQVEGESLFNDGVGL
HHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCHH
VIFTTIFAVAFGGHAPTLAGITELFLQEAVGGILFGLVIGFVAHLLISSTDDGSLEILLT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
LTIPTAGFMLANMLHVSGALAMVVAGILIGNWTRHTGFSKQSQLYLDHFWEMIDHFLNSL
EECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LFLLIGLALLLVDFGAQGFILLILAIPICLIGRYISVWMPFKVMQRFRSYNPYTLRILTW
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEE
GGLRGGLSLAMALSIPKGMLYLEHIGMDVRDLLLVMTYAVVTFSILVQGSTIETMIKKSK
CCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ESILHQRGYVGLHPNKTSSED
HHHHHHCCCEECCCCCCCCCC
>Mature Secondary Structure
MNIYTYICFLSAISIFIGFVTRKLSDKIQYTIAITATSIIVSVLFLIFGHLSWFKLDIIA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TQVMEQLDFKSFLLNGILGFLLFAGALGIKLPVLKNQKWEITVFALFSTLASTFIIGVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
YSVAYLIGLPIDLIYCILFGALISPTDPIAVLAIIKNLKAPKRLSMQVEGESLFNDGVGL
HHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCHH
VIFTTIFAVAFGGHAPTLAGITELFLQEAVGGILFGLVIGFVAHLLISSTDDGSLEILLT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
LTIPTAGFMLANMLHVSGALAMVVAGILIGNWTRHTGFSKQSQLYLDHFWEMIDHFLNSL
EECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LFLLIGLALLLVDFGAQGFILLILAIPICLIGRYISVWMPFKVMQRFRSYNPYTLRILTW
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEE
GGLRGGLSLAMALSIPKGMLYLEHIGMDVRDLLLVMTYAVVTFSILVQGSTIETMIKKSK
CCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ESILHQRGYVGLHPNKTSSED
HHHHHHCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]