Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 15602033

GI number: 15602033

Start: 193886

End: 195223

Strand: Direct

Name: xseA

Synonym: PM0168

Alternate gene names: 15602033

Gene position: 193886-195223 (Clockwise)

Preceding gene: 15602032

Following gene: 15602039

Centisome position: 8.59

GC content: 43.5

Gene sequence:

>1338_bases
ATGTCTGAACACATTTACTCAGTTTCGCAATTAAATCAAACTGTACGGGTTATGCTAGAAAATCAGCTAAGGCAAGTTTG
GTTGACGGGTGAAATTTCTAATTTCACACAACCTGTTTCGGGGCATTGGTACTTAACCTTAAAAGATGAAAATGCGCAGG
TGCGTTGCGCGATGTTTCGCATGAAAAATATGCGTGTGAGTTTCCGTCCACAAAATGGCATGCAAGTGCTGGTGCACGCC
AGTGTCAGTTTATATGAACCTCGTGGCGATTATCAGTTGATTATCGAAAGCATGCACCCTGCAGGTGAAGGCTTATTGCA
GCAGCAATTTGAAGCATTGAAAATGCAGCTAGCAGCAGAAGGTTTATTTGCTCAACATTTGAAAAAAAGCTTACCACCAT
TTTGTAAAAGTGTCGGTATTGTGACATCACAAACTGGGGCTGCATTACAGGATATTTTGCAGATTTTGCGTCGTCGTGAT
CCGAGCTTACAGGTCGTGATTTATCCTACAGCTGTACAAGGTAAAGAGGCGAGTGCGGAAATTGTACAAATGATTGAACT
GGCAAATCGTCGTCAAGAAGTAGATGCCTTGATAGTGGGGCGTGGTGGTGGCTCATTAGAAGATTTGTGGTGTTTTAATG
AAGAAATGGTGGCAAGGGCAATTTTCCATTCTCAACTCCCGATTATTAGTGCGGTAGGGCATGAAACCGATGTGACGATT
GCGGATTTTGTGGCTGATTTACGTGCCCCTACGCCGTCAGCGGCAGCCGAACTCGTTAGCCGAGATCAGCAGGCCTTATT
ACAGCAACTTGTTTATCAACGTCAACGTCTAGAGATGGCGTTAGATCGTTTATTTAAACAAAAAGACGATAGATTACAGC
GTTTACGCTTGCGCTTGCATAACCAGCATCCACAAAGACAACTTTCGGCTCAGAAACAGTTAATGCAACAACTGGCACAT
CGTTTAGATTGGTCAATGCAAGCGGTATTACAACAAAAACAGGCGCAACTTCGTGTATTGTGGGCAAGGGTTGAGAAAAA
TCCCTTACCATTTACGTTGCAGAAACAAAAACAGGATTTGGCACAACTTAAAGTCCGTTTAGATGTAGCTTTGAAACGAG
AGCTCACTTTCAAACACCATCAATTCGCCGCTTTATGTACGAAATTAGATAGCATAAGCCCACTCAAAGTCTTTGCAAGA
GGCTATTCGATTGCACAAAATGCGCAAGGTGTGGCAATTACACAACTTAAGCAGGTTAGTGTCGGTGAACGTGTGATCAC
GCGTTTGGCAGACGGCGAAATTGTTAGCCAAGTAACGGATTTAAGACCGCGAAGTTAG

Upstream 100 bases:

>100_bases
GCTGGGTATTGCTGGAATAACCACGTATTTTTCATTTTAGGGGATCTTGTTCGCGGTTGGGCAAGATAACCGATCATAAA
TCATTACAAAGGCTATCACC

Downstream 100 bases:

>100_bases
CTTATTGTGTATTCGCTTTTTTATGTTTTGCTAAGGATTTATGCTGAATTTGCACGTTTTTCCCCTTAGCTTGGAAATAT
TCCCCTAACTGTTCGGTGAT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSEHIYSVSQLNQTVRVMLENQLRQVWLTGEISNFTQPVSGHWYLTLKDENAQVRCAMFRMKNMRVSFRPQNGMQVLVHA
SVSLYEPRGDYQLIIESMHPAGEGLLQQQFEALKMQLAAEGLFAQHLKKSLPPFCKSVGIVTSQTGAALQDILQILRRRD
PSLQVVIYPTAVQGKEASAEIVQMIELANRRQEVDALIVGRGGGSLEDLWCFNEEMVARAIFHSQLPIISAVGHETDVTI
ADFVADLRAPTPSAAAELVSRDQQALLQQLVYQRQRLEMALDRLFKQKDDRLQRLRLRLHNQHPQRQLSAQKQLMQQLAH
RLDWSMQAVLQQKQAQLRVLWARVEKNPLPFTLQKQKQDLAQLKVRLDVALKRELTFKHHQFAALCTKLDSISPLKVFAR
GYSIAQNAQGVAITQLKQVSVGERVITRLADGEIVSQVTDLRPRS

Sequences:

>Translated_445_residues
MSEHIYSVSQLNQTVRVMLENQLRQVWLTGEISNFTQPVSGHWYLTLKDENAQVRCAMFRMKNMRVSFRPQNGMQVLVHA
SVSLYEPRGDYQLIIESMHPAGEGLLQQQFEALKMQLAAEGLFAQHLKKSLPPFCKSVGIVTSQTGAALQDILQILRRRD
PSLQVVIYPTAVQGKEASAEIVQMIELANRRQEVDALIVGRGGGSLEDLWCFNEEMVARAIFHSQLPIISAVGHETDVTI
ADFVADLRAPTPSAAAELVSRDQQALLQQLVYQRQRLEMALDRLFKQKDDRLQRLRLRLHNQHPQRQLSAQKQLMQQLAH
RLDWSMQAVLQQKQAQLRVLWARVEKNPLPFTLQKQKQDLAQLKVRLDVALKRELTFKHHQFAALCTKLDSISPLKVFAR
GYSIAQNAQGVAITQLKQVSVGERVITRLADGEIVSQVTDLRPRS
>Mature_444_residues
SEHIYSVSQLNQTVRVMLENQLRQVWLTGEISNFTQPVSGHWYLTLKDENAQVRCAMFRMKNMRVSFRPQNGMQVLVHAS
VSLYEPRGDYQLIIESMHPAGEGLLQQQFEALKMQLAAEGLFAQHLKKSLPPFCKSVGIVTSQTGAALQDILQILRRRDP
SLQVVIYPTAVQGKEASAEIVQMIELANRRQEVDALIVGRGGGSLEDLWCFNEEMVARAIFHSQLPIISAVGHETDVTIA
DFVADLRAPTPSAAAELVSRDQQALLQQLVYQRQRLEMALDRLFKQKDDRLQRLRLRLHNQHPQRQLSAQKQLMQQLAHR
LDWSMQAVLQQKQAQLRVLWARVEKNPLPFTLQKQKQDLAQLKVRLDVALKRELTFKHHQFAALCTKLDSISPLKVFARG
YSIAQNAQGVAITQLKQVSVGERVITRLADGEIVSQVTDLRPRS

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=443, Percent_Identity=55.9819413092551, Blast_Score=504, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_PASMU (Q9CP86)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245105.1
- GeneID:   1243515
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0168
- NMPDR:   fig|272843.1.peg.168
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- ProtClustDB:   PRK00286
- BioCyc:   PMUL272843:PM0168-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50596; Mature: 50465

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHIYSVSQLNQTVRVMLENQLRQVWLTGEISNFTQPVSGHWYLTLKDENAQVRCAMFR
CCCHHHHHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEEEEEECCCCCCHHHHHH
MKNMRVSFRPQNGMQVLVHASVSLYEPRGDYQLIIESMHPAGEGLLQQQFEALKMQLAAE
HHCCEEEECCCCCCEEEEEECEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GLFAQHLKKSLPPFCKSVGIVTSQTGAALQDILQILRRRDPSLQVVIYPTAVQGKEASAE
HHHHHHHHHHCCHHHHHCCCEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
IVQMIELANRRQEVDALIVGRGGGSLEDLWCFNEEMVARAIFHSQLPIISAVGHETDVTI
HHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCHH
ADFVADLRAPTPSAAAELVSRDQQALLQQLVYQRQRLEMALDRLFKQKDDRLQRLRLRLH
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQHPQRQLSAQKQLMQQLAHRLDWSMQAVLQQKQAQLRVLWARVEKNPLPFTLQKQKQDL
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
AQLKVRLDVALKRELTFKHHQFAALCTKLDSISPLKVFARGYSIAQNAQGVAITQLKQVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
VGERVITRLADGEIVSQVTDLRPRS
HHHHHHHHHCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SEHIYSVSQLNQTVRVMLENQLRQVWLTGEISNFTQPVSGHWYLTLKDENAQVRCAMFR
CCHHHHHHHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEEEEEECCCCCCHHHHHH
MKNMRVSFRPQNGMQVLVHASVSLYEPRGDYQLIIESMHPAGEGLLQQQFEALKMQLAAE
HHCCEEEECCCCCCEEEEEECEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GLFAQHLKKSLPPFCKSVGIVTSQTGAALQDILQILRRRDPSLQVVIYPTAVQGKEASAE
HHHHHHHHHHCCHHHHHCCCEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
IVQMIELANRRQEVDALIVGRGGGSLEDLWCFNEEMVARAIFHSQLPIISAVGHETDVTI
HHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCHH
ADFVADLRAPTPSAAAELVSRDQQALLQQLVYQRQRLEMALDRLFKQKDDRLQRLRLRLH
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQHPQRQLSAQKQLMQQLAHRLDWSMQAVLQQKQAQLRVLWARVEKNPLPFTLQKQKQDL
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
AQLKVRLDVALKRELTFKHHQFAALCTKLDSISPLKVFARGYSIAQNAQGVAITQLKQVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
VGERVITRLADGEIVSQVTDLRPRS
HHHHHHHHHCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100