Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 15601986

GI number: 15601986

Start: 147603

End: 148142

Strand: Direct

Name: hpt [H]

Synonym: PM0121

Alternate gene names: 15601986

Gene position: 147603-148142 (Clockwise)

Preceding gene: 15601985

Following gene: 15601987

Centisome position: 6.54

GC content: 39.81

Gene sequence:

>540_bases
ATGAAAAAACATCATGTTGGTATTTTAATCTCGGAACAAGACGTACGTGCACGTATTCAAACGCTTGGTCGTGAAATTAC
GCAATATTACCAACAAAAAGCAGTCGAGAAAGTCATTGTTGTTGGGCTCTTACGTGGTTCGTTTATGTTTATGGCAGATT
TAGTGCGTGAGCTGAATTTACCGGTAGAAATCGAATTTATGACCACCTCTAGTTATGGTTCAGGCATGACGACCAATCAC
GATGTAAAAATCAGTAAAGATCTGGATGGTGACATTAAAGGTGAGCATGTTTTAATTATCGAAGATATTATCGATACAGG
TTACACCTTACAAAAAGTGCGTGAGATTCTGAAATTACGTGAACCTGCCTCGCTGCGCATTTGTACCTTGTTAGATAAGC
CGTCACGTAGAGAAGTGGAAGTGCCGGTGGAATGGGTAGGATTTAGTATCCCTGATGAATTTGTGGTGGGTTATGGCATT
GATTATGCACAACGTTATCGTAATTTAGGGTATATTGGCCATGTGGTCTTAGAAGAATAA

Upstream 100 bases:

>100_bases
GAAAGTAAATTCGTTAGGGTATTTATGGGCTGAAGGTTTAAACTTCAGCCTTTTTTTTGTAGAATACGCTTTTATAACCC
GATATAAAAGGTAAATTAGA

Downstream 100 bases:

>100_bases
CCAATATGCTTGATGGCTTAAAAGGAGAACAAATGTATCTAGAACAGATTAAAGCAGAGTTAAATGAAGCTGCGACAGTA
TTAAATAAGTTTATTAACGA

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKKHHVGILISEQDVRARIQTLGREITQYYQQKAVEKVIVVGLLRGSFMFMADLVRELNLPVEIEFMTTSSYGSGMTTNH
DVKISKDLDGDIKGEHVLIIEDIIDTGYTLQKVREILKLREPASLRICTLLDKPSRREVEVPVEWVGFSIPDEFVVGYGI
DYAQRYRNLGYIGHVVLEE

Sequences:

>Translated_179_residues
MKKHHVGILISEQDVRARIQTLGREITQYYQQKAVEKVIVVGLLRGSFMFMADLVRELNLPVEIEFMTTSSYGSGMTTNH
DVKISKDLDGDIKGEHVLIIEDIIDTGYTLQKVREILKLREPASLRICTLLDKPSRREVEVPVEWVGFSIPDEFVVGYGI
DYAQRYRNLGYIGHVVLEE
>Mature_179_residues
MKKHHVGILISEQDVRARIQTLGREITQYYQQKAVEKVIVVGLLRGSFMFMADLVRELNLPVEIEFMTTSSYGSGMTTNH
DVKISKDLDGDIKGEHVLIIEDIIDTGYTLQKVREILKLREPASLRICTLLDKPSRREVEVPVEWVGFSIPDEFVVGYGI
DYAQRYRNLGYIGHVVLEE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=174, Percent_Identity=30.4597701149425, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI9910262, Length=183, Percent_Identity=27.3224043715847, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI87081689, Length=175, Percent_Identity=69.1428571428571, Blast_Score=246, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17510817, Length=174, Percent_Identity=36.2068965517241, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20482; Mature: 20482

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHHVGILISEQDVRARIQTLGREITQYYQQKAVEKVIVVGLLRGSFMFMADLVRELNL
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEIEFMTTSSYGSGMTTNHDVKISKDLDGDIKGEHVLIIEDIIDTGYTLQKVREILKLR
CEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHCCCHHHHHHHHHHHHC
EPASLRICTLLDKPSRREVEVPVEWVGFSIPDEFVVGYGIDYAQRYRNLGYIGHVVLEE
CCCCEEEEEEECCCCCCEEECCHHEECCCCCCHHEEECCCHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MKKHHVGILISEQDVRARIQTLGREITQYYQQKAVEKVIVVGLLRGSFMFMADLVRELNL
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVEIEFMTTSSYGSGMTTNHDVKISKDLDGDIKGEHVLIIEDIIDTGYTLQKVREILKLR
CEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHCCCHHHHHHHHHHHHC
EPASLRICTLLDKPSRREVEVPVEWVGFSIPDEFVVGYGIDYAQRYRNLGYIGHVVLEE
CCCCEEEEEEECCCCCCEEECCHHEECCCCCCHHEEECCCHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]