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The map label for this gene is ccmE

Identifier: 15601874

GI number: 15601874

Start: 7872

End: 8411

Strand: Direct

Name: ccmE

Synonym: PM0009

Alternate gene names: 15601874

Gene position: 7872-8411 (Clockwise)

Preceding gene: 15601873

Following gene: 15601875

Centisome position: 0.35

GC content: 40.93

Gene sequence:

>540_bases
ATGACTCCAAGACGTAAGTCAAGAATGACTGTGATTTTATTTGTATTACTCGGGATTTCCATTGCTTCTGCCTTAGTGCT
CTATGCATTACGCCAAAATATTGATTTATTTTATACCCCAACAGAAGTGGTGTATGGTAAGAATGAAGACGCAACTCAGA
AACCTAGCGTAGGACAACGTATTCGTGTGGGGGGCATGGTTGTGGCTGGTACAGTAGAACGTGATCCAAAGAGCTTGAAA
GTCAAATTTGATCTCAATGATATTGGACCTTCCATCAGTGTGGAATATGAAGGCATTCTGCCAGATTTATTCCGAGAAGG
ACAAGGGATCGTGGCACAAGGCGTATTAAAAACACCAACTTTACTGGAAGCGACAGAAGTATTAGCTAAACATGATGAAA
ATTATGTGCCACCAGAATTAGATGCACAAATGCAAAAAGTACATAAACCTATGGGGGTCGCTGATTTGAAAGGGGAAAGC
GAGCGAGATCGTCAAGAAAAAGCTTACCAGAAAACATCGATGCAAGAAGGTCAAAAATGA

Upstream 100 bases:

>100_bases
TTGTACAAAGTGTGAAGGAGAGAAAAGCGATTTTGCGTGATGTACTGCGTGAACAGCAACGCCAAGCACGTTTACAAAAG
AATAAAACAAGAGGTGCGCT

Downstream 100 bases:

>100_bases
TCGCTGAATTAGGAAATTATGCTTTAGCGTTAAGTCTTGCCATCGCGATGCTAGTGGCAATTTTTGCCTTGTGGGGCGCA
GAAAAAAATCATATACAACT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MTPRRKSRMTVILFVLLGISIASALVLYALRQNIDLFYTPTEVVYGKNEDATQKPSVGQRIRVGGMVVAGTVERDPKSLK
VKFDLNDIGPSISVEYEGILPDLFREGQGIVAQGVLKTPTLLEATEVLAKHDENYVPPELDAQMQKVHKPMGVADLKGES
ERDRQEKAYQKTSMQEGQK

Sequences:

>Translated_179_residues
MTPRRKSRMTVILFVLLGISIASALVLYALRQNIDLFYTPTEVVYGKNEDATQKPSVGQRIRVGGMVVAGTVERDPKSLK
VKFDLNDIGPSISVEYEGILPDLFREGQGIVAQGVLKTPTLLEATEVLAKHDENYVPPELDAQMQKVHKPMGVADLKGES
ERDRQEKAYQKTSMQEGQK
>Mature_178_residues
TPRRKSRMTVILFVLLGISIASALVLYALRQNIDLFYTPTEVVYGKNEDATQKPSVGQRIRVGGMVVAGTVERDPKSLKV
KFDLNDIGPSISVEYEGILPDLFREGQGIVAQGVLKTPTLLEATEVLAKHDENYVPPELDAQMQKVHKPMGVADLKGESE
RDRQEKAYQKTSMQEGQK

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=149, Percent_Identity=58.3892617449664, Blast_Score=179, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_PASMU (Q9CPM8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244946.1
- ProteinModelPortal:   Q9CPM8
- SMR:   Q9CPM8
- GeneID:   1243356
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0009
- NMPDR:   fig|272843.1.peg.9
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- ProtClustDB:   PRK13165
- BioCyc:   PMUL272843:PM0009-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 19901; Mature: 19770

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: BINDING 131-131

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRRKSRMTVILFVLLGISIASALVLYALRQNIDLFYTPTEVVYGKNEDATQKPSVGQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEECCCCCCCCCCCCCCE
IRVGGMVVAGTVERDPKSLKVKFDLNDIGPSISVEYEGILPDLFREGQGIVAQGVLKTPT
EEECCEEEEEECCCCCCEEEEEEEHHHCCCCEEEEECCCCHHHHHCCCCCEECCCCCCCH
LLEATEVLAKHDENYVPPELDAQMQKVHKPMGVADLKGESERDRQEKAYQKTSMQEGQK
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
TPRRKSRMTVILFVLLGISIASALVLYALRQNIDLFYTPTEVVYGKNEDATQKPSVGQR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEECCCCCCCCCCCCCCE
IRVGGMVVAGTVERDPKSLKVKFDLNDIGPSISVEYEGILPDLFREGQGIVAQGVLKTPT
EEECCEEEEEECCCCCCEEEEEEEHHHCCCCEEEEECCCCHHHHHCCCCCEECCCCCCCH
LLEATEVLAKHDENYVPPELDAQMQKVHKPMGVADLKGESERDRQEKAYQKTSMQEGQK
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100