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The map label for this gene is clpP

Identifier: 15595102

GI number: 15595102

Start: 800452

End: 801072

Strand: Direct

Name: clpP

Synonym: BB0757

Alternate gene names: 15595102

Gene position: 800452-801072 (Clockwise)

Preceding gene: 15595095

Following gene: 15595103

Centisome position: 87.89

GC content: 32.85

Gene sequence:

>621_bases
ATGTTTTTGTATAAGGGATGTTTTATGACCGGGAAAGAAGATAATGATGCTTGTGTTTTGCATGATAAATCATTGAAGTT
AGTTTTAAAGAGCAGATCAATAGTTATTGCTGGTGAGATTACCAAGGATGTTTCCAGGCTTTTTCAGGAAAAAATATTAT
TGCTAGAGGCTCTAGATTTTAAAAAGCCTATATTTGTGTATATTGATTCAGAAGGAGGCGACATTGATGCTGGATTTGCT
ATTTTTAATATGATTCGCTTTGTTAAGCCTAAAGTTTTTACAGTTGGAGTAGGGCTTGTTGCTAGCGCTGCTGCTTTAAT
TTTTTTGGCTGCAAAATTAGAAAATAGATTTTCACTGCCCTTTGCCAGATATTTATTGCACCAGCCCTTGAGTGGATTTA
AGGGAGTTGCTACAGATATTGAGATTTACACTAATGAGTTAAATAAAGTTAAAAAAGAACTTAATAATATTATTTCAAAA
GAAACGGGTCAAAAAATTTCTAAAATAGAAAAGGATACTGATAGAGATTTTTGGTTGGATAGTAGTGCTGCAAAAAAGTA
TGGGCTTGTATTTGAAGTTGTTGAGACAAAGTATCAACTTGAAGAGTTTATTTCCGCTTAG

Upstream 100 bases:

>100_bases
TTTATTAGTCTTTTGCTTTTCAGAAATTAAGTGCAATTGTTTAATTTTTGTGCTTTTTTATCATTTAAAAACCTTTTATT
TTCAATTATAATATATCATT

Downstream 100 bases:

>100_bases
TGTTTTATTTTTTTCCTGTAATGTTGTAGATACAGATTTTAGTGTTTTGGAGTTTAAGGTTGCAAATTTTAATTTAAATG
ATGATTTTTCTCAAGGGTTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MFLYKGCFMTGKEDNDACVLHDKSLKLVLKSRSIVIAGEITKDVSRLFQEKILLLEALDFKKPIFVYIDSEGGDIDAGFA
IFNMIRFVKPKVFTVGVGLVASAAALIFLAAKLENRFSLPFARYLLHQPLSGFKGVATDIEIYTNELNKVKKELNNIISK
ETGQKISKIEKDTDRDFWLDSSAAKKYGLVFEVVETKYQLEEFISA

Sequences:

>Translated_206_residues
MFLYKGCFMTGKEDNDACVLHDKSLKLVLKSRSIVIAGEITKDVSRLFQEKILLLEALDFKKPIFVYIDSEGGDIDAGFA
IFNMIRFVKPKVFTVGVGLVASAAALIFLAAKLENRFSLPFARYLLHQPLSGFKGVATDIEIYTNELNKVKKELNNIISK
ETGQKISKIEKDTDRDFWLDSSAAKKYGLVFEVVETKYQLEEFISA
>Mature_206_residues
MFLYKGCFMTGKEDNDACVLHDKSLKLVLKSRSIVIAGEITKDVSRLFQEKILLLEALDFKKPIFVYIDSEGGDIDAGFA
IFNMIRFVKPKVFTVGVGLVASAAALIFLAAKLENRFSLPFARYLLHQPLSGFKGVATDIEIYTNELNKVKKELNNIISK
ETGQKISKIEKDTDRDFWLDSSAAKKYGLVFEVVETKYQLEEFISA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=167, Percent_Identity=35.9281437125749, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786641, Length=163, Percent_Identity=41.7177914110429, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17538017, Length=166, Percent_Identity=32.5301204819277, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI20129427, Length=168, Percent_Identity=36.9047619047619, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_BORBU (O51698)

Other databases:

- EMBL:   AE000783
- PIR:   D70194
- RefSeq:   NP_212891.1
- ProteinModelPortal:   O51698
- SMR:   O51698
- EnsemblBacteria:   EBBORT00000009006
- GeneID:   1195613
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0757
- NMPDR:   fig|224326.1.peg.1141
- TIGR:   BB_0757
- GeneTree:   EBGT00050000007013
- HOGENOM:   HBG558421
- OMA:   IHDMIKF
- ProtClustDB:   PRK14512
- BioCyc:   BBUR224326:BB_0757-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23206; Mature: 23206

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 102-102 ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLYKGCFMTGKEDNDACVLHDKSLKLVLKSRSIVIAGEITKDVSRLFQEKILLLEALDF
CEEECCEEECCCCCCCEEEEECCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCC
KKPIFVYIDSEGGDIDAGFAIFNMIRFVKPKVFTVGVGLVASAAALIFLAAKLENRFSLP
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCH
FARYLLHQPLSGFKGVATDIEIYTNELNKVKKELNNIISKETGQKISKIEKDTDRDFWLD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
SSAAKKYGLVFEVVETKYQLEEFISA
CHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFLYKGCFMTGKEDNDACVLHDKSLKLVLKSRSIVIAGEITKDVSRLFQEKILLLEALDF
CEEECCEEECCCCCCCEEEEECCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCC
KKPIFVYIDSEGGDIDAGFAIFNMIRFVKPKVFTVGVGLVASAAALIFLAAKLENRFSLP
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCH
FARYLLHQPLSGFKGVATDIEIYTNELNKVKKELNNIISKETGQKISKIEKDTDRDFWLD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
SSAAKKYGLVFEVVETKYQLEEFISA
CHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685