Click here to switch to the map view.

The map label for this gene is lctP [H]

Identifier: 15594949

GI number: 15594949

Start: 629196

End: 630698

Strand: Reverse

Name: lctP [H]

Synonym: BB0604

Alternate gene names: 15594949

Gene position: 630698-629196 (Counterclockwise)

Preceding gene: 15594954

Following gene: 15594948

Centisome position: 69.25

GC content: 33.2

Gene sequence:

>1503_bases
ATGAATTCTTATGATTTTATAACAGCTTTGGTACCAATAATCCTAATAATTATTGGACTTGGCATAATAAAAAAGCCAGC
TTACTATGTAATACCCATATCATTAATAGCCACCGTTGCTATAGTTATATTTTATAAAAACTTGGGAATAGTAAACACAA
GTCTTGCAATGCTTGAGGGCGCCTTAATGGGGATATGGCCAATAGCAACTGTAATTATTGCTGCCATATTTACATACAAA
ATGTCAGAAGATCAAAAAGATATAGAAACTATTAAAAATATTTTATCAAACGTATCTTCTGATAGAAGAATTATAGTATT
ACTAGTTGCATGGGGATTTGGAAATTTTTTAGAAGGAGTTGCTGGATATGGAACTGCTGTTGCAATTCCTGTATCAATAT
TAATAGCAATGGGATTTGAACCATTTTTTGCCTGCTTAATCTGTTTAATAATGAACACCTCATCAACCGCCTACGGATCT
GTGGGAATCCCTATAACATCTTTAGCTCAAGCAACTAACTTGGATGTTAACATTGTTTCATCTGAGATTGCATTCCAACT
AATACTTCCAACCTTAACAATACCTTTTGTACTGGTAATTCTTACAGGAGGGGGCATTAAAGGATTAAAAGGAGTATTCC
TTCTTACCTTACTCTCAGGAATGTCAATGGCAATATCTCAAGTATTTATATCAAAAACTTTGGGTCCAGAACTTCCTGCA
ATCCTTGGAAGCATTCTTTCTATGACAATAACAATAGTTTATGCAAGGTTTTTTGGAAATAAAGAAACTACTGAGCGCCA
AAGCAAAAACACAATATCCTTATCAAAAGGAATTATTGCCTGCTCACCCTACATTTTAATAGTAACTTTTATAGTGCTTG
TATCTCCTCTTTTTAACAAAATTCATGAATACCTAAAAACTTTTCAAAGCACTATTAGCATTTATCCAGAAGCAAATCCC
TTACACTTTAAATGGATTATCTCTCCGGGCTTCTTGATTATACTTGCAACAACAATATCCTATTCAATACGGGGAGTTCC
AATGTTAAAACAGCTAAAAATATTTACATTAACCTTGAAAAAAATGGCATTATCTTCCTTTATAATCATATGCATTGTTG
CAATATCAAGATTAATGACACATAGTGGAATGATAAGAGATCTTGCTAATGGAATCTCAATAATAACAGGTAAATTTGGA
CCATTATTTAGCCCACTAATTGGAGCTATTGGGACATTTTTAACAGGAAGTGATACGGTTTCAAATGTTCTTTTTGGACC
TTTACAAACACAAATGGCAGAAAATATTGGAGCAAATCCTTACTGGCTTGCAGCAGCAAATACAACAGGAGCAACTGGAG
GGAAAATGATTTCTCCCCAAAACATCACAATAGCAACAACAACTGCTGGATTAATTGGACAAGAAGGCAAGCTTTTATCA
AAAACAATAATTTATGCTTTATACTACATTTTAGCAACAGGATTGCTAGTTTATTTAGTATAA

Upstream 100 bases:

>100_bases
CAATTTCCCAATAACATAGATACTATTCATGTTGTAATATTAAAATTATATATTATTTATTGATTGTTAATTACAATACA
ATTAAAAAGGAGCCATTTTT

Downstream 100 bases:

>100_bases
ATTAATCATTTAAAATAAATAAGATTAATTTATACTAAAATTAATCTTATTTATAGATTTGAATAATACAAAAATCACAA
AATAATAATATGGCCTTGAA

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MNSYDFITALVPIILIIIGLGIIKKPAYYVIPISLIATVAIVIFYKNLGIVNTSLAMLEGALMGIWPIATVIIAAIFTYK
MSEDQKDIETIKNILSNVSSDRRIIVLLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLICLIMNTSSTAYGS
VGIPITSLAQATNLDVNIVSSEIAFQLILPTLTIPFVLVILTGGGIKGLKGVFLLTLLSGMSMAISQVFISKTLGPELPA
ILGSILSMTITIVYARFFGNKETTERQSKNTISLSKGIIACSPYILIVTFIVLVSPLFNKIHEYLKTFQSTISIYPEANP
LHFKWIISPGFLIILATTISYSIRGVPMLKQLKIFTLTLKKMALSSFIIICIVAISRLMTHSGMIRDLANGISIITGKFG
PLFSPLIGAIGTFLTGSDTVSNVLFGPLQTQMAENIGANPYWLAAANTTGATGGKMISPQNITIATTTAGLIGQEGKLLS
KTIIYALYYILATGLLVYLV

Sequences:

>Translated_500_residues
MNSYDFITALVPIILIIIGLGIIKKPAYYVIPISLIATVAIVIFYKNLGIVNTSLAMLEGALMGIWPIATVIIAAIFTYK
MSEDQKDIETIKNILSNVSSDRRIIVLLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLICLIMNTSSTAYGS
VGIPITSLAQATNLDVNIVSSEIAFQLILPTLTIPFVLVILTGGGIKGLKGVFLLTLLSGMSMAISQVFISKTLGPELPA
ILGSILSMTITIVYARFFGNKETTERQSKNTISLSKGIIACSPYILIVTFIVLVSPLFNKIHEYLKTFQSTISIYPEANP
LHFKWIISPGFLIILATTISYSIRGVPMLKQLKIFTLTLKKMALSSFIIICIVAISRLMTHSGMIRDLANGISIITGKFG
PLFSPLIGAIGTFLTGSDTVSNVLFGPLQTQMAENIGANPYWLAAANTTGATGGKMISPQNITIATTTAGLIGQEGKLLS
KTIIYALYYILATGLLVYLV
>Mature_500_residues
MNSYDFITALVPIILIIIGLGIIKKPAYYVIPISLIATVAIVIFYKNLGIVNTSLAMLEGALMGIWPIATVIIAAIFTYK
MSEDQKDIETIKNILSNVSSDRRIIVLLVAWGFGNFLEGVAGYGTAVAIPVSILIAMGFEPFFACLICLIMNTSSTAYGS
VGIPITSLAQATNLDVNIVSSEIAFQLILPTLTIPFVLVILTGGGIKGLKGVFLLTLLSGMSMAISQVFISKTLGPELPA
ILGSILSMTITIVYARFFGNKETTERQSKNTISLSKGIIACSPYILIVTFIVLVSPLFNKIHEYLKTFQSTISIYPEANP
LHFKWIISPGFLIILATTISYSIRGVPMLKQLKIFTLTLKKMALSSFIIICIVAISRLMTHSGMIRDLANGISIITGKFG
PLFSPLIGAIGTFLTGSDTVSNVLFGPLQTQMAENIGANPYWLAAANTTGATGGKMISPQNITIATTTAGLIGQEGKLLS
KTIIYALYYILATGLLVYLV

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=534, Percent_Identity=31.6479400749064, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1790031, Length=525, Percent_Identity=30.2857142857143, Blast_Score=217, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 53681; Mature: 53681

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSYDFITALVPIILIIIGLGIIKKPAYYVIPISLIATVAIVIFYKNLGIVNTSLAMLEG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALMGIWPIATVIIAAIFTYKMSEDQKDIETIKNILSNVSSDRRIIVLLVAWGFGNFLEGV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHH
AGYGTAVAIPVSILIAMGFEPFFACLICLIMNTSSTAYGSVGIPITSLAQATNLDVNIVS
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEH
SEIAFQLILPTLTIPFVLVILTGGGIKGLKGVFLLTLLSGMSMAISQVFISKTLGPELPA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ILGSILSMTITIVYARFFGNKETTERQSKNTISLSKGIIACSPYILIVTFIVLVSPLFNK
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEHHCCCHHHCHHHHHHHHHHHHHHHHHH
IHEYLKTFQSTISIYPEANPLHFKWIISPGFLIILATTISYSIRGVPMLKQLKIFTLTLK
HHHHHHHHHHHHEECCCCCCEEEEEEECCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHH
KMALSSFIIICIVAISRLMTHSGMIRDLANGISIITGKFGPLFSPLIGAIGTFLTGSDTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCHHH
SNVLFGPLQTQMAENIGANPYWLAAANTTGATGGKMISPQNITIATTTAGLIGQEGKLLS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECCHHCCCCCHHHH
KTIIYALYYILATGLLVYLV
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSYDFITALVPIILIIIGLGIIKKPAYYVIPISLIATVAIVIFYKNLGIVNTSLAMLEG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ALMGIWPIATVIIAAIFTYKMSEDQKDIETIKNILSNVSSDRRIIVLLVAWGFGNFLEGV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHH
AGYGTAVAIPVSILIAMGFEPFFACLICLIMNTSSTAYGSVGIPITSLAQATNLDVNIVS
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEH
SEIAFQLILPTLTIPFVLVILTGGGIKGLKGVFLLTLLSGMSMAISQVFISKTLGPELPA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ILGSILSMTITIVYARFFGNKETTERQSKNTISLSKGIIACSPYILIVTFIVLVSPLFNK
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEHHCCCHHHCHHHHHHHHHHHHHHHHHH
IHEYLKTFQSTISIYPEANPLHFKWIISPGFLIILATTISYSIRGVPMLKQLKIFTLTLK
HHHHHHHHHHHHEECCCCCCEEEEEEECCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHH
KMALSSFIIICIVAISRLMTHSGMIRDLANGISIITGKFGPLFSPLIGAIGTFLTGSDTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCHHH
SNVLFGPLQTQMAENIGANPYWLAAANTTGATGGKMISPQNITIATTTAGLIGQEGKLLS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEECCCCEEEEEECCHHCCCCCHHHH
KTIIYALYYILATGLLVYLV
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]