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The map label for this gene is murB

Identifier: 15594943

GI number: 15594943

Start: 621045

End: 621953

Strand: Reverse

Name: murB

Synonym: BB0598

Alternate gene names: 15594943

Gene position: 621953-621045 (Counterclockwise)

Preceding gene: 15594948

Following gene: 15594941

Centisome position: 68.29

GC content: 28.49

Gene sequence:

>909_bases
ATGCCTAAAAGCCTAAATAATTTTCTTAAAAAAATCAATATTAAGCCTCAAACAAAAAATCTAGCTAACTATACAACATA
TAAAATTGGAAACATTTCGAAATTATTTCTCACCCCTAAAAATATTAAAGAGGCTGAAAATATTTTTAAAGCAGCAATAG
AAGAAAAAATTAAACTATTTATTCTTGGGGGAGGATCAAATATTTTAGTCAATGACGAGAGAGAGATTGATTTTCCAATA
ATATACACCGGATATCTAAACAAAATAGAAATTCACGAAAATAAAATTGTCGGCGAATGTGGTGCAGATTTTGAAAGTTT
ATGTAAAATTGCACTTGATAACAGCTTAAGTGGCCTAGAATTTATCTATGGACTACCCGGAACACTAGGGGGCGCTGTGT
GGATGAATGCTAGATGTTTCGGGAATGAAATCTCTGAGATACTAAAAAAAATTACATTTATAGATGATAAAGGAAAAACT
ATTTGCAAAGAATTTAAAAAAGAAGACTTTAAGTATAAAATATCGCCTTTTCAAAATAAAAACTTTTTCATATTAAAAAT
TGAATTAAATTTAAAAAAAGACAATAAGAAAATTATTGAAGAAAAAATGAATAAAAATAAACAAGCAAGAATAAATAGAG
GTCATTATTTATTTCCAAGTGGTGGAAGCACTTTTAAAAACAATAAAGCATTTCTCAAGCCTAGTGGACAAATAATTGAA
GAGTGCAAGCTCAAAGGATTAAGCATTGGAGGCGCCACAGTATCTAAATATCATGGAAACTTTATTATCAATATTAACAA
TGCCACTTCTAAAGACATAAAAAGCTTAATTGAAAAAGTAAAAGCTGAGGTCTACTTGAAAACTGGACTTTTACTAGAAG
AAGAAGTTCTTTACATAGGATTCAAATAA

Upstream 100 bases:

>100_bases
TTAATTCTGAAAAATCCTTTGTTCTAGTATTATATAACTTTAAAATCATACATTTCTCAAAATTGAAAAAATAAAAAATC
TAATTTATTATTAAGTACGT

Downstream 100 bases:

>100_bases
TCAAAAAAACTAAAAAAGAATATCTTTAATCTCATCATTAATCTTTTGAATCAATTCCTTTGTCTTTAATATCTTATCCT
TAGAAGACTTTACTAAAGAT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPKSLNNFLKKINIKPQTKNLANYTTYKIGNISKLFLTPKNIKEAENIFKAAIEEKIKLFILGGGSNILVNDEREIDFPI
IYTGYLNKIEIHENKIVGECGADFESLCKIALDNSLSGLEFIYGLPGTLGGAVWMNARCFGNEISEILKKITFIDDKGKT
ICKEFKKEDFKYKISPFQNKNFFILKIELNLKKDNKKIIEEKMNKNKQARINRGHYLFPSGGSTFKNNKAFLKPSGQIIE
ECKLKGLSIGGATVSKYHGNFIININNATSKDIKSLIEKVKAEVYLKTGLLLEEEVLYIGFK

Sequences:

>Translated_302_residues
MPKSLNNFLKKINIKPQTKNLANYTTYKIGNISKLFLTPKNIKEAENIFKAAIEEKIKLFILGGGSNILVNDEREIDFPI
IYTGYLNKIEIHENKIVGECGADFESLCKIALDNSLSGLEFIYGLPGTLGGAVWMNARCFGNEISEILKKITFIDDKGKT
ICKEFKKEDFKYKISPFQNKNFFILKIELNLKKDNKKIIEEKMNKNKQARINRGHYLFPSGGSTFKNNKAFLKPSGQIIE
ECKLKGLSIGGATVSKYHGNFIININNATSKDIKSLIEKVKAEVYLKTGLLLEEEVLYIGFK
>Mature_301_residues
PKSLNNFLKKINIKPQTKNLANYTTYKIGNISKLFLTPKNIKEAENIFKAAIEEKIKLFILGGGSNILVNDEREIDFPII
YTGYLNKIEIHENKIVGECGADFESLCKIALDNSLSGLEFIYGLPGTLGGAVWMNARCFGNEISEILKKITFIDDKGKTI
CKEFKKEDFKYKISPFQNKNFFILKIELNLKKDNKKIIEEKMNKNKQARINRGHYLFPSGGSTFKNNKAFLKPSGQIIEE
CKLKGLSIGGATVSKYHGNFIININNATSKDIKSLIEKVKAEVYLKTGLLLEEEVLYIGFK

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_BORBU (O51544)

Other databases:

- EMBL:   AE000783
- PIR:   E70174
- RefSeq:   NP_212732.1
- ProteinModelPortal:   O51544
- EnsemblBacteria:   EBBORT00000008851
- GeneID:   1195445
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0598
- NMPDR:   fig|224326.1.peg.982
- TIGR:   BB_0598
- GeneTree:   EBGT00050000007374
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- PhylomeDB:   O51544
- ProtClustDB:   PRK14650
- BioCyc:   BBUR224326:BB_0598-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 34182; Mature: 34051

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 223-223 ACT_SITE 295-295

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSLNNFLKKINIKPQTKNLANYTTYKIGNISKLFLTPKNIKEAENIFKAAIEEKIKLF
CCCHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHCCEEEE
ILGGGSNILVNDEREIDFPIIYTGYLNKIEIHENKIVGECGADFESLCKIALDNSLSGLE
EEECCCEEEEECCCCCCCCEEEECCCCEEEEECCEEEECCCCCHHHHHHHHHCCCCCCCH
FIYGLPGTLGGAVWMNARCFGNEISEILKKITFIDDKGKTICKEFKKEDFKYKISPFQNK
HEECCCCCCCCHHEEECEECHHHHHHHHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCC
NFFILKIELNLKKDNKKIIEEKMNKNKQARINRGHYLFPSGGSTFKNNKAFLKPSGQIIE
CEEEEEEEEEECCCHHHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCEEEECCCHHHHH
ECKLKGLSIGGATVSKYHGNFIININNATSKDIKSLIEKVKAEVYLKTGLLLEEEVLYIG
HHHHCCEEECCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHHEEEECCCEEECCEEEEE
FK
CC
>Mature Secondary Structure 
PKSLNNFLKKINIKPQTKNLANYTTYKIGNISKLFLTPKNIKEAENIFKAAIEEKIKLF
CCHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHCCEEEE
ILGGGSNILVNDEREIDFPIIYTGYLNKIEIHENKIVGECGADFESLCKIALDNSLSGLE
EEECCCEEEEECCCCCCCCEEEECCCCEEEEECCEEEECCCCCHHHHHHHHHCCCCCCCH
FIYGLPGTLGGAVWMNARCFGNEISEILKKITFIDDKGKTICKEFKKEDFKYKISPFQNK
HEECCCCCCCCHHEEECEECHHHHHHHHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCC
NFFILKIELNLKKDNKKIIEEKMNKNKQARINRGHYLFPSGGSTFKNNKAFLKPSGQIIE
CEEEEEEEEEECCCHHHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCEEEECCCHHHHH
ECKLKGLSIGGATVSKYHGNFIININNATSKDIKSLIEKVKAEVYLKTGLLLEEEVLYIG
HHHHCCEEECCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHHEEEECCCEEECCEEEEE
FK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685