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The map label for this gene is uvrC

Identifier: 15594802

GI number: 15594802

Start: 476263

End: 478074

Strand: Reverse

Name: uvrC

Synonym: BB0457

Alternate gene names: 15594802

Gene position: 478074-476263 (Counterclockwise)

Preceding gene: 15594805

Following gene: 15594799

Centisome position: 52.49

GC content: 27.15

Gene sequence:

>1812_bases
ATGAAAGAGAACCTAACAAATTTATTCGAAAAAGTAATAAAATTACCAACCACAAGCGGTTGCTATAAGATGCTAAATGA
AAATAAAAAAATACTCTATATTGGAAAAGCAAAAAATCTAAGATCAAGAGTAAAAAGTTATTTTTTAGAAAAAAATAGTC
ACAAAATCAAAATATTAATGAAAAATGTAAAATCAATAGAAGTTATTACAACAAATAGCGAATACGAAGCATTGCTTCTA
GAGTGCAATCTAATTAAAACCCACAAACCTGATTACAATGTAAAATTAAAAGATGGAAAAGGTTACCCCATGGTGAGAAT
AACCCATGAAAAATATCCAAGAATTTTCAAAACCAGAAAAATAATTAATGACAAAAGCGAATATTTTGGACCATTTACCA
ATGTAAAAAAATTAGATCAAGTACTAGATTTTATTAACAAAACATTTAAGATTAGAAAGTGTAAAAAAAAATCCAATGCT
CCTTGCCTATATTACCATATGGGACAGTGCCTTGGAGTATGCTACAAGGAAAACCTTGAAAAAGAATATCAAAAAGAGCT
AGATAAGGCAAAATCCATACTAAATGGAAATATATCCGAAATATCAAGTCAAATTGATATCAAATTAAAACATGCCATAC
AAAAAGAAGATTTTGAAACCGCTATCAAATTAAAAGAAATTAGAAATTCTTTAATAGAAATTAATCAAATCCAAATCGTT
ACAAAAACCAATAATTTAAACATAGATTATGTCCATGTTCATCCAGGAGAAAATGTAAATACAATAATAGTATTAAAATA
TAGAAATGGAAAATTAGTTGAAAGAGATGCAAACTTTGATGAGAGTATATGCAAAGAAAATGAGCTGATTTTACAATTTT
TGATTCAATATTACACATCTATTAATATGATAGTACCAGACAAAATTCATATTTTTCTCAAAGATATCGACACTAAAAAT
GTTGAAAAACTAATAAATGAAATTAAAAATACAAAAACAGAAATTATTTACAAAGAAACAGAAGAAATTTTAAAAATAAT
GGAAATGGCCATATCTAATGCTGAATTATCTTTAAGAGAATATGAGAATAAAAGCACCAAAGCACTTGAAAGTTTGAAAA
TTGTTTTAGAAATGGACAAACTTCCCAAAATAATTGAAGGATTTGACATTGCTCATCTTAAAGGTCAAGAAACAGTAGCT
TCTATGGTTACTTTTAAAATGGGAATGCCTTTTAAAGAAAACTACAGGCTTTACAAACTAAATTCACTATTAAAAGGAGA
AATTGACGACTTTAAGGCAATAAAAGAAGTAATATCAAGAAGATATTCAGAAATAATTAATAACAACTTAGAACTACCGA
ATTTAATTTTAATTGACGGGGGCAAAGGACAATTAAATGCCGCTCTTTCTATCTTAAAGGGCTTAAAAATAGAAAACAAA
GTTAAAGTCTGCTCGTTGGCAAAAAAACAAGAAACAATATTCTTAACAACTAACAAAAAAGGAATAAATCTACCCCAAGG
ACATCCTGCTCTTAGAATACTGCAAAATGTAAGAGACGAAGCACACAGAAAGGCCAACGGATTTAACAAAAAAAGAAGAG
AAAAAATAACCCTATTGTATACAAAAATACACGGAATTGGAGAAAAAACAGCCCAAAAAATATTAAAATCAATTGGAACC
TATAAAGATATATTGCCTTTAAGTGAAAACGAAATTTCAGAAAAAATAAAAGTAAACGTGCAACTTGCAAAAAGAATAAA
AGAATTTGCAATAAAAGAGAACTCCATAAAAAATAATAATCAAGATAAATAA

Upstream 100 bases:

>100_bases
TACCCATATTTTTAAATACCTCAAAACATAAAACAAACTGCCTTATGATACAATATTATATCATAAGATGATTTTTAAAA
TCTAAAAACTGCCTAACATT

Downstream 100 bases:

>100_bases
ATTTTAAACTAGATTATTATTTATTAATATTTTTTAAAATAAAACACTATTTTAAATTCCAGGCGATAAAACCAAAAAAA
GATCATTAATAAGCTTATTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MKENLTNLFEKVIKLPTTSGCYKMLNENKKILYIGKAKNLRSRVKSYFLEKNSHKIKILMKNVKSIEVITTNSEYEALLL
ECNLIKTHKPDYNVKLKDGKGYPMVRITHEKYPRIFKTRKIINDKSEYFGPFTNVKKLDQVLDFINKTFKIRKCKKKSNA
PCLYYHMGQCLGVCYKENLEKEYQKELDKAKSILNGNISEISSQIDIKLKHAIQKEDFETAIKLKEIRNSLIEINQIQIV
TKTNNLNIDYVHVHPGENVNTIIVLKYRNGKLVERDANFDESICKENELILQFLIQYYTSINMIVPDKIHIFLKDIDTKN
VEKLINEIKNTKTEIIYKETEEILKIMEMAISNAELSLREYENKSTKALESLKIVLEMDKLPKIIEGFDIAHLKGQETVA
SMVTFKMGMPFKENYRLYKLNSLLKGEIDDFKAIKEVISRRYSEIINNNLELPNLILIDGGKGQLNAALSILKGLKIENK
VKVCSLAKKQETIFLTTNKKGINLPQGHPALRILQNVRDEAHRKANGFNKKRREKITLLYTKIHGIGEKTAQKILKSIGT
YKDILPLSENEISEKIKVNVQLAKRIKEFAIKENSIKNNNQDK

Sequences:

>Translated_603_residues
MKENLTNLFEKVIKLPTTSGCYKMLNENKKILYIGKAKNLRSRVKSYFLEKNSHKIKILMKNVKSIEVITTNSEYEALLL
ECNLIKTHKPDYNVKLKDGKGYPMVRITHEKYPRIFKTRKIINDKSEYFGPFTNVKKLDQVLDFINKTFKIRKCKKKSNA
PCLYYHMGQCLGVCYKENLEKEYQKELDKAKSILNGNISEISSQIDIKLKHAIQKEDFETAIKLKEIRNSLIEINQIQIV
TKTNNLNIDYVHVHPGENVNTIIVLKYRNGKLVERDANFDESICKENELILQFLIQYYTSINMIVPDKIHIFLKDIDTKN
VEKLINEIKNTKTEIIYKETEEILKIMEMAISNAELSLREYENKSTKALESLKIVLEMDKLPKIIEGFDIAHLKGQETVA
SMVTFKMGMPFKENYRLYKLNSLLKGEIDDFKAIKEVISRRYSEIINNNLELPNLILIDGGKGQLNAALSILKGLKIENK
VKVCSLAKKQETIFLTTNKKGINLPQGHPALRILQNVRDEAHRKANGFNKKRREKITLLYTKIHGIGEKTAQKILKSIGT
YKDILPLSENEISEKIKVNVQLAKRIKEFAIKENSIKNNNQDK
>Mature_603_residues
MKENLTNLFEKVIKLPTTSGCYKMLNENKKILYIGKAKNLRSRVKSYFLEKNSHKIKILMKNVKSIEVITTNSEYEALLL
ECNLIKTHKPDYNVKLKDGKGYPMVRITHEKYPRIFKTRKIINDKSEYFGPFTNVKKLDQVLDFINKTFKIRKCKKKSNA
PCLYYHMGQCLGVCYKENLEKEYQKELDKAKSILNGNISEISSQIDIKLKHAIQKEDFETAIKLKEIRNSLIEINQIQIV
TKTNNLNIDYVHVHPGENVNTIIVLKYRNGKLVERDANFDESICKENELILQFLIQYYTSINMIVPDKIHIFLKDIDTKN
VEKLINEIKNTKTEIIYKETEEILKIMEMAISNAELSLREYENKSTKALESLKIVLEMDKLPKIIEGFDIAHLKGQETVA
SMVTFKMGMPFKENYRLYKLNSLLKGEIDDFKAIKEVISRRYSEIINNNLELPNLILIDGGKGQLNAALSILKGLKIENK
VKVCSLAKKQETIFLTTNKKGINLPQGHPALRILQNVRDEAHRKANGFNKKRREKITLLYTKIHGIGEKTAQKILKSIGT
YKDILPLSENEISEKIKVNVQLAKRIKEFAIKENSIKNNNQDK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uvrC family

Homologues:

Organism=Escherichia coli, GI87081999, Length=594, Percent_Identity=30.4713804713805, Blast_Score=295, Evalue=6e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_BORBU (O51413)

Other databases:

- EMBL:   AE000783
- PIR:   H70156
- RefSeq:   NP_212591.1
- ProteinModelPortal:   O51413
- EnsemblBacteria:   EBBORT00000008926
- GeneID:   1195302
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0457
- NMPDR:   fig|224326.1.peg.841
- TIGR:   BB_0457
- GeneTree:   EBGT00050000007493
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK14670
- BioCyc:   BBUR224326:BB_0457-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69834; Mature: 69834

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENLTNLFEKVIKLPTTSGCYKMLNENKKILYIGKAKNLRSRVKSYFLEKNSHKIKILM
CCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEE
KNVKSIEVITTNSEYEALLLECNLIKTHKPDYNVKLKDGKGYPMVRITHEKYPRIFKTRK
ECCCEEEEEEECCCCEEEEEEEEEEECCCCCCEEEEECCCCCCEEEEEHHHCCHHHHHHH
IINDKSEYFGPFTNVKKLDQVLDFINKTFKIRKCKKKSNAPCLYYHMGQCLGVCYKENLE
HHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
KEYQKELDKAKSILNGNISEISSQIDIKLKHAIQKEDFETAIKLKEIRNSLIEINQIQIV
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEE
TKTNNLNIDYVHVHPGENVNTIIVLKYRNGKLVERDANFDESICKENELILQFLIQYYTS
EECCCCEEEEEEECCCCCCCEEEEEEECCCEEEECCCCCCHHHHCCHHHHHHHHHHHHHC
INMIVPDKIHIFLKDIDTKNVEKLINEIKNTKTEIIYKETEEILKIMEMAISNAELSLRE
CCEEECCEEEEEEECCCCHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHCCCHHHHHH
YENKSTKALESLKIVLEMDKLPKIIEGFDIAHLKGQETVASMVTFKMGMPFKENYRLYKL
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHCCEEEEE
NSLLKGEIDDFKAIKEVISRRYSEIINNNLELPNLILIDGGKGQLNAALSILKGLKIENK
CHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
VKVCSLAKKQETIFLTTNKKGINLPQGHPALRILQNVRDEAHRKANGFNKKRREKITLLY
HHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEE
TKIHGIGEKTAQKILKSIGTYKDILPLSENEISEKIKVNVQLAKRIKEFAIKENSIKNNN
EEHHCCCHHHHHHHHHHHCCHHHCCCCCCHHCCHHHEEHHHHHHHHHHHHHCCCCCCCCC
QDK
CCC
>Mature Secondary Structure
MKENLTNLFEKVIKLPTTSGCYKMLNENKKILYIGKAKNLRSRVKSYFLEKNSHKIKILM
CCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEE
KNVKSIEVITTNSEYEALLLECNLIKTHKPDYNVKLKDGKGYPMVRITHEKYPRIFKTRK
ECCCEEEEEEECCCCEEEEEEEEEEECCCCCCEEEEECCCCCCEEEEEHHHCCHHHHHHH
IINDKSEYFGPFTNVKKLDQVLDFINKTFKIRKCKKKSNAPCLYYHMGQCLGVCYKENLE
HHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
KEYQKELDKAKSILNGNISEISSQIDIKLKHAIQKEDFETAIKLKEIRNSLIEINQIQIV
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEE
TKTNNLNIDYVHVHPGENVNTIIVLKYRNGKLVERDANFDESICKENELILQFLIQYYTS
EECCCCEEEEEEECCCCCCCEEEEEEECCCEEEECCCCCCHHHHCCHHHHHHHHHHHHHC
INMIVPDKIHIFLKDIDTKNVEKLINEIKNTKTEIIYKETEEILKIMEMAISNAELSLRE
CCEEECCEEEEEEECCCCHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHCCCHHHHHH
YENKSTKALESLKIVLEMDKLPKIIEGFDIAHLKGQETVASMVTFKMGMPFKENYRLYKL
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHCCEEEEE
NSLLKGEIDDFKAIKEVISRRYSEIINNNLELPNLILIDGGKGQLNAALSILKGLKIENK
CHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
VKVCSLAKKQETIFLTTNKKGINLPQGHPALRILQNVRDEAHRKANGFNKKRREKITLLY
HHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEE
TKIHGIGEKTAQKILKSIGTYKDILPLSENEISEKIKVNVQLAKRIKEFAIKENSIKNNN
EEHHCCCHHHHHHHHHHHCCHHHCCCCCCHHCCHHHEEHHHHHHHHHHHHHCCCCCCCCC
QDK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685