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The map label for this gene is manA [H]

Identifier: 15594752

GI number: 15594752

Start: 418388

End: 419506

Strand: Reverse

Name: manA [H]

Synonym: BB0407

Alternate gene names: 15594752

Gene position: 419506-418388 (Counterclockwise)

Preceding gene: 15594753

Following gene: 15594748

Centisome position: 46.06

GC content: 29.31

Gene sequence:

>1119_bases
ATGAATAATGAAGATAATATTTTTTTAATGAAAAATAATATTAAAGAATATGATTGGGGCGGAATTAATTTTATTCCCAA
TCTTTTGGGTGATAAGATTGATGGAAAGCCCAAGGCTGAAATGTGGCTTGGAGCACACAAGACATTTTCTAGTAAGATTT
TGTATAAAAATGAATATGTGCTTTTAAGCGATTTTTTAGAAGATCATAAAGAGCTTTTAGGCTGTAATGACGAATTTCCT
TTTTTGCTTAAGGTATTGTCTGCAAATAAGCCCCTGTCTATTCAAATTCATCCTTCTAAAGATATTGCCTTAAAAGGGTA
TGAATCAGAGAATAATAAAGGGATAGACATTAATGATCCCAAAAGGACATACAAAGACAAAAACCCCAAAATTGAACTTA
TTTATGCTCTTAGTGATTTTTATGCTCTTAAAGGCTTTTTACCCTTAGATGAGATTAAAAAAATTTATGAAATTCTGGAA
TTAAATTTCGACTTTCAATCACATAAAGATTTTGTAAAGACTATTTTTGATTTACAAATGTATGAACTTGAGAAGATTAT
TGAAAAAATTTTAAAAAATTTGGATCTTATTGATAATTTTAGGGGCTATTGGTTTAATGAAATTTACAATATTTATGGTA
TAGATGTGGGCCTTTTGGTATTTTTAGGTATGAATATTTTAAAACTAAAACCAGGAGAAGTTGTTTATACAAATAGTCAG
GAGGTGCATGCATATCTTAAGGGAGATTGCATTGAGCTTATGACCAATTCCGACAATGTTATTAGGGCTGGGCTTACTAC
AAAGTATATTGATAAAGACGAGATGTTAAGAGTTGGTCAATTTGAGGAAGGAAAGTTATCATTTTTAAATCCCGATTTTC
AAGATAATTTTAGCGTATTTAGACTTCCAAATACTAATTTGAAATTGATTCAAAAAAAAATAAATGAGAACATTTGTATT
AATAGAAATAGTGCAATGGTCTTGCTAGTTTTAAATGGGTGCGTGAGTATAAATAAATCCTTAAATCTTAAGAAAGGTGA
GAGCATATTTATAGGTAAAAAAGCAGAAAACTTGTTTATTGATGGGGACGGCGAAGCTTTTATTGCTGGTTTTAATTAA

Upstream 100 bases:

>100_bases
TTGATAATAAATTTGGGTTTATTATTGCAATTGCTGTTGGAGTTGCGGTTGCAACAGCTTTGGTAATTTTTTTGAAATCT
TTAAAATTAAAGGAATCTGA

Downstream 100 bases:

>100_bases
AATTAAGCTTGCTTATGCGAGCTTAATTTTAATTACCAATTTAATTATTTGGTTAATTAAATGCAAATTTTATGAATCCA
AATCCAAAAAAATTGAATTT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNNEDNIFLMKNNIKEYDWGGINFIPNLLGDKIDGKPKAEMWLGAHKTFSSKILYKNEYVLLSDFLEDHKELLGCNDEFP
FLLKVLSANKPLSIQIHPSKDIALKGYESENNKGIDINDPKRTYKDKNPKIELIYALSDFYALKGFLPLDEIKKIYEILE
LNFDFQSHKDFVKTIFDLQMYELEKIIEKILKNLDLIDNFRGYWFNEIYNIYGIDVGLLVFLGMNILKLKPGEVVYTNSQ
EVHAYLKGDCIELMTNSDNVIRAGLTTKYIDKDEMLRVGQFEEGKLSFLNPDFQDNFSVFRLPNTNLKLIQKKINENICI
NRNSAMVLLVLNGCVSINKSLNLKKGESIFIGKKAENLFIDGDGEAFIAGFN

Sequences:

>Translated_372_residues
MNNEDNIFLMKNNIKEYDWGGINFIPNLLGDKIDGKPKAEMWLGAHKTFSSKILYKNEYVLLSDFLEDHKELLGCNDEFP
FLLKVLSANKPLSIQIHPSKDIALKGYESENNKGIDINDPKRTYKDKNPKIELIYALSDFYALKGFLPLDEIKKIYEILE
LNFDFQSHKDFVKTIFDLQMYELEKIIEKILKNLDLIDNFRGYWFNEIYNIYGIDVGLLVFLGMNILKLKPGEVVYTNSQ
EVHAYLKGDCIELMTNSDNVIRAGLTTKYIDKDEMLRVGQFEEGKLSFLNPDFQDNFSVFRLPNTNLKLIQKKINENICI
NRNSAMVLLVLNGCVSINKSLNLKKGESIFIGKKAENLFIDGDGEAFIAGFN
>Mature_372_residues
MNNEDNIFLMKNNIKEYDWGGINFIPNLLGDKIDGKPKAEMWLGAHKTFSSKILYKNEYVLLSDFLEDHKELLGCNDEFP
FLLKVLSANKPLSIQIHPSKDIALKGYESENNKGIDINDPKRTYKDKNPKIELIYALSDFYALKGFLPLDEIKKIYEILE
LNFDFQSHKDFVKTIFDLQMYELEKIIEKILKNLDLIDNFRGYWFNEIYNIYGIDVGLLVFLGMNILKLKPGEVVYTNSQ
EVHAYLKGDCIELMTNSDNVIRAGLTTKYIDKDEMLRVGQFEEGKLSFLNPDFQDNFSVFRLPNTNLKLIQKKINENICI
NRNSAMVLLVLNGCVSINKSLNLKKGESIFIGKKAENLFIDGDGEAFIAGFN

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=405, Percent_Identity=28.1481481481481, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1787899, Length=380, Percent_Identity=32.6315789473684, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71997620, Length=388, Percent_Identity=31.9587628865979, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17557650, Length=324, Percent_Identity=29.0123456790123, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320839, Length=320, Percent_Identity=28.75, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356061, Length=334, Percent_Identity=31.7365269461078, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42840; Mature: 42840

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNEDNIFLMKNNIKEYDWGGINFIPNLLGDKIDGKPKAEMWLGAHKTFSSKILYKNEYV
CCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHEEECCCCCCCCEEEEECCEE
LLSDFLEDHKELLGCNDEFPFLLKVLSANKPLSIQIHPSKDIALKGYESENNKGIDINDP
EHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCC
KRTYKDKNPKIELIYALSDFYALKGFLPLDEIKKIYEILELNFDFQSHKDFVKTIFDLQM
HHHHCCCCCCEEEEEEEHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
YELEKIIEKILKNLDLIDNFRGYWFNEIYNIYGIDVGLLVFLGMNILKLKPGEVVYTNSQ
HHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCEEEECCH
EVHAYLKGDCIELMTNSDNVIRAGLTTKYIDKDEMLRVGQFEEGKLSFLNPDFQDNFSVF
HEEEEECCCEEEEEECCCCEEEECCCEEECCHHHHEECCCCCCCCEEEECCCCCCCCEEE
RLPNTNLKLIQKKINENICINRNSAMVLLVLNGCVSINKSLNLKKGESIFIGKKAENLFI
EECCCCHHHHHHHHCCCEEEECCCCEEEEEEECCEECCCCCCCCCCCEEEEEECCCEEEE
DGDGEAFIAGFN
ECCCCEEEEECC
>Mature Secondary Structure
MNNEDNIFLMKNNIKEYDWGGINFIPNLLGDKIDGKPKAEMWLGAHKTFSSKILYKNEYV
CCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHEEECCCCCCCCEEEEECCEE
LLSDFLEDHKELLGCNDEFPFLLKVLSANKPLSIQIHPSKDIALKGYESENNKGIDINDP
EHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCC
KRTYKDKNPKIELIYALSDFYALKGFLPLDEIKKIYEILELNFDFQSHKDFVKTIFDLQM
HHHHCCCCCCEEEEEEEHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
YELEKIIEKILKNLDLIDNFRGYWFNEIYNIYGIDVGLLVFLGMNILKLKPGEVVYTNSQ
HHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCEEEECCH
EVHAYLKGDCIELMTNSDNVIRAGLTTKYIDKDEMLRVGQFEEGKLSFLNPDFQDNFSVF
HEEEEECCCEEEEEECCCCEEEECCCEEECCHHHHEECCCCCCCCEEEECCCCCCCCEEE
RLPNTNLKLIQKKINENICINRNSAMVLLVLNGCVSINKSLNLKKGESIFIGKKAENLFI
EECCCCHHHHHHHHCCCEEEECCCCEEEEEEECCEECCCCCCCCCCCEEEEEECCCEEEE
DGDGEAFIAGFN
ECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]