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The map label for this gene is uppS

Identifier: 15594465

GI number: 15594465

Start: 117678

End: 118370

Strand: Reverse

Name: uppS

Synonym: BB0120

Alternate gene names: 15594465

Gene position: 118370-117678 (Counterclockwise)

Preceding gene: 15594466

Following gene: 15595197

Centisome position: 13.0

GC content: 28.72

Gene sequence:

>693_bases
ATGAATAAAGGTTCTCTTCCAAGTCATGTTGGAATTATTATGGATGGCAATAGAAGGTGGGCTTTAGGTAAAAGATTGTC
TTCTTTAGAAGGTTATAAAGAAGGTCTTAAAAGAGCAAAAGAAATAGTTAAGTATTCTTTAAGGGTAGGTATTAAATGTT
TATCCTTTTATGTATTTTCTACTGAGAATTGGAGAAGGGATGATTGTGAGATAGAAAATTTAATGTTTTTAATTGCTAAT
TATTTGAGAGCCGAATTTGATTTTTACGAAAAAAATGGAATAAAAATAATAGTTTCAGGAGATGTTGAGTCTTTAAGTGG
GGAAGTAAAAAGTTCTATAAAAGACTCTATTAGCTTTTCTAAAAATTTCAACAACCTTATTTTAAATTTAGCAATCAATT
ATGGGGGTCGTAATGAAATACTTAGAGCTGTTAAAAAATTTGTTTCAAGTGATTTTGATTTAGAGTCTTTGAATGAGAAT
ATTTTTTCCAGTTTTTTAGACAATCCAGAACTACCCGATCTTGATCTTTTAATACGTACAGGCGGAAATATTAGAATAAG
TAATTTTTTCTTATGGAGGATTGCTTATTCTGAATTAATTTTTTCAAATGTTTTGTGGCCTGAATATTATGACACTAGAT
ATAGTAAGGATTTGGAATGTTTCCAATTTAGAAGAAGAAATTTTGGGAGATGA

Upstream 100 bases:

>100_bases
AGAATTTTAGATGATATTCAGAAATCCACAGATATGTATATTAAAAAGATAGATTCAATTTTAGAATCTAAAATTCAAGA
AATAATGGAAGCTTAAATCC

Downstream 100 bases:

>100_bases
TTTGTTGAGTAAGGTTAAGAGATTTGCTTTTTTTGCAAGGTTGGGAACATTTCTATTTTTTGTTCCTTTGATTTTATTTT
TAATATTTTTAGATTTTAAA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNKGSLPSHVGIIMDGNRRWALGKRLSSLEGYKEGLKRAKEIVKYSLRVGIKCLSFYVFSTENWRRDDCEIENLMFLIAN
YLRAEFDFYEKNGIKIIVSGDVESLSGEVKSSIKDSISFSKNFNNLILNLAINYGGRNEILRAVKKFVSSDFDLESLNEN
IFSSFLDNPELPDLDLLIRTGGNIRISNFFLWRIAYSELIFSNVLWPEYYDTRYSKDLECFQFRRRNFGR

Sequences:

>Translated_230_residues
MNKGSLPSHVGIIMDGNRRWALGKRLSSLEGYKEGLKRAKEIVKYSLRVGIKCLSFYVFSTENWRRDDCEIENLMFLIAN
YLRAEFDFYEKNGIKIIVSGDVESLSGEVKSSIKDSISFSKNFNNLILNLAINYGGRNEILRAVKKFVSSDFDLESLNEN
IFSSFLDNPELPDLDLLIRTGGNIRISNFFLWRIAYSELIFSNVLWPEYYDTRYSKDLECFQFRRRNFGR
>Mature_230_residues
MNKGSLPSHVGIIMDGNRRWALGKRLSSLEGYKEGLKRAKEIVKYSLRVGIKCLSFYVFSTENWRRDDCEIENLMFLIAN
YLRAEFDFYEKNGIKIIVSGDVESLSGEVKSSIKDSISFSKNFNNLILNLAINYGGRNEILRAVKKFVSSDFDLESLNEN
IFSSFLDNPELPDLDLLIRTGGNIRISNFFLWRIAYSELIFSNVLWPEYYDTRYSKDLECFQFRRRNFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=216, Percent_Identity=33.7962962962963, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI45580738, Length=216, Percent_Identity=33.7962962962963, Blast_Score=141, Evalue=4e-34,
Organism=Escherichia coli, GI1786371, Length=225, Percent_Identity=35.5555555555556, Blast_Score=156, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI71993029, Length=215, Percent_Identity=31.6279069767442, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=227, Percent_Identity=32.5991189427313, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=31.390134529148, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18857969, Length=211, Percent_Identity=32.7014218009479, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_BORBU (O51146)

Other databases:

- EMBL:   AE000783
- PIR:   H70114
- RefSeq:   NP_212254.1
- ProteinModelPortal:   O51146
- SMR:   O51146
- EnsemblBacteria:   EBBORT00000008861
- GeneID:   1194955
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0120
- NMPDR:   fig|224326.1.peg.504
- TIGR:   BB_0120
- GeneTree:   EBGT00050000007082
- HOGENOM:   HBG627837
- OMA:   FLWRIAY
- ProtClustDB:   PRK14837
- BioCyc:   BBUR224326:BB_0120-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 26790; Mature: 26790

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 15-15

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGSLPSHVGIIMDGNRRWALGKRLSSLEGYKEGLKRAKEIVKYSLRVGIKCLSFYVFS
CCCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
TENWRRDDCEIENLMFLIANYLRAEFDFYEKNGIKIIVSGDVESLSGEVKSSIKDSISFS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHHH
KNFNNLILNLAINYGGRNEILRAVKKFVSSDFDLESLNENIFSSFLDNPELPDLDLLIRT
CCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEC
GGNIRISNFFLWRIAYSELIFSNVLWPEYYDTRYSKDLECFQFRRRNFGR
CCCEEEHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNKGSLPSHVGIIMDGNRRWALGKRLSSLEGYKEGLKRAKEIVKYSLRVGIKCLSFYVFS
CCCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
TENWRRDDCEIENLMFLIANYLRAEFDFYEKNGIKIIVSGDVESLSGEVKSSIKDSISFS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHHH
KNFNNLILNLAINYGGRNEILRAVKKFVSSDFDLESLNENIFSSFLDNPELPDLDLLIRT
CCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEC
GGNIRISNFFLWRIAYSELIFSNVLWPEYYDTRYSKDLECFQFRRRNFGR
CCCEEEHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685