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The map label for this gene is phbA [H]

Identifier: 15594455

GI number: 15594455

Start: 106974

End: 108170

Strand: Reverse

Name: phbA [H]

Synonym: BB0109

Alternate gene names: 15594455

Gene position: 108170-106974 (Counterclockwise)

Preceding gene: 15594457

Following gene: 15594454

Centisome position: 11.88

GC content: 33.5

Gene sequence:

>1197_bases
GTGATAAAAAAGGTAGCTATTATTGATGGACTTAGAACACCCAATTTCAAGTTTGGAGGTTCTTTTAAGGGTTTAAATAT
TATTGATGAATCTTCAAAAGTTGTTAAAGCTTTGCTTGAAAGAAATAAGTTATACAAAGTGGATGAGGTTATTATTGGTA
ATGTAATATCTGCGGGACTTGGTCAAAATATTGCAAGACAAATTGCTTTAAAGTCTGACTTAGGCGATACTGTGCCTGCA
TTTAGCGTTAATAAAGTTTGTGGTTCTGGGCTTAAGGCCTTGGAGCTTGCATTTAATTCTATTGCCCTTGGAGACAATGA
TATTGTTTTAGCTGGAGGAGTTGAAGATTTAACCAATTCTCCTTATTTATTACCTAGAAAGATTAGATTTGACGGTCTTA
AATTTGGTAATTTTGGAATTGAAGATTCAATCCAAAAAGACGCCTTAATAGATTCTCTGAATTTTATTTCTATGGGGCTT
ACGGCTGAAAATCTTTCAGAAAAATATAGAATAACAAGAGAAATGCAAGATGAATTTGCATATAATTCTCATGTAAAGGC
ATTAAAGGCAAGAGAGCTTGGATATTTTGAGGATGAAATTTATCCCCTGACTGTTTTTGATAAGAAGACCAACTCTAGCG
TAACTATCTCAAGTGATGAGGAAATAAGAGATAATTTAACTTTAAATAAGCTAGCATCTCTTAATCCTGTTTTTAAAGAA
TCAGGCACAGTAACTGCCGGAAATTCTTCAAGTTTAAATGATGGTGCTTGTTTTTTAATTTTAGCAAGTGAGGAAAGAGT
AAAAAGCTTGGGGTTAAGTCCATTAGCTTATATTGGAGGATTTAAAAGCGTGGGGCTTGATCCACTTTATATGGGTTTTG
GAGCTTATATGGCTATTGAAGGCATTATTAGTAAATTAAGTTTAAATCCTAGCGAAATAGATTTGATTGAGGTAAATGAG
GCATTTGCAGCTCAAGCATTAAGCATTGAAAAGGCCTTGTTTAAAAAATACAATATAACTAGCGATATTATTAATGTAAA
TGGTGGTGCTATTGCTTTGGGGCATCCATTTGCCGTTAGCGGTTCAAGAATTTTATTAACACTTTCTCGCTCTATGAAAA
TGAAGAATAAAACAAAAGGGATAGCATCTGTTTGTATTGGTGGCGGACAAGGAATTTCTAGTTTTTTGTATAGATGA

Upstream 100 bases:

>100_bases
ATTCAGGTTAAATAGTTTATTTTTATTAAATAAACTTAGTTTTTATATGATCTATTGTATTGTATAATTCAATAAGTTTA
TTAAGACTTTAGGAGTAATT

Downstream 100 bases:

>100_bases
AAATGTTTTATTAACTAGATTTAAATGTAAAATTTTGTTAAATTAGTGGGTAAGTGATTCTTTAATAAGAGGTTATGTTA
TGAAGAGTTTTTTATTTTGG

Product: acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MIKKVAIIDGLRTPNFKFGGSFKGLNIIDESSKVVKALLERNKLYKVDEVIIGNVISAGLGQNIARQIALKSDLGDTVPA
FSVNKVCGSGLKALELAFNSIALGDNDIVLAGGVEDLTNSPYLLPRKIRFDGLKFGNFGIEDSIQKDALIDSLNFISMGL
TAENLSEKYRITREMQDEFAYNSHVKALKARELGYFEDEIYPLTVFDKKTNSSVTISSDEEIRDNLTLNKLASLNPVFKE
SGTVTAGNSSSLNDGACFLILASEERVKSLGLSPLAYIGGFKSVGLDPLYMGFGAYMAIEGIISKLSLNPSEIDLIEVNE
AFAAQALSIEKALFKKYNITSDIINVNGGAIALGHPFAVSGSRILLTLSRSMKMKNKTKGIASVCIGGGQGISSFLYR

Sequences:

>Translated_398_residues
MIKKVAIIDGLRTPNFKFGGSFKGLNIIDESSKVVKALLERNKLYKVDEVIIGNVISAGLGQNIARQIALKSDLGDTVPA
FSVNKVCGSGLKALELAFNSIALGDNDIVLAGGVEDLTNSPYLLPRKIRFDGLKFGNFGIEDSIQKDALIDSLNFISMGL
TAENLSEKYRITREMQDEFAYNSHVKALKARELGYFEDEIYPLTVFDKKTNSSVTISSDEEIRDNLTLNKLASLNPVFKE
SGTVTAGNSSSLNDGACFLILASEERVKSLGLSPLAYIGGFKSVGLDPLYMGFGAYMAIEGIISKLSLNPSEIDLIEVNE
AFAAQALSIEKALFKKYNITSDIINVNGGAIALGHPFAVSGSRILLTLSRSMKMKNKTKGIASVCIGGGQGISSFLYR
>Mature_398_residues
MIKKVAIIDGLRTPNFKFGGSFKGLNIIDESSKVVKALLERNKLYKVDEVIIGNVISAGLGQNIARQIALKSDLGDTVPA
FSVNKVCGSGLKALELAFNSIALGDNDIVLAGGVEDLTNSPYLLPRKIRFDGLKFGNFGIEDSIQKDALIDSLNFISMGL
TAENLSEKYRITREMQDEFAYNSHVKALKARELGYFEDEIYPLTVFDKKTNSSVTISSDEEIRDNLTLNKLASLNPVFKE
SGTVTAGNSSSLNDGACFLILASEERVKSLGLSPLAYIGGFKSVGLDPLYMGFGAYMAIEGIISKLSLNPSEIDLIEVNE
AFAAQALSIEKALFKKYNITSDIINVNGGAIALGHPFAVSGSRILLTLSRSMKMKNKTKGIASVCIGGGQGISSFLYR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=37.4371859296482, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=39.5465994962217, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4557237, Length=400, Percent_Identity=37, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4501853, Length=403, Percent_Identity=37.2208436724566, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=31.924882629108, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI194353979, Length=401, Percent_Identity=27.1820448877805, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI87082165, Length=399, Percent_Identity=44.8621553884712, Blast_Score=333, Evalue=8e-93,
Organism=Escherichia coli, GI1788554, Length=399, Percent_Identity=45.8646616541353, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1787663, Length=414, Percent_Identity=35.7487922705314, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=38.9705882352941, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788683, Length=393, Percent_Identity=30.5343511450382, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=41.6243654822335, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=400, Percent_Identity=38.25, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=36.2467866323907, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17551802, Length=419, Percent_Identity=31.2649164677804, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=26.972010178117, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=37.3134328358209, Blast_Score=246, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6322031, Length=359, Percent_Identity=36.4902506963788, Blast_Score=203, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24655093, Length=396, Percent_Identity=42.4242424242424, Blast_Score=311, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=38.1909547738693, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=39.1959798994975, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=31.6397228637413, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42941; Mature: 42941

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVAIIDGLRTPNFKFGGSFKGLNIIDESSKVVKALLERNKLYKVDEVIIGNVISAGL
CCCEEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHH
GQNIARQIALKSDLGDTVPAFSVNKVCGSGLKALELAFNSIALGDNDIVLAGGVEDLTNS
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCCEEEECCHHHHCCC
PYLLPRKIRFDGLKFGNFGIEDSIQKDALIDSLNFISMGLTAENLSEKYRITREMQDEFA
CCEEEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHH
YNSHVKALKARELGYFEDEIYPLTVFDKKTNSSVTISSDEEIRDNLTLNKLASLNPVFKE
HHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCHHHHHCCCHHHHHCCCCHHHC
SGTVTAGNSSSLNDGACFLILASEERVKSLGLSPLAYIGGFKSVGLDPLYMGFGAYMAIE
CCCEECCCCCCCCCCEEEEEEECHHHHHHCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHH
GIISKLSLNPSEIDLIEVNEAFAAQALSIEKALFKKYNITSDIINVNGGAIALGHPFAVS
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCEEEECCCEEEC
GSRILLTLSRSMKMKNKTKGIASVCIGGGQGISSFLYR
CCEEEEEEEHHHHHHHHHCCHHHEEECCCCCHHHHHCC
>Mature Secondary Structure
MIKKVAIIDGLRTPNFKFGGSFKGLNIIDESSKVVKALLERNKLYKVDEVIIGNVISAGL
CCCEEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHH
GQNIARQIALKSDLGDTVPAFSVNKVCGSGLKALELAFNSIALGDNDIVLAGGVEDLTNS
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCCEEEECCHHHHCCC
PYLLPRKIRFDGLKFGNFGIEDSIQKDALIDSLNFISMGLTAENLSEKYRITREMQDEFA
CCEEEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHH
YNSHVKALKARELGYFEDEIYPLTVFDKKTNSSVTISSDEEIRDNLTLNKLASLNPVFKE
HHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCHHHHHCCCHHHHHCCCCHHHC
SGTVTAGNSSSLNDGACFLILASEERVKSLGLSPLAYIGGFKSVGLDPLYMGFGAYMAIE
CCCEECCCCCCCCCCEEEEEEECHHHHHHCCCCHHHHHCCHHHCCCCHHHHHHHHHHHHH
GIISKLSLNPSEIDLIEVNEAFAAQALSIEKALFKKYNITSDIINVNGGAIALGHPFAVS
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCEEEECCCEEEC
GSRILLTLSRSMKMKNKTKGIASVCIGGGQGISSFLYR
CCEEEEEEEHHHHHHHHHCCHHHEEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]