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The map label for this gene is trxA

Identifier: 15594407

GI number: 15594407

Start: 56832

End: 57185

Strand: Reverse

Name: trxA

Synonym: BB0061

Alternate gene names: 15594407

Gene position: 57185-56832 (Counterclockwise)

Preceding gene: 15594409

Following gene: 15594406

Centisome position: 6.28

GC content: 31.07

Gene sequence:

>354_bases
ATGGCTATTTCTTTAACCGAAGAAGATTTTGTTGTTAAAGTTTTTGATTATAAAAATGATAAAGAGTGGAGTTTTAGAGG
TGATAGACCCGCAATAATTGATTTTTATGCTAATTGGTGTGGTCCATGTAAAATGCTTTCTCCGATTTTTGAAAAACTTT
CTAAAAAGTACGAGAATAGCATTGATTTTTACAAAGTAGATACAGATAAGGAACAAGATATTTCTTCTGCGATTGGAGTA
CAAAGTCTTCCAACTATTCTTTTTATTCCTGTTGATGGCAAGCCAAAGGTTTCTGTTGGCTTTTTGCAAGAAGATGCTTT
TGAAAACATAATTAAGGATTTTTTTGGTTTTTAG

Upstream 100 bases:

>100_bases
ATTAAAAGTTATTAACATTAGATTCATTTCTTATAATTCCTTATTATTAATATTGTATTTGTGATATAATTTTAAGTCGA
TAGGGGGGCATGTAAAATAT

Downstream 100 bases:

>100_bases
TTTGCAAAATAAAATAATTTAATTGCTATAGCAATTAATCATACTTGTAAGTTATATGTGGATTATTTTAGGGTATATTT
AATTTGTCCAAATCTGATTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MAISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENSIDFYKVDTDKEQDISSAIGV
QSLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF

Sequences:

>Translated_117_residues
MAISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENSIDFYKVDTDKEQDISSAIGV
QSLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF
>Mature_116_residues
AISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENSIDFYKVDTDKEQDISSAIGVQ
SLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI50592994, Length=62, Percent_Identity=50, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI21361403, Length=89, Percent_Identity=34.8314606741573, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788936, Length=64, Percent_Identity=42.1875, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI87082331, Length=80, Percent_Identity=28.75, Blast_Score=62, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=63, Percent_Identity=47.6190476190476, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17510299, Length=72, Percent_Identity=44.4444444444444, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=95, Percent_Identity=30.5263157894737, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=62, Percent_Identity=43.5483870967742, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=78, Percent_Identity=38.4615384615385, Blast_Score=71, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639826, Length=70, Percent_Identity=38.5714285714286, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658597, Length=67, Percent_Identity=46.2686567164179, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17648013, Length=70, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583090, Length=70, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THIO_BORBU (O51088)

Other databases:

- EMBL:   AE000783
- PIR:   E70107
- RefSeq:   NP_212195.1
- ProteinModelPortal:   O51088
- SMR:   O51088
- EnsemblBacteria:   EBBORT00000008467
- GeneID:   1194897
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0061
- NMPDR:   fig|224326.1.peg.445
- TIGR:   BB_0061
- GeneTree:   EBGT00050000007483
- HOGENOM:   HBG493509
- OMA:   VFDYKNN
- ProtClustDB:   CLSK507325
- BioCyc:   BBUR224326:BB_0061-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 13467; Mature: 13336

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENS
CEECCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHCC
IDFYKVDTDKEQDISSAIGVQSLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF
CCEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AISLTEEDFVVKVFDYKNDKEWSFRGDRPAIIDFYANWCGPCKMLSPIFEKLSKKYENS
EECCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHCC
IDFYKVDTDKEQDISSAIGVQSLPTILFIPVDGKPKVSVGFLQEDAFENIIKDFFGF
CCEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685