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The map label for this gene is ung [H]

Identifier: 15594399

GI number: 15594399

Start: 49341

End: 50012

Strand: Direct

Name: ung [H]

Synonym: BB0053

Alternate gene names: 15594399

Gene position: 49341-50012 (Clockwise)

Preceding gene: 15594397

Following gene: 15594408

Centisome position: 5.42

GC content: 27.98

Gene sequence:

>672_bases
ATGAAAGTAAAAATTGAAGAATCTTGGAAAGAAGTTTTAAACAATGAATTTAACAAAGAGTACTTTAAAAAGCTCGTGAA
ATTTATTAAACATGAATATAAAACAAAAAATGGAAAAATATTTCCTCCCCCAAAACTCATATTCAATGCTTTTAATTCTT
TACCATTTAAAGACATAAAAGTGGTAATAATTGGACAAGATCCATACCATGGAAAAAACCAAGCAAATGGACTTGCTTTT
TCTGTAGATTCAAAAATTAAAATTCCACCATCTTTGCAGAACATATTTAAAGAAATAGAAAAAAGCTTAAAAATAAAAAC
CATCCCAAACGGAGATTTAAAAAGATGGGCAATTCAAGGTGTATTTCTAATAAATACAATTTTAACAGTCGAAGAAGGCA
AACCTTCTTCTCACAAAGCTATTGGGTGGGAAATTTTTACAGATGAAGTAATAAAAATAATCTCTAAAAATTTGAAAAAC
ATTGTGTTTATGCTTTGGGGCAATTTAGCAAGAAGTAAAAAAGGGCTAATTGACCCAACAAAGCATCTAATTCTTGAAAC
AAGTCACCCATCTCCATATTCAGCAAACAATGGATTTTTAGGATCAAATCATTTTAGCAGTGCTTTAGATTATTTAAAAA
AACACAATAAAAACATAATAAACTTTCAATAA

Upstream 100 bases:

>100_bases
TTAATACATCATCATCCATAATAAAAATTAAATTTCAAAAATAACAAATCAGTCCTTTAATATATTTCAAATTGCAAACT
ATTTCTTATATAATACAAAA

Downstream 100 bases:

>100_bases
AATTAATAAATTTAATAATGGTTATGATTTAAAATTCCTTTATGTAAAAAACTCTGAGTAAATACTACTCATAGTATACA
CAACAGTAACCAATTTAAAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKVKIEESWKEVLNNEFNKEYFKKLVKFIKHEYKTKNGKIFPPPKLIFNAFNSLPFKDIKVVIIGQDPYHGKNQANGLAF
SVDSKIKIPPSLQNIFKEIEKSLKIKTIPNGDLKRWAIQGVFLINTILTVEEGKPSSHKAIGWEIFTDEVIKIISKNLKN
IVFMLWGNLARSKKGLIDPTKHLILETSHPSPYSANNGFLGSNHFSSALDYLKKHNKNIINFQ

Sequences:

>Translated_223_residues
MKVKIEESWKEVLNNEFNKEYFKKLVKFIKHEYKTKNGKIFPPPKLIFNAFNSLPFKDIKVVIIGQDPYHGKNQANGLAF
SVDSKIKIPPSLQNIFKEIEKSLKIKTIPNGDLKRWAIQGVFLINTILTVEEGKPSSHKAIGWEIFTDEVIKIISKNLKN
IVFMLWGNLARSKKGLIDPTKHLILETSHPSPYSANNGFLGSNHFSSALDYLKKHNKNIINFQ
>Mature_223_residues
MKVKIEESWKEVLNNEFNKEYFKKLVKFIKHEYKTKNGKIFPPPKLIFNAFNSLPFKDIKVVIIGQDPYHGKNQANGLAF
SVDSKIKIPPSLQNIFKEIEKSLKIKTIPNGDLKRWAIQGVFLINTILTVEEGKPSSHKAIGWEIFTDEVIKIISKNLKN
IVFMLWGNLARSKKGLIDPTKHLILETSHPSPYSANNGFLGSNHFSSALDYLKKHNKNIINFQ

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=224, Percent_Identity=45.0892857142857, Blast_Score=203, Evalue=8e-53,
Organism=Homo sapiens, GI19718751, Length=224, Percent_Identity=45.0892857142857, Blast_Score=203, Evalue=1e-52,
Organism=Escherichia coli, GI1788934, Length=218, Percent_Identity=45.8715596330275, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=48.6238532110092, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6323620, Length=224, Percent_Identity=41.9642857142857, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25561; Mature: 25561

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKIEESWKEVLNNEFNKEYFKKLVKFIKHEYKTKNGKIFPPPKLIFNAFNSLPFKDIK
CEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEE
VVIIGQDPYHGKNQANGLAFSVDSKIKIPPSLQNIFKEIEKSLKIKTIPNGDLKRWAIQG
EEEECCCCCCCCCCCCCEEEECCCCEECCHHHHHHHHHHHHHCEEEECCCCCHHHHHHHH
VFLINTILTVEEGKPSSHKAIGWEIFTDEVIKIISKNLKNIVFMLWGNLARSKKGLIDPT
HEEHHHEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KHLILETSHPSPYSANNGFLGSNHFSSALDYLKKHNKNIINFQ
HHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKVKIEESWKEVLNNEFNKEYFKKLVKFIKHEYKTKNGKIFPPPKLIFNAFNSLPFKDIK
CEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEE
VVIIGQDPYHGKNQANGLAFSVDSKIKIPPSLQNIFKEIEKSLKIKTIPNGDLKRWAIQG
EEEECCCCCCCCCCCCCEEEECCCCEECCHHHHHHHHHHHHHCEEEECCCCCHHHHHHHH
VFLINTILTVEEGKPSSHKAIGWEIFTDEVIKIISKNLKNIVFMLWGNLARSKKGLIDPT
HEEHHHEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KHLILETSHPSPYSANNGFLGSNHFSSALDYLKKHNKNIINFQ
HHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA