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The map label for this gene is murC

Identifier: 154687119

GI number: 154687119

Start: 2815663

End: 2816961

Strand: Reverse

Name: murC

Synonym: RBAM_026910

Alternate gene names: 154687119

Gene position: 2816961-2815663 (Counterclockwise)

Preceding gene: 154687120

Following gene: 154687118

Centisome position: 71.89

GC content: 47.65

Gene sequence:

>1299_bases
ATGACTGTTTATCATTTTGTTGGAATAAAAGGGACAGGTATGAGCCCGCTTGCTCAAATCCTGCATGATACAGGGTATCA
GGTGCAGGGATCGGATATCGAGAAGCAGATTTTCACTCAGGCTGCCCTTGAAAAAAGAAATATCCCGATCTATCCGTTCA
GCGCCGATAACATCAAACCCGGCTTAACGGTAATCGCCGGAAACGCATTCCCTGATTCTCATCCGGAAATCGCAAAGGCG
CTCGCTGAAGGGATTCCTGTCATCAGATATCATAAATTTTTAGCTGAATATATGAAAAAATACACAAGTGTCGCGGTAAC
GGGCGCACACGGCAAGACGTCCACAACGGGCCTCTTGGCACACGTGATGCAGCAGGCGAAGCCGACTTCGTTTCTTATCG
GGGACGGAACGGGCAGAGGAAATGAAAGCAGCGAATACTTTGTATTTGAAGCCTGCGAGTACCGCCGTCATTTCTTAAGC
TATCAGCCTGATTATGCGATTATGACGAATATTGATTTTGACCACCCTGATTATTTCGCCAACATTGACGATGTGTTTGA
TGCTTTCCAAAACATGGCGCTTCAAGTCAACAAAGGCATCATTGCCTGCGGTGATGACGAGTACCTGCCGAAAATTCACG
CCAATGTGCCTGTCGTGTATTACGGCACGGGAGAAGAAAATGATTTTCAAGCGAGAAACATCGTAAAAAATACGGAAGGC
ACGACATTTGACGTCTTTGTCCGCAATACGTTTTACGATACGTTCTACATCCCGGCATACGGCCATCACAATGTCCTCAA
TTCCTTAGCGGTCATTGCGCTCTGCCACTATGAAGAGATAGACGTGAACATGATTAAGCTCGGGCTTGAATCATTCGGCG
GCGTCAAACGCAGATTCAATGAAAAAGTGATCGGCAGCCAGGTACTGATCGACGACTACGCCCACCATCCGACTGAAATC
AAAGTCACGATTGAGGCGGCGCGCCAAAAATATCCCGAACGTGAAATCATCGCGGTATTTCAGCCGCATACGTTTACACG
GACGCAATCATTCCTGGATGAATTCGCAGAAAGCTTAAGCGCGGCCGATCGCGTGTATCTGTGCGACATTTTCGGCTCTG
CCCGCGAGAACGTCGGCAAGCTCACGATCACGGATCTTCAGGAAAAAATCGCCAACGCAGAACTCATTGAAGAAAATGAC
ACATCCGTGTTAAAAGCGCATGAAGGCGCAGTGCTGATCTTCATGGGCGCCGGAGACATTCAAAAATATATGAGAGCCTA
TGAAAACGTCATAGCGTAA

Upstream 100 bases:

>100_bases
ATGGAAGCGCCGCTGTGCGGGCTTTTTGCCCGCGGCGGTCGCAAAATGAAATGAGCGTCATATACTGGGGAACAGATAGA
CGTTTGTTGGAGGTACGATT

Downstream 100 bases:

>100_bases
CGAAAAAGCAGTGGGGCTCTCACTGCTTTTTTGTGCGTGCTGCAAAGGGATTTACCGAGAAACGGAGAAATAGTATACAT
ACAGATCTTTCATATATGTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTVYHFVGIKGTGMSPLAQILHDTGYQVQGSDIEKQIFTQAALEKRNIPIYPFSADNIKPGLTVIAGNAFPDSHPEIAKA
LAEGIPVIRYHKFLAEYMKKYTSVAVTGAHGKTSTTGLLAHVMQQAKPTSFLIGDGTGRGNESSEYFVFEACEYRRHFLS
YQPDYAIMTNIDFDHPDYFANIDDVFDAFQNMALQVNKGIIACGDDEYLPKIHANVPVVYYGTGEENDFQARNIVKNTEG
TTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCHYEEIDVNMIKLGLESFGGVKRRFNEKVIGSQVLIDDYAHHPTEI
KVTIEAARQKYPEREIIAVFQPHTFTRTQSFLDEFAESLSAADRVYLCDIFGSARENVGKLTITDLQEKIANAELIEEND
TSVLKAHEGAVLIFMGAGDIQKYMRAYENVIA

Sequences:

>Translated_432_residues
MTVYHFVGIKGTGMSPLAQILHDTGYQVQGSDIEKQIFTQAALEKRNIPIYPFSADNIKPGLTVIAGNAFPDSHPEIAKA
LAEGIPVIRYHKFLAEYMKKYTSVAVTGAHGKTSTTGLLAHVMQQAKPTSFLIGDGTGRGNESSEYFVFEACEYRRHFLS
YQPDYAIMTNIDFDHPDYFANIDDVFDAFQNMALQVNKGIIACGDDEYLPKIHANVPVVYYGTGEENDFQARNIVKNTEG
TTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCHYEEIDVNMIKLGLESFGGVKRRFNEKVIGSQVLIDDYAHHPTEI
KVTIEAARQKYPEREIIAVFQPHTFTRTQSFLDEFAESLSAADRVYLCDIFGSARENVGKLTITDLQEKIANAELIEEND
TSVLKAHEGAVLIFMGAGDIQKYMRAYENVIA
>Mature_431_residues
TVYHFVGIKGTGMSPLAQILHDTGYQVQGSDIEKQIFTQAALEKRNIPIYPFSADNIKPGLTVIAGNAFPDSHPEIAKAL
AEGIPVIRYHKFLAEYMKKYTSVAVTGAHGKTSTTGLLAHVMQQAKPTSFLIGDGTGRGNESSEYFVFEACEYRRHFLSY
QPDYAIMTNIDFDHPDYFANIDDVFDAFQNMALQVNKGIIACGDDEYLPKIHANVPVVYYGTGEENDFQARNIVKNTEGT
TFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCHYEEIDVNMIKLGLESFGGVKRRFNEKVIGSQVLIDDYAHHPTEIK
VTIEAARQKYPEREIIAVFQPHTFTRTQSFLDEFAESLSAADRVYLCDIFGSARENVGKLTITDLQEKIANAELIEENDT
SVLKAHEGAVLIFMGAGDIQKYMRAYENVIA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=465, Percent_Identity=29.6774193548387, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1790680, Length=386, Percent_Identity=30.5699481865285, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_BACA2 (A7Z7S3)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001422280.1
- ProteinModelPortal:   A7Z7S3
- SMR:   A7Z7S3
- STRING:   A7Z7S3
- EnsemblBacteria:   EBBACT00000004877
- GeneID:   5459602
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_026910
- eggNOG:   COG0773
- GeneTree:   EBGT00050000000630
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   BAMY326423:RBAM_026910-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 48384; Mature: 48253

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYHFVGIKGTGMSPLAQILHDTGYQVQGSDIEKQIFTQAALEKRNIPIYPFSADNIKP
CEEEEEEEECCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
GLTVIAGNAFPDSHPEIAKALAEGIPVIRYHKFLAEYMKKYTSVAVTGAHGKTSTTGLLA
CEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHH
HVMQQAKPTSFLIGDGTGRGNESSEYFVFEACEYRRHFLSYQPDYAIMTNIDFDHPDYFA
HHHHHCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHC
NIDDVFDAFQNMALQVNKGIIACGDDEYLPKIHANVPVVYYGTGEENDFQARNIVKNTEG
CHHHHHHHHHHCEEEECCCEEEECCCCCCCEEECCCCEEEEECCCCCCCHHHHHHCCCCC
TTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCHYEEIDVNMIKLGLESFGGVKRRFN
CEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHEEHHHHHHCHHHHHHH
EKVIGSQVLIDDYAHHPTEIKVTIEAARQKYPEREIIAVFQPHTFTRTQSFLDEFAESLS
HHHCCCEEEEHHCCCCCCEEEEEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
AADRVYLCDIFGSARENVGKLTITDLQEKIANAELIEENDTSVLKAHEGAVLIFMGAGDI
HCCEEEEEEEHHHHHHCCCCEEHHHHHHHHCCCCEECCCCCCEEEECCCEEEEEECCHHH
QKYMRAYENVIA
HHHHHHHHHHCC
>Mature Secondary Structure 
TVYHFVGIKGTGMSPLAQILHDTGYQVQGSDIEKQIFTQAALEKRNIPIYPFSADNIKP
EEEEEEEECCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
GLTVIAGNAFPDSHPEIAKALAEGIPVIRYHKFLAEYMKKYTSVAVTGAHGKTSTTGLLA
CEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHH
HVMQQAKPTSFLIGDGTGRGNESSEYFVFEACEYRRHFLSYQPDYAIMTNIDFDHPDYFA
HHHHHCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHC
NIDDVFDAFQNMALQVNKGIIACGDDEYLPKIHANVPVVYYGTGEENDFQARNIVKNTEG
CHHHHHHHHHHCEEEECCCEEEECCCCCCCEEECCCCEEEEECCCCCCCHHHHHHCCCCC
TTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCHYEEIDVNMIKLGLESFGGVKRRFN
CEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHEEHHHHHHCHHHHHHH
EKVIGSQVLIDDYAHHPTEIKVTIEAARQKYPEREIIAVFQPHTFTRTQSFLDEFAESLS
HHHCCCEEEEHHCCCCCCEEEEEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
AADRVYLCDIFGSARENVGKLTITDLQEKIANAELIEENDTSVLKAHEGAVLIFMGAGDI
HCCEEEEEEEHHHHHHCCCCEEHHHHHHHHCCCCEECCCCCCEEEECCCEEEEEECCHHH
QKYMRAYENVIA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA