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The map label for this gene is yrhB [H]

Identifier: 154686865

GI number: 154686865

Start: 2555609

End: 2556751

Strand: Reverse

Name: yrhB [H]

Synonym: RBAM_024350

Alternate gene names: 154686865

Gene position: 2556751-2555609 (Counterclockwise)

Preceding gene: 154686866

Following gene: 154686864

Centisome position: 65.25

GC content: 51.44

Gene sequence:

>1143_bases
ATGAAGAAAAAAACGCTGATGGTGCACGGAGGAATTACGGGAGATGAAAAAACAGGAGCGGTTTCCGTACCGATTTATCA
AGTAAGCACGTACCAACAGCCGAAAGCGGGCGAGCATACGGGTTATGAATATTCAAGAACGGCCAATCCGACGCGCACGG
CGCTTGAAAGCTTAATTGCGGAGCTTGAAGGCGGCGCGGCGGGATATGCGTTCGGCTCAGGCATGGCTGCGATTACTGCC
GTCATGATGCTGTTTGACAGCGGCGATCATGTTATTTTGACGGATGATGTATACGGCGGCACTTACCGGGTGATGACAGG
CGTGCTGAACCGCTTCGGCATTGAAGCGGACTTTGTCGATACGAGCAGCAAAGAAAAAGTCCAAAAAGCCATTCGCCCGA
ATACGAAAGCCATTTATATCGAAACACCGACAAACCCGCTATTGAAAGTGACTGACCTCAAACTGATGTCTGACATCGCA
AAAGAAGCGGGTGTATTGCTTATCGTCGATAATACGTTTTACACGCCGTATTTCCAACAGCCGCTGAGCTTCGGAGCGGA
CATCGTGCTTCACAGCGCGACAAAATATCTCGGCGGCCACAGTGATGTCGTCGGCGGCTTAGTCGTTACGGCTGATAAAG
AACTGGGCGAAAAGCTTCATTATGTGCAAAACTCAACGGGCGGCGTTTTAGGACCGCAGGATTCATGGCTTTTGATGAGA
GGCATTAAAACGCTGGGACTCAGAATGGATGCCATCAATTACAGCGCCGGAAAAATCGCCGGGCTGCTTGAAGCGCATGA
TGCCGTTCAGACGCTCTACTATCCCGGATCAGCGAAACACCCGGGCCATGAGCTGACAAAAGCGCAAAGCTCCGGTTTCG
GCGGAATGATTTCCTTTGATGTCGGCAGCAGCGAACGCGTCGACGCGTTTTTAGAAAAATTGAACCTGTTTACGATCGCG
GAAAGTTTAGGAGCGGTTGAAAGCTTAATCTCCGTGCCGTCCAGAATGACGCACGCATCGATCCCGCGCGACCGCCGGCT
TGCGCTTGGCATTACCGACGGGCTCGTGCGGATCTCAGTCGGTATTGAGGATACTGAGGATTTAACGGCGGATGTGAAAC
AGGCGCTTGATTCACTTTTATAA

Upstream 100 bases:

>100_bases
GAAGCGAAAAAAGCGCCCGCCGGATCAAATATCGTCACTATTTTCCCTGACGGCAGCGATCGATATATAAGCAAAAACAT
TTTTCAAGGAGGTCAGTAAG

Downstream 100 bases:

>100_bases
AGAATGGATAGATTTACATTCTCTGTCGGCTGTCAGCTTGTATTATAATGTTGGTAGACTATAAAACTGGCAGGTGACCT
TATATGGAGAAGAAAAGACT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKKKTLMVHGGITGDEKTGAVSVPIYQVSTYQQPKAGEHTGYEYSRTANPTRTALESLIAELEGGAAGYAFGSGMAAITA
VMMLFDSGDHVILTDDVYGGTYRVMTGVLNRFGIEADFVDTSSKEKVQKAIRPNTKAIYIETPTNPLLKVTDLKLMSDIA
KEAGVLLIVDNTFYTPYFQQPLSFGADIVLHSATKYLGGHSDVVGGLVVTADKELGEKLHYVQNSTGGVLGPQDSWLLMR
GIKTLGLRMDAINYSAGKIAGLLEAHDAVQTLYYPGSAKHPGHELTKAQSSGFGGMISFDVGSSERVDAFLEKLNLFTIA
ESLGAVESLISVPSRMTHASIPRDRRLALGITDGLVRISVGIEDTEDLTADVKQALDSLL

Sequences:

>Translated_380_residues
MKKKTLMVHGGITGDEKTGAVSVPIYQVSTYQQPKAGEHTGYEYSRTANPTRTALESLIAELEGGAAGYAFGSGMAAITA
VMMLFDSGDHVILTDDVYGGTYRVMTGVLNRFGIEADFVDTSSKEKVQKAIRPNTKAIYIETPTNPLLKVTDLKLMSDIA
KEAGVLLIVDNTFYTPYFQQPLSFGADIVLHSATKYLGGHSDVVGGLVVTADKELGEKLHYVQNSTGGVLGPQDSWLLMR
GIKTLGLRMDAINYSAGKIAGLLEAHDAVQTLYYPGSAKHPGHELTKAQSSGFGGMISFDVGSSERVDAFLEKLNLFTIA
ESLGAVESLISVPSRMTHASIPRDRRLALGITDGLVRISVGIEDTEDLTADVKQALDSLL
>Mature_380_residues
MKKKTLMVHGGITGDEKTGAVSVPIYQVSTYQQPKAGEHTGYEYSRTANPTRTALESLIAELEGGAAGYAFGSGMAAITA
VMMLFDSGDHVILTDDVYGGTYRVMTGVLNRFGIEADFVDTSSKEKVQKAIRPNTKAIYIETPTNPLLKVTDLKLMSDIA
KEAGVLLIVDNTFYTPYFQQPLSFGADIVLHSATKYLGGHSDVVGGLVVTADKELGEKLHYVQNSTGGVLGPQDSWLLMR
GIKTLGLRMDAINYSAGKIAGLLEAHDAVQTLYYPGSAKHPGHELTKAQSSGFGGMISFDVGSSERVDAFLEKLNLFTIA
ESLGAVESLISVPSRMTHASIPRDRRLALGITDGLVRISVGIEDTEDLTADVKQALDSLL

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=377, Percent_Identity=45.8885941644562, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI299473759, Length=377, Percent_Identity=42.1750663129974, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI25453487, Length=376, Percent_Identity=40.1595744680851, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1790375, Length=375, Percent_Identity=42.1333333333333, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1789383, Length=386, Percent_Identity=27.720207253886, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=357, Percent_Identity=48.7394957983193, Blast_Score=339, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17538055, Length=357, Percent_Identity=48.1792717086835, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=43.3962264150943, Blast_Score=283, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6319307, Length=384, Percent_Identity=46.3541666666667, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6321254, Length=401, Percent_Identity=34.4139650872818, Blast_Score=208, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6323333, Length=433, Percent_Identity=34.8729792147806, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321170, Length=293, Percent_Identity=33.7883959044369, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321904, Length=342, Percent_Identity=31.2865497076023, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323557, Length=343, Percent_Identity=26.8221574344023, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322970, Length=349, Percent_Identity=25.214899713467, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322590, Length=369, Percent_Identity=23.5772357723577, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922554, Length=377, Percent_Identity=45.3580901856764, Blast_Score=340, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 40727; Mature: 40727

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKTLMVHGGITGDEKTGAVSVPIYQVSTYQQPKAGEHTGYEYSRTANPTRTALESLIA
CCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELEGGAAGYAFGSGMAAITAVMMLFDSGDHVILTDDVYGGTYRVMTGVLNRFGIEADFVD
HHCCCCCCHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEECC
TSSKEKVQKAIRPNTKAIYIETPTNPLLKVTDLKLMSDIAKEAGVLLIVDNTFYTPYFQQ
CCCHHHHHHHHCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
PLSFGADIVLHSATKYLGGHSDVVGGLVVTADKELGEKLHYVQNSTGGVLGPQDSWLLMR
HHHCCCCEEEEHHHHHHCCCCHHHCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHH
GIKTLGLRMDAINYSAGKIAGLLEAHDAVQTLYYPGSAKHPGHELTKAQSSGFGGMISFD
HHHHHCEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHCCCCCCEEEEE
VGSSERVDAFLEKLNLFTIAESLGAVESLISVPSRMTHASIPRDRRLALGITDGLVRISV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCCEEEEEE
GIEDTEDLTADVKQALDSLL
CCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKKTLMVHGGITGDEKTGAVSVPIYQVSTYQQPKAGEHTGYEYSRTANPTRTALESLIA
CCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELEGGAAGYAFGSGMAAITAVMMLFDSGDHVILTDDVYGGTYRVMTGVLNRFGIEADFVD
HHCCCCCCHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEECC
TSSKEKVQKAIRPNTKAIYIETPTNPLLKVTDLKLMSDIAKEAGVLLIVDNTFYTPYFQQ
CCCHHHHHHHHCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
PLSFGADIVLHSATKYLGGHSDVVGGLVVTADKELGEKLHYVQNSTGGVLGPQDSWLLMR
HHHCCCCEEEEHHHHHHCCCCHHHCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHH
GIKTLGLRMDAINYSAGKIAGLLEAHDAVQTLYYPGSAKHPGHELTKAQSSGFGGMISFD
HHHHHCEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHCCCCCCEEEEE
VGSSERVDAFLEKLNLFTIAESLGAVESLISVPSRMTHASIPRDRRLALGITDGLVRISV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCCEEEEEE
GIEDTEDLTADVKQALDSLL
CCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]