Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 154686810

GI number: 154686810

Start: 2499231

End: 2500370

Strand: Reverse

Name: hemN [H]

Synonym: RBAM_023800

Alternate gene names: 154686810

Gene position: 2500370-2499231 (Counterclockwise)

Preceding gene: 154686811

Following gene: 154686809

Centisome position: 63.81

GC content: 47.11

Gene sequence:

>1140_bases
ATGAAATCAGCTTATATTCATATTCCGTTTTGTGAGCATATCTGCCACTATTGCGATTTCAATAAATATTTTATTCAGAG
CCAGCCTGTCGATGAGTACTTAAACTCACTCGAAAAGGAAATGATAAATACAATAGAACGGACGGGACGCCCTGATCTCC
GCACGATTTTTATCGGGGGAGGCACGCCGACATCGCTCTCACCCGTCCAGCTGGAAAAATTGATGGATTCCATTCACCGC
GTGCTGAAGCCTTCTGACGGACTCATAGAATTTGCCGCGGAAGCGAATCCGGATGATTTGTCCCCGGAAAAATTAAAAAT
CATGAAAAATGCCGGTGTCAACCGGCTGAGCTTCGGTGTTCAAACCTTTGAAGATGAGCTTTTACAAAAAATCGGAAGAG
TGCATAAACAAAAGGACGTATTCACTTCCTTTGAACGTGCGAGGGCTCTCGGCTTCGACAACATCAGTCTCGATTTAATG
TTCGGCCTGCCGGGTCAGACGCTGGCCGATCTTGACAATTCCGTCAAAACGGCTTTGTCTCTTGATGCGGAGCACTACTC
CGTTTACTCGCTGATCGTAGAGCCGAAAACGGTGTTTTATAATTTAATGCAAAAAGGCCGCCTGCATCTCCCGGCGCAAG
AACAAGAGGCCGAGATGTATGAAACGGTCATGAGGCAGATGAGTGAAGCGGGCATCCGTCAATACGAGATCAGTAACTTT
GCAAAGCCCGGATACGAGTCCCAGCATAATCTGACGTATTGGAGCAATGAAGAGTATTTCGGTTTTGGCGCAGGCGCTCA
CGGATATATCAGCGGCACGCGCACCGTCAACGCCGGGCCTGTGAAACATTACATGCAGCTCATCGAAGAAAAGGGGCTGC
CTTACCGTGACACGCACGAGGTGACACGTGAGGAGCAGATTGAAGAAGAAATGTTCCTCGGTCTCAGAAAAATGTCCGGC
GTACAAAAGCAAGCTTTTCTTGATAAATTCGGACGCTCGGTCGACGAACTGTTTCCCGATGTTCTCAAAGATTTAACCGA
AAAAGGCCTGATTTGTGACACGGAAGAATCGGTTGCATTAACGCATGAGGGCAAATTATTAGGAAATGAGGTTTTTGGCG
CTTTTTTGGGTGAGTTATAA

Upstream 100 bases:

>100_bases
TTATGGCCGTTCTTAAAATGGATGACAGCCCGAAAAAATAACGGAAGCCGCCGCAGTCCCGCGCTGCGGCTTCTTTCTGT
AAAGAAGAAGGTGTTTCAAA

Downstream 100 bases:

>100_bases
TTGACATTTTTCTTTTGGTTTGTTACTTTTGATATAGAATTAGCACTCGCTGACCTTGAGTGCTAACAGGGGTGATGATG
ATGTTAACAAATCGTCAGCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNSLEKEMINTIERTGRPDLRTIFIGGGTPTSLSPVQLEKLMDSIHR
VLKPSDGLIEFAAEANPDDLSPEKLKIMKNAGVNRLSFGVQTFEDELLQKIGRVHKQKDVFTSFERARALGFDNISLDLM
FGLPGQTLADLDNSVKTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPAQEQEAEMYETVMRQMSEAGIRQYEISNF
AKPGYESQHNLTYWSNEEYFGFGAGAHGYISGTRTVNAGPVKHYMQLIEEKGLPYRDTHEVTREEQIEEEMFLGLRKMSG
VQKQAFLDKFGRSVDELFPDVLKDLTEKGLICDTEESVALTHEGKLLGNEVFGAFLGEL

Sequences:

>Translated_379_residues
MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNSLEKEMINTIERTGRPDLRTIFIGGGTPTSLSPVQLEKLMDSIHR
VLKPSDGLIEFAAEANPDDLSPEKLKIMKNAGVNRLSFGVQTFEDELLQKIGRVHKQKDVFTSFERARALGFDNISLDLM
FGLPGQTLADLDNSVKTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPAQEQEAEMYETVMRQMSEAGIRQYEISNF
AKPGYESQHNLTYWSNEEYFGFGAGAHGYISGTRTVNAGPVKHYMQLIEEKGLPYRDTHEVTREEQIEEEMFLGLRKMSG
VQKQAFLDKFGRSVDELFPDVLKDLTEKGLICDTEESVALTHEGKLLGNEVFGAFLGEL
>Mature_379_residues
MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNSLEKEMINTIERTGRPDLRTIFIGGGTPTSLSPVQLEKLMDSIHR
VLKPSDGLIEFAAEANPDDLSPEKLKIMKNAGVNRLSFGVQTFEDELLQKIGRVHKQKDVFTSFERARALGFDNISLDLM
FGLPGQTLADLDNSVKTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPAQEQEAEMYETVMRQMSEAGIRQYEISNF
AKPGYESQHNLTYWSNEEYFGFGAGAHGYISGTRTVNAGPVKHYMQLIEEKGLPYRDTHEVTREEQIEEEMFLGLRKMSG
VQKQAFLDKFGRSVDELFPDVLKDLTEKGLICDTEESVALTHEGKLLGNEVFGAFLGEL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=36.6037735849057, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1789325, Length=380, Percent_Identity=32.6315789473684, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87082341, Length=394, Percent_Identity=25.3807106598985, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43035; Mature: 43035

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNSLEKEMINTIERTGRPDLRTIFIGG
CCCCEEECCHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GTPTSLSPVQLEKLMDSIHRVLKPSDGLIEFAAEANPDDLSPEKLKIMKNAGVNRLSFGV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHH
QTFEDELLQKIGRVHKQKDVFTSFERARALGFDNISLDLMFGLPGQTLADLDNSVKTALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
LDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPAQEQEAEMYETVMRQMSEAGIRQYEISNF
CCCHHEEEEHEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHC
AKPGYESQHNLTYWSNEEYFGFGAGAHGYISGTRTVNAGPVKHYMQLIEEKGLPYRDTHE
CCCCCCCCCCCEEECCCCEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHH
VTREEQIEEEMFLGLRKMSGVQKQAFLDKFGRSVDELFPDVLKDLTEKGLICDTEESVAL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEECCCCCEEE
THEGKLLGNEVFGAFLGEL
EECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNSLEKEMINTIERTGRPDLRTIFIGG
CCCCEEECCHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GTPTSLSPVQLEKLMDSIHRVLKPSDGLIEFAAEANPDDLSPEKLKIMKNAGVNRLSFGV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHH
QTFEDELLQKIGRVHKQKDVFTSFERARALGFDNISLDLMFGLPGQTLADLDNSVKTALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
LDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPAQEQEAEMYETVMRQMSEAGIRQYEISNF
CCCHHEEEEHEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHC
AKPGYESQHNLTYWSNEEYFGFGAGAHGYISGTRTVNAGPVKHYMQLIEEKGLPYRDTHE
CCCCCCCCCCCEEECCCCEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHH
VTREEQIEEEMFLGLRKMSGVQKQAFLDKFGRSVDELFPDVLKDLTEKGLICDTEESVAL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEECCCCCEEE
THEGKLLGNEVFGAFLGEL
EECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]