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The map label for this gene is accC [H]

Identifier: 154686698

GI number: 154686698

Start: 2404148

End: 2405500

Strand: Reverse

Name: accC [H]

Synonym: RBAM_022670

Alternate gene names: 154686698

Gene position: 2405500-2404148 (Counterclockwise)

Preceding gene: 154686699

Following gene: 154686697

Centisome position: 61.39

GC content: 48.78

Gene sequence:

>1353_bases
ATGATTAAAAAGCTATTGATCGCCAACCGAGGAGAAATCGCCGTCAGAATCATCCGGGCCTGCAAAGAGCTGGGCATTGA
AACTGTAGCCGTTTATTCTGAGGCAGATAAAGACGCCCTGCATGTCCAAATGGCCGATGAGGCTTTTTGTATCGGGCCGA
AAACATCAAAAGAAAGCTATTTAAATGTAACGAACATCGTCAGCGTCGCAAAGCTGACCGGCACGGATGCGATTCATCCG
GGATACGGATTTTTAGCTGAAAACGCCGACTTTGCCGAGCTGTGCGAGGAATTAAACGTAACGTTTGTCGGCCCTACGGC
TGACGCCATTTCAAAAATGGGAACAAAAGATATCGCGCGCGACACGATGCAGCTGGCGGGCGTGCCGATTGTGCCCGGTT
CAAAAGGAATCATAAAAAATACGGAAGAAGCGGTTTCGCTTGCAGGTGAAATTGGGTATCCTGTCATTATAAAAGCCACT
GCGGGCGGAGGCGGAAAAGGCATCCGGGTCGCACGCACAGAAGAAGAACTGATCAAAGGCATTGAGATTACCCAGCAGGA
AGCCGCTACGGCATTCGGAAATCCGGGTGTGTACATCGAGAAGTACATAGAAGATTTCCGCCATGTTGAAATTCAGGTGC
TTGCGGATAATTACGGAAACACGATCCATCTCGGAGAGCGTGACTGTTCTATCCAAAGACGTCTGCAAAAACTTCTTGAA
GAGTCACCGTCACCTGCGCTTGATTCTGAAATCAGGGAGCAGATGGGTGAAGCAGCGGTAAAAGCAGCGAAGGCCGTCGG
TTACACGGGAGCCGGCACAGTAGAATTCATCTATGACTACAGAGAACAGCGCTACTACTTCATGGAAATGAACACGCGTA
TTCAAGTAGAGCATCCTGTCACAGAAATGGTGACGGGAACGGATCTGATCAAAGAACAGATCAAAGTGGCATCCGGACAG
GAGCTTTCGCTCAGACAGGAAGACGTTGAATTTAACGGCTGGGCGATTGAATGCCGCATCAACGCTGAAAATCCTGCGAA
AAACTTCATGCCTTCACCCGGTAAAATTAACATGTACCTGCCGCCGGGCGGACTCGGCGTACGCGTGGATTCAGCCGCAT
ATCCCGGCTATTCGATCCCGCCGTACTATGACAGTATGATTGCTAAAGTCATCACATACGGAACAACGCGTGATGAGGCA
GTCGCACGGATGAAACGCGCGCTGAGCGAATTCGTGATTGAAGGTATTGAAACGACGATTCCGTTCCATTTGAAACTGCT
TGAACACGAAACATTTGTCAGCGGAGAGTTTAATACAAAGTTTTTAGAAACATATGATGTAATGGGCTCATAA

Upstream 100 bases:

>100_bases
TAAAAGGAGAAATCGTTGAAGTGTTAGTTGAAAACGGCCAGCTGGTCGAATACGGACAACCTCTATTTCTTGTAAAAGCT
GAGTAAGGAGACCTGCTATT

Downstream 100 bases:

>100_bases
TTTTTGCGGGAGGTGAATTGAATGGAAGACAACAGTGTGCTTAAAATGGATCATGATGAGGCTCATTTAGGCAAGGTTGA
AATTGCTCCTGAGGTCATTG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIKKLLIANRGEIAVRIIRACKELGIETVAVYSEADKDALHVQMADEAFCIGPKTSKESYLNVTNIVSVAKLTGTDAIHP
GYGFLAENADFAELCEELNVTFVGPTADAISKMGTKDIARDTMQLAGVPIVPGSKGIIKNTEEAVSLAGEIGYPVIIKAT
AGGGGKGIRVARTEEELIKGIEITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
ESPSPALDSEIREQMGEAAVKAAKAVGYTGAGTVEFIYDYREQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGQ
ELSLRQEDVEFNGWAIECRINAENPAKNFMPSPGKINMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGTTRDEA
VARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS

Sequences:

>Translated_450_residues
MIKKLLIANRGEIAVRIIRACKELGIETVAVYSEADKDALHVQMADEAFCIGPKTSKESYLNVTNIVSVAKLTGTDAIHP
GYGFLAENADFAELCEELNVTFVGPTADAISKMGTKDIARDTMQLAGVPIVPGSKGIIKNTEEAVSLAGEIGYPVIIKAT
AGGGGKGIRVARTEEELIKGIEITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
ESPSPALDSEIREQMGEAAVKAAKAVGYTGAGTVEFIYDYREQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGQ
ELSLRQEDVEFNGWAIECRINAENPAKNFMPSPGKINMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGTTRDEA
VARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS
>Mature_450_residues
MIKKLLIANRGEIAVRIIRACKELGIETVAVYSEADKDALHVQMADEAFCIGPKTSKESYLNVTNIVSVAKLTGTDAIHP
GYGFLAENADFAELCEELNVTFVGPTADAISKMGTKDIARDTMQLAGVPIVPGSKGIIKNTEEAVSLAGEIGYPVIIKAT
AGGGGKGIRVARTEEELIKGIEITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
ESPSPALDSEIREQMGEAAVKAAKAVGYTGAGTVEFIYDYREQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGQ
ELSLRQEDVEFNGWAIECRINAENPAKNFMPSPGKINMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGTTRDEA
VARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=51.7006802721088, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=51.7006802721088, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=51.7006802721088, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=47.4157303370787, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=47.2035794183445, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=47.2035794183445, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=47.2035794183445, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI38679960, Length=510, Percent_Identity=32.156862745098, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=32.156862745098, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=32.156862745098, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=32.156862745098, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=32.156862745098, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=31.8982387475538, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=56.3063063063063, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1786216, Length=247, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=46.4852607709751, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71987519, Length=445, Percent_Identity=46.9662921348315, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=44.1241685144124, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71997168, Length=505, Percent_Identity=31.6831683168317, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71997163, Length=505, Percent_Identity=31.6831683168317, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=28.6585365853659, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI193204318, Length=417, Percent_Identity=23.9808153477218, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=44.6188340807175, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=44.7427293064877, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.6375838926174, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=32.7519379844961, Blast_Score=250, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=468, Percent_Identity=32.6923076923077, Blast_Score=240, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=45.2115812917595, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=47.2160356347439, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=44.2822384428224, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=32.8712871287129, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=32.8712871287129, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=32.8712871287129, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=32.8712871287129, Blast_Score=249, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49435; Mature: 49435

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLLIANRGEIAVRIIRACKELGIETVAVYSEADKDALHVQMADEAFCIGPKTSKESY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCHHH
LNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEELNVTFVGPTADAISKMGTKDIAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
DTMQLAGVPIVPGSKGIIKNTEEAVSLAGEIGYPVIIKATAGGGGKGIRVARTEEELIKG
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECHHHHHCC
IEITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
CHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDSEIREQMGEAAVKAAKAVGYTGAGTVEFIYDYREQRYYFMEMNTRIQVEHPV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEHHHCEEEEEEECCEEEEECCH
TEMVTGTDLIKEQIKVASGQELSLRQEDVEFNGWAIECRINAENPAKNFMPSPGKINMYL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCEEEEEE
PPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGTTRDEAVARMKRALSEFVIEGIETTI
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PFHLKLLEHETFVSGEFNTKFLETYDVMGS
CEEEEEEECCEEECCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MIKKLLIANRGEIAVRIIRACKELGIETVAVYSEADKDALHVQMADEAFCIGPKTSKESY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCHHH
LNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEELNVTFVGPTADAISKMGTKDIAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
DTMQLAGVPIVPGSKGIIKNTEEAVSLAGEIGYPVIIKATAGGGGKGIRVARTEEELIKG
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECHHHHHCC
IEITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
CHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDSEIREQMGEAAVKAAKAVGYTGAGTVEFIYDYREQRYYFMEMNTRIQVEHPV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEHHHCEEEEEEECCEEEEECCH
TEMVTGTDLIKEQIKVASGQELSLRQEDVEFNGWAIECRINAENPAKNFMPSPGKINMYL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCEEEEEE
PPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGTTRDEAVARMKRALSEFVIEGIETTI
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PFHLKLLEHETFVSGEFNTKFLETYDVMGS
CEEEEEEECCEEECCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]