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The map label for this gene is xseA [H]

Identifier: 154686694

GI number: 154686694

Start: 2400732

End: 2402093

Strand: Reverse

Name: xseA [H]

Synonym: RBAM_022630

Alternate gene names: 154686694

Gene position: 2402093-2400732 (Counterclockwise)

Preceding gene: 154686695

Following gene: 154686693

Centisome position: 61.3

GC content: 49.41

Gene sequence:

>1362_bases
ATGAAAGGAGTGCAGGATATGAGTGAAGCGGCATATGTCACGGTTTCCGCGCTGACCAAATACATTAAACGAAAATTCGA
TGTGGACCCTCATCTTGAAGACATTTGGATTAAGGGTGAGCTCTCCAATGTTAAAATTCATACGAGAGGCCACATCTATT
TTACATTAAAAGATGAGCATGCCCGCATGCAGGCCGTCATGTTTCAGAGGCAAAGTTCGAGGCTTGCGTTTAAGCCAGAA
GACGGAATGAAGGTCATCGTAAGAGGCGGCATCTCCGTCTATGAACCGAGCGGAAGCTATCAGCTGTACGCGAAAGAAAT
GCAGCCGGACGGTGTGGGGGCGCTCTACTTAGCATATGAAGAATTAAAGAAAAAACTTGCCGGCGAAGGGTTGTTTGATG
ACCGGCATAAGCAGGCCATCCCCGCTTTTCCGGCCACGATCGGGGTCGTCACGTCACCGACGGGAGCAGCCGTCAGAGAC
GTCATTACCACACTCAAAAGAAGATACCCCCTTGTGAAAGTCATTGTGCTTCCCGCGCTCGTTCAAGGTGAAAATGCCAG
CAGATCGATTGTGAAGCGCATTGAAGAAGCCAATGCACAAAAAATGTGTGACGTCCTGATCGTCGGAAGGGGAGGGGGCT
CGATCGAAGAATTGTGGGCATTTAACGAAGAAATCGTGGCCCGGGCGATTTTTGCTTCCGCCATTCCGATTATATCAGCC
GTCGGACATGAAACAGATTTTACAATCAGTGATTTCGTCGCGGATATCCGGGCGGCAACGCCGACAGGAGCGGCAGAAAT
CGCCGTCCCCCACACGACGGACTTAATGGAACGGACAAAAACGGCGGAAGTCCGCCTGACAAGAGCGATGCAGCAGCATA
TCAGCAAGAAAAAAGAACGGGTTCAATCGCTCCAGTCATCCTACGCGTTCCGTTTTCCGAAACGATTGTATACCCAAAAA
GAACAGCAGTTTGACCTTTTGTATCAGCAGTTCCAGTCACAGCTCACAGGGCTTACGGACAGGAAACAAAGGCAGCTGGA
GCGGAATACGTACAGATTAACGGCGCTCCACCCTGAAACCCAGCTGAAACAGGCGAAAAAACGGTACGAGGAGCGCTCAA
ATCAGCTCGCCCGAAGCATGAATGTCCAGCTGAAGCAGCTTCATTCGCAGTTTCAGACGGTTCTTGGTAAACTGAATGCA
TTAAGTCCCCTTCAGGTGATGGAGAGAGGATACAGTCTGGCCTATAAAGACAAAAAGCTGATCAAAAGCGTTGATCAAGT
GGAACAAAATGATACGCTTGAAGTAAAGATGACAGACGGCGTTCTGACGTGTGAAGTATTGCAAAAGAGAGGCGAACGAT
AA

Upstream 100 bases:

>100_bases
CGGAGACAGTCACAAAAATTGTGACAATGAGCACGATACCCGCTTCTTAAGGCTCCTTTCAGCCAGAGCGGGTTTTCTTA
GTTTAGGGCAAAAAGCCTTT

Downstream 100 bases:

>100_bases
TGACAGAAACCAAAAAAAGTGAAGAGCTGACATTTGAAGAGGCGATGAAAGGCCTTGAAGGCATTGTGGCAAAGCTTGAA
GAAGGAGACGTGCCGCTGGA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKGVQDMSEAAYVTVSALTKYIKRKFDVDPHLEDIWIKGELSNVKIHTRGHIYFTLKDEHARMQAVMFQRQSSRLAFKPE
DGMKVIVRGGISVYEPSGSYQLYAKEMQPDGVGALYLAYEELKKKLAGEGLFDDRHKQAIPAFPATIGVVTSPTGAAVRD
VITTLKRRYPLVKVIVLPALVQGENASRSIVKRIEEANAQKMCDVLIVGRGGGSIEELWAFNEEIVARAIFASAIPIISA
VGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLMERTKTAEVRLTRAMQQHISKKKERVQSLQSSYAFRFPKRLYTQK
EQQFDLLYQQFQSQLTGLTDRKQRQLERNTYRLTALHPETQLKQAKKRYEERSNQLARSMNVQLKQLHSQFQTVLGKLNA
LSPLQVMERGYSLAYKDKKLIKSVDQVEQNDTLEVKMTDGVLTCEVLQKRGER

Sequences:

>Translated_453_residues
MKGVQDMSEAAYVTVSALTKYIKRKFDVDPHLEDIWIKGELSNVKIHTRGHIYFTLKDEHARMQAVMFQRQSSRLAFKPE
DGMKVIVRGGISVYEPSGSYQLYAKEMQPDGVGALYLAYEELKKKLAGEGLFDDRHKQAIPAFPATIGVVTSPTGAAVRD
VITTLKRRYPLVKVIVLPALVQGENASRSIVKRIEEANAQKMCDVLIVGRGGGSIEELWAFNEEIVARAIFASAIPIISA
VGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLMERTKTAEVRLTRAMQQHISKKKERVQSLQSSYAFRFPKRLYTQK
EQQFDLLYQQFQSQLTGLTDRKQRQLERNTYRLTALHPETQLKQAKKRYEERSNQLARSMNVQLKQLHSQFQTVLGKLNA
LSPLQVMERGYSLAYKDKKLIKSVDQVEQNDTLEVKMTDGVLTCEVLQKRGER
>Mature_453_residues
MKGVQDMSEAAYVTVSALTKYIKRKFDVDPHLEDIWIKGELSNVKIHTRGHIYFTLKDEHARMQAVMFQRQSSRLAFKPE
DGMKVIVRGGISVYEPSGSYQLYAKEMQPDGVGALYLAYEELKKKLAGEGLFDDRHKQAIPAFPATIGVVTSPTGAAVRD
VITTLKRRYPLVKVIVLPALVQGENASRSIVKRIEEANAQKMCDVLIVGRGGGSIEELWAFNEEIVARAIFASAIPIISA
VGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLMERTKTAEVRLTRAMQQHISKKKERVQSLQSSYAFRFPKRLYTQK
EQQFDLLYQQFQSQLTGLTDRKQRQLERNTYRLTALHPETQLKQAKKRYEERSNQLARSMNVQLKQLHSQFQTVLGKLNA
LSPLQVMERGYSLAYKDKKLIKSVDQVEQNDTLEVKMTDGVLTCEVLQKRGER

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=437, Percent_Identity=39.8169336384439, Blast_Score=330, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 51310; Mature: 51310

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVQDMSEAAYVTVSALTKYIKRKFDVDPHLEDIWIKGELSNVKIHTRGHIYFTLKDEH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEECCEEEEEECCHH
ARMQAVMFQRQSSRLAFKPEDGMKVIVRGGISVYEPSGSYQLYAKEMQPDGVGALYLAYE
HHHHHHHHHHHCCCEEECCCCCCEEEEECCCEEECCCCCEEEEEECCCCCCCCHHHHHHH
ELKKKLAGEGLFDDRHKQAIPAFPATIGVVTSPTGAAVRDVITTLKRRYPLVKVIVLPAL
HHHHHHCCCCCCCCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHH
VQGENASRSIVKRIEEANAQKMCDVLIVGRGGGSIEELWAFNEEIVARAIFASAIPIISA
HCCCCCHHHHHHHHHHCCHHHEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHH
VGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLMERTKTAEVRLTRAMQQHISKKKER
CCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQSLQSSYAFRFPKRLYTQKEQQFDLLYQQFQSQLTGLTDRKQRQLERNTYRLTALHPET
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCHH
QLKQAKKRYEERSNQLARSMNVQLKQLHSQFQTVLGKLNALSPLQVMERGYSLAYKDKKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHH
IKSVDQVEQNDTLEVKMTDGVLTCEVLQKRGER
HHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure
MKGVQDMSEAAYVTVSALTKYIKRKFDVDPHLEDIWIKGELSNVKIHTRGHIYFTLKDEH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEECCEEEEEECCHH
ARMQAVMFQRQSSRLAFKPEDGMKVIVRGGISVYEPSGSYQLYAKEMQPDGVGALYLAYE
HHHHHHHHHHHCCCEEECCCCCCEEEEECCCEEECCCCCEEEEEECCCCCCCCHHHHHHH
ELKKKLAGEGLFDDRHKQAIPAFPATIGVVTSPTGAAVRDVITTLKRRYPLVKVIVLPAL
HHHHHHCCCCCCCCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHH
VQGENASRSIVKRIEEANAQKMCDVLIVGRGGGSIEELWAFNEEIVARAIFASAIPIISA
HCCCCCHHHHHHHHHHCCHHHEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHH
VGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLMERTKTAEVRLTRAMQQHISKKKER
CCCCCCCCHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQSLQSSYAFRFPKRLYTQKEQQFDLLYQQFQSQLTGLTDRKQRQLERNTYRLTALHPET
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCHH
QLKQAKKRYEERSNQLARSMNVQLKQLHSQFQTVLGKLNALSPLQVMERGYSLAYKDKKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHH
IKSVDQVEQNDTLEVKMTDGVLTCEVLQKRGER
HHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]