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The map label for this gene is dxs

Identifier: 154686691

GI number: 154686691

Start: 2397553

End: 2399454

Strand: Reverse

Name: dxs

Synonym: RBAM_022600

Alternate gene names: 154686691

Gene position: 2399454-2397553 (Counterclockwise)

Preceding gene: 154686692

Following gene: 154686690

Centisome position: 61.23

GC content: 50.21

Gene sequence:

>1902_bases
TTGGATCTTTTATCAATACAGGACCCGTCATTTCTTAAAAAGATGTCAATTGAACAGCTGGAAGAGCTGAGTGAGGAGAT
CCGCAATTTCCTCATCACATCGCTGTCTGCCTCTGGCGGCCATATCGGGCCGAACCTCGGGGTTGTCGAGCTGACAATTG
CGCTTCACAAAGAATTTGACAGTCCGAAAGATAAATTTTTATGGGATGTCGGACATCAGTCCTATGTTCATAAACTGTTA
ACCGGACGCGGCAAGGAGTTTGAAACCTTGCGCCAATATAAAGGGCTTTGCGGTTTCCCGAAACGCAGCGAAAGCGAACA
TGACGTATGGGAAACAGGCCACAGCTCAACCTCGCTCTCAGGCGCGATGGGAATGGCTGCCGCCCGTGATATTAAAGGAT
CGAAAGAATATATCATCCCGATTATCGGAGACGGCGCTTTAACCGGAGGAATGGCGCTTGAAGCGCTGAACCATATCGGT
GATGAGAAAAAAGACATGATCGTCATCCTGAATGATAATGAGATGAGCATTGCGCCGAATGTCGGGGCGATTCATTCTAT
GCTTGGACGGCTTCGCACGGCCGGCAAATATCAATGGGTAAAAGACGAGCTTGAATATTTATTTAAGCGCATCCCGGCCG
TCGGCGGAAAATTGGCCGCCACAGCTGAACGGATAAAAGACAGTTTGAAATATATGCTTGTGTCAGGCATGTTTTTTGAA
GAGCTGGGCTTTACGTATTTAGGCCCGGTTGACGGTCATTCCTACCACGAACTGTTTGAAAACCTGCAATACGCCAAAAA
AACGAAAGGCCCTGTCCTGTTACATGTCATCACGAAAAAGGGCAAAGGCTATAAACCGGCTGAGACCGACACAATCGGCA
CATGGCACGGAACGGGTCCGTATAAAATCAATACGGGTGATTTCGTCAAGCCGAAAGCCGCGGCGCCTTCATGGAGCGGA
CTTGTCAGCGGCACCGTGCAGGAGCTGGCACGTGAGGATGACAGAATTGTTGCCATTACACCGGCCATGCCGGTCGGCTC
TAAACTGGAAGGGTTTGCGAAAGAATTCCCTGAACGCATGTTTGATGTCGGAATCGCAGAACAGCATGCGGCGACGATGG
CGGCTGGAATGGCGCTCCAAGGCATGAAGCCGTTTCTTGCGATTTATTCGACCTTTTTGCAGCGGGCGTACGATCAGGTC
GTCCATGACATCTGCCGTCAAAACGCGAATGTATTTATCGGCATTGACCGCGCCGGTTTGGTCGGCGCCGACGGGGAGAC
GCATCAAGGCGTCTTTGACATCGCCTTTTTGCGGCATATACCAAACCTCGTTTTAATGATGCCGAAGGATGAAAATGAAG
GCCGCCATATGGTCAATACAGCCCTTAATTATGAGGAGGGCCCGATCGCGATGCGCTTCCCGCGCGGAAACGGGCTCGGC
GTAAAGATGGATAAAGAGCTGAAAACCATTCCGATCGGAACATGGGAAGTGCTCCGTCCCGGAAAAGACGCGGTCATTTT
AACATTCGGTACGACCATTGAAATGGCGCTGGAAGCGGCTGAAGAACTGCAAAAAGAAGGCCTGTCCGTGCGTGTCGTGA
ATGCGCGGTTCATAAAACCGATTGATAAACAAATGATGAAGGCCATTCTTAATGAAGGTCTGCCGATTTTAACGATAGAA
GAAGCCGTGCTTGAAGGCGGATTCGGCAGCACGATTCTTGAATACGCTCATGACCTCGGCATGTATCATACACCGATTGA
CAGAATGGGCATCCCAGACCGGTTTATTGAACACGGCAGCGTAACCGCCCTGCTTGAAGAAATCGGTCTCACGAAGGCTG
AGGTTATGAACCGGATCAAACTGCTGATGCCGCCGAAGACACATAAAGGAATTGGATCATGA

Upstream 100 bases:

>100_bases
GTAAGCAGTTTCGATGAAAATACAAAGGGAGTCTTTTTCTTTTTTCAAAAAGACACTGTTTAATTTGCAGAAATTCATGC
TGAAAGTGAGTTGATCCGCT

Downstream 100 bases:

>100_bases
CAGCAAAAAAAGAACGATTAGATGTACTTCTTGTAGAAAAAGGCCTTGCGGAAACGCGGGAAAAAGCGAAACGCGCCATT
ATGGCGGGCATCGTATACTC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MDLLSIQDPSFLKKMSIEQLEELSEEIRNFLITSLSASGGHIGPNLGVVELTIALHKEFDSPKDKFLWDVGHQSYVHKLL
TGRGKEFETLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGSKEYIIPIIGDGALTGGMALEALNHIG
DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYMLVSGMFFE
ELGFTYLGPVDGHSYHELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSG
LVSGTVQELAREDDRIVAITPAMPVGSKLEGFAKEFPERMFDVGIAEQHAATMAAGMALQGMKPFLAIYSTFLQRAYDQV
VHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGRHMVNTALNYEEGPIAMRFPRGNGLG
VKMDKELKTIPIGTWEVLRPGKDAVILTFGTTIEMALEAAEELQKEGLSVRVVNARFIKPIDKQMMKAILNEGLPILTIE
EAVLEGGFGSTILEYAHDLGMYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKAEVMNRIKLLMPPKTHKGIGS

Sequences:

>Translated_633_residues
MDLLSIQDPSFLKKMSIEQLEELSEEIRNFLITSLSASGGHIGPNLGVVELTIALHKEFDSPKDKFLWDVGHQSYVHKLL
TGRGKEFETLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGSKEYIIPIIGDGALTGGMALEALNHIG
DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYMLVSGMFFE
ELGFTYLGPVDGHSYHELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSG
LVSGTVQELAREDDRIVAITPAMPVGSKLEGFAKEFPERMFDVGIAEQHAATMAAGMALQGMKPFLAIYSTFLQRAYDQV
VHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGRHMVNTALNYEEGPIAMRFPRGNGLG
VKMDKELKTIPIGTWEVLRPGKDAVILTFGTTIEMALEAAEELQKEGLSVRVVNARFIKPIDKQMMKAILNEGLPILTIE
EAVLEGGFGSTILEYAHDLGMYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKAEVMNRIKLLMPPKTHKGIGS
>Mature_633_residues
MDLLSIQDPSFLKKMSIEQLEELSEEIRNFLITSLSASGGHIGPNLGVVELTIALHKEFDSPKDKFLWDVGHQSYVHKLL
TGRGKEFETLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGSKEYIIPIIGDGALTGGMALEALNHIG
DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYMLVSGMFFE
ELGFTYLGPVDGHSYHELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSG
LVSGTVQELAREDDRIVAITPAMPVGSKLEGFAKEFPERMFDVGIAEQHAATMAAGMALQGMKPFLAIYSTFLQRAYDQV
VHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGRHMVNTALNYEEGPIAMRFPRGNGLG
VKMDKELKTIPIGTWEVLRPGKDAVILTFGTTIEMALEAAEELQKEGLSVRVVNARFIKPIDKQMMKAILNEGLPILTIE
EAVLEGGFGSTILEYAHDLGMYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKAEVMNRIKLLMPPKTHKGIGS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=621, Percent_Identity=25.6038647342995, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4507521, Length=621, Percent_Identity=25.6038647342995, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI225637463, Length=335, Percent_Identity=27.1641791044776, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637459, Length=335, Percent_Identity=27.1641791044776, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=335, Percent_Identity=27.1641791044776, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI133778974, Length=434, Percent_Identity=26.036866359447, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI156564403, Length=230, Percent_Identity=23.9130434782609, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI291084858, Length=221, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786622, Length=612, Percent_Identity=45.2614379084967, Blast_Score=530, Evalue=1e-151,
Organism=Escherichia coli, GI48994911, Length=266, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=420, Percent_Identity=25.7142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538422, Length=231, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=299, Percent_Identity=26.7558528428094, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666278, Length=617, Percent_Identity=23.9870340356564, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645119, Length=530, Percent_Identity=23.7735849056604, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45551847, Length=533, Percent_Identity=24.202626641651, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45550715, Length=533, Percent_Identity=24.202626641651, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21358145, Length=233, Percent_Identity=26.6094420600858, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650940, Length=233, Percent_Identity=26.6094420600858, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_BACA2 (A7Z6J5)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421852.1
- ProteinModelPortal:   A7Z6J5
- SMR:   A7Z6J5
- STRING:   A7Z6J5
- EnsemblBacteria:   EBBACT00000007731
- GeneID:   5462341
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_022600
- eggNOG:   COG1154
- GeneTree:   EBGT00070000031844
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- ProtClustDB:   PRK05444
- BioCyc:   BAMY326423:RBAM_022600-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69718; Mature: 69718

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLSIQDPSFLKKMSIEQLEELSEEIRNFLITSLSASGGHIGPNLGVVELTIALHKEFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHCCC
SPKDKFLWDVGHQSYVHKLLTGRGKEFETLRQYKGLCGFPKRSESEHDVWETGHSSTSLS
CCHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCH
GAMGMAAARDIKGSKEYIIPIIGDGALTGGMALEALNHIGDEKKDMIVILNDNEMSIAPN
HHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYMLVSGMFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHSYHELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGP
HCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKINTGDFVKPKAAAPSWSGLVSGTVQELAREDDRIVAITPAMPVGSKLEGFAKEFPERM
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
FDVGIAEQHAATMAAGMALQGMKPFLAIYSTFLQRAYDQVVHDICRQNANVFIGIDRAGL
HHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
VGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGRHMVNTALNYEEGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCC
VKMDKELKTIPIGTWEVLRPGKDAVILTFGTTIEMALEAAEELQKEGLSVRVVNARFIKP
EEECCCCCEECCCCHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHHCH
IDKQMMKAILNEGLPILTIEEAVLEGGFGSTILEYAHDLGMYHTPIDRMGIPDRFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCCCHHHCCCCHHHHHCCH
VTALLEEIGLTKAEVMNRIKLLMPPKTHKGIGS
HHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCC
>Mature Secondary Structure
MDLLSIQDPSFLKKMSIEQLEELSEEIRNFLITSLSASGGHIGPNLGVVELTIALHKEFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHCCC
SPKDKFLWDVGHQSYVHKLLTGRGKEFETLRQYKGLCGFPKRSESEHDVWETGHSSTSLS
CCHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCH
GAMGMAAARDIKGSKEYIIPIIGDGALTGGMALEALNHIGDEKKDMIVILNDNEMSIAPN
HHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYMLVSGMFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHSYHELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGP
HCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKINTGDFVKPKAAAPSWSGLVSGTVQELAREDDRIVAITPAMPVGSKLEGFAKEFPERM
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
FDVGIAEQHAATMAAGMALQGMKPFLAIYSTFLQRAYDQVVHDICRQNANVFIGIDRAGL
HHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
VGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGRHMVNTALNYEEGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCC
VKMDKELKTIPIGTWEVLRPGKDAVILTFGTTIEMALEAAEELQKEGLSVRVVNARFIKP
EEECCCCCEECCCCHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHHCH
IDKQMMKAILNEGLPILTIEEAVLEGGFGSTILEYAHDLGMYHTPIDRMGIPDRFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCCCHHHCCCCHHHHHCCH
VTALLEEIGLTKAEVMNRIKLLMPPKTHKGIGS
HHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA