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The map label for this gene is recQ [H]

Identifier: 154686548

GI number: 154686548

Start: 2212287

End: 2213777

Strand: Reverse

Name: recQ [H]

Synonym: RBAM_021170

Alternate gene names: 154686548

Gene position: 2213777-2212287 (Counterclockwise)

Preceding gene: 154686549

Following gene: 154686547

Centisome position: 56.49

GC content: 48.96

Gene sequence:

>1491_bases
ATGACTGAGCTGCATAAAGCTTTATCCAAGTATTTTGGTTTGCATTCCTTTAAAAAAGGGCAGGAAGAGATTATGACTAG
CGTGCTCCAAAAAAAGGATACGATCGCCATGCTTCCGACCGGCGGGGGAAAATCATTATGCTATCAGCTCCCGGGTTACA
TGATGGACGGGCTGGTGCTGATTATTTCGCCGCTCCTTTCATTAATGGAAGATCAGGTGCAGCAGCTGAAAGCGAAAGGA
GAAAAGCGGGTTGCGGCATTAAACAGCATGCTGAATTCCGCAGAGCGGCATTTTATCCTCAGCAACATCAGCCGGTATAA
ATTTCTCTATATGTCTCCTGAAGCCCTTTCTTCACCTTATGTGCTGAACCGTTTGAAAAATGTCCCGGTCAGTTTATTTG
TTATTGATGAGGCTCATTGCATATCAGAATGGGGACATGATTTCAGGCCTGATTACTCGAAGCTCGGACCTTTCAGGCAG
GCACTCGGAAAGCCGCCTGTATTGGCGCTGACCGCAACAGCGACAAAAGAAACGCTCAGAGACGTGACGGATGTGCTCGG
ACTTGAGCATGCGGTGCGTCATCTTTATTCAGTCAACCGGCCGAATATTCTCCTGGCGGCAGAACATTTGGCGGATAATG
CCGAAAAAATAAGCAGGCTCACGGAGCTTGCCGAAAAGCTTGAAGGCCCGGGTATCATATATTGTCCGACCAGAAAATGG
GCGGAAGAGCTTGCGGCTGAGCTGAACGAAAAAACGGGAAAGCGGACGGATTATTATCACGGCGGAATGGATACAGGCGA
CAGGATTTTAATCCAGCAGCAATTTATCCATAACCAGCTTGATTGCATCTGCTGCACCAATGCGTTCGGCATGGGTGTGG
ATAAGTCAGATATCCGCTTTGTCATTCACTTTTATCCTCCCCAAACGGCCGAGGCCTTTATGCAGGAAATCGGCAGAGCG
GGACGCGACGGCAGCCCGAGTGTCAGTATTTTGCTGAGGGCGCCCGGCGATACCGAGCTTCAGCAGCAGATTATTCAGAC
AGAAAGCCTGTCTGATTATGACCTGGAAGGCATTTTGGCTATCATACGGGATGCCGGTACGGGTGATGAACGAAAGCTTC
GGGACGTTCTGATCAATAAAGGCGTCCAGGAAACACAGGCGCGAACGGCCGTCCATCTGTATCTGCAAGGAAAAACCACA
AAAGAGCAGCTGCAGGAAGAACTGACATACCGCGTGGAAAAGAAGCTGCGTAAAATGAATCGTTTTTCGGCGTTATTAGA
GCGGAAAGAATGTATAAGAGAAGCGCTGCTGTCTTATTTTGATGAACCGTATGAGCCTGATGGTCAAACCGGACAATGCT
GCAGCAGCTGCGGACTTGATCTGGCTCCGTACGAGCAAAAAGGAGAACGTAAAAATATGGAACGGTTTGAAGATTGGAAG
CTGGAATTAGGCCGGATTTTCGGATCAGAGTCTGCGGGTGAGTTCAGCTGA

Upstream 100 bases:

>100_bases
CAGCATCAAACGAATAAAATTAAACAGATTCGCGAAGGAATGCAGATGCGCTTCAGCTATTTCCAGATCAGGCTGGCGCT
GGCAAAGACGGTGAATCAGC

Downstream 100 bases:

>100_bases
GACGGCAAAGCGAATTGATCCGGCAGCTCTCAGACCGGGAGATTGTGATGCAGCTGTACGCCACCCAATTGCTCATATTG
GCGGTTTCAGCTGTTATCGG

Product: RecQ

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTELHKALSKYFGLHSFKKGQEEIMTSVLQKKDTIAMLPTGGGKSLCYQLPGYMMDGLVLIISPLLSLMEDQVQQLKAKG
EKRVAALNSMLNSAERHFILSNISRYKFLYMSPEALSSPYVLNRLKNVPVSLFVIDEAHCISEWGHDFRPDYSKLGPFRQ
ALGKPPVLALTATATKETLRDVTDVLGLEHAVRHLYSVNRPNILLAAEHLADNAEKISRLTELAEKLEGPGIIYCPTRKW
AEELAAELNEKTGKRTDYYHGGMDTGDRILIQQQFIHNQLDCICCTNAFGMGVDKSDIRFVIHFYPPQTAEAFMQEIGRA
GRDGSPSVSILLRAPGDTELQQQIIQTESLSDYDLEGILAIIRDAGTGDERKLRDVLINKGVQETQARTAVHLYLQGKTT
KEQLQEELTYRVEKKLRKMNRFSALLERKECIREALLSYFDEPYEPDGQTGQCCSSCGLDLAPYEQKGERKNMERFEDWK
LELGRIFGSESAGEFS

Sequences:

>Translated_496_residues
MTELHKALSKYFGLHSFKKGQEEIMTSVLQKKDTIAMLPTGGGKSLCYQLPGYMMDGLVLIISPLLSLMEDQVQQLKAKG
EKRVAALNSMLNSAERHFILSNISRYKFLYMSPEALSSPYVLNRLKNVPVSLFVIDEAHCISEWGHDFRPDYSKLGPFRQ
ALGKPPVLALTATATKETLRDVTDVLGLEHAVRHLYSVNRPNILLAAEHLADNAEKISRLTELAEKLEGPGIIYCPTRKW
AEELAAELNEKTGKRTDYYHGGMDTGDRILIQQQFIHNQLDCICCTNAFGMGVDKSDIRFVIHFYPPQTAEAFMQEIGRA
GRDGSPSVSILLRAPGDTELQQQIIQTESLSDYDLEGILAIIRDAGTGDERKLRDVLINKGVQETQARTAVHLYLQGKTT
KEQLQEELTYRVEKKLRKMNRFSALLERKECIREALLSYFDEPYEPDGQTGQCCSSCGLDLAPYEQKGERKNMERFEDWK
LELGRIFGSESAGEFS
>Mature_495_residues
TELHKALSKYFGLHSFKKGQEEIMTSVLQKKDTIAMLPTGGGKSLCYQLPGYMMDGLVLIISPLLSLMEDQVQQLKAKGE
KRVAALNSMLNSAERHFILSNISRYKFLYMSPEALSSPYVLNRLKNVPVSLFVIDEAHCISEWGHDFRPDYSKLGPFRQA
LGKPPVLALTATATKETLRDVTDVLGLEHAVRHLYSVNRPNILLAAEHLADNAEKISRLTELAEKLEGPGIIYCPTRKWA
EELAAELNEKTGKRTDYYHGGMDTGDRILIQQQFIHNQLDCICCTNAFGMGVDKSDIRFVIHFYPPQTAEAFMQEIGRAG
RDGSPSVSILLRAPGDTELQQQIIQTESLSDYDLEGILAIIRDAGTGDERKLRDVLINKGVQETQARTAVHLYLQGKTTK
EQLQEELTYRVEKKLRKMNRFSALLERKECIREALLSYFDEPYEPDGQTGQCCSSCGLDLAPYEQKGERKNMERFEDWKL
ELGRIFGSESAGEFS

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI110735439, Length=348, Percent_Identity=39.6551724137931, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI169218196, Length=348, Percent_Identity=39.6551724137931, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI51242947, Length=365, Percent_Identity=38.6301369863014, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI51242943, Length=365, Percent_Identity=37.5342465753425, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI148612816, Length=365, Percent_Identity=38.6301369863014, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI4557365, Length=365, Percent_Identity=38.0821917808219, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI14591902, Length=348, Percent_Identity=35.3448275862069, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI14591904, Length=348, Percent_Identity=35.3448275862069, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI284005309, Length=365, Percent_Identity=34.7945205479452, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI148613856, Length=349, Percent_Identity=23.2091690544413, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI38201710, Length=349, Percent_Identity=23.2091690544413, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI48994977, Length=335, Percent_Identity=40.5970149253731, Blast_Score=264, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25145561, Length=380, Percent_Identity=37.6315789473684, Blast_Score=251, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI71987997, Length=385, Percent_Identity=37.1428571428571, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71987993, Length=385, Percent_Identity=37.1428571428571, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI32564293, Length=343, Percent_Identity=38.4839650145773, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17552866, Length=333, Percent_Identity=38.1381381381381, Blast_Score=207, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323844, Length=358, Percent_Identity=37.7094972067039, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324217, Length=325, Percent_Identity=24.3076923076923, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646066, Length=373, Percent_Identity=37.5335120643432, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24664226, Length=347, Percent_Identity=38.0403458213257, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI62472181, Length=478, Percent_Identity=32.6359832635983, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24664230, Length=478, Percent_Identity=32.6359832635983, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI21358123, Length=450, Percent_Identity=32.2222222222222, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21355075, Length=355, Percent_Identity=22.8169014084507, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644479, Length=326, Percent_Identity=23.0061349693252, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281361218, Length=326, Percent_Identity=23.0061349693252, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644481, Length=326, Percent_Identity=23.0061349693252, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644483, Length=326, Percent_Identity=23.0061349693252, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24644487, Length=324, Percent_Identity=23.1481481481481, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45551833, Length=324, Percent_Identity=23.1481481481481, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24644485, Length=324, Percent_Identity=23.1481481481481, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24666101, Length=375, Percent_Identity=22.6666666666667, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28574962, Length=387, Percent_Identity=22.9974160206718, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 55956; Mature: 55825

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELHKALSKYFGLHSFKKGQEEIMTSVLQKKDTIAMLPTGGGKSLCYQLPGYMMDGLVL
CCHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCHHHHHHHHH
IISPLLSLMEDQVQQLKAKGEKRVAALNSMLNSAERHFILSNISRYKFLYMSPEALSSPY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHCCCH
VLNRLKNVPVSLFVIDEAHCISEWGHDFRPDYSKLGPFRQALGKPPVLALTATATKETLR
HHHHHHCCCEEEEEECCHHHHHHCCCCCCCCHHHCCHHHHHHCCCCEEEEECHHHHHHHH
DVTDVLGLEHAVRHLYSVNRPNILLAAEHLADNAEKISRLTELAEKLEGPGIIYCPTRKW
HHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCHHH
AEELAAELNEKTGKRTDYYHGGMDTGDRILIQQQFIHNQLDCICCTNAFGMGVDKSDIRF
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHCCCCCCCCCEE
VIHFYPPQTAEAFMQEIGRAGRDGSPSVSILLRAPGDTELQQQIIQTESLSDYDLEGILA
EEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHH
IIRDAGTGDERKLRDVLINKGVQETQARTAVHLYLQGKTTKEQLQEELTYRVEKKLRKMN
HHHCCCCCHHHHHHHHHHHCCHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
RFSALLERKECIREALLSYFDEPYEPDGQTGQCCSSCGLDLAPYEQKGERKNMERFEDWK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHH
LELGRIFGSESAGEFS
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TELHKALSKYFGLHSFKKGQEEIMTSVLQKKDTIAMLPTGGGKSLCYQLPGYMMDGLVL
CHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCHHHHHHHHH
IISPLLSLMEDQVQQLKAKGEKRVAALNSMLNSAERHFILSNISRYKFLYMSPEALSSPY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHCCCH
VLNRLKNVPVSLFVIDEAHCISEWGHDFRPDYSKLGPFRQALGKPPVLALTATATKETLR
HHHHHHCCCEEEEEECCHHHHHHCCCCCCCCHHHCCHHHHHHCCCCEEEEECHHHHHHHH
DVTDVLGLEHAVRHLYSVNRPNILLAAEHLADNAEKISRLTELAEKLEGPGIIYCPTRKW
HHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCHHH
AEELAAELNEKTGKRTDYYHGGMDTGDRILIQQQFIHNQLDCICCTNAFGMGVDKSDIRF
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHCCCCCCCCCEE
VIHFYPPQTAEAFMQEIGRAGRDGSPSVSILLRAPGDTELQQQIIQTESLSDYDLEGILA
EEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHH
IIRDAGTGDERKLRDVLINKGVQETQARTAVHLYLQGKTTKEQLQEELTYRVEKKLRKMN
HHHCCCCCHHHHHHHHHHHCCHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
RFSALLERKECIREALLSYFDEPYEPDGQTGQCCSSCGLDLAPYEQKGERKNMERFEDWK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHH
LELGRIFGSESAGEFS
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]