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The map label for this gene is hisC

Identifier: 154686510

GI number: 154686510

Start: 2176916

End: 2177998

Strand: Reverse

Name: hisC

Synonym: RBAM_020780

Alternate gene names: 154686510

Gene position: 2177998-2176916 (Counterclockwise)

Preceding gene: 154686511

Following gene: 154686509

Centisome position: 55.58

GC content: 48.57

Gene sequence:

>1083_bases
TTGCAGATTAAAGAACAGCTGCGGCAGCTGAAACCGTATCAGCCGGGCAAACCAATAGAAGAAGTGAAAATGGAATACGG
GCTTGAGAAAGTAGTAAAACTCGCTTCTAACGAAAATCCGTTCGGCTGTTCACAGGCCGCTAAAGATGCGCTGCATCAGG
AGATTGAGCAGCTTGCGCTGTATCCCGACGGTTACAGTGCCGCTTTGAGAACACGGCTCAGTGAGCATCTGCAGGTCAGT
GAATCTTCGATCATTTTCGGCAACGGCTCTGATGAGCTTGTGCAGATTATCTGCCGTTCTTTATTAAATGATCAGGCAAA
CACGATTACCGCCGCCCCGACTTTCCCGCAATACAGACACAATGCGGTGATTGAAGGCGCTGAGGTGCGCGAGGTTCCGC
TCCGCAGTGACGGCGCTCATGATTTGGACCGGATGCTGGAAGCAATTGACGGCGAGACGAAAATCATATGGGTATGCAAC
CCCAATAATCCGACGGGGACATATACTTCTGAGCAAGAGCTAATTGCCTTTTTAAACAGAGTTCCCGAGCATATACTCGT
TGTACTTGATGAAGCGTACTACGAGTATGTTACGGCGGAAGATTACCCAGAAAGCATTCCGCTTTTAAAGCAATATCCGA
ATGTTATGATCCTCCGCACCTTCTCTAAAGCGTACGGACTTGCCGCGCTGCGCGTCGGATACGGCATTGCGGACGAAGCG
CTGATCCGCCAGATTGAACCGGCGAGAGAGCCGTTCAATACGAGCAGAATCGGTCAGGCTTCGGCACTGGCAGCGCTTGA
TGACCAGACATTTATTCAGGAATGCGTCGAGAAAAATAAAGCAGGCCTTAAGCAGTATTATGATTTTGCAGAAACTCACG
GATTAACTTGTTATCCTTCACAAACCAACTTTGTGCTCATTGATTTTAACCGCCCGGCGGATGAACTGTTCCAAGCCCTG
TTGGAAAAAGGATATATCGTCCGCTCAGGACAGGCGCTCGGATTTCCGACAGCGTTAAGGATTACGGTCGGTACGAAAGA
GCAGAATGAGGAAATTCTCACAATTTTAGCTGAAATATTATAA

Upstream 100 bases:

>100_bases
AGCTTGTGAATCCCGGAACAAGAGCTGATGCGCTTCTTGAATTTGAAGAATACGCAAAGACGTTCGGACGACTGTACAGT
GTAAAATGAGGTGACTGGAT

Downstream 100 bases:

>100_bases
GAGGTGATCAGGCATCACCTCTTTGCTCTATTAAAATAGTTGAAAAAGGAAATGAGTGAAATGAAGGATACTATATTGCT
TGCGGGGATCGGGCTGATCG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MQIKEQLRQLKPYQPGKPIEEVKMEYGLEKVVKLASNENPFGCSQAAKDALHQEIEQLALYPDGYSAALRTRLSEHLQVS
ESSIIFGNGSDELVQIICRSLLNDQANTITAAPTFPQYRHNAVIEGAEVREVPLRSDGAHDLDRMLEAIDGETKIIWVCN
PNNPTGTYTSEQELIAFLNRVPEHILVVLDEAYYEYVTAEDYPESIPLLKQYPNVMILRTFSKAYGLAALRVGYGIADEA
LIRQIEPAREPFNTSRIGQASALAALDDQTFIQECVEKNKAGLKQYYDFAETHGLTCYPSQTNFVLIDFNRPADELFQAL
LEKGYIVRSGQALGFPTALRITVGTKEQNEEILTILAEIL

Sequences:

>Translated_360_residues
MQIKEQLRQLKPYQPGKPIEEVKMEYGLEKVVKLASNENPFGCSQAAKDALHQEIEQLALYPDGYSAALRTRLSEHLQVS
ESSIIFGNGSDELVQIICRSLLNDQANTITAAPTFPQYRHNAVIEGAEVREVPLRSDGAHDLDRMLEAIDGETKIIWVCN
PNNPTGTYTSEQELIAFLNRVPEHILVVLDEAYYEYVTAEDYPESIPLLKQYPNVMILRTFSKAYGLAALRVGYGIADEA
LIRQIEPAREPFNTSRIGQASALAALDDQTFIQECVEKNKAGLKQYYDFAETHGLTCYPSQTNFVLIDFNRPADELFQAL
LEKGYIVRSGQALGFPTALRITVGTKEQNEEILTILAEIL
>Mature_360_residues
MQIKEQLRQLKPYQPGKPIEEVKMEYGLEKVVKLASNENPFGCSQAAKDALHQEIEQLALYPDGYSAALRTRLSEHLQVS
ESSIIFGNGSDELVQIICRSLLNDQANTITAAPTFPQYRHNAVIEGAEVREVPLRSDGAHDLDRMLEAIDGETKIIWVCN
PNNPTGTYTSEQELIAFLNRVPEHILVVLDEAYYEYVTAEDYPESIPLLKQYPNVMILRTFSKAYGLAALRVGYGIADEA
LIRQIEPAREPFNTSRIGQASALAALDDQTFIQECVEKNKAGLKQYYDFAETHGLTCYPSQTNFVLIDFNRPADELFQAL
LEKGYIVRSGQALGFPTALRITVGTKEQNEEILTILAEIL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=359, Percent_Identity=28.4122562674095, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788627, Length=233, Percent_Identity=27.8969957081545, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=398, Percent_Identity=27.3869346733668, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BACA2 (A7Z614)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421671.1
- ProteinModelPortal:   A7Z614
- SMR:   A7Z614
- STRING:   A7Z614
- EnsemblBacteria:   EBBACT00000006501
- GeneID:   5460942
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_020780
- eggNOG:   COG0079
- GeneTree:   EBGT00050000000787
- HOGENOM:   HBG646350
- OMA:   KLIYIAN
- ProtClustDB:   PRK03158
- BioCyc:   BAMY326423:RBAM_020780-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40347; Mature: 40347

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKEQLRQLKPYQPGKPIEEVKMEYGLEKVVKLASNENPFGCSQAAKDALHQEIEQLAL
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
YPDGYSAALRTRLSEHLQVSESSIIFGNGSDELVQIICRSLLNDQANTITAAPTFPQYRH
CCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHC
NAVIEGAEVREVPLRSDGAHDLDRMLEAIDGETKIIWVCNPNNPTGTYTSEQELIAFLNR
CCEECCCCCEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
VPEHILVVLDEAYYEYVTAEDYPESIPLLKQYPNVMILRTFSKAYGLAALRVGYGIADEA
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHH
LIRQIEPAREPFNTSRIGQASALAALDDQTFIQECVEKNKAGLKQYYDFAETHGLTCYPS
HHHHHHHHCCCCCCHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
QTNFVLIDFNRPADELFQALLEKGYIVRSGQALGFPTALRITVGTKEQNEEILTILAEIL
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MQIKEQLRQLKPYQPGKPIEEVKMEYGLEKVVKLASNENPFGCSQAAKDALHQEIEQLAL
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
YPDGYSAALRTRLSEHLQVSESSIIFGNGSDELVQIICRSLLNDQANTITAAPTFPQYRH
CCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHC
NAVIEGAEVREVPLRSDGAHDLDRMLEAIDGETKIIWVCNPNNPTGTYTSEQELIAFLNR
CCEECCCCCEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
VPEHILVVLDEAYYEYVTAEDYPESIPLLKQYPNVMILRTFSKAYGLAALRVGYGIADEA
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHH
LIRQIEPAREPFNTSRIGQASALAALDDQTFIQECVEKNKAGLKQYYDFAETHGLTCYPS
HHHHHHHHCCCCCCHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
QTNFVLIDFNRPADELFQALLEKGYIVRSGQALGFPTALRITVGTKEQNEEILTILAEIL
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA