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The map label for this gene is birA [H]

Identifier: 154686491

GI number: 154686491

Start: 2160262

End: 2161239

Strand: Reverse

Name: birA [H]

Synonym: RBAM_020590

Alternate gene names: 154686491

Gene position: 2161239-2160262 (Counterclockwise)

Preceding gene: 154686492

Following gene: 154686490

Centisome position: 55.15

GC content: 50.72

Gene sequence:

>978_bases
ATGGGATCAACATTAAGAACCCGATTAATTGATTTATTTTCTGAGGCGGGTGACGGCTTTATCTCCGGGCAGAAAATAAG
TGACGCGCTCGGCTGCTCGAGAACCGCCGTTTGGAAACATATAGAGGAGCTCCGCAAAGAGGGCTATGAGGTTGAGGCGG
TCAGGCGAAAAGGGTACAGGCTCATTAAAAAACCGGGGAAACTCAGTGAATCCGAAATCCGTTTCGGGCTGAAAACAGAG
GTTTTGGGCAAACAGCTTCATTACCGGGACGTCCTGCCGTCCACCCAAAAAACCGCTCATGAACTTGCCAATGACGGCGC
GCCGGAAGGGACGCTCGTAGTCGCCGATAAACAAACGGCAGGCAGAGGAAGAATGGCCAGAGTATGGCATTCACAGGAGG
GAAACGGGATTTGGATGAGCCTCATTCTGAGACCCGACGTTCCTTTGCAAAAAACGCCGCAGCTCACCCTGTTATCTGCC
GTTGCGGTCGTTCAGGCCATCGAGGCTTTTACAGGTGTACAGCCCGCCATTAAATGGCCGAATGATTTAATGATTCACGG
CAAAAAAGCCGTCGGGATTTTAACTGAGCTGCAGGCAGAAGAAGACCGTGTCCGTTCGGTTATTCTCGGGATCGGCATCA
ACGTGAACCAGCAGGAAACCGATTTTCCCGGCGAGCTTCAGGACATTGCGACAAGCCTCAGCATGGAAGCCGGCGAGAAA
ATTGACAGAGCGGGTCTGATACAAGAGATTCTGCTGACTTTTGAAAAACGCTATCAGGATTACTTGAACCACGGCTTTAC
ACCGATCAAGCTGCTATGGGAAAGCTATGCGGTCGGACTGGGGAACGAGCTCAGAGCGAGAACGCTGCAAGGGACGTTTT
ACGGGAAATCGCTCGGCATTGATGATGAGGGAGTTCTTCTCTTGGAAACGAGAGATGGTATAAAGAAGATCTATTCTGCC
GATATTGAGCTCAATTAA

Upstream 100 bases:

>100_bases
CGGGTAAATGGGTGGCCGAAGAACTTCGCCGGATCGAAGAAGCGGTATTGGCAGGGAAGCTCCCTAACCGAAAACATGAC
ATAAAGGAGTGGCTCGCATC

Downstream 100 bases:

>100_bases
TCTTAGTTGGTACAAGCCTCGTGAATTTGGTATACTTCCTATGGGCAGTATCATAATGAACTGCACCCGATCAGCAGAAC
AGAGATTACGAAAAGTCTGC

Product: hypothetical protein

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MGSTLRTRLIDLFSEAGDGFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTE
VLGKQLHYRDVLPSTQKTAHELANDGAPEGTLVVADKQTAGRGRMARVWHSQEGNGIWMSLILRPDVPLQKTPQLTLLSA
VAVVQAIEAFTGVQPAIKWPNDLMIHGKKAVGILTELQAEEDRVRSVILGIGINVNQQETDFPGELQDIATSLSMEAGEK
IDRAGLIQEILLTFEKRYQDYLNHGFTPIKLLWESYAVGLGNELRARTLQGTFYGKSLGIDDEGVLLLETRDGIKKIYSA
DIELN

Sequences:

>Translated_325_residues
MGSTLRTRLIDLFSEAGDGFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTE
VLGKQLHYRDVLPSTQKTAHELANDGAPEGTLVVADKQTAGRGRMARVWHSQEGNGIWMSLILRPDVPLQKTPQLTLLSA
VAVVQAIEAFTGVQPAIKWPNDLMIHGKKAVGILTELQAEEDRVRSVILGIGINVNQQETDFPGELQDIATSLSMEAGEK
IDRAGLIQEILLTFEKRYQDYLNHGFTPIKLLWESYAVGLGNELRARTLQGTFYGKSLGIDDEGVLLLETRDGIKKIYSA
DIELN
>Mature_324_residues
GSTLRTRLIDLFSEAGDGFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEV
LGKQLHYRDVLPSTQKTAHELANDGAPEGTLVVADKQTAGRGRMARVWHSQEGNGIWMSLILRPDVPLQKTPQLTLLSAV
AVVQAIEAFTGVQPAIKWPNDLMIHGKKAVGILTELQAEEDRVRSVILGIGINVNQQETDFPGELQDIATSLSMEAGEKI
DRAGLIQEILLTFEKRYQDYLNHGFTPIKLLWESYAVGLGNELRARTLQGTFYGKSLGIDDEGVLLLETRDGIKKIYSAD
IELN

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=252, Percent_Identity=25.7936507936508, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790408, Length=316, Percent_Identity=28.4810126582279, Blast_Score=107, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 36081; Mature: 35950

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSTLRTRLIDLFSEAGDGFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYR
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCEEHHHHHCCHH
LIKKPGKLSESEIRFGLKTEVLGKQLHYRDVLPSTQKTAHELANDGAPEGTLVVADKQTA
HHCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCC
GRGRMARVWHSQEGNGIWMSLILRPDVPLQKTPQLTLLSAVAVVQAIEAFTGVQPAIKWP
CCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
NDLMIHGKKAVGILTELQAEEDRVRSVILGIGINVNQQETDFPGELQDIATSLSMEAGEK
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IDRAGLIQEILLTFEKRYQDYLNHGFTPIKLLWESYAVGLGNELRARTLQGTFYGKSLGI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHEECCEEECCCCCC
DDEGVLLLETRDGIKKIYSADIELN
CCCCEEEEECCHHHHHHHHCCCCCC
>Mature Secondary Structure 
GSTLRTRLIDLFSEAGDGFISGQKISDALGCSRTAVWKHIEELRKEGYEVEAVRRKGYR
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCEEHHHHHCCHH
LIKKPGKLSESEIRFGLKTEVLGKQLHYRDVLPSTQKTAHELANDGAPEGTLVVADKQTA
HHCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCC
GRGRMARVWHSQEGNGIWMSLILRPDVPLQKTPQLTLLSAVAVVQAIEAFTGVQPAIKWP
CCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
NDLMIHGKKAVGILTELQAEEDRVRSVILGIGINVNQQETDFPGELQDIATSLSMEAGEK
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IDRAGLIQEILLTFEKRYQDYLNHGFTPIKLLWESYAVGLGNELRARTLQGTFYGKSLGI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHEECCEEECCCCCC
DDEGVLLLETRDGIKKIYSADIELN
CCCCEEEEECCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]