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The map label for this gene is panC

Identifier: 154686489

GI number: 154686489

Start: 2158320

End: 2159180

Strand: Reverse

Name: panC

Synonym: RBAM_020570

Alternate gene names: 154686489

Gene position: 2159180-2158320 (Counterclockwise)

Preceding gene: 154686490

Following gene: 154686488

Centisome position: 55.1

GC content: 47.85

Gene sequence:

>861_bases
ATGAAACAACTGACAGAAACTCAACAGCTGAAAGAATTGATTGCACAATACCGCTCAGAAGGCCGGACGATCGGATTCGT
CCCGACAATGGGTTTTCTTCATGAAGGACATCTGACGCTGGTTGAAAAAGCAAGCAAAGAAAACGATATTGTCGTGATGA
GCATCTTTGTCAATCCGACTCAATTCGGACCGGGCGAGGATTACGAAGCATATCCGCGAGATTTAAAGCGCGATGCCCGG
CTTGCAGAACAGGCGGGGGCAGATGTTTTGTTTACGCCGTCTCCAAGTGATATGTACAAAGGCGAGCAAAATGTTGCCGT
GCAAGTGAAAAGGAGAACTGACGTGTTGTGCGGCGCCTCCCGCGTCGGCCATTTTGACGGAGTGGCCACTGTGCTGACGA
AGTTTTTCAATCTCGTTAAACCGACCCGCGCCTACTTCGGCCTGAAAGATGCCCAGCAGGCAGCGGTTGTGGACGGATTG
ATTGAGGATTTCTTTATGGATATCGAATTGGTTGCAGTGGACACGGTCAGAGAAGAAGACGGACTTGCCAAAAGCTCTCG
CAACGTCTATCTGACTGAGCAGGAACGCAAAGAAGCGCCGATGATCTATAAAGCATTGCAGCAAGGTGCCGAACTGATTA
GAGACGGTGAAAGAAATCCGGAAACCGTTATAAAAACCGTCACCGATATCATCGAAAACACAAGCGGCGTCATTGATTAT
GCCGAACTGTACGCTTATCCGGAGCTGACTCCGCTTAAAACATTAAACGGCAAGGTCATTCTGGCCTGTGCCGTCCAATT
TTCTAAAGCCAGACTGATTGATAATATCATTATTGATATTGATGAATGGGAGAGATCATAA

Upstream 100 bases:

>100_bases
TTATGTCCGTGATGTGAAAGAACGGGTTTTCCCGGAAGAAAAGCATTCCTTTCAGATAAACCAAACTGTGCTGCAAGGCT
TGTACGGAGGAAAGTAAGCG

Downstream 100 bases:

>100_bases
TATGTACCGCACTATGATGGCCGGAAAACTGCACCGCGCTACCGTGACGGAAGCCAATTTAAACTATGTCGGCAGCATTA
CGATTGATGAAGATCTTTTA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKQLTETQQLKELIAQYRSEGRTIGFVPTMGFLHEGHLTLVEKASKENDIVVMSIFVNPTQFGPGEDYEAYPRDLKRDAR
LAEQAGADVLFTPSPSDMYKGEQNVAVQVKRRTDVLCGASRVGHFDGVATVLTKFFNLVKPTRAYFGLKDAQQAAVVDGL
IEDFFMDIELVAVDTVREEDGLAKSSRNVYLTEQERKEAPMIYKALQQGAELIRDGERNPETVIKTVTDIIENTSGVIDY
AELYAYPELTPLKTLNGKVILACAVQFSKARLIDNIIIDIDEWERS

Sequences:

>Translated_286_residues
MKQLTETQQLKELIAQYRSEGRTIGFVPTMGFLHEGHLTLVEKASKENDIVVMSIFVNPTQFGPGEDYEAYPRDLKRDAR
LAEQAGADVLFTPSPSDMYKGEQNVAVQVKRRTDVLCGASRVGHFDGVATVLTKFFNLVKPTRAYFGLKDAQQAAVVDGL
IEDFFMDIELVAVDTVREEDGLAKSSRNVYLTEQERKEAPMIYKALQQGAELIRDGERNPETVIKTVTDIIENTSGVIDY
AELYAYPELTPLKTLNGKVILACAVQFSKARLIDNIIIDIDEWERS
>Mature_286_residues
MKQLTETQQLKELIAQYRSEGRTIGFVPTMGFLHEGHLTLVEKASKENDIVVMSIFVNPTQFGPGEDYEAYPRDLKRDAR
LAEQAGADVLFTPSPSDMYKGEQNVAVQVKRRTDVLCGASRVGHFDGVATVLTKFFNLVKPTRAYFGLKDAQQAAVVDGL
IEDFFMDIELVAVDTVREEDGLAKSSRNVYLTEQERKEAPMIYKALQQGAELIRDGERNPETVIKTVTDIIENTSGVIDY
AELYAYPELTPLKTLNGKVILACAVQFSKARLIDNIIIDIDEWERS

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=273, Percent_Identity=39.1941391941392, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322046, Length=300, Percent_Identity=37.6666666666667, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_BACA2 (A7Z5Z3)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421650.1
- ProteinModelPortal:   A7Z5Z3
- SMR:   A7Z5Z3
- STRING:   A7Z5Z3
- EnsemblBacteria:   EBBACT00000006848
- GeneID:   5461212
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_020570
- eggNOG:   COG0414
- GeneTree:   EBGT00050000001451
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- ProtClustDB:   PRK00380
- BioCyc:   BAMY326423:RBAM_020570-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32060; Mature: 32060

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLTETQQLKELIAQYRSEGRTIGFVPTMGFLHEGHLTLVEKASKENDIVVMSIFVNPT
CCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCEEECCCCCCCEEEEEEEECCC
QFGPGEDYEAYPRDLKRDARLAEQAGADVLFTPSPSDMYKGEQNVAVQVKRRTDVLCGAS
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCEEEEEECHHHHHHCCH
RVGHFDGVATVLTKFFNLVKPTRAYFGLKDAQQAAVVDGLIEDFFMDIELVAVDTVREED
HCCCCCHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHC
GLAKSSRNVYLTEQERKEAPMIYKALQQGAELIRDGERNPETVIKTVTDIIENTSGVIDY
CCCCCCCCEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEH
AELYAYPELTPLKTLNGKVILACAVQFSKARLIDNIIIDIDEWERS
HHHHCCCCCCCCHHCCCCEEEEEEHHHHHHHHHHHHEEECHHCCCC
>Mature Secondary Structure
MKQLTETQQLKELIAQYRSEGRTIGFVPTMGFLHEGHLTLVEKASKENDIVVMSIFVNPT
CCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCEEECCCCCCCEEEEEEEECCC
QFGPGEDYEAYPRDLKRDARLAEQAGADVLFTPSPSDMYKGEQNVAVQVKRRTDVLCGAS
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCEEEEEECHHHHHHCCH
RVGHFDGVATVLTKFFNLVKPTRAYFGLKDAQQAAVVDGLIEDFFMDIELVAVDTVREED
HCCCCCHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHC
GLAKSSRNVYLTEQERKEAPMIYKALQQGAELIRDGERNPETVIKTVTDIIENTSGVIDY
CCCCCCCCEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEH
AELYAYPELTPLKTLNGKVILACAVQFSKARLIDNIIIDIDEWERS
HHHHCCCCCCCCHHCCCCEEEEEEHHHHHHHHHHHHEEECHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA