Click here to switch to the map view.

The map label for this gene is fenE [H]

Identifier: 154686275

GI number: 154686275

Start: 1931328

End: 1935131

Strand: Reverse

Name: fenE [H]

Synonym: RBAM_018420

Alternate gene names: 154686275

Gene position: 1935131-1931328 (Counterclockwise)

Preceding gene: 154686276

Following gene: 154686274

Centisome position: 49.38

GC content: 49.95

Gene sequence:

>3804_bases
ATGGACAAAACAAAAAATATCCAAAATATTTATCCCCTCAGCCGAATGCAGGAAGGAATGCTTTTTCATTCCTTTCTGCA
AAAGGAGGGGGCTGCATATATCGAGCAATCCGTCTTCACCATAAAAGGCCGGCTTCGTCCGGAATTGTTTGAGCAAAGCG
TACAGTCTGTCATCAGACGCCACGATATTTTCAGAACGGTTTTTTTACCTCATGTCGCTCAGCTGAACGGCCCCCGCCAA
GTTGTGCTGCGTGAGCGGGAATTCCGGCTGCACCGCGAAGATCTTACACATTTGGACGAACCGGAACAGAGCATCTATTT
ACAGCGATTTAAGGAACGTGACCGCTTAAAAGGCTTTGACTTGCAAAAGGATATGCTGATGCGTGTTTCTTTGTTTAAAA
CGGCTGACGAAAAATATGTATGCGTCTGGAGCCACCATCACATCCTTATGGACGGCTGGTGCCTCGGCATCGTCCTTCAG
GAATTCATGCATATGTACCGGGCGATTGAAACAGGCTCACCCGTCACACTGGCGCCCGCAAAGCCTTACAGCACTTATAT
TACATGGCTGACGGATCAGGACAAAGACGCGGCTTCTGAGTATTGGAAAGGATATTTAGCAGGCTGTGAGACACCCTCAG
GACTCCCGAAAATATCGGCCCGTCCCCAGGAAAAAGGCTACCGTAAGAAAGAGCTGCTGTTTTCTATAGATCAAAACCTG
ACGGACAAGCTGAAAACCATCGCCAAAGAAGAGGGCGCTACGCTCGCGGTTCTTATGCAGACTGTATGGGGCCTGATGCT
GCAGCGCTACAACCGGACGGATGATGCCGTATTCGGCGCCGTCGTATCAGGGCGGCCTTCCGTCATTGACGGCGTGGAAA
GCATGATCGGGTTGTTTATCAATACCGTGCCGGTACGCATTAAAACGGGTGACGAAAGCTTTAGAGAACTGCTGGGCCGC
TTGCAGAAAGAAATGCTTGATTCAGAGGCGTTCAGCTATCATCCGCTTGCTGACATCCAATCTCAGACTGAGCTGAAACA
GGATTTAATCGACCATATCATCGTGTTTGAAAATTATCCGATTCAGCAGCAGATGAAAGACGCGGAAAAGGAATCGGATG
CACCGTTCCGGATCGGGAATGTCAACGTTTCGGAACAATCGGGTTACGATTTTAACCTCATCATAGCGCCTGGCGATGAG
CTGCTCATCAAATTCAGCTACAATGCGAACGTTTATGACGAAGTATGGATAGAGAGCGTAAAAGGACACTTGGAAGAAGC
TCTGCGCGGCGCCGCCTTCAATCCCGATTTTCCGGCTGATCGGCTTCCGATGCTCGGACAAAAGGAAAAATCAAGAATAA
TCGGCGAATTTAATGACACGAAAACAACTTATGAAAGAGATGAAAGCATCATCAGCCTGTTCAGCCGACAGGTAAAGAAA
ACCCCGGACCATCAGGCGCTTCACGCCGGCGGGCTGACGATGACGTACCGGGAGCTCGATGAACGGTCAACTGCATTCGC
CCGCACCCTGCTGGAAAACGGTTTGGCGCCAAAGGGAATTGCCGGGATTCTGGCCGAACGCTCACCGGAATTTATCATCG
CTGTTCTCGCTGTATTGAAAGCGGGAGGGACGTACCTTCCTCTTGATGCAGAACTGCCAACCGACAGGATCGCCGATATG
CTCACTGAGAGCGGAGCACAGCTGTTAACGGTGCAAAAAGGAATTGAGACTGACATTGACTTTTCTCACATCATCTCTAT
CCCGGCTGCAGCTGAAAAACAAACACCTGATGCGGGAAAACTGAATACCGATACAGCACCTGATGACCTTGCCTATATTA
TGTATACATCCGGTTCAACAGGAAAACCGAAGGGCGTGATGATTTCCAACCGAAACGTCGTATCGCTCGTGTCAAACAGC
AATTACACGTCGGCTGGCATGTCGGACCGTCTCATTCTGACAGGGTCCATCGGTTTTGACGCAGTGACGTTTGAAATCTT
CGGAGCACTTTTGAACGGAGCATGTCTTCATGTGGTTGACCGCTCGACAATGCTTGCCCCTGAGAGGTTCGGCAATTATC
TTTCTTCCAACCGTATTACGATTCTGTTTTTGACGACGGCACTCTTTAACCAGTTCGCCCAGGCAGATCCGGAGATGTTT
TCTGGGTTGCACACCTTATATGTCGGCGGAGAAGCATTGTCCCCGGCGCTCATCAATAAGGTCAGACACCGCTGTCCGAA
TCTCAGCCTTTATAACATATACGGACCGACAGAAAATACGACATTTTCTACCTTTTACGAAATCAGGCACGATTTTTCTC
AGCCGATCCCAATCGGAAAACCGATCAGCAATTCAACCGCGTATATCATTGATAAAAATGGCGGACTTGCGCCGATCGGC
GTGCCCGGTGAGCTTTGTGTCGGCGGTGACGGGGTTGCCAAAGGCTATTTAAACAGGCCTGACTTAACAAGTGAAGCGTT
TGTCAGCCACCCGGTTCATCCTGAAGAAAAGATCTACAAAACAGGCGACTTGGCACACTGGCTGCCTGATGGAAGCATCG
GATACATCAGCCGTATCGACCGTCAATTCAAGATTCGCGGGAAGCGGATTGAGCCGGCCGAAATCGAAGCGCGCTTGACT
GAAATCGATGGAATCAGGGAAGCGGCAGTCATCGTGTCAGACGAAGGACAAGAAGCAACCCTTTGTGCGTATTATACGGG
CGCGCATGCTGAAGAAAGAGCCATTCAATCCCTGCTGGCCAGGTCGCTTCCCGACTATATGATTCCGCAGTATGTGATGA
AGCTTGACCGTATGCCGCTTACTGCAAACGGCAAAGTGGACCGCCGCGGGCTGCCTGCGCCAGAACGGAAAAAAACGTCA
TCAAAAGCCGTTCCGCCACGAAACTGGGTAGAGCGTGAGCTGATCGACATTTGGACGCCGATCCTCGGCTGCGGGGAGCT
GGGCATACAGGATGACTTCTTTGAGCTGGGCGGCCATTCTTTGAAAGCATTGCAAGTGATTCATCAGCTGAAGACCAGGC
AGCAGATGGATGTGCCGATTGAAATGATATTTGAATATCCGACAATTGAACAATTGGCTGAAAAGCTGTATTCAAACACA
CTGTCAGAAGCTGCAGAGCAGCATATCAGCAGACTGAACCAGCCGAAAGGCCGCAATCTATTCTGTTTTCCGCCTATCTC
AGGTTTCGGCATTTTCTTTAAAGATCTTGCGGCGGCATTAAACGGACGGGCTGCTGTGTACGGTTTTAACTTTATTGAAG
AAGACAGCAGAATGGAACAATACATTGATAAAATGCTGGAAATACAGCCGGAAGGCCCTTATATCCTCTTCGGATATTCA
GCGGGCGGCAATACGGCATTCGAGGCGGCAAAAGCGATGGAAAAGCGCGGCTTAGAAATCAGCGACGTCATTATCGCAGA
CGCGTACAGAAAGCTTGACGCACTGCCGCCGCAGCCAACAAACGCAACAGCCGAAAATGTCCCGGAAGCCGTCAGAGAAG
CGGTCATCAAAAAGACAGAGCGCTATCAAACGTACTGGGCGGAACTGATAAATGATGGCCAAATTGCGGCAAACCTCCAT
TTTATCGAGGCCGGTATAAAGGAAGAGCACAGTGATAAGACCGAGCCGATGAAATGGGAAGGCGCCACAACGGGACTCTA
TCAGGAATATCAAGGCGGGGGCGCCCATAAAGATATGTTTGAACCCGCCTTTGCACATCAAAATGCTGAGGTCATACTCG
ACATCATTGCAAACAGCGGAAGACGCTTGGCGCGGAATCTGTAA

Upstream 100 bases:

>100_bases
GAAGACCGTCAGTGACTTTGATGATCGGGAGCTGACTGAGGAAGCATTGCAGGATATTGCCGACTTACTCAGCTTCCACT
AAACCGAGCGGGAGGAACAC

Downstream 100 bases:

>100_bases
CATCCGGCAGAATGGTTCAGGATGACAGAGGGCAAGATAGGGGAATCAAACCAGTTTTTTGGAGGCTTTGACATGACGAA
CCTATCTTGGCTTACGTATG

Product: FenE

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Peptide synthase 5; ATP-dependent isoleucine adenylase; IsoA; Isoleucine activase [H]

Number of amino acids: Translated: 1267; Mature: 1267

Protein sequence:

>1267_residues
MDKTKNIQNIYPLSRMQEGMLFHSFLQKEGAAYIEQSVFTIKGRLRPELFEQSVQSVIRRHDIFRTVFLPHVAQLNGPRQ
VVLREREFRLHREDLTHLDEPEQSIYLQRFKERDRLKGFDLQKDMLMRVSLFKTADEKYVCVWSHHHILMDGWCLGIVLQ
EFMHMYRAIETGSPVTLAPAKPYSTYITWLTDQDKDAASEYWKGYLAGCETPSGLPKISARPQEKGYRKKELLFSIDQNL
TDKLKTIAKEEGATLAVLMQTVWGLMLQRYNRTDDAVFGAVVSGRPSVIDGVESMIGLFINTVPVRIKTGDESFRELLGR
LQKEMLDSEAFSYHPLADIQSQTELKQDLIDHIIVFENYPIQQQMKDAEKESDAPFRIGNVNVSEQSGYDFNLIIAPGDE
LLIKFSYNANVYDEVWIESVKGHLEEALRGAAFNPDFPADRLPMLGQKEKSRIIGEFNDTKTTYERDESIISLFSRQVKK
TPDHQALHAGGLTMTYRELDERSTAFARTLLENGLAPKGIAGILAERSPEFIIAVLAVLKAGGTYLPLDAELPTDRIADM
LTESGAQLLTVQKGIETDIDFSHIISIPAAAEKQTPDAGKLNTDTAPDDLAYIMYTSGSTGKPKGVMISNRNVVSLVSNS
NYTSAGMSDRLILTGSIGFDAVTFEIFGALLNGACLHVVDRSTMLAPERFGNYLSSNRITILFLTTALFNQFAQADPEMF
SGLHTLYVGGEALSPALINKVRHRCPNLSLYNIYGPTENTTFSTFYEIRHDFSQPIPIGKPISNSTAYIIDKNGGLAPIG
VPGELCVGGDGVAKGYLNRPDLTSEAFVSHPVHPEEKIYKTGDLAHWLPDGSIGYISRIDRQFKIRGKRIEPAEIEARLT
EIDGIREAAVIVSDEGQEATLCAYYTGAHAEERAIQSLLARSLPDYMIPQYVMKLDRMPLTANGKVDRRGLPAPERKKTS
SKAVPPRNWVERELIDIWTPILGCGELGIQDDFFELGGHSLKALQVIHQLKTRQQMDVPIEMIFEYPTIEQLAEKLYSNT
LSEAAEQHISRLNQPKGRNLFCFPPISGFGIFFKDLAAALNGRAAVYGFNFIEEDSRMEQYIDKMLEIQPEGPYILFGYS
AGGNTAFEAAKAMEKRGLEISDVIIADAYRKLDALPPQPTNATAENVPEAVREAVIKKTERYQTYWAELINDGQIAANLH
FIEAGIKEEHSDKTEPMKWEGATTGLYQEYQGGGAHKDMFEPAFAHQNAEVILDIIANSGRRLARNL

Sequences:

>Translated_1267_residues
MDKTKNIQNIYPLSRMQEGMLFHSFLQKEGAAYIEQSVFTIKGRLRPELFEQSVQSVIRRHDIFRTVFLPHVAQLNGPRQ
VVLREREFRLHREDLTHLDEPEQSIYLQRFKERDRLKGFDLQKDMLMRVSLFKTADEKYVCVWSHHHILMDGWCLGIVLQ
EFMHMYRAIETGSPVTLAPAKPYSTYITWLTDQDKDAASEYWKGYLAGCETPSGLPKISARPQEKGYRKKELLFSIDQNL
TDKLKTIAKEEGATLAVLMQTVWGLMLQRYNRTDDAVFGAVVSGRPSVIDGVESMIGLFINTVPVRIKTGDESFRELLGR
LQKEMLDSEAFSYHPLADIQSQTELKQDLIDHIIVFENYPIQQQMKDAEKESDAPFRIGNVNVSEQSGYDFNLIIAPGDE
LLIKFSYNANVYDEVWIESVKGHLEEALRGAAFNPDFPADRLPMLGQKEKSRIIGEFNDTKTTYERDESIISLFSRQVKK
TPDHQALHAGGLTMTYRELDERSTAFARTLLENGLAPKGIAGILAERSPEFIIAVLAVLKAGGTYLPLDAELPTDRIADM
LTESGAQLLTVQKGIETDIDFSHIISIPAAAEKQTPDAGKLNTDTAPDDLAYIMYTSGSTGKPKGVMISNRNVVSLVSNS
NYTSAGMSDRLILTGSIGFDAVTFEIFGALLNGACLHVVDRSTMLAPERFGNYLSSNRITILFLTTALFNQFAQADPEMF
SGLHTLYVGGEALSPALINKVRHRCPNLSLYNIYGPTENTTFSTFYEIRHDFSQPIPIGKPISNSTAYIIDKNGGLAPIG
VPGELCVGGDGVAKGYLNRPDLTSEAFVSHPVHPEEKIYKTGDLAHWLPDGSIGYISRIDRQFKIRGKRIEPAEIEARLT
EIDGIREAAVIVSDEGQEATLCAYYTGAHAEERAIQSLLARSLPDYMIPQYVMKLDRMPLTANGKVDRRGLPAPERKKTS
SKAVPPRNWVERELIDIWTPILGCGELGIQDDFFELGGHSLKALQVIHQLKTRQQMDVPIEMIFEYPTIEQLAEKLYSNT
LSEAAEQHISRLNQPKGRNLFCFPPISGFGIFFKDLAAALNGRAAVYGFNFIEEDSRMEQYIDKMLEIQPEGPYILFGYS
AGGNTAFEAAKAMEKRGLEISDVIIADAYRKLDALPPQPTNATAENVPEAVREAVIKKTERYQTYWAELINDGQIAANLH
FIEAGIKEEHSDKTEPMKWEGATTGLYQEYQGGGAHKDMFEPAFAHQNAEVILDIIANSGRRLARNL
>Mature_1267_residues
MDKTKNIQNIYPLSRMQEGMLFHSFLQKEGAAYIEQSVFTIKGRLRPELFEQSVQSVIRRHDIFRTVFLPHVAQLNGPRQ
VVLREREFRLHREDLTHLDEPEQSIYLQRFKERDRLKGFDLQKDMLMRVSLFKTADEKYVCVWSHHHILMDGWCLGIVLQ
EFMHMYRAIETGSPVTLAPAKPYSTYITWLTDQDKDAASEYWKGYLAGCETPSGLPKISARPQEKGYRKKELLFSIDQNL
TDKLKTIAKEEGATLAVLMQTVWGLMLQRYNRTDDAVFGAVVSGRPSVIDGVESMIGLFINTVPVRIKTGDESFRELLGR
LQKEMLDSEAFSYHPLADIQSQTELKQDLIDHIIVFENYPIQQQMKDAEKESDAPFRIGNVNVSEQSGYDFNLIIAPGDE
LLIKFSYNANVYDEVWIESVKGHLEEALRGAAFNPDFPADRLPMLGQKEKSRIIGEFNDTKTTYERDESIISLFSRQVKK
TPDHQALHAGGLTMTYRELDERSTAFARTLLENGLAPKGIAGILAERSPEFIIAVLAVLKAGGTYLPLDAELPTDRIADM
LTESGAQLLTVQKGIETDIDFSHIISIPAAAEKQTPDAGKLNTDTAPDDLAYIMYTSGSTGKPKGVMISNRNVVSLVSNS
NYTSAGMSDRLILTGSIGFDAVTFEIFGALLNGACLHVVDRSTMLAPERFGNYLSSNRITILFLTTALFNQFAQADPEMF
SGLHTLYVGGEALSPALINKVRHRCPNLSLYNIYGPTENTTFSTFYEIRHDFSQPIPIGKPISNSTAYIIDKNGGLAPIG
VPGELCVGGDGVAKGYLNRPDLTSEAFVSHPVHPEEKIYKTGDLAHWLPDGSIGYISRIDRQFKIRGKRIEPAEIEARLT
EIDGIREAAVIVSDEGQEATLCAYYTGAHAEERAIQSLLARSLPDYMIPQYVMKLDRMPLTANGKVDRRGLPAPERKKTS
SKAVPPRNWVERELIDIWTPILGCGELGIQDDFFELGGHSLKALQVIHQLKTRQQMDVPIEMIFEYPTIEQLAEKLYSNT
LSEAAEQHISRLNQPKGRNLFCFPPISGFGIFFKDLAAALNGRAAVYGFNFIEEDSRMEQYIDKMLEIQPEGPYILFGYS
AGGNTAFEAAKAMEKRGLEISDVIIADAYRKLDALPPQPTNATAENVPEAVREAVIKKTERYQTYWAELINDGQIAANLH
FIEAGIKEEHSDKTEPMKWEGATTGLYQEYQGGGAHKDMFEPAFAHQNAEVILDIIANSGRRLARNL

Specific function: This protein is a multifunctional enzyme, able to activate and polymerize the amino acid Ile as part of the biosynthesis of the lipopeptide antibiotic plipastatin. The activation sites for this amino acid consist of individual domains [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=446, Percent_Identity=26.0089686098655, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI156151445, Length=538, Percent_Identity=24.907063197026, Blast_Score=98, Evalue=6e-20,
Organism=Homo sapiens, GI38505220, Length=508, Percent_Identity=24.6062992125984, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI42544132, Length=505, Percent_Identity=23.3663366336634, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI122937307, Length=505, Percent_Identity=23.960396039604, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI157311624, Length=508, Percent_Identity=22.8346456692913, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI157311622, Length=508, Percent_Identity=22.8346456692913, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI195947378, Length=391, Percent_Identity=25.5754475703325, Blast_Score=73, Evalue=2e-12,
Organism=Escherichia coli, GI1786801, Length=1106, Percent_Identity=27.0343580470163, Blast_Score=321, Evalue=2e-88,
Organism=Escherichia coli, GI1788107, Length=566, Percent_Identity=24.2049469964664, Blast_Score=129, Evalue=1e-30,
Organism=Escherichia coli, GI145693145, Length=532, Percent_Identity=23.4962406015038, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=448, Percent_Identity=28.3482142857143, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17556356, Length=660, Percent_Identity=25.1515151515152, Blast_Score=145, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=505, Percent_Identity=24.3564356435644, Blast_Score=102, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=411, Percent_Identity=25.7907542579075, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=370, Percent_Identity=25.4054054054054, Blast_Score=94, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=370, Percent_Identity=24.8648648648649, Blast_Score=94, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=370, Percent_Identity=24.8648648648649, Blast_Score=94, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=384, Percent_Identity=25.78125, Blast_Score=91, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32564420, Length=466, Percent_Identity=24.8927038626609, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32564422, Length=466, Percent_Identity=24.8927038626609, Blast_Score=89, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=361, Percent_Identity=23.8227146814404, Blast_Score=85, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=329, Percent_Identity=26.1398176291793, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71985884, Length=428, Percent_Identity=24.0654205607477, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983001, Length=525, Percent_Identity=21.5238095238095, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982997, Length=523, Percent_Identity=21.414913957935, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319591, Length=651, Percent_Identity=26.2672811059908, Blast_Score=212, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319699, Length=367, Percent_Identity=25.3405994550409, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24648676, Length=611, Percent_Identity=27.986906710311, Blast_Score=177, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24582852, Length=486, Percent_Identity=24.0740740740741, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355181, Length=495, Percent_Identity=26.4646464646465, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24581924, Length=392, Percent_Identity=26.0204081632653, Blast_Score=97, Evalue=9e-20,
Organism=Drosophila melanogaster, GI18859661, Length=514, Percent_Identity=26.6536964980545, Blast_Score=96, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356947, Length=354, Percent_Identity=25.7062146892655, Blast_Score=89, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281365686, Length=297, Percent_Identity=25.5892255892256, Blast_Score=77, Evalue=7e-14,
Organism=Drosophila melanogaster, GI20130357, Length=413, Percent_Identity=24.9394673123487, Blast_Score=77, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24653035, Length=535, Percent_Identity=23.7383177570093, Blast_Score=77, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 141999; Mature: 141999

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTKNIQNIYPLSRMQEGMLFHSFLQKEGAAYIEQSVFTIKGRLRPELFEQSVQSVIRR
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
HDIFRTVFLPHVAQLNGPRQVVLREREFRLHREDLTHLDEPEQSIYLQRFKERDRLKGFD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
LQKDMLMRVSLFKTADEKYVCVWSHHHILMDGWCLGIVLQEFMHMYRAIETGSPVTLAPA
CHHHHHHHHHHHHCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
KPYSTYITWLTDQDKDAASEYWKGYLAGCETPSGLPKISARPQEKGYRKKELLFSIDQNL
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHH
TDKLKTIAKEEGATLAVLMQTVWGLMLQRYNRTDDAVFGAVVSGRPSVIDGVESMIGLFI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
NTVPVRIKTGDESFRELLGRLQKEMLDSEAFSYHPLADIQSQTELKQDLIDHIIVFENYP
HCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCC
IQQQMKDAEKESDAPFRIGNVNVSEQSGYDFNLIIAPGDELLIKFSYNANVYDEVWIESV
HHHHHHHHHHCCCCCEEECCEEECCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHH
KGHLEEALRGAAFNPDFPADRLPMLGQKEKSRIIGEFNDTKTTYERDESIISLFSRQVKK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
TPDHQALHAGGLTMTYRELDERSTAFARTLLENGLAPKGIAGILAERSPEFIIAVLAVLK
CCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHH
AGGTYLPLDAELPTDRIADMLTESGAQLLTVQKGIETDIDFSHIISIPAAAEKQTPDAGK
CCCCEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHEECCCCCCCCCCCCCC
LNTDTAPDDLAYIMYTSGSTGKPKGVMISNRNVVSLVSNSNYTSAGMSDRLILTGSIGFD
CCCCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEECCCCH
AVTFEIFGALLNGACLHVVDRSTMLAPERFGNYLSSNRITILFLTTALFNQFAQADPEMF
HHHHHHHHHHHCCHHEEEECCCHHCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHH
SGLHTLYVGGEALSPALINKVRHRCPNLSLYNIYGPTENTTFSTFYEIRHDFSQPIPIGK
CCCCEEEECCHHCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
PISNSTAYIIDKNGGLAPIGVPGELCVGGDGVAKGYLNRPDLTSEAFVSHPVHPEEKIYK
CCCCCEEEEEECCCCEEECCCCCCEEECCCCHHCCCCCCCCCCHHHHHCCCCCCHHHHCC
TGDLAHWLPDGSIGYISRIDRQFKIRGKRIEPAEIEARLTEIDGIREAAVIVSDEGQEAT
CCCCHHCCCCCCCHHHHHHCHHHEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCE
LCAYYTGAHAEERAIQSLLARSLPDYMIPQYVMKLDRMPLTANGKVDRRGLPAPERKKTS
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCC
SKAVPPRNWVERELIDIWTPILGCGELGIQDDFFELGGHSLKALQVIHQLKTRQQMDVPI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCH
EMIFEYPTIEQLAEKLYSNTLSEAAEQHISRLNQPKGRNLFCFPPISGFGIFFKDLAAAL
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHH
NGRAAVYGFNFIEEDSRMEQYIDKMLEIQPEGPYILFGYSAGGNTAFEAAKAMEKRGLEI
CCCEEEEECCHHCCHHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
SDVIIADAYRKLDALPPQPTNATAENVPEAVREAVIKKTERYQTYWAELINDGQIAANLH
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FIEAGIKEEHSDKTEPMKWEGATTGLYQEYQGGGAHKDMFEPAFAHQNAEVILDIIANSG
HHHHCCHHCCCCCCCCEEECCCCCHHHHHHCCCCCCHHHCCHHHHCCCHHHHHHHHHCCC
RRLARNL
HHHHHCC
>Mature Secondary Structure
MDKTKNIQNIYPLSRMQEGMLFHSFLQKEGAAYIEQSVFTIKGRLRPELFEQSVQSVIRR
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
HDIFRTVFLPHVAQLNGPRQVVLREREFRLHREDLTHLDEPEQSIYLQRFKERDRLKGFD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
LQKDMLMRVSLFKTADEKYVCVWSHHHILMDGWCLGIVLQEFMHMYRAIETGSPVTLAPA
CHHHHHHHHHHHHCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
KPYSTYITWLTDQDKDAASEYWKGYLAGCETPSGLPKISARPQEKGYRKKELLFSIDQNL
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHH
TDKLKTIAKEEGATLAVLMQTVWGLMLQRYNRTDDAVFGAVVSGRPSVIDGVESMIGLFI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
NTVPVRIKTGDESFRELLGRLQKEMLDSEAFSYHPLADIQSQTELKQDLIDHIIVFENYP
HCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCC
IQQQMKDAEKESDAPFRIGNVNVSEQSGYDFNLIIAPGDELLIKFSYNANVYDEVWIESV
HHHHHHHHHHCCCCCEEECCEEECCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHH
KGHLEEALRGAAFNPDFPADRLPMLGQKEKSRIIGEFNDTKTTYERDESIISLFSRQVKK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
TPDHQALHAGGLTMTYRELDERSTAFARTLLENGLAPKGIAGILAERSPEFIIAVLAVLK
CCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHH
AGGTYLPLDAELPTDRIADMLTESGAQLLTVQKGIETDIDFSHIISIPAAAEKQTPDAGK
CCCCEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHEECCCCCCCCCCCCCC
LNTDTAPDDLAYIMYTSGSTGKPKGVMISNRNVVSLVSNSNYTSAGMSDRLILTGSIGFD
CCCCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEECCCCH
AVTFEIFGALLNGACLHVVDRSTMLAPERFGNYLSSNRITILFLTTALFNQFAQADPEMF
HHHHHHHHHHHCCHHEEEECCCHHCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHH
SGLHTLYVGGEALSPALINKVRHRCPNLSLYNIYGPTENTTFSTFYEIRHDFSQPIPIGK
CCCCEEEECCHHCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
PISNSTAYIIDKNGGLAPIGVPGELCVGGDGVAKGYLNRPDLTSEAFVSHPVHPEEKIYK
CCCCCEEEEEECCCCEEECCCCCCEEECCCCHHCCCCCCCCCCHHHHHCCCCCCHHHHCC
TGDLAHWLPDGSIGYISRIDRQFKIRGKRIEPAEIEARLTEIDGIREAAVIVSDEGQEAT
CCCCHHCCCCCCCHHHHHHCHHHEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCE
LCAYYTGAHAEERAIQSLLARSLPDYMIPQYVMKLDRMPLTANGKVDRRGLPAPERKKTS
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCC
SKAVPPRNWVERELIDIWTPILGCGELGIQDDFFELGGHSLKALQVIHQLKTRQQMDVPI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCH
EMIFEYPTIEQLAEKLYSNTLSEAAEQHISRLNQPKGRNLFCFPPISGFGIFFKDLAAAL
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHH
NGRAAVYGFNFIEEDSRMEQYIDKMLEIQPEGPYILFGYSAGGNTAFEAAKAMEKRGLEI
CCCEEEEECCHHCCHHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
SDVIIADAYRKLDALPPQPTNATAENVPEAVREAVIKKTERYQTYWAELINDGQIAANLH
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FIEAGIKEEHSDKTEPMKWEGATTGLYQEYQGGGAHKDMFEPAFAHQNAEVILDIIANSG
HHHHCCHHCCCCCCCCEEECCCCCHHHHHHCCCCCCHHHCCHHHHCCCHHHHHHHHHCCC
RRLARNL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377; 10471562 [H]