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The map label for this gene is nprE [H]

Identifier: 154685888

GI number: 154685888

Start: 1456714

End: 1458279

Strand: Reverse

Name: nprE [H]

Synonym: RBAM_014550

Alternate gene names: 154685888

Gene position: 1458279-1456714 (Counterclockwise)

Preceding gene: 154685894

Following gene: 154685884

Centisome position: 37.21

GC content: 46.36

Gene sequence:

>1566_bases
GTGGGTTTAGGTAAGAAATTGTCTGTTGCTGTCGCCGCTTCCTTTATGAGTTTAACTATCAGTCTTCCGGGTGTTCAGGC
CGCTGAGAATCCTCAGCTTAAAGAAAACCTGACGAACTTTGTGCCGAAGCATTCTTTGGTGCAGTCTGAGTTGCCTTCAG
TCAGTGACAAAGCAATCAAGCAATACTTGAAACAAAACGGCAAAGTCTTCAAAGGCAACCCTTCTGAGAGACTGAAGCTG
ATTGACCACACGACCGATGATCTCGGCTACAAGCACTTCCGTTATGTGCCTGTCGTTAACGGTGTGCCTGTGAAAGACTC
GCAAGTCATTATTCACGTCGATAAATCCAACAATGTCTATGCGATTAACGGTGAATTAAACAACGATGCTTCTGCCAAAA
CGGCAAACAGCAAAAAATTATCTGCAAATCAGGCGCTGGATCATGCTTTTAAAGCAATCGGCAAATCACCTGAAGCCGTC
TCTAACGGCAACGTTGCAAACAAAAACAAAGCCGAGCTGAAAGCAGCGGCCACAAAAGACGGTAAATACCGCCTCGCCTA
TGATGTAACCATCCGCTACATCGAACCGGAACCAGCTAACTGGGAAGTAACCGTTGATGCGGAAACAGGGAAAGTCCTGA
AAAAGCAAAACAAAGTGGAGCATGCAGCTGCAACCGGAACAGGTACGACTCTTAAAGGAAAAACGGTCTCATTAAATATT
TCTTCTGAAAGCGGCAAATATGTAATGCGTGATCTTTCTAAACCTACCGGAACGCAAATTATTACGTACGATCTGCAAAA
CCGACAATATAACCTGCCGGGCACACTCGTATCAAGCACTACCAACCAGTTCACAACTTCTTCTCAGCGCGCTGCCGTTG
ATGCGCATTACAATCTCGGCAAAGTGTACGATTATTTCTATCAGACGTTTAAACGCAACAGTTACGACAATAAAGGCGGC
AAAATCGTATCTTCCGTTCATTACGGCAGCAAATACAATAACGCGGCCTGGATCGGCGACCAAATGATTTACGGTGACGG
TGACGGCTCATTCTTCTCGCCTCTTTCCGGTTCAATGGACGTAACGGCCCATGAAATGACACACGGTGTTACACAGGAAA
CAGCCAACCTAAACTATGAAAATCAGCCGGGCGCTTTAAACGAATCCTTCTCTGATGTATTCGGATACTTCAATGATACT
GAGGACTGGGATATCGGTGAAGATATTACGGTCAGCCAGCCGGCTCTCCGCAGTTTATCTACTCCGACAAAATACGGACA
GCCCGACCATTACAAAAATTATCAAAACCTTCCGAACACTGATGCCGGCGACTACGGCGGCGTGCATACAAACAGCGGAA
TTCCGAACAAAGCCGCTTACAACACGATTACTAAAATCGGCGTGAAAAAAGCGGAGCAGATTTACTATCGCGCACTAACG
GTATATCTCACTCCGTCATCAAACTTTAAAGATGCAAAAGCAGCTTTGATTCAATCAGCGCGGGACCTTTACGGCTCTCA
AGACGCTGCAAGCGTAGAAGCGGCCTGGAATGCGGTCGGCTTGTAA

Upstream 100 bases:

>100_bases
CAATTCATCAGCGGAGTCTAGTTTTATATTGCAGAATGAGAGAATGCTGGTTTATTATAACAATATAAGTTTTCATTATT
TTCAAAAAGGGGGATTTATT

Downstream 100 bases:

>100_bases
ACAAGAAAAGAGACCGGAGAAATCCGGTCTCTTTTTTATACCTGAAACATTTCACAATGGCTTCACCATGATCATATATG
TCTTTTCCCGATCGTCTTTT

Product: NprE

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MGLGKKLSVAVAASFMSLTISLPGVQAAENPQLKENLTNFVPKHSLVQSELPSVSDKAIKQYLKQNGKVFKGNPSERLKL
IDHTTDDLGYKHFRYVPVVNGVPVKDSQVIIHVDKSNNVYAINGELNNDASAKTANSKKLSANQALDHAFKAIGKSPEAV
SNGNVANKNKAELKAAATKDGKYRLAYDVTIRYIEPEPANWEVTVDAETGKVLKKQNKVEHAAATGTGTTLKGKTVSLNI
SSESGKYVMRDLSKPTGTQIITYDLQNRQYNLPGTLVSSTTNQFTTSSQRAAVDAHYNLGKVYDYFYQTFKRNSYDNKGG
KIVSSVHYGSKYNNAAWIGDQMIYGDGDGSFFSPLSGSMDVTAHEMTHGVTQETANLNYENQPGALNESFSDVFGYFNDT
EDWDIGEDITVSQPALRSLSTPTKYGQPDHYKNYQNLPNTDAGDYGGVHTNSGIPNKAAYNTITKIGVKKAEQIYYRALT
VYLTPSSNFKDAKAALIQSARDLYGSQDAASVEAAWNAVGL

Sequences:

>Translated_521_residues
MGLGKKLSVAVAASFMSLTISLPGVQAAENPQLKENLTNFVPKHSLVQSELPSVSDKAIKQYLKQNGKVFKGNPSERLKL
IDHTTDDLGYKHFRYVPVVNGVPVKDSQVIIHVDKSNNVYAINGELNNDASAKTANSKKLSANQALDHAFKAIGKSPEAV
SNGNVANKNKAELKAAATKDGKYRLAYDVTIRYIEPEPANWEVTVDAETGKVLKKQNKVEHAAATGTGTTLKGKTVSLNI
SSESGKYVMRDLSKPTGTQIITYDLQNRQYNLPGTLVSSTTNQFTTSSQRAAVDAHYNLGKVYDYFYQTFKRNSYDNKGG
KIVSSVHYGSKYNNAAWIGDQMIYGDGDGSFFSPLSGSMDVTAHEMTHGVTQETANLNYENQPGALNESFSDVFGYFNDT
EDWDIGEDITVSQPALRSLSTPTKYGQPDHYKNYQNLPNTDAGDYGGVHTNSGIPNKAAYNTITKIGVKKAEQIYYRALT
VYLTPSSNFKDAKAALIQSARDLYGSQDAASVEAAWNAVGL
>Mature_520_residues
GLGKKLSVAVAASFMSLTISLPGVQAAENPQLKENLTNFVPKHSLVQSELPSVSDKAIKQYLKQNGKVFKGNPSERLKLI
DHTTDDLGYKHFRYVPVVNGVPVKDSQVIIHVDKSNNVYAINGELNNDASAKTANSKKLSANQALDHAFKAIGKSPEAVS
NGNVANKNKAELKAAATKDGKYRLAYDVTIRYIEPEPANWEVTVDAETGKVLKKQNKVEHAAATGTGTTLKGKTVSLNIS
SESGKYVMRDLSKPTGTQIITYDLQNRQYNLPGTLVSSTTNQFTTSSQRAAVDAHYNLGKVYDYFYQTFKRNSYDNKGGK
IVSSVHYGSKYNNAAWIGDQMIYGDGDGSFFSPLSGSMDVTAHEMTHGVTQETANLNYENQPGALNESFSDVFGYFNDTE
DWDIGEDITVSQPALRSLSTPTKYGQPDHYKNYQNLPNTDAGDYGGVHTNSGIPNKAAYNTITKIGVKKAEQIYYRALTV
YLTPSSNFKDAKAALIQSARDLYGSQDAASVEAAWNAVGL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 56804; Mature: 56672

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGKKLSVAVAASFMSLTISLPGVQAAENPQLKENLTNFVPKHSLVQSELPSVSDKAIK
CCCCCHHHHHHHHEEHEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
QYLKQNGKVFKGNPSERLKLIDHTTDDLGYKHFRYVPVVNGVPVKDSQVIIHVDKSNNVY
HHHHHCCCEEECCHHHHEEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCEE
AINGELNNDASAKTANSKKLSANQALDHAFKAIGKSPEAVSNGNVANKNKAELKAAATKD
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEECCC
GKYRLAYDVTIRYIEPEPANWEVTVDAETGKVLKKQNKVEHAAATGTGTTLKGKTVSLNI
CCEEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEECCEEEEEEE
SSESGKYVMRDLSKPTGTQIITYDLQNRQYNLPGTLVSSTTNQFTTSSQRAAVDAHYNLG
CCCCCCHHHHHCCCCCCCEEEEEEECCCEECCCCCEEECCCCCCCCCCCCEEEECCCCHH
KVYDYFYQTFKRNSYDNKGGKIVSSVHYGSKYNNAAWIGDQMIYGDGDGSFFSPLSGSMD
HHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEECCEEEEECCCCCCCCCCCCCCC
VTAHEMTHGVTQETANLNYENQPGALNESFSDVFGYFNDTEDWDIGEDITVSQPALRSLS
EEHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCC
TPTKYGQPDHYKNYQNLPNTDAGDYGGVHTNSGIPNKAAYNTITKIGVKKAEQIYYRALT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEE
VYLTPSSNFKDAKAALIQSARDLYGSQDAASVEAAWNAVGL
EEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GLGKKLSVAVAASFMSLTISLPGVQAAENPQLKENLTNFVPKHSLVQSELPSVSDKAIK
CCCCHHHHHHHHEEHEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
QYLKQNGKVFKGNPSERLKLIDHTTDDLGYKHFRYVPVVNGVPVKDSQVIIHVDKSNNVY
HHHHHCCCEEECCHHHHEEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCEE
AINGELNNDASAKTANSKKLSANQALDHAFKAIGKSPEAVSNGNVANKNKAELKAAATKD
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEECCC
GKYRLAYDVTIRYIEPEPANWEVTVDAETGKVLKKQNKVEHAAATGTGTTLKGKTVSLNI
CCEEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEECCEEEEEEE
SSESGKYVMRDLSKPTGTQIITYDLQNRQYNLPGTLVSSTTNQFTTSSQRAAVDAHYNLG
CCCCCCHHHHHCCCCCCCEEEEEEECCCEECCCCCEEECCCCCCCCCCCCEEEECCCCHH
KVYDYFYQTFKRNSYDNKGGKIVSSVHYGSKYNNAAWIGDQMIYGDGDGSFFSPLSGSMD
HHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEEECCEEEEECCCCCCCCCCCCCCC
VTAHEMTHGVTQETANLNYENQPGALNESFSDVFGYFNDTEDWDIGEDITVSQPALRSLS
EEHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCC
TPTKYGQPDHYKNYQNLPNTDAGDYGGVHTNSGIPNKAAYNTITKIGVKKAEQIYYRALT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEE
VYLTPSSNFKDAKAALIQSARDLYGSQDAASVEAAWNAVGL
EEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6090391 [H]