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The map label for this gene is kinD [H]

Identifier: 154685775

GI number: 154685775

Start: 1303764

End: 1305263

Strand: Reverse

Name: kinD [H]

Synonym: RBAM_013420

Alternate gene names: 154685775

Gene position: 1305263-1303764 (Counterclockwise)

Preceding gene: 154685777

Following gene: 154685768

Centisome position: 33.31

GC content: 45.0

Gene sequence:

>1500_bases
GTGAATACATTTAAAGGTGCCCGGGGAAAGATCAAGCTTTATCTCATATTGGTGATCATCCCGGCACTTATTATCAGCTT
TTTCATTTATGAAAAAGAAAAGCAGAAAATAGCCGATAAACACATACAGGAAGCCAGTATGATGCTCAACCTTCACCGCA
ATAAGCTCAATTATTTAATCGGTGAAACAAAAGCCCGGATGACAACACTTGCGATCGCTGTCGATAAGCCTGTCAATGAA
GAAAAGATCATTGACATTCTCGATCAGGCTTTTGAGGATGAACCCAGATTCAGCGGTCTGTATATGCTGAATTCCAAAGG
TGATGTCATCGCAAGCACGACTGATCTGAAATCAAAGGTGAATTTGGCCGACAGACCGTATTTTACGAAGGCGAAAAAGA
CGAAAAAAACGGTCATCACAAATGACTACTCCAGCAGAATTACAGGCCAGCGCATCTTCACGATCTGCGTGCCGGTGTTA
GACGCAAAACGGGAAGTCACGGATTATTTAGTAGCCGCCATACAAGTCGATTATTTGAGAAATATGATCAATATGCTGAG
CCCTGACGTTTATGTCAAGGCAACCAATCAGAATAAAGTGATATTTGCCAGCGGACGGGCTGATCAATCAGAAGGTGTGA
AACCGGTCAGCGGCTATCTGGATGATATTAATTGGAATATCAATGTTTATCCGAAACCGGTTGAGCTGAATGAGCTGACC
AAAAGCGTGCTGCTGCCGATGTCCAGTATTGCCGTGCTGCTGAATATTCTGTTCATCCTCGTTCAATATTATCTGCTTAA
GCGCAAGACCCAGCTGGAGCGCGCTCAAAATGAAGCGCAGAAATTGGAGCTGATCGGAACGCTTGCCGCCAGCACCGCCC
ATGAAATCCGCAACCCGCTTACAGGGATCAGCGGCTTCATTCAGCTTTTGCAGAAAAAATACAAATCGGAGGAAGATCAG
CTGTATTTCTCAATTATTGAGCAGGAGATTAAACGGATCAATCAGATTGTCAGTGAGTTTTTAGTGCTTGGAAAACCCAC
TGCTGAACGGTTGGAAGTGAACTCGCTGCAGGATATTCTTGATGAGATTATGCCGATTATTTATTCTGAAGGGAATCTAT
ACAATGTGGAAGTGAATGTGGAGATTCTCGTCAATCGGCCGCTCAAGGTCAACTGCACGAAAGACCATATTAAACAGGTG
ATTTTAAATGTCGCGAAAAACGCGCTGGAATCCATGCAGGAAGGCGGCCGGCTGTCCATCTATTTAGAAGCCCGCGATCA
TAAAGCAGTCATTAAGGTGGCCGACAACGGAATGGGCATTTCTGAAGATATGCTTGAGCACATTTTTCTTCCGTTTGTAA
CGTCAAAGGAAAAAGGCACCGGCCTCGGCCTTGTCGTATGTAAACGAATCATGCTGATGTACGGCGGTTCGATTGACATT
CAAAGCGAAGTCGATAAGGGCACAGAGGTCACCATTACCCTCCCTGCCGCTTCTCGATGA

Upstream 100 bases:

>100_bases
AATAATTTGTTTTTCTATCATTTTGGTTATTTTTTCTTATTAAAGAAGTATAAAAATGATATAATACCTCTATTCAAGTG
TAATGTTGGAGCGATGCAGA

Downstream 100 bases:

>100_bases
AAAAAACACCCTGGATCGGGGTGTTTTTTATTTAAAGAAGAGTATGTGTAAGAGGATATACCAGAGGAACGGCATCATAG
CCGGCAGATAGTACGAGGCG

Product: KinD

Products: NA

Alternate protein names: Sensor histidine kinase D [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MNTFKGARGKIKLYLILVIIPALIISFFIYEKEKQKIADKHIQEASMMLNLHRNKLNYLIGETKARMTTLAIAVDKPVNE
EKIIDILDQAFEDEPRFSGLYMLNSKGDVIASTTDLKSKVNLADRPYFTKAKKTKKTVITNDYSSRITGQRIFTICVPVL
DAKREVTDYLVAAIQVDYLRNMINMLSPDVYVKATNQNKVIFASGRADQSEGVKPVSGYLDDINWNINVYPKPVELNELT
KSVLLPMSSIAVLLNILFILVQYYLLKRKTQLERAQNEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKSEEDQ
LYFSIIEQEIKRINQIVSEFLVLGKPTAERLEVNSLQDILDEIMPIIYSEGNLYNVEVNVEILVNRPLKVNCTKDHIKQV
ILNVAKNALESMQEGGRLSIYLEARDHKAVIKVADNGMGISEDMLEHIFLPFVTSKEKGTGLGLVVCKRIMLMYGGSIDI
QSEVDKGTEVTITLPAASR

Sequences:

>Translated_499_residues
MNTFKGARGKIKLYLILVIIPALIISFFIYEKEKQKIADKHIQEASMMLNLHRNKLNYLIGETKARMTTLAIAVDKPVNE
EKIIDILDQAFEDEPRFSGLYMLNSKGDVIASTTDLKSKVNLADRPYFTKAKKTKKTVITNDYSSRITGQRIFTICVPVL
DAKREVTDYLVAAIQVDYLRNMINMLSPDVYVKATNQNKVIFASGRADQSEGVKPVSGYLDDINWNINVYPKPVELNELT
KSVLLPMSSIAVLLNILFILVQYYLLKRKTQLERAQNEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKSEEDQ
LYFSIIEQEIKRINQIVSEFLVLGKPTAERLEVNSLQDILDEIMPIIYSEGNLYNVEVNVEILVNRPLKVNCTKDHIKQV
ILNVAKNALESMQEGGRLSIYLEARDHKAVIKVADNGMGISEDMLEHIFLPFVTSKEKGTGLGLVVCKRIMLMYGGSIDI
QSEVDKGTEVTITLPAASR
>Mature_499_residues
MNTFKGARGKIKLYLILVIIPALIISFFIYEKEKQKIADKHIQEASMMLNLHRNKLNYLIGETKARMTTLAIAVDKPVNE
EKIIDILDQAFEDEPRFSGLYMLNSKGDVIASTTDLKSKVNLADRPYFTKAKKTKKTVITNDYSSRITGQRIFTICVPVL
DAKREVTDYLVAAIQVDYLRNMINMLSPDVYVKATNQNKVIFASGRADQSEGVKPVSGYLDDINWNINVYPKPVELNELT
KSVLLPMSSIAVLLNILFILVQYYLLKRKTQLERAQNEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKSEEDQ
LYFSIIEQEIKRINQIVSEFLVLGKPTAERLEVNSLQDILDEIMPIIYSEGNLYNVEVNVEILVNRPLKVNCTKDHIKQV
ILNVAKNALESMQEGGRLSIYLEARDHKAVIKVADNGMGISEDMLEHIFLPFVTSKEKGTGLGLVVCKRIMLMYGGSIDI
QSEVDKGTEVTITLPAASR

Specific function: Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=32.0675105485232, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790436, Length=256, Percent_Identity=31.640625, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=26.7782426778243, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=27.0042194092827, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786600, Length=326, Percent_Identity=22.6993865030675, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=24.2677824267782, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=233, Percent_Identity=28.755364806867, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=213, Percent_Identity=26.2910798122066, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=247, Percent_Identity=25.9109311740891, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=23.5555555555556, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=26.1261261261261, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56280; Mature: 56280

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFKGARGKIKLYLILVIIPALIISFFIYEKEKQKIADKHIQEASMMLNLHRNKLNYLI
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GETKARMTTLAIAVDKPVNEEKIIDILDQAFEDEPRFSGLYMLNSKGDVIASTTDLKSKV
CCHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECHHHHHHC
NLADRPYFTKAKKTKKTVITNDYSSRITGQRIFTICVPVLDAKREVTDYLVAAIQVDYLR
CCCCCCCCCHHHHCCCEEEECCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
NMINMLSPDVYVKATNQNKVIFASGRADQSEGVKPVSGYLDDINWNINVYPKPVELNELT
HHHHHHCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEECCCCCHHHHH
KSVLLPMSSIAVLLNILFILVQYYLLKRKTQLERAQNEAQKLELIGTLAASTAHEIRNPL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
TGISGFIQLLQKKYKSEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAERLEVNSLQDIL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DEIMPIIYSEGNLYNVEVNVEILVNRPLKVNCTKDHIKQVILNVAKNALESMQEGGRLSI
HHHHHHEECCCCEEEEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
YLEARDHKAVIKVADNGMGISEDMLEHIFLPFVTSKEKGTGLGLVVCKRIMLMYGGSIDI
EEEECCCEEEEEEECCCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCEEE
QSEVDKGTEVTITLPAASR
HHHCCCCCEEEEEECCCCC
>Mature Secondary Structure
MNTFKGARGKIKLYLILVIIPALIISFFIYEKEKQKIADKHIQEASMMLNLHRNKLNYLI
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GETKARMTTLAIAVDKPVNEEKIIDILDQAFEDEPRFSGLYMLNSKGDVIASTTDLKSKV
CCHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECHHHHHHC
NLADRPYFTKAKKTKKTVITNDYSSRITGQRIFTICVPVLDAKREVTDYLVAAIQVDYLR
CCCCCCCCCHHHHCCCEEEECCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
NMINMLSPDVYVKATNQNKVIFASGRADQSEGVKPVSGYLDDINWNINVYPKPVELNELT
HHHHHHCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEECCCCCHHHHH
KSVLLPMSSIAVLLNILFILVQYYLLKRKTQLERAQNEAQKLELIGTLAASTAHEIRNPL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
TGISGFIQLLQKKYKSEEDQLYFSIIEQEIKRINQIVSEFLVLGKPTAERLEVNSLQDIL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DEIMPIIYSEGNLYNVEVNVEILVNRPLKVNCTKDHIKQVILNVAKNALESMQEGGRLSI
HHHHHHEECCCCEEEEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
YLEARDHKAVIKVADNGMGISEDMLEHIFLPFVTSKEKGTGLGLVVCKRIMLMYGGSIDI
EEEECCCEEEEEEECCCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCEEE
QSEVDKGTEVTITLPAASR
HHHCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]