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The map label for this gene is mtnA

Identifier: 154685766

GI number: 154685766

Start: 1295064

End: 1296125

Strand: Reverse

Name: mtnA

Synonym: RBAM_013330

Alternate gene names: 154685766

Gene position: 1296125-1295064 (Counterclockwise)

Preceding gene: 154685767

Following gene: 154685763

Centisome position: 33.08

GC content: 50.09

Gene sequence:

>1062_bases
ATGACCAATGAATTTGCCATCCCCCGTTCTGTAGAATGGAAAGAAACCTACATCCGCATTTTAAATCAGCAAAAGCTTCC
CGACGTCACTGAATATGTGGAACTTGAAACAAAGGAAGATGTATTCGACGCGATTGTCACGCTGAAAGTAAGGGGCGCCC
CGGCCATCGGTATAACCGCGGCGTTCGGACTCGCGCTCTCCGCCAAGTCGTTTGAAGCCCGCGACCTTTCAGATTTCCGA
CGTCAGTTCGCAGATGTCAAAACGTATTTAAACAGTTCGAGGCCCACTGCCGTCAACCTCGCGTGGGCGCTTGACAGACT
GACGGATTCCATCAGGGATGCGATCTCAATCAATGAAGCGAAGACAACGCTCGTTCATGAAGCCATTCAAATTCAGATTG
AGGATGAAGAAACATGCCGAATGATCGGCCAGAATGCGCTGCACCTTTTTAAAAAAGGCGACCAGATCATGACCATCTGC
AATGCGGGCTCGATTGCCACAAGCCGATACGGTACGGCGCTTGCCCCCTTTTACTTAGCGAAACAAAAAGATCTCGGCCT
TCATATCTACGCATGTGAAACAAGACCCGTTCTCCAAGGATCACGGCTGACGGCGTGGGAGCTGATGCAGGGCGGAATTG
ATGTCACGCTCATTACCGACAGCATGGCCGCCCATACAATGAAGGAAAAACATATTTCTGCGGTCATTGTCGGCGCTGAC
AGAATTGCAAAAAACGGTGATACGGCCAACAAAATCGGAACGTACGGCCTCGCTATTTTGGCAAACGCCTTTCAAATTCC
GTTTTTTGTGGCCGCACCGCTTTCGACATTTGACTTGCAGATTGAAAACGGCGATCAGATTCCGATTGAAGAGAGAGATC
CGGATGAAGTCAGACAGATCTCCGGCATACGCACCGCTCCCGAAGATGTGCCGGTCTTCAATCCGGCCTTTGACATCACA
CCGGGCAGCCTGATTTCCGGCATTATAACCGAGAAAGGAATTGTGACCGGTTCTTACACGGAAGAAATTGAACAATTATT
CGCTGACTGCCAGCTGAGCTGA

Upstream 100 bases:

>100_bases
GCTTGACATCGGCGCCTATTATATCGAAAACAGAAAAGAACTGAAGCATATCACCGAGGTTCTGGACCAATTTAAGCTCC
GTGTAAAGGAATGATGCAGC

Downstream 100 bases:

>100_bases
AAAACCGCTGATGATATTGCCTCAGGCAATGTCAGCGGTTTTTTTGTCTGCACAATGTAATCACTTCATCTTTTTGGACG
GCTGTAATGAGATGCATTTT

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTNEFAIPRSVEWKETYIRILNQQKLPDVTEYVELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFR
RQFADVKTYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTIC
NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGAD
RIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDIT
PGSLISGIITEKGIVTGSYTEEIEQLFADCQLS

Sequences:

>Translated_353_residues
MTNEFAIPRSVEWKETYIRILNQQKLPDVTEYVELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFR
RQFADVKTYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTIC
NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGAD
RIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDIT
PGSLISGIITEKGIVTGSYTEEIEQLFADCQLS
>Mature_352_residues
TNEFAIPRSVEWKETYIRILNQQKLPDVTEYVELETKEDVFDAIVTLKVRGAPAIGITAAFGLALSAKSFEARDLSDFRR
QFADVKTYLNSSRPTAVNLAWALDRLTDSIRDAISINEAKTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICN
AGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGADR
IAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQISGIRTAPEDVPVFNPAFDITP
GSLISGIITEKGIVTGSYTEEIEQLFADCQLS

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=339, Percent_Identity=40.117994100295, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI23943880, Length=331, Percent_Identity=36.2537764350453, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17557462, Length=331, Percent_Identity=36.2537764350453, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17557123, Length=138, Percent_Identity=31.1594202898551, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6325375, Length=400, Percent_Identity=37, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6322878, Length=185, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357667, Length=347, Percent_Identity=39.193083573487, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24651647, Length=347, Percent_Identity=39.193083573487, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI21358605, Length=210, Percent_Identity=28.0952380952381, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_BACA2 (A7Z3X0)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001420927.1
- ProteinModelPortal:   A7Z3X0
- SMR:   A7Z3X0
- STRING:   A7Z3X0
- EnsemblBacteria:   EBBACT00000004712
- GeneID:   5462386
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_013330
- eggNOG:   COG0182
- GeneTree:   EBGT00050000000839
- HOGENOM:   HBG682649
- OMA:   LNQTKLP
- ProtClustDB:   PRK05720
- BioCyc:   BAMY326423:RBAM_013330-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38860; Mature: 38728

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: ACT_SITE 240-240 BINDING 94-94 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNEFAIPRSVEWKETYIRILNQQKLPDVTEYVELETKEDVFDAIVTLKVRGAPAIGITA
CCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHEEEEEEECCCCCCHHHH
AFGLALSAKSFEARDLSDFRRQFADVKTYLNSSRPTAVNLAWALDRLTDSIRDAISINEA
HHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCHH
KTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIATSRYGTALAPFYLA
HHHHEEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHC
KQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGAD
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCEEEEEEECHHHHHHHHHHCEEEEEEEHH
RIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQI
HHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHH
SGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVTGSYTEEIEQLFADCQLS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TNEFAIPRSVEWKETYIRILNQQKLPDVTEYVELETKEDVFDAIVTLKVRGAPAIGITA
CCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHEEEEEEECCCCCCHHHH
AFGLALSAKSFEARDLSDFRRQFADVKTYLNSSRPTAVNLAWALDRLTDSIRDAISINEA
HHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCHH
KTTLVHEAIQIQIEDEETCRMIGQNALHLFKKGDQIMTICNAGSIATSRYGTALAPFYLA
HHHHEEEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHC
KQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKHISAVIVGAD
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCEEEEEEECHHHHHHHHHHCEEEEEEEHH
RIAKNGDTANKIGTYGLAILANAFQIPFFVAAPLSTFDLQIENGDQIPIEERDPDEVRQI
HHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHH
SGIRTAPEDVPVFNPAFDITPGSLISGIITEKGIVTGSYTEEIEQLFADCQLS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA