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The map label for this gene is htrA [H]

Identifier: 154685708

GI number: 154685708

Start: 1237407

End: 1238759

Strand: Reverse

Name: htrA [H]

Synonym: RBAM_012750

Alternate gene names: 154685708

Gene position: 1238759-1237407 (Counterclockwise)

Preceding gene: 154685719

Following gene: 154685704

Centisome position: 31.61

GC content: 49.89

Gene sequence:

>1353_bases
ATGATGGATAACTATCGTGATGAAAATCGGACAGACCAAAAAGAACAGGAAGTCCTTTTAGTAAAAGAAAACCCGCAGCC
GGCCGGATATTCCGCGCCGGACGAGGACAAGAAAAAACGAAGCTTCGGCTGGTTCAGACCGCTTCTCGGCGGAGTGATCG
GCGGAGGGCTCGCCCTCGGCATCTATACATTTACGCCGCTTGGAGACCATCAGACTCAAGATACTTCCAATCCGGCTCCC
GCTCAGGAAACGTCATCGGTAACCGCCAAGCAGACATCTTCTGAATCAGACAGCGGCAAATCGGCAAACAGCTCATCGGC
AAATTCAAGCAGCATTTCGAATATGGTGGAAGACATTTCACCGGCGATCGTCGGGATCACCAATCTGCAGAAGCAGCAAA
GCAGTTCCGATTTATTCGGATTCGGATCAAGCTCAGATTCAAACTCTAATTCGTCGGGTGATGATGCGGAAACGGGATCG
GGTTCAGGCGTTATTTTTAAGAAAGCAAACGGCAAAGCGTATATCATTACGAATAACCACGTGGTCGAAGGCGCCTCTTC
CCTTAAAGTGTCATTATTTGACGGCACCGATGTAACAGCTAAACTCGTCGGCAGCGACTCTCTGACAGACTTGGCCGTTT
TAGAAATCAGCGATAAACACGTGACAAAAACGGCAAGTTTCGGCAGCTCATCCGCTCTCAGAACGGGTGAATCCGTCATC
GCCATCGGTGATCCGCTCGGAAAAGACCTTTCCCGCACCGTCACACAAGGCATCGTGAGCGGCTTAAACAGAACCGTCTC
GATCTCTACGTCAGCCGGCGAGTCGAGCATCAACGTCATCCAAACCGATGCCGCCATCAATCCCGGAAACAGCGGCGGAC
CGCTCTTGAATACAGACGGCAAAATCATCGGCATCAACAGCATGAAAATCAGCGAAAGTGATGTAGAAGGCATCGGCTTT
GCCATCCCGAGCAACGATGTAAAACCGATCGCCGAAGAGCTTCTCACGAAAGGACAGGTGGAGCGCCCTTATATCGGCGT
GAGCATGATCGACTTGGAACAAGTGCCGCAAAACTATCAGGAAGGCACACTCGGGCTTTTCGGCAAACAGCTGAATAAAG
GCGTTTATATTCGCGAAGTGGCGCAGGGCTCACCTGCTGCCAAAGCCGGATTAAAAGCAGAAGACATCATTATCAGCTTA
AAAGGGAAAGAAACCGGCACGGGCAGCGAACTCCGCAATATTCTCTACAAGAATACGAAAGTCGGCAGCACCGTTGACGT
GAAGATTATCAGAAACGGCAAGGAAATGACGAAAAAAATGAAACTGACTCAAAAAGAAGAAACATCTTCTTAA

Upstream 100 bases:

>100_bases
TCCCACAATCTTTTCATTATTATCCCACACTTTTTGTTTAAGATGGAGTCAGTAATAATAGGCAAATCATGCTATGATGA
AATAGAGAAACGGAGTGAAC

Downstream 100 bases:

>100_bases
CAAAAATCCAAGGCAGCCGCCTTGGATTTTTTATATACAGATGAAACTTTAGGCCTGGATCAGCCGTATGACTTAGTGTA
CAGGAGGATACATACACATG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MMDNYRDENRTDQKEQEVLLVKENPQPAGYSAPDEDKKKRSFGWFRPLLGGVIGGGLALGIYTFTPLGDHQTQDTSNPAP
AQETSSVTAKQTSSESDSGKSANSSSANSSSISNMVEDISPAIVGITNLQKQQSSSDLFGFGSSSDSNSNSSGDDAETGS
GSGVIFKKANGKAYIITNNHVVEGASSLKVSLFDGTDVTAKLVGSDSLTDLAVLEISDKHVTKTASFGSSSALRTGESVI
AIGDPLGKDLSRTVTQGIVSGLNRTVSISTSAGESSINVIQTDAAINPGNSGGPLLNTDGKIIGINSMKISESDVEGIGF
AIPSNDVKPIAEELLTKGQVERPYIGVSMIDLEQVPQNYQEGTLGLFGKQLNKGVYIREVAQGSPAAKAGLKAEDIIISL
KGKETGTGSELRNILYKNTKVGSTVDVKIIRNGKEMTKKMKLTQKEETSS

Sequences:

>Translated_450_residues
MMDNYRDENRTDQKEQEVLLVKENPQPAGYSAPDEDKKKRSFGWFRPLLGGVIGGGLALGIYTFTPLGDHQTQDTSNPAP
AQETSSVTAKQTSSESDSGKSANSSSANSSSISNMVEDISPAIVGITNLQKQQSSSDLFGFGSSSDSNSNSSGDDAETGS
GSGVIFKKANGKAYIITNNHVVEGASSLKVSLFDGTDVTAKLVGSDSLTDLAVLEISDKHVTKTASFGSSSALRTGESVI
AIGDPLGKDLSRTVTQGIVSGLNRTVSISTSAGESSINVIQTDAAINPGNSGGPLLNTDGKIIGINSMKISESDVEGIGF
AIPSNDVKPIAEELLTKGQVERPYIGVSMIDLEQVPQNYQEGTLGLFGKQLNKGVYIREVAQGSPAAKAGLKAEDIIISL
KGKETGTGSELRNILYKNTKVGSTVDVKIIRNGKEMTKKMKLTQKEETSS
>Mature_450_residues
MMDNYRDENRTDQKEQEVLLVKENPQPAGYSAPDEDKKKRSFGWFRPLLGGVIGGGLALGIYTFTPLGDHQTQDTSNPAP
AQETSSVTAKQTSSESDSGKSANSSSANSSSISNMVEDISPAIVGITNLQKQQSSSDLFGFGSSSDSNSNSSGDDAETGS
GSGVIFKKANGKAYIITNNHVVEGASSLKVSLFDGTDVTAKLVGSDSLTDLAVLEISDKHVTKTASFGSSSALRTGESVI
AIGDPLGKDLSRTVTQGIVSGLNRTVSISTSAGESSINVIQTDAAINPGNSGGPLLNTDGKIIGINSMKISESDVEGIGF
AIPSNDVKPIAEELLTKGQVERPYIGVSMIDLEQVPQNYQEGTLGLFGKQLNKGVYIREVAQGSPAAKAGLKAEDIIISL
KGKETGTGSELRNILYKNTKVGSTVDVKIIRNGKEMTKKMKLTQKEETSS

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=338, Percent_Identity=34.0236686390533, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI22129776, Length=310, Percent_Identity=34.8387096774194, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI7019477, Length=335, Percent_Identity=33.4328358208955, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI24308541, Length=332, Percent_Identity=31.3253012048193, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786356, Length=300, Percent_Identity=39, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1789629, Length=337, Percent_Identity=36.4985163204748, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1789630, Length=306, Percent_Identity=36.6013071895425, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24646839, Length=308, Percent_Identity=36.038961038961, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 47241; Mature: 47241

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDNYRDENRTDQKEQEVLLVKENPQPAGYSAPDEDKKKRSFGWFRPLLGGVIGGGLALG
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHEEE
IYTFTPLGDHQTQDTSNPAPAQETSSVTAKQTSSESDSGKSANSSSANSSSISNMVEDIS
EEEECCCCCCCCCCCCCCCCCCHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PAIVGITNLQKQQSSSDLFGFGSSSDSNSNSSGDDAETGSGSGVIFKKANGKAYIITNNH
CCEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCE
VVEGASSLKVSLFDGTDVTAKLVGSDSLTDLAVLEISDKHVTKTASFGSSSALRTGESVI
EECCCCCEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCEEEECCCCCCCHHCCCCEEE
AIGDPLGKDLSRTVTQGIVSGLNRTVSISTSAGESSINVIQTDAAINPGNSGGPLLNTDG
EECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCEECCCCCCCCEEECCC
KIIGINSMKISESDVEGIGFAIPSNDVKPIAEELLTKGQVERPYIGVSMIDLEQVPQNYQ
CEEEEECEEECCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCEECEEEEEHHHHCCCCC
EGTLGLFGKQLNKGVYIREVAQGSPAAKAGLKAEDIIISLKGKETGTGSELRNILYKNTK
CCCHHHHHHHHCCCEEEEEHHCCCCHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCC
VGSTVDVKIIRNGKEMTKKMKLTQKEETSS
CCCEEEEEEEECCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMDNYRDENRTDQKEQEVLLVKENPQPAGYSAPDEDKKKRSFGWFRPLLGGVIGGGLALG
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHEEE
IYTFTPLGDHQTQDTSNPAPAQETSSVTAKQTSSESDSGKSANSSSANSSSISNMVEDIS
EEEECCCCCCCCCCCCCCCCCCHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PAIVGITNLQKQQSSSDLFGFGSSSDSNSNSSGDDAETGSGSGVIFKKANGKAYIITNNH
CCEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCE
VVEGASSLKVSLFDGTDVTAKLVGSDSLTDLAVLEISDKHVTKTASFGSSSALRTGESVI
EECCCCCEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCEEEECCCCCCCHHCCCCEEE
AIGDPLGKDLSRTVTQGIVSGLNRTVSISTSAGESSINVIQTDAAINPGNSGGPLLNTDG
EECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCEECCCCCCCCEEECCC
KIIGINSMKISESDVEGIGFAIPSNDVKPIAEELLTKGQVERPYIGVSMIDLEQVPQNYQ
CEEEEECEEECCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCEECEEEEEHHHHCCCCC
EGTLGLFGKQLNKGVYIREVAQGSPAAKAGLKAEDIIISLKGKETGTGSELRNILYKNTK
CCCHHHHHHHHCCCEEEEEHHCCCCHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCC
VGSTVDVKIIRNGKEMTKKMKLTQKEETSS
CCCEEEEEEEECCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]