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The map label for this gene is prsA [H]

Identifier: 154685453

GI number: 154685453

Start: 997920

End: 998771

Strand: Reverse

Name: prsA [H]

Synonym: RBAM_010190

Alternate gene names: 154685453

Gene position: 998771-997920 (Counterclockwise)

Preceding gene: 154685454

Following gene: 154685445

Centisome position: 25.49

GC content: 43.31

Gene sequence:

>852_bases
ATGAAGAAAATCGCGATAGCAGCTATTACGGCAACGAGCGTCCTGGCTCTCAGCGCTTGCAGCAGCGGCGACAACGACGT
GATTGCCAAGACGGATGCCGGAAATGTAACAAAAGGCGAGCTCTACACGAACATGAAAAAAACCGCGGGCGCAAGTGTGC
TGACACAGCTCGTACAAGAAAAAGTATTAGCAAAAAAATACAAAGTAACGGATAAAGAAATCGATACCAAGCTGAAAGAG
TACAAAACGCAGCTCGGCGATCAGTACAGCTCCCTTAAACAGCAGTACGGCGAAGATTACCTGAAAGATCAGGTGAAGTA
CGAACTGCTTGCACAAAAAGCGGCGAAAGACAACATCAAAGTGACTGACTCCGATACGAAAGAATATTACGACGGCTTAA
AAGGTAAAATCCGCGCGAGCCACATCCTTGTCGCTGACAAAAAGACAGCTGACGAAGTGGAGAAAAAGCTGAAAAAAGGC
GAGAAGTTTGAAACGCTTGCGAAAGAATATTCAACTGACAGCTCAAAAGACAACGGCGGCGACCTTGGCTGGTTCGATAA
AAAGTCAATGGATGAAACATTCAGCAAAGCTGCATTCGGCCTGAAAGTCGGACAAGTCAGCGATCCGGTCAAAACAAAAT
TCGGTTATCATATCATCAAAAAGACAGAAGAACGCGGCAAATATGATGACATGAAAAAAGAACTGAAAGAAGAAGTTCTT
AAGCAGAAATTAAACGACAACTCAGCTGTACAGGCGGCAATTCAAAAAGTCATGAAAAAAGCTGACGTAAAAGTGGAAGA
CAAAGACTTAAAAGACACGTTTAACACTTCAACTTCTTCTGAATCTAAATAA

Upstream 100 bases:

>100_bases
TAGACGAATGCCCTTTATTTAAAATCTTTTTACAGAAAGCCACAATATGTTATGATACGCATATGCAATTTAATTTGGAT
GATTAGGAGTGTTTAAAGGA

Downstream 100 bases:

>100_bases
AAAAACTGTGCGGGCTCTCGGTGAGCCGCACAGTTTTTTTATGCGATGGAATGATTGGAGTTTTCTTCCGCGTCCCCGTT
TTCACTTGCGGGCGCCGCCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MKKIAIAAITATSVLALSACSSGDNDVIAKTDAGNVTKGELYTNMKKTAGASVLTQLVQEKVLAKKYKVTDKEIDTKLKE
YKTQLGDQYSSLKQQYGEDYLKDQVKYELLAQKAAKDNIKVTDSDTKEYYDGLKGKIRASHILVADKKTADEVEKKLKKG
EKFETLAKEYSTDSSKDNGGDLGWFDKKSMDETFSKAAFGLKVGQVSDPVKTKFGYHIIKKTEERGKYDDMKKELKEEVL
KQKLNDNSAVQAAIQKVMKKADVKVEDKDLKDTFNTSTSSESK

Sequences:

>Translated_283_residues
MKKIAIAAITATSVLALSACSSGDNDVIAKTDAGNVTKGELYTNMKKTAGASVLTQLVQEKVLAKKYKVTDKEIDTKLKE
YKTQLGDQYSSLKQQYGEDYLKDQVKYELLAQKAAKDNIKVTDSDTKEYYDGLKGKIRASHILVADKKTADEVEKKLKKG
EKFETLAKEYSTDSSKDNGGDLGWFDKKSMDETFSKAAFGLKVGQVSDPVKTKFGYHIIKKTEERGKYDDMKKELKEEVL
KQKLNDNSAVQAAIQKVMKKADVKVEDKDLKDTFNTSTSSESK
>Mature_283_residues
MKKIAIAAITATSVLALSACSSGDNDVIAKTDAGNVTKGELYTNMKKTAGASVLTQLVQEKVLAKKYKVTDKEIDTKLKE
YKTQLGDQYSSLKQQYGEDYLKDQVKYELLAQKAAKDNIKVTDSDTKEYYDGLKGKIRASHILVADKKTADEVEKKLKKG
EKFETLAKEYSTDSSKDNGGDLGWFDKKSMDETFSKAAFGLKVGQVSDPVKTKFGYHIIKKTEERGKYDDMKKELKEEVL
KQKLNDNSAVQAAIQKVMKKADVKVEDKDLKDTFNTSTSSESK

Specific function: Essential protein that plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Has PPIase activity but it is not essential for its function in vivo [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=89, Percent_Identity=42.6966292134831, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1790211, Length=82, Percent_Identity=42.6829268292683, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17537235, Length=89, Percent_Identity=43.8202247191011, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=90, Percent_Identity=42.2222222222222, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356303, Length=89, Percent_Identity=42.6966292134831, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF05698 Trigger_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 31523; Mature: 31523

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAIAAITATSVLALSACSSGDNDVIAKTDAGNVTKGELYTNMKKTAGASVLTQLVQE
CCCEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KVLAKKYKVTDKEIDTKLKEYKTQLGDQYSSLKQQYGEDYLKDQVKYELLAQKAAKDNIK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCE
VTDSDTKEYYDGLKGKIRASHILVADKKTADEVEKKLKKGEKFETLAKEYSTDSSKDNGG
ECCCCHHHHHCCCCCCEEHHEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
DLGWFDKKSMDETFSKAAFGLKVGQVSDPVKTKFGYHIIKKTEERGKYDDMKKELKEEVL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KQKLNDNSAVQAAIQKVMKKADVKVEDKDLKDTFNTSTSSESK
HHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKKIAIAAITATSVLALSACSSGDNDVIAKTDAGNVTKGELYTNMKKTAGASVLTQLVQE
CCCEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KVLAKKYKVTDKEIDTKLKEYKTQLGDQYSSLKQQYGEDYLKDQVKYELLAQKAAKDNIK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCE
VTDSDTKEYYDGLKGKIRASHILVADKKTADEVEKKLKKGEKFETLAKEYSTDSSKDNGG
ECCCCHHHHHCCCCCCEEHHEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
DLGWFDKKSMDETFSKAAFGLKVGQVSDPVKTKFGYHIIKKTEERGKYDDMKKELKEEVL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KQKLNDNSAVQAAIQKVMKKADVKVEDKDLKDTFNTSTSSESK
HHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1956302; 9579061; 9384377; 3145906 [H]