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The map label for this gene is gabP [H]

Identifier: 154685126

GI number: 154685126

Start: 645504

End: 646889

Strand: Reverse

Name: gabP [H]

Synonym: RBAM_006710

Alternate gene names: 154685126

Gene position: 646889-645504 (Counterclockwise)

Preceding gene: 154685154

Following gene: 154685125

Centisome position: 16.51

GC content: 48.34

Gene sequence:

>1386_bases
ATGAATCAGCCTAACTCTTTATCAAAGGGATTAAAAACCCGGCATATGACTATGATTTCAATTGCCGGCGTGATCGGCGC
CGGATTATTTGTCGGAAGCGGATCAGTCATTCATTCCACCGGACCCGGAGCGATTGTCTCCTACGCTTTAGCAGGATTAT
TAGTGATTTTTATTATGAGAATGCTGGGGGAAATGTCCTCCGTCAACCCGACAAGCGGTTCATTTTCACAGTACGCGCAT
GACGCCATCGGTCCTTGGGCCGGTTTTACGATCGGATGGCTGTATTGGTTTTTCTGGGTCATCGTCATTGCCATTGAAGC
CATTGCAGGCGCCGGAATCATACAGTACTGGTTCCCGGGCATTCCGTTATGGCTGACGAGTCTGCTTCTGACCGTGCTGT
TAACACTGACGAATATTTATTCAGTTAAATCGTTCGGCGAATTTGAATACTGGCTTTCCTTAGTGAAGGTAGCGACGATC
GTTGTCTTCTTAATCGCGGGATTTGCGTTCATTTTCGGAATCGTCCCCGGCAGCAAACCGGTCGGGCTGGAAAATCTGGC
GGGCAGCGGCGGATTTTTCCCTAAAGGTCCAAGTTCCGTTCTGCTCGGCATTGTCGTTGTCATTTTTTCTTTCATGGGAT
CTGAAATCGTCGCAATCGCAGCGGGAGAAACGTCAAATCCGGTCGAATCCGTCACAAAGGCGACCCGCTCAGTCGTTTGG
CGGATCATTATTTTTTACGTCGGCTCCATTGCGGTTGTGGTCACACTGCTGCCGTGGGATTCAGCCAATATTTTGGAAAG
CCCCTTCGTTGCCGTTTTGAGCCATATCGGGGTTCCCGCAGCCGCTCAAATCATGAATTTCATCGTCCTGACAGCCGTTC
TGTCCTGCCTGAACTCCGGGCTTTATACGACGTCACGGATGCTGTATTCACTGGCAGAGCGAAATGAAGCGCCGCGGCGT
TTTATGAAACTGAGTAAAAGAGGCGTACCGGTTCAAGCCATTATCGCCGGCACCTTTTTCTCCTATATTGCCGTTGTTAT
GAACTACTTTTCTCCCGACTCCGTATTTTTGTTCCTGGTCAATTCATCAGGGGCGATCGCACTGCTCGTCTATCTCGTCA
TCGCCGTCTCACATCTGAGAATGAGAAAGAAAATCGAACGGACAAACCCTGAATCTCTTAAAATCAAAATGTGGTTCTAT
CCGTACTTAACCTACCTGACGATCATCGCCATTTGCGCCATCTTGTTATCTATGCTGTTTATCAGTTCAATGCGGTCTGA
ATTTCTGCTGACAGGATTTATTACTCTGCTGGTACTTGCCTCATATGTATTCCGCAAAAAACAAAAACCGAAAGAGAGCG
CTTCCGAAAGCCGGGTTGCGCAATAA

Upstream 100 bases:

>100_bases
TGTCATATTTTCTTACATCATTTTCAACTGCCTGTGGCATTTATGATAGAATAATACTTGTCGGAATATTCAGCATAAAC
AAACCAAAAGGAGGCAAAGA

Downstream 100 bases:

>100_bases
CCGTAAACACCCCCCTCAAAAAGGGCGGGTGTTTTTTTAACCAACCTGTTCCAGGCAGCATTAACTGTAGTACAGGATTT
CAATAAATGATAAGGACAGG

Product: GabP

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNQPNSLSKGLKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPGAIVSYALAGLLVIFIMRMLGEMSSVNPTSGSFSQYAH
DAIGPWAGFTIGWLYWFFWVIVIAIEAIAGAGIIQYWFPGIPLWLTSLLLTVLLTLTNIYSVKSFGEFEYWLSLVKVATI
VVFLIAGFAFIFGIVPGSKPVGLENLAGSGGFFPKGPSSVLLGIVVVIFSFMGSEIVAIAAGETSNPVESVTKATRSVVW
RIIIFYVGSIAVVVTLLPWDSANILESPFVAVLSHIGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRR
FMKLSKRGVPVQAIIAGTFFSYIAVVMNYFSPDSVFLFLVNSSGAIALLVYLVIAVSHLRMRKKIERTNPESLKIKMWFY
PYLTYLTIIAICAILLSMLFISSMRSEFLLTGFITLLVLASYVFRKKQKPKESASESRVAQ

Sequences:

>Translated_461_residues
MNQPNSLSKGLKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPGAIVSYALAGLLVIFIMRMLGEMSSVNPTSGSFSQYAH
DAIGPWAGFTIGWLYWFFWVIVIAIEAIAGAGIIQYWFPGIPLWLTSLLLTVLLTLTNIYSVKSFGEFEYWLSLVKVATI
VVFLIAGFAFIFGIVPGSKPVGLENLAGSGGFFPKGPSSVLLGIVVVIFSFMGSEIVAIAAGETSNPVESVTKATRSVVW
RIIIFYVGSIAVVVTLLPWDSANILESPFVAVLSHIGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRR
FMKLSKRGVPVQAIIAGTFFSYIAVVMNYFSPDSVFLFLVNSSGAIALLVYLVIAVSHLRMRKKIERTNPESLKIKMWFY
PYLTYLTIIAICAILLSMLFISSMRSEFLLTGFITLLVLASYVFRKKQKPKESASESRVAQ
>Mature_461_residues
MNQPNSLSKGLKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPGAIVSYALAGLLVIFIMRMLGEMSSVNPTSGSFSQYAH
DAIGPWAGFTIGWLYWFFWVIVIAIEAIAGAGIIQYWFPGIPLWLTSLLLTVLLTLTNIYSVKSFGEFEYWLSLVKVATI
VVFLIAGFAFIFGIVPGSKPVGLENLAGSGGFFPKGPSSVLLGIVVVIFSFMGSEIVAIAAGETSNPVESVTKATRSVVW
RIIIFYVGSIAVVVTLLPWDSANILESPFVAVLSHIGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRR
FMKLSKRGVPVQAIIAGTFFSYIAVVMNYFSPDSVFLFLVNSSGAIALLVYLVIAVSHLRMRKKIERTNPESLKIKMWFY
PYLTYLTIIAICAILLSMLFISSMRSEFLLTGFITLLVLASYVFRKKQKPKESASESRVAQ

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=335, Percent_Identity=26.2686567164179, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258645169, Length=367, Percent_Identity=22.8882833787466, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789017, Length=449, Percent_Identity=48.7750556792873, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1788480, Length=411, Percent_Identity=40.3892944038929, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1786302, Length=446, Percent_Identity=36.322869955157, Blast_Score=312, Evalue=4e-86,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=36.9127516778523, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI48994972, Length=461, Percent_Identity=36.8763557483731, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI87081708, Length=464, Percent_Identity=35.5603448275862, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1790653, Length=395, Percent_Identity=38.2278481012658, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1786602, Length=399, Percent_Identity=38.0952380952381, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=37.7450980392157, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI2367353, Length=328, Percent_Identity=26.5243902439024, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081869, Length=328, Percent_Identity=26.219512195122, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=436, Percent_Identity=32.5688073394495, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=462, Percent_Identity=30.7359307359307, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6324924, Length=439, Percent_Identity=29.6127562642369, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=434, Percent_Identity=30.8755760368664, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=410, Percent_Identity=33.1707317073171, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6320717, Length=399, Percent_Identity=28.8220551378446, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=434, Percent_Identity=31.1059907834101, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=418, Percent_Identity=28.4688995215311, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=394, Percent_Identity=31.2182741116751, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=29.3532338308458, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319824, Length=402, Percent_Identity=27.6119402985075, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=397, Percent_Identity=26.448362720403, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=29.3233082706767, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=403, Percent_Identity=28.0397022332506, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=351, Percent_Identity=31.3390313390313, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=25.629290617849, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324981, Length=406, Percent_Identity=29.5566502463054, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320364, Length=492, Percent_Identity=26.4227642276423, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221512776, Length=413, Percent_Identity=22.0338983050847, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666159, Length=413, Percent_Identity=22.0338983050847, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667468, Length=413, Percent_Identity=23.0024213075061, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161077963, Length=357, Percent_Identity=26.0504201680672, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24668806, Length=411, Percent_Identity=24.0875912408759, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21356285, Length=411, Percent_Identity=24.0875912408759, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24668802, Length=411, Percent_Identity=24.0875912408759, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50195; Mature: 50195

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]