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The map label for this gene is ycsA [H]

Identifier: 154685071

GI number: 154685071

Start: 586058

End: 586906

Strand: Reverse

Name: ycsA [H]

Synonym: RBAM_006090

Alternate gene names: 154685071

Gene position: 586906-586058 (Counterclockwise)

Preceding gene: 154685074

Following gene: 154685066

Centisome position: 14.98

GC content: 51.35

Gene sequence:

>849_bases
TTGTTTTTGGGAGCGGCGGGGAATCAAAAACTCGTCCCCGATCATGTTTCGCTGAGGGGGCTGCTCATCAAGATACGCCG
GGAATTTGAACAGGTGATTAATGTGCGGCCGGCGAAGCTCCTGCCGGGAATCACTTCCCCCCTCGTTAACCCGAAAGATT
TTGATCTGATAGTCGTCCGCGAAAACAGTGAGGGCGAGTACAGCTCTGTCGGCGGCAGAATCTATCAGGGTGAGGACGAA
ATCGCCATACAAAACGCGGTCTTTTCCCGACGGGGTACGGAAAGAGTGATGCGGTATGCTTTCGAACTGGCGGCAAGTCG
GCGGAAACACGTCACAAGCGCGACGAAATCAAACGGTATTGTTCACTCGATGCCGTTCTGGGATGACATCTTTAAAGAGG
TCAGCCGGGAGTACGCCGGGATTGAGACGGATTCCCAGCACATCGATGCACTGGCGGCCTTCTATGTCACGCAGCCGGAA
CGCTTTGATGTCATTGTCGCTTCGAATCTGTTCGGAGATGTGCTGACAGATATCGGCGCGGCGATTATGGGAAGCATCGG
AATCGCTCCCGCAGCCAACATCAATGTAAACGGCAAATATCCTTCCATGTTTGAGCCTGTTCACGGCTCCGCCCCGGATA
TTGTCGGGAAAGGAATTGCCAATCCTATAGGCCAAATATGGACGGCGAAATTAATGCTCGATTCATTCCGAGAAGAGGAA
CTGGGCCATCTCCTCTTACAATCTATTGAAATGGTCACAAACAGCGGCATTCTGACTCCTGATGTCGGCGGAAAACATTC
AACGGAAGATGTCACTTCCGCTATTATTTCTCAAATCAAGAACAGATAA

Upstream 100 bases:

>100_bases
CTTTGATTTCACTTCTTTTCCGCGGAGCTGCGAGTATTATTTGGAGCACGGGACGATGATGCCGGATGATGGATGAGAAA
CGTTACAGCACTTTGATGCT

Downstream 100 bases:

>100_bases
TACGAAAAAAACCGCGGGCAGGAAAACGGCACAGCGGTTTTTTTCGTCTCAGACGGGACGGATCGCGCAGAAACAGGCCG
ATTCACCTGTGAAGCCCGCA

Product: YcsA

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MFLGAAGNQKLVPDHVSLRGLLIKIRREFEQVINVRPAKLLPGITSPLVNPKDFDLIVVRENSEGEYSSVGGRIYQGEDE
IAIQNAVFSRRGTERVMRYAFELAASRRKHVTSATKSNGIVHSMPFWDDIFKEVSREYAGIETDSQHIDALAAFYVTQPE
RFDVIVASNLFGDVLTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIVGKGIANPIGQIWTAKLMLDSFREEE
LGHLLLQSIEMVTNSGILTPDVGGKHSTEDVTSAIISQIKNR

Sequences:

>Translated_282_residues
MFLGAAGNQKLVPDHVSLRGLLIKIRREFEQVINVRPAKLLPGITSPLVNPKDFDLIVVRENSEGEYSSVGGRIYQGEDE
IAIQNAVFSRRGTERVMRYAFELAASRRKHVTSATKSNGIVHSMPFWDDIFKEVSREYAGIETDSQHIDALAAFYVTQPE
RFDVIVASNLFGDVLTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIVGKGIANPIGQIWTAKLMLDSFREEE
LGHLLLQSIEMVTNSGILTPDVGGKHSTEDVTSAIISQIKNR
>Mature_282_residues
MFLGAAGNQKLVPDHVSLRGLLIKIRREFEQVINVRPAKLLPGITSPLVNPKDFDLIVVRENSEGEYSSVGGRIYQGEDE
IAIQNAVFSRRGTERVMRYAFELAASRRKHVTSATKSNGIVHSMPFWDDIFKEVSREYAGIETDSQHIDALAAFYVTQPE
RFDVIVASNLFGDVLTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIVGKGIANPIGQIWTAKLMLDSFREEE
LGHLLLQSIEMVTNSGILTPDVGGKHSTEDVTSAIISQIKNR

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=270, Percent_Identity=31.4814814814815, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4758582, Length=280, Percent_Identity=30, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI28178838, Length=236, Percent_Identity=31.7796610169492, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI28178816, Length=263, Percent_Identity=27.7566539923954, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI28178821, Length=266, Percent_Identity=27.0676691729323, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI28178819, Length=202, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788101, Length=288, Percent_Identity=53.8194444444444, Blast_Score=310, Evalue=5e-86,
Organism=Escherichia coli, GI87081683, Length=272, Percent_Identity=37.8676470588235, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1787381, Length=289, Percent_Identity=29.0657439446367, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=266, Percent_Identity=30.8270676691729, Blast_Score=133, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17550882, Length=270, Percent_Identity=31.8518518518519, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=247, Percent_Identity=28.3400809716599, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25144293, Length=283, Percent_Identity=25.4416961130742, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322097, Length=270, Percent_Identity=34.8148148148148, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6324709, Length=270, Percent_Identity=33.7037037037037, Blast_Score=128, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6324291, Length=287, Percent_Identity=31.3588850174216, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319830, Length=294, Percent_Identity=29.9319727891156, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24643268, Length=267, Percent_Identity=31.8352059925094, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24643270, Length=267, Percent_Identity=31.8352059925094, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24661184, Length=279, Percent_Identity=30.4659498207885, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI161078635, Length=262, Percent_Identity=30.9160305343511, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI161078637, Length=262, Percent_Identity=30.9160305343511, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI161078633, Length=262, Percent_Identity=30.9160305343511, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24650122, Length=262, Percent_Identity=30.9160305343511, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI161078639, Length=262, Percent_Identity=30.9160305343511, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI281362242, Length=277, Percent_Identity=28.8808664259928, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648872, Length=277, Percent_Identity=28.8808664259928, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130355, Length=263, Percent_Identity=28.1368821292776, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 30862; Mature: 30862

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLGAAGNQKLVPDHVSLRGLLIKIRREFEQVINVRPAKLLPGITSPLVNPKDFDLIVVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCEEEEEE
ENSEGEYSSVGGRIYQGEDEIAIQNAVFSRRGTERVMRYAFELAASRRKHVTSATKSNGI
ECCCCCHHHCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VHSMPFWDDIFKEVSREYAGIETDSQHIDALAAFYVTQPERFDVIVASNLFGDVLTDIGA
EECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHH
AIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIVGKGIANPIGQIWTAKLMLDSFREEE
HHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LGHLLLQSIEMVTNSGILTPDVGGKHSTEDVTSAIISQIKNR
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFLGAAGNQKLVPDHVSLRGLLIKIRREFEQVINVRPAKLLPGITSPLVNPKDFDLIVVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCEEEEEE
ENSEGEYSSVGGRIYQGEDEIAIQNAVFSRRGTERVMRYAFELAASRRKHVTSATKSNGI
ECCCCCHHHCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VHSMPFWDDIFKEVSREYAGIETDSQHIDALAAFYVTQPERFDVIVASNLFGDVLTDIGA
EECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHH
AIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIVGKGIANPIGQIWTAKLMLDSFREEE
HHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LGHLLLQSIEMVTNSGILTPDVGGKHSTEDVTSAIISQIKNR
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]