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The map label for this gene is fabF [H]

Identifier: 154685063

GI number: 154685063

Start: 578775

End: 580010

Strand: Reverse

Name: fabF [H]

Synonym: RBAM_006010

Alternate gene names: 154685063

Gene position: 580010-578775 (Counterclockwise)

Preceding gene: 154685065

Following gene: 154685060

Centisome position: 14.8

GC content: 53.24

Gene sequence:

>1236_bases
ATGAAAAGAGTTGTGATCACCGGAATGGGAGTGATTTCACCTCTCGGCAATGATGTGCATACATTTTGGAAACACCTGAC
GGAAGGAAAATCAGGAATCTCTCCTATCGATTCGTTTGATGTCTCCGGCTCAAAGACAAAAATAGCCGGTACCGTCCGTG
ATTTTGACGCAGAAGAAAGATGGGGCAGAAAAGAAGCTAGACGCCTTGACCGTTTCAGCCAGTTTGCTTTAGCGGCAGCG
GAACAGGCGCTTGAAAGCTCCGGGATTCAGCTCGATCAGATTGACCGTGAACGCCTCGGCGTGTACGTCGGCTCTGGAAT
CGGCGGCATCACGACTTTGATTGATAACGTTCATACTTTAAATGAACGGGGAGCGCGAAAAGTGAGCCCAAGCCTTGTCC
CCATGATGATCTCAAATGCGGCCGCCGCTCAAATCAGCATCAGATTAGGCGCGCTCGGCCCCTCACTTTCTCCCGTCACC
GCGTGTTCCATCGGCAATACGTCGATCGGGGAAGCATTCAACGCCATCCGGAATGATGACGCAGATATCATGTTTGCCGG
GGGAGCGGAAGCGGCGATTACGAATTTGTCATTAGCCAGCTTCGGCAATGCCCACGCGCTGTCAGCGAGAAACGAAGACC
CCGCCGCGGCAAGCCGGCCGTTTGACGCGGATCGCGATGGATTTGTCATGAGTGAAGGCGCGGGCATCTTAGTATTGGAA
TCATTGGAAAGCGCAATCGGCAGAAATGCCCCGATCCTTTGTGAGGTGCTCGGCTACGGCGCGAGCTCTGACGCCTATCA
TATGGTGGCCTCCCATCCGGAAGGAACGGGCGCATACCTGGCGATGAAAAACGCTTTGAAAAAGGCGAACGTTTCAGCGG
AAGACATTGATGTCGTAAGCGCCCATGCGACAAGCACAAAAGCCGGAGATCTTTCTGAAACATTGGCCATCAAGACATTA
TTCGGGGAGCTTGCGTATGATATTCCGGTTACGGCCAACAAATCAATGCTCGGCCACATGCTTGGCGCGGCAGGCGGCGT
TGAAGCCATCGCTTTGACAGAGAGCCTGAGACACGGCATCATTCCGCCGACGATCAATCTGCAGCACCCTGATTCGGCAT
GTGATTTGGACTATGTAGCAGACGGGCCCCGCCAGCAATCATTAACGATCGGCCTTTCCAACTCATTCGGCTTTGGCGGG
CATAATTCGGCGATCGTGCTGAAGAAATATGAATAG

Upstream 100 bases:

>100_bases
TCTCCTCTCTTACCCTGGTATTTATTATACTAGGATAATCAACAACTTGTAATAGGATAATTGCGAGTTACAATAAATAC
ATACCGAAGGAGGAATGACC

Downstream 100 bases:

>100_bases
CGGGCATCAAAAAAAGGAGTGAATCATTTCACTCCTTTTTTGCTTTCTCCGGTTTTGTTGTTAAGGCGAAAAAAGCGATG
GAACCGATAACGGATGTCGT

Product: putative beta-ketoacyl-acyl carrier protein synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKRVVITGMGVISPLGNDVHTFWKHLTEGKSGISPIDSFDVSGSKTKIAGTVRDFDAEERWGRKEARRLDRFSQFALAAA
EQALESSGIQLDQIDRERLGVYVGSGIGGITTLIDNVHTLNERGARKVSPSLVPMMISNAAAAQISIRLGALGPSLSPVT
ACSIGNTSIGEAFNAIRNDDADIMFAGGAEAAITNLSLASFGNAHALSARNEDPAAASRPFDADRDGFVMSEGAGILVLE
SLESAIGRNAPILCEVLGYGASSDAYHMVASHPEGTGAYLAMKNALKKANVSAEDIDVVSAHATSTKAGDLSETLAIKTL
FGELAYDIPVTANKSMLGHMLGAAGGVEAIALTESLRHGIIPPTINLQHPDSACDLDYVADGPRQQSLTIGLSNSFGFGG
HNSAIVLKKYE

Sequences:

>Translated_411_residues
MKRVVITGMGVISPLGNDVHTFWKHLTEGKSGISPIDSFDVSGSKTKIAGTVRDFDAEERWGRKEARRLDRFSQFALAAA
EQALESSGIQLDQIDRERLGVYVGSGIGGITTLIDNVHTLNERGARKVSPSLVPMMISNAAAAQISIRLGALGPSLSPVT
ACSIGNTSIGEAFNAIRNDDADIMFAGGAEAAITNLSLASFGNAHALSARNEDPAAASRPFDADRDGFVMSEGAGILVLE
SLESAIGRNAPILCEVLGYGASSDAYHMVASHPEGTGAYLAMKNALKKANVSAEDIDVVSAHATSTKAGDLSETLAIKTL
FGELAYDIPVTANKSMLGHMLGAAGGVEAIALTESLRHGIIPPTINLQHPDSACDLDYVADGPRQQSLTIGLSNSFGFGG
HNSAIVLKKYE
>Mature_411_residues
MKRVVITGMGVISPLGNDVHTFWKHLTEGKSGISPIDSFDVSGSKTKIAGTVRDFDAEERWGRKEARRLDRFSQFALAAA
EQALESSGIQLDQIDRERLGVYVGSGIGGITTLIDNVHTLNERGARKVSPSLVPMMISNAAAAQISIRLGALGPSLSPVT
ACSIGNTSIGEAFNAIRNDDADIMFAGGAEAAITNLSLASFGNAHALSARNEDPAAASRPFDADRDGFVMSEGAGILVLE
SLESAIGRNAPILCEVLGYGASSDAYHMVASHPEGTGAYLAMKNALKKANVSAEDIDVVSAHATSTKAGDLSETLAIKTL
FGELAYDIPVTANKSMLGHMLGAAGGVEAIALTESLRHGIIPPTINLQHPDSACDLDYVADGPRQQSLTIGLSNSFGFGG
HNSAIVLKKYE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=41.1057692307692, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI223972627, Length=150, Percent_Identity=45.3333333333333, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=26.5734265734266, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=49.8777506112469, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=36.6265060240964, Blast_Score=222, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=36.8674698795181, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=41.3127413127413, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=27.7310924369748, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI212642053, Length=361, Percent_Identity=26.0387811634349, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=36.6890380313199, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=40, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI221330659, Length=376, Percent_Identity=24.7340425531915, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920632, Length=376, Percent_Identity=24.7340425531915, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581345, Length=358, Percent_Identity=22.9050279329609, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43007; Mature: 43007

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGMGVISPLGNDVHTFWKHLTEGKSGISPIDSFDVSGSKTKIAGTVRDFDAEER
CCEEEEECCCHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCHHH
WGRKEARRLDRFSQFALAAAEQALESSGIQLDQIDRERLGVYVGSGIGGITTLIDNVHTL
HCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHCEEEECCCHHHHHHHHHHHHH
NERGARKVSPSLVPMMISNAAAAQISIRLGALGPSLSPVTACSIGNTSIGEAFNAIRNDD
HHCCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCCCC
ADIMFAGGAEAAITNLSLASFGNAHALSARNEDPAAASRPFDADRDGFVMSEGAGILVLE
CCEEEECCCCHHHHEEHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEH
SLESAIGRNAPILCEVLGYGASSDAYHMVASHPEGTGAYLAMKNALKKANVSAEDIDVVS
HHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHEEEEE
AHATSTKAGDLSETLAIKTLFGELAYDIPVTANKSMLGHMLGAAGGVEAIALTESLRHGI
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
IPPTINLQHPDSACDLDYVADGPRQQSLTIGLSNSFGFGGHNSAIVLKKYE
CCCEEECCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKRVVITGMGVISPLGNDVHTFWKHLTEGKSGISPIDSFDVSGSKTKIAGTVRDFDAEER
CCEEEEECCCHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCHHH
WGRKEARRLDRFSQFALAAAEQALESSGIQLDQIDRERLGVYVGSGIGGITTLIDNVHTL
HCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHCEEEECCCHHHHHHHHHHHHH
NERGARKVSPSLVPMMISNAAAAQISIRLGALGPSLSPVTACSIGNTSIGEAFNAIRNDD
HHCCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCCCC
ADIMFAGGAEAAITNLSLASFGNAHALSARNEDPAAASRPFDADRDGFVMSEGAGILVLE
CCEEEECCCCHHHHEEHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEH
SLESAIGRNAPILCEVLGYGASSDAYHMVASHPEGTGAYLAMKNALKKANVSAEDIDVVS
HHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHEEEEE
AHATSTKAGDLSETLAIKTLFGELAYDIPVTANKSMLGHMLGAAGGVEAIALTESLRHGI
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
IPPTINLQHPDSACDLDYVADGPRQQSLTIGLSNSFGFGGHNSAIVLKKYE
CCCEEECCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]