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The map label for this gene is adhB [H]

Identifier: 154685051

GI number: 154685051

Start: 565303

End: 566439

Strand: Reverse

Name: adhB [H]

Synonym: RBAM_005890

Alternate gene names: 154685051

Gene position: 566439-565303 (Counterclockwise)

Preceding gene: 154685052

Following gene: 154685050

Centisome position: 14.46

GC content: 47.93

Gene sequence:

>1137_bases
ATGAAGGCCGTAACATATCAAGGAGTGAAAAACGTCGTTGTGAAAGACGTGCCTGATCCGAAGATTGAAAAACACGATGA
CATGATTATAAAAGTCACAAGTACGGCAATTTGCGGATCAGATTTACATTTAATCCACGGACTCATCCCGAATTTGCAGG
AAGACTACATCATCGGCCATGAACCGATGGGCATCGTGGAAGAAACCGGTCCCGGCGTGACGAAAGTCAAAAAAGGGGAC
CGCGTCATTATTCCTTTTAATATCGCCTGCGGAGAATGCGTTTATTGTAAAAATCACCTGGAAAGCCAATGTGATCAATC
AAATGAGAACGGCGATATAGGCGCTTATTTCGGCTATTCAGGAAATGCCGGCGGCTATCCGGGAGGCCAGGCGGAGTATT
TGCGCGTTCCATTTGCGAACTTTACTCATTTTAAAGTTCCCGAAACATGCGAAGAACCGGATGAGAAACTGAGTGTTATT
GCCGATGCGATGACAACCGGCTTTTGGAGCGTTGACAATGCCGGCGTAAAAGAAGGCGATACAGTTATCGTTCTCGGCTG
CGGGCCCGTGGGCCTTTTCGCTCAAAAATTCTGCTGGTTAAAGGGAGCGAAACGCGTAATAGCCGTAGACTATGTCTACT
ACCGTCTCCAGCATGCGAAACGGACGAATAAAGTGGAAATCGTGAACTTCGAAGACCACGAAAATACGGGCAGCTACCTG
AAGGAAATAACCAAAGGCGGCGCCGACGTGGTCATTGACGCCGTCGGCATGGACGGGAAAATGACAGACCTTGAGTTCCT
CGCCAGCGGATTAAAACTTCAAGGCGGAGCGATGAGCGCTTTAGTCATTGCCTCCCAAGCGGTGCGCAAAGGCGGAACGA
TCCAGATTACGGGTGTGTATGGCGGGAGATATAACGGTTTTCCTCTTGGCGATATCATGCAGCGAAACGTCAATATCCGA
TCAGGACAAGCTCCGGTTATCCATTATATGCCGTATATGTTTGAACTGGTGTCAACCGGCAAAATTGATCCGGGCGATGT
TGTAAGCCATGTCATTCCGCTTAGTGAAGCGAAGCACGGCTATGAGATGTTTGACACGAAAACAGATGATTGCATAAAAG
TTGTACTCAAACCTTAA

Upstream 100 bases:

>100_bases
CCTCATGGTCGGAAGCATGAACCTGTTTCCCGTTGAAACGAACAGAAAAGGGATGTTTGACCGCACACCTGATGAACATT
AACACTGGAGGTATTACAGC

Downstream 100 bases:

>100_bases
AGAACGGAGGCTACAGAAATGGCCCGCGCCTTACATGAATTACTCGAAATTCAGGAGATGGCTTCTTTTAAGTCACTTTG
TCTGACGAAATCTAAAACCA

Product: AdhB

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKAVTYQGVKNVVVKDVPDPKIEKHDDMIIKVTSTAICGSDLHLIHGLIPNLQEDYIIGHEPMGIVEETGPGVTKVKKGD
RVIIPFNIACGECVYCKNHLESQCDQSNENGDIGAYFGYSGNAGGYPGGQAEYLRVPFANFTHFKVPETCEEPDEKLSVI
ADAMTTGFWSVDNAGVKEGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVYYRLQHAKRTNKVEIVNFEDHENTGSYL
KEITKGGADVVIDAVGMDGKMTDLEFLASGLKLQGGAMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIR
SGQAPVIHYMPYMFELVSTGKIDPGDVVSHVIPLSEAKHGYEMFDTKTDDCIKVVLKP

Sequences:

>Translated_378_residues
MKAVTYQGVKNVVVKDVPDPKIEKHDDMIIKVTSTAICGSDLHLIHGLIPNLQEDYIIGHEPMGIVEETGPGVTKVKKGD
RVIIPFNIACGECVYCKNHLESQCDQSNENGDIGAYFGYSGNAGGYPGGQAEYLRVPFANFTHFKVPETCEEPDEKLSVI
ADAMTTGFWSVDNAGVKEGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVYYRLQHAKRTNKVEIVNFEDHENTGSYL
KEITKGGADVVIDAVGMDGKMTDLEFLASGLKLQGGAMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIR
SGQAPVIHYMPYMFELVSTGKIDPGDVVSHVIPLSEAKHGYEMFDTKTDDCIKVVLKP
>Mature_378_residues
MKAVTYQGVKNVVVKDVPDPKIEKHDDMIIKVTSTAICGSDLHLIHGLIPNLQEDYIIGHEPMGIVEETGPGVTKVKKGD
RVIIPFNIACGECVYCKNHLESQCDQSNENGDIGAYFGYSGNAGGYPGGQAEYLRVPFANFTHFKVPETCEEPDEKLSVI
ADAMTTGFWSVDNAGVKEGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVYYRLQHAKRTNKVEIVNFEDHENTGSYL
KEITKGGADVVIDAVGMDGKMTDLEFLASGLKLQGGAMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIR
SGQAPVIHYMPYMFELVSTGKIDPGDVVSHVIPLSEAKHGYEMFDTKTDDCIKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=30.188679245283, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4501933, Length=255, Percent_Identity=34.1176470588235, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=28.3333333333333, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=27.2237196765499, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=25.1989389920424, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501939, Length=259, Percent_Identity=30.5019305019305, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=27.1954674220963, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=27.1954674220963, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI71565154, Length=265, Percent_Identity=29.4339622641509, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1786825, Length=390, Percent_Identity=40.2564102564103, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI87082125, Length=368, Percent_Identity=26.3586956521739, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788073, Length=378, Percent_Identity=26.7195767195767, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787863, Length=372, Percent_Identity=25, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790045, Length=247, Percent_Identity=29.1497975708502, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=26.2162162162162, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI226510992, Length=377, Percent_Identity=22.5464190981432, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788075, Length=371, Percent_Identity=23.7196765498652, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788407, Length=247, Percent_Identity=29.5546558704453, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790718, Length=350, Percent_Identity=22, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081918, Length=89, Percent_Identity=37.0786516853933, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=383, Percent_Identity=26.3707571801567, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=249, Percent_Identity=29.3172690763052, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=243, Percent_Identity=29.2181069958848, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=235, Percent_Identity=28.936170212766, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=223, Percent_Identity=27.3542600896861, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=399, Percent_Identity=26.3157894736842, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=311, Percent_Identity=28.2958199356913, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=392, Percent_Identity=25.2551020408163, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=391, Percent_Identity=25.3196930946292, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=385, Percent_Identity=23.8961038961039, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=321, Percent_Identity=23.0529595015576, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17137530, Length=385, Percent_Identity=26.7532467532467, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737897, Length=373, Percent_Identity=26.2734584450402, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737895, Length=379, Percent_Identity=26.1213720316623, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1; 1.2.1.1

Molecular weight: Translated: 41134; Mature: 41134

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVTYQGVKNVVVKDVPDPKIEKHDDMIIKVTSTAICGSDLHLIHGLIPNLQEDYIIGH
CCCEECCCHHHHEEECCCCCCCCCCCCEEEEEECCEECCCCHHHHHHHCCCCCCCEEECC
EPMGIVEETGPGVTKVKKGDRVIIPFNIACGECVYCKNHLESQCDQSNENGDIGAYFGYS
CCCCCEECCCCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
GNAGGYPGGQAEYLRVPFANFTHFKVPETCEEPDEKLSVIADAMTTGFWSVDNAGVKEGD
CCCCCCCCCCCCEEEECCCCCCEEECCHHHCCHHHHHHHHHHHHHHCCEECCCCCCCCCC
TVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVYYRLQHAKRTNKVEIVNFEDHENTGSYL
EEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
KEITKGGADVVIDAVGMDGKMTDLEFLASGLKLQGGAMSALVIASQAVRKGGTIQITGVY
HHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCEEEEEEE
GGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMFELVSTGKIDPGDVVSHVIPLSEAKHG
CCCCCCCCHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHCHHHCCCC
YEMFDTKTDDCIKVVLKP
CHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAVTYQGVKNVVVKDVPDPKIEKHDDMIIKVTSTAICGSDLHLIHGLIPNLQEDYIIGH
CCCEECCCHHHHEEECCCCCCCCCCCCEEEEEECCEECCCCHHHHHHHCCCCCCCEEECC
EPMGIVEETGPGVTKVKKGDRVIIPFNIACGECVYCKNHLESQCDQSNENGDIGAYFGYS
CCCCCEECCCCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCC
GNAGGYPGGQAEYLRVPFANFTHFKVPETCEEPDEKLSVIADAMTTGFWSVDNAGVKEGD
CCCCCCCCCCCCEEEECCCCCCEEECCHHHCCHHHHHHHHHHHHHHCCEECCCCCCCCCC
TVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVYYRLQHAKRTNKVEIVNFEDHENTGSYL
EEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
KEITKGGADVVIDAVGMDGKMTDLEFLASGLKLQGGAMSALVIASQAVRKGGTIQITGVY
HHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCEEEEEEE
GGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMFELVSTGKIDPGDVVSHVIPLSEAKHG
CCCCCCCCHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHCHHHCCCC
YEMFDTKTDDCIKVVLKP
CHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]