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The map label for this gene is mntH [H]

Identifier: 154684935

GI number: 154684935

Start: 464982

End: 466256

Strand: Reverse

Name: mntH [H]

Synonym: RBAM_004660

Alternate gene names: 154684935

Gene position: 466256-464982 (Counterclockwise)

Preceding gene: 154684936

Following gene: 154684934

Centisome position: 11.9

GC content: 52.71

Gene sequence:

>1275_bases
ATGAGCAAAGACATCTCAGCACAATCACTGCAAGCAAAAGCCGTGCAGGATGCACTTGACGGCAAAAGCAAGGGATTCAA
GCGGCTTCTGCCTTTTTTAGGCCCCGCCTTTATCGCGGCGATTGCCTACATTGATCCGGGAAACTTCGCTACGAATATCT
CAGCTGGTTCGAAGTATGGGTATATGCTGCTGTGGGTCATCCTCTTTTCAAACTTGATGGCTTTTTTAATTCAAGTTCTT
TCCGCGAAGCTCGGCATTGCCACGGGTAAAAACCTTCCGGAAATCGCCAGAGACCGGTATCCGAAATGGGTATCAGCCGG
GCTGTGGATACAGGGTGAACTGGTGATTATGGCAACTGATCTGGCAGAATTTATCGGGGCGGCGCTCGGACTCAACCTGC
TGTTCGGCATACCGATGGTTGAAGCGGCCATTATCGCGGCGATCGGATCATTCGCGATTTTAGAGCTGCAGCGCCGGGGT
TACCGGGCGCTGGAAGCGGGCATTGCCGGACTTCTGTTCGTCGTGGTGATCGCCTTCGCTCTGCAAACCTTCTTTGCCAA
ACCTGACGCCGCCTCCGTTCTCGAGGGGCTGTTTATCCCGAAAATTGACGGAATGGACAGTGTGCTCTTGGCAACCGGGA
TACTCGGCGCAACCGTGATGCCGCATGCCATTTACTTACATTCCGCACTGACACAGCGCCGTGTCGTCGGAAAAACGGAT
AGTGAGCGGAAAAAGATTTTTAGATTCGAGACGATTGACATTCTCATCGCGATGGTGATCGCCGGGGCGATTAACGCAAG
CATGCTCATCGTCGCTGCCGCGCTTTTCTTCAAGAACGGGCTGTATGTAGAAGATTTAGACGTGGCTTATCAGCAATTCG
GCCACTATATCGGACCGGCTTCAGCCGTTCTCTTCGGGATCGGGCTGCTGGCCGCAGGGCTTTCAAGCTCTTCTGTCGGC
ACATTGTCAGGCGATATTATCATGCAGGGCTTCATCCGTTACCGTATCCCGCTTTATTTGCGGCGTTTCATTACCATCAT
TCCGCCGATGATCATCATTATCTCGGGGGTCAACGCCACAGAAGCGCTCGTATGGAGCCAGGTCGTTCTTTCATTCGGCA
TCTCCTTTGCGCTCGTGCCGCTGATTATGTTTACAAGCAACAAACGCCTGATGGGCGCCCTGACGAACCGAAAATGGGTG
ACGGCTCTCGCCTGGCTGATTGCGGTTTTGGTGATCGCGCTTAATCTGTTTGTGATCTACGATTCATTCCGTTAG

Upstream 100 bases:

>100_bases
CATCTCATAATAGCGGATTTATGATGTAGATAAAATAATTTGCATCTAGGAAACTTTTTGTTATTTAGCTAAAAATCTAT
CGGAATTTAGGTGAGACATA

Downstream 100 bases:

>100_bases
AAAAAACCGACCATAGCGGCCGGTTTTTCTTTTGACGCCGGGTGCCGTTCGTATCTTTTTCCGGGCGTTTTTGGTATGAT
AGAAGAAAAATCGGAGTTTT

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSKDISAQSLQAKAVQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNISAGSKYGYMLLWVILFSNLMAFLIQVL
SAKLGIATGKNLPEIARDRYPKWVSAGLWIQGELVIMATDLAEFIGAALGLNLLFGIPMVEAAIIAAIGSFAILELQRRG
YRALEAGIAGLLFVVVIAFALQTFFAKPDAASVLEGLFIPKIDGMDSVLLATGILGATVMPHAIYLHSALTQRRVVGKTD
SERKKIFRFETIDILIAMVIAGAINASMLIVAAALFFKNGLYVEDLDVAYQQFGHYIGPASAVLFGIGLLAAGLSSSSVG
TLSGDIIMQGFIRYRIPLYLRRFITIIPPMIIIISGVNATEALVWSQVVLSFGISFALVPLIMFTSNKRLMGALTNRKWV
TALAWLIAVLVIALNLFVIYDSFR

Sequences:

>Translated_424_residues
MSKDISAQSLQAKAVQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNISAGSKYGYMLLWVILFSNLMAFLIQVL
SAKLGIATGKNLPEIARDRYPKWVSAGLWIQGELVIMATDLAEFIGAALGLNLLFGIPMVEAAIIAAIGSFAILELQRRG
YRALEAGIAGLLFVVVIAFALQTFFAKPDAASVLEGLFIPKIDGMDSVLLATGILGATVMPHAIYLHSALTQRRVVGKTD
SERKKIFRFETIDILIAMVIAGAINASMLIVAAALFFKNGLYVEDLDVAYQQFGHYIGPASAVLFGIGLLAAGLSSSSVG
TLSGDIIMQGFIRYRIPLYLRRFITIIPPMIIIISGVNATEALVWSQVVLSFGISFALVPLIMFTSNKRLMGALTNRKWV
TALAWLIAVLVIALNLFVIYDSFR
>Mature_423_residues
SKDISAQSLQAKAVQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNISAGSKYGYMLLWVILFSNLMAFLIQVLS
AKLGIATGKNLPEIARDRYPKWVSAGLWIQGELVIMATDLAEFIGAALGLNLLFGIPMVEAAIIAAIGSFAILELQRRGY
RALEAGIAGLLFVVVIAFALQTFFAKPDAASVLEGLFIPKIDGMDSVLLATGILGATVMPHAIYLHSALTQRRVVGKTDS
ERKKIFRFETIDILIAMVIAGAINASMLIVAAALFFKNGLYVEDLDVAYQQFGHYIGPASAVLFGIGLLAAGLSSSSVGT
LSGDIIMQGFIRYRIPLYLRRFITIIPPMIIIISGVNATEALVWSQVVLSFGISFALVPLIMFTSNKRLMGALTNRKWVT
ALAWLIAVLVIALNLFVIYDSFR

Specific function: H(+)-stimulated, highly selective, manganese uptake system. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=446, Percent_Identity=32.5112107623318, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI295293167, Length=440, Percent_Identity=32.0454545454545, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI295293178, Length=440, Percent_Identity=32.0454545454545, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI295293175, Length=440, Percent_Identity=32.0454545454545, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI295293173, Length=440, Percent_Identity=32.0454545454545, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI10835169, Length=440, Percent_Identity=32.0454545454545, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI295293171, Length=440, Percent_Identity=32.0454545454545, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI295293169, Length=440, Percent_Identity=32.0454545454545, Blast_Score=189, Evalue=5e-48,
Organism=Escherichia coli, GI1788736, Length=394, Percent_Identity=51.7766497461929, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17569473, Length=372, Percent_Identity=34.4086021505376, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI193210616, Length=460, Percent_Identity=30, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71999499, Length=461, Percent_Identity=28.4164859002169, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71993856, Length=236, Percent_Identity=33.0508474576271, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323062, Length=396, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324450, Length=420, Percent_Identity=31.9047619047619, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321841, Length=431, Percent_Identity=31.554524361949, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24648607, Length=444, Percent_Identity=29.5045045045045, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI281362176, Length=444, Percent_Identity=29.5045045045045, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24648609, Length=444, Percent_Identity=29.5045045045045, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI45553443, Length=421, Percent_Identity=29.9287410926366, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 45806; Mature: 45675

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDISAQSLQAKAVQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNISAGSKYG
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEECCCCCCCHH
YMLLWVILFSNLMAFLIQVLSAKLGIATGKNLPEIARDRYPKWVSAGLWIQGELVIMATD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHCCCEEECEEEEEEHH
LAEFIGAALGLNLLFGIPMVEAAIIAAIGSFAILELQRRGYRALEAGIAGLLFVVVIAFA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQTFFAKPDAASVLEGLFIPKIDGMDSVLLATGILGATVMPHAIYLHSALTQRRVVGKTD
HHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SERKKIFRFETIDILIAMVIAGAINASMLIVAAALFFKNGLYVEDLDVAYQQFGHYIGPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCHH
SAVLFGIGLLAAGLSSSSVGTLSGDIIMQGFIRYRIPLYLRRFITIIPPMIIIISGVNAT
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCHH
EALVWSQVVLSFGISFALVPLIMFTSNKRLMGALTNRKWVTALAWLIAVLVIALNLFVIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DSFR
CCCC
>Mature Secondary Structure 
SKDISAQSLQAKAVQDALDGKSKGFKRLLPFLGPAFIAAIAYIDPGNFATNISAGSKYG
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEECCCCCCCHH
YMLLWVILFSNLMAFLIQVLSAKLGIATGKNLPEIARDRYPKWVSAGLWIQGELVIMATD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHCCCEEECEEEEEEHH
LAEFIGAALGLNLLFGIPMVEAAIIAAIGSFAILELQRRGYRALEAGIAGLLFVVVIAFA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQTFFAKPDAASVLEGLFIPKIDGMDSVLLATGILGATVMPHAIYLHSALTQRRVVGKTD
HHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SERKKIFRFETIDILIAMVIAGAINASMLIVAAALFFKNGLYVEDLDVAYQQFGHYIGPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCHH
SAVLFGIGLLAAGLSSSSVGTLSGDIIMQGFIRYRIPLYLRRFITIIPPMIIIISGVNAT
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEECCCHH
EALVWSQVVLSFGISFALVPLIMFTSNKRLMGALTNRKWVTALAWLIAVLVIALNLFVIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
DSFR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10760146 [H]