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The map label for this gene is hxlA [H]

Identifier: 154684832

GI number: 154684832

Start: 340797

End: 341432

Strand: Reverse

Name: hxlA [H]

Synonym: RBAM_003630

Alternate gene names: 154684832

Gene position: 341432-340797 (Counterclockwise)

Preceding gene: 154684840

Following gene: 154684831

Centisome position: 8.71

GC content: 44.18

Gene sequence:

>636_bases
GTGGAATTACAGCTGGCATTAGACTTAGTGAATATCCCGGAAGCAATTGAGCTTGTGAAAGAGGTCGAACCATATATAGA
TGTTGTAGAAATCGGCACTCCCGTTGTCATTAATGAAGGCCTGAAAGCCGTACAGGAAATGAAATCAGCCTTTCCTCACT
TGAAAGTGCTTGCCGATCTTAAAATCATGGATGCAGGCGGCTACGAGATCATGAAAGCGGCAGAAGCGGGAGCCGACATC
ATCACCGTTTTAGGAGCGACAGACGACTCAACGATCAAAGGGGCGGTTGCCGAAGCAAAAAAACAGCAGAAAAAAATTCT
CGTCGACATGATTAACGTAAAAAACCTTGAAACACGGGCAAAAGAAATTGACCAGCTCGGTGTTGATTATATTTGTGTTC
ACACAGGTTATGATCTTCAAGCAGAAGGAAAAAATTCATTCGAGGAACTGACGGCGATTAAAAAAGCGGTCAAGAGCGCT
AAAACCGCAATTGCCGGAGGCATTAAACTTGATACGCTTCCTGAAGCCATCAAACAAAACCCAGATTTAATCATTGTCGG
CGGAGGCATTACGGGAGCTGACAATAAAGCGGATGCTGCTGCTAAAATAAAACAGCTGATCACACAAGGATCATGA

Upstream 100 bases:

>100_bases
AGTATCCTCAAAGTAACTATTAGACTTCAAAGTGCGTACTTCTCAACATGCGGGGCACTCTATAGAATGAAAATACATAA
AAAAGAGGAGTGGATATAAA

Downstream 100 bases:

>100_bases
AAACGACTGAATACTTACATGAAATACTAAATGAAATATCCCGCACCGCAGCATTAATATCCGACAGTGAAGCTGACAAG
CTTGCGGATCAGATTTTATC

Product: HxlA

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase; HUMPS [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MELQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVQEMKSAFPHLKVLADLKIMDAGGYEIMKAAEAGADI
ITVLGATDDSTIKGAVAEAKKQQKKILVDMINVKNLETRAKEIDQLGVDYICVHTGYDLQAEGKNSFEELTAIKKAVKSA
KTAIAGGIKLDTLPEAIKQNPDLIIVGGGITGADNKADAAAKIKQLITQGS

Sequences:

>Translated_211_residues
MELQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVQEMKSAFPHLKVLADLKIMDAGGYEIMKAAEAGADI
ITVLGATDDSTIKGAVAEAKKQQKKILVDMINVKNLETRAKEIDQLGVDYICVHTGYDLQAEGKNSFEELTAIKKAVKSA
KTAIAGGIKLDTLPEAIKQNPDLIIVGGGITGADNKADAAAKIKQLITQGS
>Mature_211_residues
MELQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVQEMKSAFPHLKVLADLKIMDAGGYEIMKAAEAGADI
ITVLGATDDSTIKGAVAEAKKQQKKILVDMINVKNLETRAKEIDQLGVDYICVHTGYDLQAEGKNSFEELTAIKKAVKSA
KTAIAGGIKLDTLPEAIKQNPDLIIVGGGITGADNKADAAAKIKQLITQGS

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with hxlB, may act as a formaldehyde detoxification system [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790640, Length=210, Percent_Identity=32.8571428571429, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790006, Length=200, Percent_Identity=31.5, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017553
- InterPro:   IPR013785
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 22433; Mature: 22433

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVQEMKSAFPHLKVLADL
CCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCHHHHHHCE
KIMDAGGYEIMKAAEAGADIITVLGATDDSTIKGAVAEAKKQQKKILVDMINVKNLETRA
EEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KEIDQLGVDYICVHTGYDLQAEGKNSFEELTAIKKAVKSAKTAIAGGIKLDTLPEAIKQN
HHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
PDLIIVGGGITGADNKADAAAKIKQLITQGS
CCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVQEMKSAFPHLKVLADL
CCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCHHHHHHCE
KIMDAGGYEIMKAAEAGADIITVLGATDDSTIKGAVAEAKKQQKKILVDMINVKNLETRA
EEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KEIDQLGVDYICVHTGYDLQAEGKNSFEELTAIKKAVKSAKTAIAGGIKLDTLPEAIKQN
HHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
PDLIIVGGGITGADNKADAAAKIKQLITQGS
CCEEEECCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704255; 8969502; 9384377 [H]