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The map label for this gene is hisG

Identifier: 154248665

GI number: 154248665

Start: 5268124

End: 5269098

Strand: Direct

Name: hisG

Synonym: Xaut_4747

Alternate gene names: 154248665

Gene position: 5268124-5269098 (Clockwise)

Preceding gene: 154248664

Following gene: 154248667

Centisome position: 99.23

GC content: 68.92

Gene sequence:

>975_bases
ATGACCAGCCCGCTCATTCTCGCCGTGCCCTCCAAGGGCCGGCTGCAGGAGAATGTCCACGCCTTCTTCTCCCGGGCCGG
CATGCCGCTGACGCAGGCGCGCGGCGCCCGCGACTATCGCGGCGCCCTCGGCGGCGTGGACAATGTGGAGGTGGCTTATC
TCTCCGCCTCCGAGATCGCGGCAGCTCTTGCCGCCGGCGCCGCCCACATCGGGGTGACGGGCGAGGACCTGGTGCGCGAG
AACATCCTGGAGGCCGACAGCCGGGTCGCGCTGCTGGAAAAGCTGGGCTTCGGCCACGCCAACGTGGTGGTGGCGGTGCC
GCAGGCCTGGATCGACGTGCGCACCATGGACGATCTCGACGACGTAGCGAGCCACTTCCACGGCCGCACCGGCCGACGCA
TCCGCGTCGCCACCAAATATGTGAACCTGACCCGGGGCTTCTTTGCCCGCTACGGCATTGTGGATTACCGCATCGTCGAA
AGCGCGGGCGCTACCGAAGGCACCCCGGCCTCCGGCTCGGCCGAGCTGATCGTGGACATCACCACCACCGGCGCGACGCT
GGCCGCCAACGCCCTGAAGGTGGTGGACGACGGCATCATCCTGAAGTCGGAAGCCAATCTCGTGGCCTCGCTCACCGCCA
ACTGGAGCGGCAGCGCGCTTTCGGCGGCGCGGGCCATGTTCGACCGGTTGGGGGCGGAAAAGCGCGCGCGAACCATGCGC
GAGGTGCGCACCCGCTTCGCGAGCTGCGACGCCTCCCTGGTGGAGCAGGCGGTGGCGCGCTATCGCTGCGTCGCACCGTT
CGGCGGCCCCACCTCCTCCGGCATGCTGACCCTGCACTGCCCGCCGGATACGCTGCACGGGCTCGCCACCTTCCTGCGTG
AGCAGGGCGCGAGCATGGTGACCGTTGGTCCCATCGAATATGTGTTCGCCGCAGACAATCCCCTGTTCGAGGCTCTGGAA
GCGCGTCTCGGCTGA

Upstream 100 bases:

>100_bases
GCGCCGAGACCAGCGTGCCCGGCGTCGGCCTCGCGGTGTGGGTTGAACGCCTCGCCGCCCTCGCCCTCGCCCCCTTCCCT
GCTGCCGTGGAGGGCGCCCG

Downstream 100 bases:

>100_bases
AACCGAGACGCCGCCGGCGCCCCGCTGCGCCGGTGCAGTGACCTCTAGTTGTTGCCGAGGCCGCGGTCACCCTGGTCGAT
AAACTCGTCATCGATCCTTC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTSPLILAVPSKGRLQENVHAFFSRAGMPLTQARGARDYRGALGGVDNVEVAYLSASEIAAALAAGAAHIGVTGEDLVRE
NILEADSRVALLEKLGFGHANVVVAVPQAWIDVRTMDDLDDVASHFHGRTGRRIRVATKYVNLTRGFFARYGIVDYRIVE
SAGATEGTPASGSAELIVDITTTGATLAANALKVVDDGIILKSEANLVASLTANWSGSALSAARAMFDRLGAEKRARTMR
EVRTRFASCDASLVEQAVARYRCVAPFGGPTSSGMLTLHCPPDTLHGLATFLREQGASMVTVGPIEYVFAADNPLFEALE
ARLG

Sequences:

>Translated_324_residues
MTSPLILAVPSKGRLQENVHAFFSRAGMPLTQARGARDYRGALGGVDNVEVAYLSASEIAAALAAGAAHIGVTGEDLVRE
NILEADSRVALLEKLGFGHANVVVAVPQAWIDVRTMDDLDDVASHFHGRTGRRIRVATKYVNLTRGFFARYGIVDYRIVE
SAGATEGTPASGSAELIVDITTTGATLAANALKVVDDGIILKSEANLVASLTANWSGSALSAARAMFDRLGAEKRARTMR
EVRTRFASCDASLVEQAVARYRCVAPFGGPTSSGMLTLHCPPDTLHGLATFLREQGASMVTVGPIEYVFAADNPLFEALE
ARLG
>Mature_323_residues
TSPLILAVPSKGRLQENVHAFFSRAGMPLTQARGARDYRGALGGVDNVEVAYLSASEIAAALAAGAAHIGVTGEDLVREN
ILEADSRVALLEKLGFGHANVVVAVPQAWIDVRTMDDLDDVASHFHGRTGRRIRVATKYVNLTRGFFARYGIVDYRIVES
AGATEGTPASGSAELIVDITTTGATLAANALKVVDDGIILKSEANLVASLTANWSGSALSAARAMFDRLGAEKRARTMRE
VRTRFASCDASLVEQAVARYRCVAPFGGPTSSGMLTLHCPPDTLHGLATFLREQGASMVTVGPIEYVFAADNPLFEALEA
RLG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=235, Percent_Identity=24.6808510638298, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 34331; Mature: 34200

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPLILAVPSKGRLQENVHAFFSRAGMPLTQARGARDYRGALGGVDNVEVAYLSASEIA
CCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEHHHHH
AALAAGAAHIGVTGEDLVRENILEADSRVALLEKLGFGHANVVVAVPQAWIDVRTMDDLD
HHHHHCCCEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECHHHEEEECCCCHH
DVASHFHGRTGRRIRVATKYVNLTRGFFARYGIVDYRIVESAGATEGTPASGSAELIVDI
HHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEE
TTTGATLAANALKVVDDGIILKSEANLVASLTANWSGSALSAARAMFDRLGAEKRARTMR
ECCCCHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHH
EVRTRFASCDASLVEQAVARYRCVAPFGGPTSSGMLTLHCPPDTLHGLATFLREQGASMV
HHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEE
TVGPIEYVFAADNPLFEALEARLG
EECCEEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure 
TSPLILAVPSKGRLQENVHAFFSRAGMPLTQARGARDYRGALGGVDNVEVAYLSASEIA
CCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEHHHHH
AALAAGAAHIGVTGEDLVRENILEADSRVALLEKLGFGHANVVVAVPQAWIDVRTMDDLD
HHHHHCCCEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECHHHEEEECCCCHH
DVASHFHGRTGRRIRVATKYVNLTRGFFARYGIVDYRIVESAGATEGTPASGSAELIVDI
HHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEE
TTTGATLAANALKVVDDGIILKSEANLVASLTANWSGSALSAARAMFDRLGAEKRARTMR
ECCCCHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHH
EVRTRFASCDASLVEQAVARYRCVAPFGGPTSSGMLTLHCPPDTLHGLATFLREQGASMV
HHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEE
TVGPIEYVFAADNPLFEALEARLG
EECCEEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA