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The map label for this gene is mutA [H]

Identifier: 154248647

GI number: 154248647

Start: 5247318

End: 5249150

Strand: Direct

Name: mutA [H]

Synonym: Xaut_4729

Alternate gene names: 154248647

Gene position: 5247318-5249150 (Clockwise)

Preceding gene: 154248646

Following gene: 154248648

Centisome position: 98.84

GC content: 72.39

Gene sequence:

>1833_bases
ATGACCGCCCTGCCCTTCGCGACCAACCTTGCCCCCGTCACCCGCGAGGACTGGCTGAAGCTGGTCGAGGGCGTGCTGAA
GGGCGCGCCCTACGACAAGCGCCTCGTCACCCGCACCTATGAGGGCCTCACCCTCGACGCTTTGCCCGAGCGCAAGGTGA
AGGCCCCCATCGTGGCGGGGCGGCCGGCCGGCGCGCCGTGGGTTATCAGCGCCCGGGTGGACCAGCCGGACCTCGCCGCC
GCCCACGCGCAGGCGCTGGAGGACCTCGACGGCGGCGCCTCCGGCCTTGCCCTGGTCTATGCTTCCTCGCCCTCGGCCTA
TGGCTTCGGCCTGCCGGACGGCGCCGACCTGAAGGTGGTGCTCAAGGACGTGCTGCTCGACCTCATCGAGACGCGCATCG
AGAGCGGCGCCTTCCAGGGTCGCGGCGAAGACCTCGCCTTCGCCGATCATGCGGAAGCCGCGGGCTTCGATCCAAAGGGC
CTCGCCGTTTCCTTCGGCCTGAACCCGCTGGGGGATTTCGCCGCCGCGGGCACCCTGCCCATGGCGTGGCCGCTGCTCGC
CAAGCGCTTCGCCGAGACCTCCGCCATTCTTGCGGCGCGCGGCTTTGCCGGGCCGTTCGCGCGGGCGGACGGCGGCGTGT
TCCATGCGGCCGGAGCATCGGACGCTCAGGAGCTGGCGGCGGTGCTCGCCACCGCCGTGGCCTATCTCAAGGCCTATGGG
GAGGCCGGCATCGCCCTGTCGGAGGCGGCGGCGCGCATCGAGGTCGCCCTGGTGGCGGACCTGAACCAGACCGCCACCAT
CGCCAAGTTCCGCGCCATCCGCCTGCTGTGGGGCGCGGTGCTGCGCGAATGCGGCCTGCCCGAAACCGCGCTGAAGGTGC
ACGCCACCACCGCGTGGCGCTCGCTGACCCGGCGCGATCCTTATGTGAACCTGCTGCGCAACACGGTGGCGGCGTTCGCG
GCCGGCGTGGGCGGGGCGGACAGCCTCACGGTGCTGCCCTTCACCCAGGCGCTGGGCCTGCCCGACGCCTTCGCCCGGCG
CCTTGCCCGCAACACCCAGGTGATGCTGCTGGAGGAGAGCAACGTCCACCGCGTGGCAGATCCCGGCGCCGGCGCCGGCG
CGGTTGAGGCCCATACCGACGGGCTCGCCGAAAAGGCGTGGGACCTGTTCCGCACCATCGAGAAGCGCGGCGGCATGGCC
GACGTGCTGGAGGACCGATGGCTGAAGGCCGAGATCACCGAGGTGAAGGCCCGCCGCGACAAGGATGTGGCCACCCGCAA
GGCGCCCATCACCGGCACCTCGGAATTCCCCATCCTGGTGCAGCAGGCGCCGGAAGTGCTGGCGCCTCTGCCCGCCACCT
TCGAGCCCGTGGCCGACGGCGCACTGACGCCCCATCGTATTGCCGAGCCGTTCGAGGCCCTGCGCGACAAGGCGGAAGCC
GCCGCCCAGGCGCCGGCCGTCTTCCTCGCCACGCTCGGTTCCGTCGCCGCCTTCACGGCGCGCGCCGGCTTCGCCAAGAA
CTTCTTCGAAGCCGGCGGCATCGCCGCCCCCGTCCCGGACGGCTTCGCCGACCGCGACGCGCTGGTAGCCGCCTTCAAGG
CCTCCGGCACGCCGTTCGCCTGCCTCGTCTCCTCGGACGAGATCTACGGCGCCGAGGGCGCCGCAACAGCCGAGGCCCTG
AAGGTTGCGGGCGCCAGCGCCATCTGGCTCGCCGGCAAGCCCGCCGAGCTGGAGGCGGCGCTCAAGGCGGCGGGCGTTTC
CGGCTTCATCTTCGCCGGCTGCGACGTGCTGGAGACGCTGACCGCCGCGCAGGCGGCGGCGGGACTGGCCTGA

Upstream 100 bases:

>100_bases
CGGGAGGGGTGGTGATGGACACCGGTTTCACCGATCCCCGGCATGACGCTGCCGTGAAGCACCCTGTTTTTCTCCTGTTC
CCTCTCCCGGAGGTCCGCTC

Downstream 100 bases:

>100_bases
GCGGGCAGGACGGGAGGCGAGCCATGGTGCACAAGATTGCGGGCCTCACCGCCCTCGCGCTCCTCTCGGCGGCCGCCGTT
GGCCCCGCCCGCGCCGACAA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTALPFATNLAPVTREDWLKLVEGVLKGAPYDKRLVTRTYEGLTLDALPERKVKAPIVAGRPAGAPWVISARVDQPDLAA
AHAQALEDLDGGASGLALVYASSPSAYGFGLPDGADLKVVLKDVLLDLIETRIESGAFQGRGEDLAFADHAEAAGFDPKG
LAVSFGLNPLGDFAAAGTLPMAWPLLAKRFAETSAILAARGFAGPFARADGGVFHAAGASDAQELAAVLATAVAYLKAYG
EAGIALSEAAARIEVALVADLNQTATIAKFRAIRLLWGAVLRECGLPETALKVHATTAWRSLTRRDPYVNLLRNTVAAFA
AGVGGADSLTVLPFTQALGLPDAFARRLARNTQVMLLEESNVHRVADPGAGAGAVEAHTDGLAEKAWDLFRTIEKRGGMA
DVLEDRWLKAEITEVKARRDKDVATRKAPITGTSEFPILVQQAPEVLAPLPATFEPVADGALTPHRIAEPFEALRDKAEA
AAQAPAVFLATLGSVAAFTARAGFAKNFFEAGGIAAPVPDGFADRDALVAAFKASGTPFACLVSSDEIYGAEGAATAEAL
KVAGASAIWLAGKPAELEAALKAAGVSGFIFAGCDVLETLTAAQAAAGLA

Sequences:

>Translated_610_residues
MTALPFATNLAPVTREDWLKLVEGVLKGAPYDKRLVTRTYEGLTLDALPERKVKAPIVAGRPAGAPWVISARVDQPDLAA
AHAQALEDLDGGASGLALVYASSPSAYGFGLPDGADLKVVLKDVLLDLIETRIESGAFQGRGEDLAFADHAEAAGFDPKG
LAVSFGLNPLGDFAAAGTLPMAWPLLAKRFAETSAILAARGFAGPFARADGGVFHAAGASDAQELAAVLATAVAYLKAYG
EAGIALSEAAARIEVALVADLNQTATIAKFRAIRLLWGAVLRECGLPETALKVHATTAWRSLTRRDPYVNLLRNTVAAFA
AGVGGADSLTVLPFTQALGLPDAFARRLARNTQVMLLEESNVHRVADPGAGAGAVEAHTDGLAEKAWDLFRTIEKRGGMA
DVLEDRWLKAEITEVKARRDKDVATRKAPITGTSEFPILVQQAPEVLAPLPATFEPVADGALTPHRIAEPFEALRDKAEA
AAQAPAVFLATLGSVAAFTARAGFAKNFFEAGGIAAPVPDGFADRDALVAAFKASGTPFACLVSSDEIYGAEGAATAEAL
KVAGASAIWLAGKPAELEAALKAAGVSGFIFAGCDVLETLTAAQAAAGLA
>Mature_609_residues
TALPFATNLAPVTREDWLKLVEGVLKGAPYDKRLVTRTYEGLTLDALPERKVKAPIVAGRPAGAPWVISARVDQPDLAAA
HAQALEDLDGGASGLALVYASSPSAYGFGLPDGADLKVVLKDVLLDLIETRIESGAFQGRGEDLAFADHAEAAGFDPKGL
AVSFGLNPLGDFAAAGTLPMAWPLLAKRFAETSAILAARGFAGPFARADGGVFHAAGASDAQELAAVLATAVAYLKAYGE
AGIALSEAAARIEVALVADLNQTATIAKFRAIRLLWGAVLRECGLPETALKVHATTAWRSLTRRDPYVNLLRNTVAAFAA
GVGGADSLTVLPFTQALGLPDAFARRLARNTQVMLLEESNVHRVADPGAGAGAVEAHTDGLAEKAWDLFRTIEKRGGMAD
VLEDRWLKAEITEVKARRDKDVATRKAPITGTSEFPILVQQAPEVLAPLPATFEPVADGALTPHRIAEPFEALRDKAEAA
AQAPAVFLATLGSVAAFTARAGFAKNFFEAGGIAAPVPDGFADRDALVAAFKASGTPFACLVSSDEIYGAEGAATAEALK
VAGASAIWLAGKPAELEAALKAAGVSGFIFAGCDVLETLTAAQAAAGLA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=242, Percent_Identity=35.5371900826446, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1789284, Length=234, Percent_Identity=35.042735042735, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25144500, Length=241, Percent_Identity=34.8547717842324, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 63160; Mature: 63029

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPFATNLAPVTREDWLKLVEGVLKGAPYDKRLVTRTYEGLTLDALPERKVKAPIVAG
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCCCCCCEEEC
RPAGAPWVISARVDQPDLAAAHAQALEDLDGGASGLALVYASSPSAYGFGLPDGADLKVV
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
LKDVLLDLIETRIESGAFQGRGEDLAFADHAEAAGFDPKGLAVSFGLNPLGDFAAAGTLP
HHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCC
MAWPLLAKRFAETSAILAARGFAGPFARADGGVFHAAGASDAQELAAVLATAVAYLKAYG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHC
EAGIALSEAAARIEVALVADLNQTATIAKFRAIRLLWGAVLRECGLPETALKVHATTAWR
CCCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEHHHHHH
SLTRRDPYVNLLRNTVAAFAAGVGGADSLTVLPFTQALGLPDAFARRLARNTQVMLLEES
HHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHCCCEEEEEECC
NVHRVADPGAGAGAVEAHTDGLAEKAWDLFRTIEKRGGMADVLEDRWLKAEITEVKARRD
CCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
KDVATRKAPITGTSEFPILVQQAPEVLAPLPATFEPVADGALTPHRIAEPFEALRDKAEA
CCHHHCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHH
AAQAPAVFLATLGSVAAFTARAGFAKNFFEAGGIAAPVPDGFADRDALVAAFKASGTPFA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
CLVSSDEIYGAEGAATAEALKVAGASAIWLAGKPAELEAALKAAGVSGFIFAGCDVLETL
EEEECCCEECCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
TAAQAAAGLA
HHHHHHHCCC
>Mature Secondary Structure 
TALPFATNLAPVTREDWLKLVEGVLKGAPYDKRLVTRTYEGLTLDALPERKVKAPIVAG
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCCCCCCEEEC
RPAGAPWVISARVDQPDLAAAHAQALEDLDGGASGLALVYASSPSAYGFGLPDGADLKVV
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
LKDVLLDLIETRIESGAFQGRGEDLAFADHAEAAGFDPKGLAVSFGLNPLGDFAAAGTLP
HHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCC
MAWPLLAKRFAETSAILAARGFAGPFARADGGVFHAAGASDAQELAAVLATAVAYLKAYG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHC
EAGIALSEAAARIEVALVADLNQTATIAKFRAIRLLWGAVLRECGLPETALKVHATTAWR
CCCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEHHHHHH
SLTRRDPYVNLLRNTVAAFAAGVGGADSLTVLPFTQALGLPDAFARRLARNTQVMLLEES
HHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHCCCEEEEEECC
NVHRVADPGAGAGAVEAHTDGLAEKAWDLFRTIEKRGGMADVLEDRWLKAEITEVKARRD
CCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
KDVATRKAPITGTSEFPILVQQAPEVLAPLPATFEPVADGALTPHRIAEPFEALRDKAEA
CCHHHCCCCCCCCCCCCCHHHCCCHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHH
AAQAPAVFLATLGSVAAFTARAGFAKNFFEAGGIAAPVPDGFADRDALVAAFKASGTPFA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
CLVSSDEIYGAEGAATAEALKVAGASAIWLAGKPAELEAALKAAGVSGFIFAGCDVLETL
EEEECCCEECCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
TAAQAAAGLA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]