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The map label for this gene is pccB [H]

Identifier: 154248643

GI number: 154248643

Start: 5241660

End: 5243192

Strand: Direct

Name: pccB [H]

Synonym: Xaut_4725

Alternate gene names: 154248643

Gene position: 5241660-5243192 (Clockwise)

Preceding gene: 154248639

Following gene: 154248644

Centisome position: 98.73

GC content: 67.19

Gene sequence:

>1533_bases
ATGAAGGACATCCTCGAAGAGCTCGAAAGCCGGCGCTCGGTCGCCCGACTCGGCGGCGGGGCACGGCGCATCGAGGCCCA
GCACGCCCGCGGCAAGCTCACCGCCCGCGAGCGTATCGAACTGCTGCTCGATCGCGGCACGTTCGAGGAATACGACACCT
TCGTGCAGCACCGCTGCGTGGACTTCGGCATGGCCGACCAGAAGGTCCCCGGCGACGGCGTCGTCACCGGCTGGGGCACG
GTCAACGGCCGCAAGGTGTTCGTCTTCGCCAAGGACTTCACCGTGTTCGGCGGCTCCCTCTCCGAGGAGCACGCCCGCAA
GATCACCAAGATCCAGGACATGGCGCTGAAGACCCGCGCCCCCATCATCGGCCTGTTCGACGCCGGCGGCGCGCGCATCC
AGGAAGGCGTCGCGGCGCTGGGCGGCTACGGCGAGGTGTTCAAGCGCAATGTCGTCGCCTCCGGCGTCATCCCGCAGATC
TCGCTGATCATGGGCCCCTGCGCCGGCGGCGACGTCTACTCCCCGGCCATGACCGACTTCATCTTCATGGTGCGCGACAC
CTCCTACATGTTCGTGACCGGCCCGGAGGTGGTGAAGACCGTCACCAACGAGACCGTCACCTCCGAGGAACTGGGCGGCG
CCAAGGTGCACACCAGCAAGTCCTCGGTGGCGGACGGCTCCTACGAGAACGACGTGGAGATGCTGCTGGAGACCCGGCGG
CTCATCGACTTCCTGCCCTCCAACAACCAGGAAGGCGCGCCCGAGTGGCCGTCCTTCGACGATCCGGGCCGCTACGACGA
GAGCCTCGACACCCTGGTCCCGGACAATCCCAACAAGCCCTACGACATCAAGGAACTGATCCTGAAGGTCGTGGACGAGG
GCGACTTCTTCGAGATCCAGGCGGCCTACGCCCGCAACATGGTCACCGGCTTCGGCCGGATCGAGGGGCGCACGGTCGGC
TTCGTCGCCAACCAGCCCATGGTGCTCGCGGGGGTGCTCGATTCGGACGCCTCCCGCAAGGCGGCCCGCTTCGTGCGCTT
CTGCGACGCCTTCGAGATCCCCATCGTGACCTTCGTGGACGTGCCCGGCTTCCTGCCCGGCACGGCGCAGGAATACGGCG
GCCTCATCAAGCACGGCGCCAAGCTGCTGTTCGCCTATTCGCAGGCCACCGTGCCGCTGGTCACCGTCATTACCCGCAAG
GCCTTCGGCGGCGCCTATGACGTGATGGCCTCCAAGCATGTGGGCGCCGACGTGAACTATGCCTGGCCCACCGCCCAGAT
CGCGGTGATGGGCGCCAAGGGCGCGGTGGAGATCATCTTCCGCGCCGACATGGGCGATCCGGACAAGATCGCCGCCCAGA
CCAAGAACTACGAGGAGCGCTTCCTGTCGCCCTTCGTGGCGGCGGAGCGCGGCTATGTGGACGAGGTGATCATGCCCCAC
TCCACCCGCCGGCGCCTCGCCCGCGCCCTCGCCATGCTGCGCACCAAGAAGCTCGAGCAGCCCTCGCGCAAGCACGACAA
CATGCCGCTTTAG

Upstream 100 bases:

>100_bases
TGGCGGCATCGCAAAGCTTGGGCTTTCGCCGCCTTTGAACCCTCGATAGTCTCGATTTCACAAACACGGTTCCAAGCACC
GCACCTGGGGAGCGCTCGGC

Downstream 100 bases:

>100_bases
GCGGCTCTGGCCGGACCGAACGACCGCAGGCCTCCACCTCAACCGCCCCGGCCCCCTCCCCAGCCCTCCCCTGCAAGCGG
GAGAGGGAGCGAGGCCGGGA

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKDILEELESRRSVARLGGGARRIEAQHARGKLTARERIELLLDRGTFEEYDTFVQHRCVDFGMADQKVPGDGVVTGWGT
VNGRKVFVFAKDFTVFGGSLSEEHARKITKIQDMALKTRAPIIGLFDAGGARIQEGVAALGGYGEVFKRNVVASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPEVVKTVTNETVTSEELGGAKVHTSKSSVADGSYENDVEMLLETRR
LIDFLPSNNQEGAPEWPSFDDPGRYDESLDTLVPDNPNKPYDIKELILKVVDEGDFFEIQAAYARNMVTGFGRIEGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFEIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTVITRK
AFGGAYDVMASKHVGADVNYAWPTAQIAVMGAKGAVEIIFRADMGDPDKIAAQTKNYEERFLSPFVAAERGYVDEVIMPH
STRRRLARALAMLRTKKLEQPSRKHDNMPL

Sequences:

>Translated_510_residues
MKDILEELESRRSVARLGGGARRIEAQHARGKLTARERIELLLDRGTFEEYDTFVQHRCVDFGMADQKVPGDGVVTGWGT
VNGRKVFVFAKDFTVFGGSLSEEHARKITKIQDMALKTRAPIIGLFDAGGARIQEGVAALGGYGEVFKRNVVASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPEVVKTVTNETVTSEELGGAKVHTSKSSVADGSYENDVEMLLETRR
LIDFLPSNNQEGAPEWPSFDDPGRYDESLDTLVPDNPNKPYDIKELILKVVDEGDFFEIQAAYARNMVTGFGRIEGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFEIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTVITRK
AFGGAYDVMASKHVGADVNYAWPTAQIAVMGAKGAVEIIFRADMGDPDKIAAQTKNYEERFLSPFVAAERGYVDEVIMPH
STRRRLARALAMLRTKKLEQPSRKHDNMPL
>Mature_510_residues
MKDILEELESRRSVARLGGGARRIEAQHARGKLTARERIELLLDRGTFEEYDTFVQHRCVDFGMADQKVPGDGVVTGWGT
VNGRKVFVFAKDFTVFGGSLSEEHARKITKIQDMALKTRAPIIGLFDAGGARIQEGVAALGGYGEVFKRNVVASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPEVVKTVTNETVTSEELGGAKVHTSKSSVADGSYENDVEMLLETRR
LIDFLPSNNQEGAPEWPSFDDPGRYDESLDTLVPDNPNKPYDIKELILKVVDEGDFFEIQAAYARNMVTGFGRIEGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFEIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTVITRK
AFGGAYDVMASKHVGADVNYAWPTAQIAVMGAKGAVEIIFRADMGDPDKIAAQTKNYEERFLSPFVAAERGYVDEVIMPH
STRRRLARALAMLRTKKLEQPSRKHDNMPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=62.32741617357, Blast_Score=651, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=60.1518026565465, Blast_Score=639, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=518, Percent_Identity=32.4324324324324, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=60.7495069033531, Blast_Score=650, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=60.7495069033531, Blast_Score=649, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=508, Percent_Identity=32.8740157480315, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71997163, Length=328, Percent_Identity=22.8658536585366, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24586065, Length=525, Percent_Identity=32.5714285714286, Blast_Score=248, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55974; Mature: 55974

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDILEELESRRSVARLGGGARRIEAQHARGKLTARERIELLLDRGTFEEYDTFVQHRCV
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
DFGMADQKVPGDGVVTGWGTVNGRKVFVFAKDFTVFGGSLSEEHARKITKIQDMALKTRA
HCCCCCCCCCCCCEEEECCCCCCCEEEEEEECEEEECCCCCHHHHHHHHHHHHHHHHHCC
PIIGLFDAGGARIQEGVAALGGYGEVFKRNVVASGVIPQISLIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPEVVKTVTNETVTSEELGGAKVHTSKSSVADGSYENDVEMLLETRR
EEEEECCCEEEEECHHHHHHHHCCCCCHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHH
LIDFLPSNNQEGAPEWPSFDDPGRYDESLDTLVPDNPNKPYDIKELILKVVDEGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEH
AAYARNMVTGFGRIEGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDAFEIPIVTFVD
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTVITRKAFGGAYDVMASKHVGADVNY
CCCCCCCCHHHHCHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AWPTAQIAVMGAKGAVEIIFRADMGDPDKIAAQTKNYEERFLSPFVAAERGYVDEVIMPH
CCCCEEEEEEECCCEEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHCCC
STRRRLARALAMLRTKKLEQPSRKHDNMPL
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure
MKDILEELESRRSVARLGGGARRIEAQHARGKLTARERIELLLDRGTFEEYDTFVQHRCV
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
DFGMADQKVPGDGVVTGWGTVNGRKVFVFAKDFTVFGGSLSEEHARKITKIQDMALKTRA
HCCCCCCCCCCCCEEEECCCCCCCEEEEEEECEEEECCCCCHHHHHHHHHHHHHHHHHCC
PIIGLFDAGGARIQEGVAALGGYGEVFKRNVVASGVIPQISLIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPEVVKTVTNETVTSEELGGAKVHTSKSSVADGSYENDVEMLLETRR
EEEEECCCEEEEECHHHHHHHHCCCCCHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHH
LIDFLPSNNQEGAPEWPSFDDPGRYDESLDTLVPDNPNKPYDIKELILKVVDEGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEH
AAYARNMVTGFGRIEGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDAFEIPIVTFVD
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQATVPLVTVITRKAFGGAYDVMASKHVGADVNY
CCCCCCCCHHHHCHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AWPTAQIAVMGAKGAVEIIFRADMGDPDKIAAQTKNYEERFLSPFVAAERGYVDEVIMPH
CCCCEEEEEEECCCEEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHCCC
STRRRLARALAMLRTKKLEQPSRKHDNMPL
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]