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The map label for this gene is icd [H]

Identifier: 154248489

GI number: 154248489

Start: 5050055

End: 5051269

Strand: Reverse

Name: icd [H]

Synonym: Xaut_4569

Alternate gene names: 154248489

Gene position: 5051269-5050055 (Counterclockwise)

Preceding gene: 154248491

Following gene: 154248484

Centisome position: 95.15

GC content: 62.96

Gene sequence:

>1215_bases
ATGGCGAAGATCAAGGTGGCAAATCCGGTCGTCGAGCTCGACGGCGACGAGATGACCCGGATCATCTGGCAGTACATCAA
GGACAAGCTGATCCACCCCTATCTCGACATCGACCTGGAATATTACGATCTTTCGGTCGAGAACCGGGACGCCACCAGCG
ACAAGGTCACGGTCGACGCGGCCAATGCCATCAAAAAGCATGGCGTGGGCGTGAAGTGCGCCACCATTACCCCGGACGAG
GCCCGCGTCGAGGAATTCAAGCTCAAGGAAATGTGGAAGTCGCCCAACGGCACCATCCGCAACATCCTGGGCGGCGTGAT
CTTCCGCGAGCCCATCATCTGCAAGAACGTGCCGCGCCTGGTGCCGGGCTGGACCCAGCCCATCGTGGTGGGCCGCCATG
CCTTCGGCGACCAGTATCGCGCCACCGATTTCAAGGTGCCGGGCAAGGGCACGCTGACCGTCACCTTCGTGGGCGAGGAC
GGCACCAAGATCGAGAAGGAAGTGTACAAGTTCCCGGGCGCCGGCGTGGCGCTGTCCATGTACAATCTCGACGAGTCGAT
CCGCGAATTCGCCCGCGCCTCGCTCAACTACGGCCTGATCCGGAACTACCCGGTCTATCTCTCCACGAAGAACACGATCC
TGAAGGCCTATGACGGCCGCTTCAAGGACATCTTCCAGGAGGTCTACGAGGCCGAGTTCAAGGCCGAGTTCGACAAGCGC
GGCCTCACCTACGAGCATCGCCTGATCGACGACATGGTGGCCTCGGCCCTCAAGTGGTCCGGCGGCTATGTGTGGGCCTG
CAAGAACTACGACGGCGACGTGCAGTCCGACATCGTGGCCCAGGGCTTCGGCTCGCTCGGCCTCATGACCTCCGTGCTGA
TGACGCCCGACGGCCAGACCGTGGAGGCCGAGGCCGCCCACGGCACCGTCACCCGTCACTATCGCGAGCACCAGAAGGGC
AAGGAGACCTCCACCAACTCCATCGCCTCCATCTTCGCCTGGACCCGCGGCCTCTCCCACCGCGCCAAGCTCGACGGCAA
CGACGAGCTGGCCAAGTTCGCCGCGACCCTTGAGAAGGTGTGCGTGGACACGGTGGAAGAAGGCTACATGACGAAGGACC
TCGCGCTCCTCGTCGGCGCCGACCAGAAGTGGCTCTCCACCACCGGCTTCCTCGACAAGATCTCCGAGAACCTCACCAAG
GCCATGGCTGCGTGA

Upstream 100 bases:

>100_bases
GCTATAGCGGCGACGCTGAAGGATTTCCCGCACGCGAGCGCAGGTCGTCCCTTCTCCGCTTTCCCTTTTGGCTCACAGAG
CAGTCCTGAAAGGCCGTCCC

Downstream 100 bases:

>100_bases
TGTCACGGCGCGGGCGGTGACGCCCGCGTTCGACTGTTCCGGAAGGGGCCGCATCGCGGCCCCTTTCTTTTTGCGCGAAT
GGACCTGCCCCAGGATCTTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATSDKVTVDAANAIKKHGVGVKCATITPDE
ARVEEFKLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTVTFVGED
GTKIEKEVYKFPGAGVALSMYNLDESIREFARASLNYGLIRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFKAEFDKR
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKG
KETSTNSIASIFAWTRGLSHRAKLDGNDELAKFAATLEKVCVDTVEEGYMTKDLALLVGADQKWLSTTGFLDKISENLTK
AMAA

Sequences:

>Translated_404_residues
MAKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATSDKVTVDAANAIKKHGVGVKCATITPDE
ARVEEFKLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTVTFVGED
GTKIEKEVYKFPGAGVALSMYNLDESIREFARASLNYGLIRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFKAEFDKR
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKG
KETSTNSIASIFAWTRGLSHRAKLDGNDELAKFAATLEKVCVDTVEEGYMTKDLALLVGADQKWLSTTGFLDKISENLTK
AMAA
>Mature_403_residues
AKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATSDKVTVDAANAIKKHGVGVKCATITPDEA
RVEEFKLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTVTFVGEDG
TKIEKEVYKFPGAGVALSMYNLDESIREFARASLNYGLIRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFKAEFDKRG
LTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKGK
ETSTNSIASIFAWTRGLSHRAKLDGNDELAKFAATLEKVCVDTVEEGYMTKDLALLVGADQKWLSTTGFLDKISENLTKA
MAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=67.6470588235294, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=65.609756097561, Blast_Score=567, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=65.8476658476659, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=67.1641791044776, Blast_Score=567, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6320137, Length=410, Percent_Identity=63.6585365853659, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=62.3471882640587, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=60.1466992665037, Blast_Score=528, Evalue=1e-151,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=64.3031784841076, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=64.3031784841076, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=64.3031784841076, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=64.3031784841076, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=64.3031784841076, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=64.3031784841076, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=64.3031784841076, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=64.3031784841076, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=64.3031784841076, Blast_Score=555, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45113; Mature: 44982

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATSDKVTVDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCEEEEEH
ANAIKKHGVGVKCATITPDEARVEEFKLKEMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTVTFVGEDGTKIEKEVYKFPGAGVALSM
CCCCCCCEEEECHHCCCCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEE
YNLDESIREFARASLNYGLIRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFKAEFDKR
EHHHHHHHHHHHHHCCCCCEECCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHC
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYREHQKGKETSTNSIASIFAWTRGLSHRAKLDGNDELAKFAATLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
CVDTVEEGYMTKDLALLVGADQKWLSTTGFLDKISENLTKAMAA
HHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVELDGDEMTRIIWQYIKDKLIHPYLDIDLEYYDLSVENRDATSDKVTVDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCEEEEEH
ANAIKKHGVGVKCATITPDEARVEEFKLKEMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYRATDFKVPGKGTLTVTFVGEDGTKIEKEVYKFPGAGVALSM
CCCCCCCEEEECHHCCCCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEE
YNLDESIREFARASLNYGLIRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFKAEFDKR
EHHHHHHHHHHHHHCCCCCEECCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHC
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGQT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYREHQKGKETSTNSIASIFAWTRGLSHRAKLDGNDELAKFAATLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
CVDTVEEGYMTKDLALLVGADQKWLSTTGFLDKISENLTKAMAA
HHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]